LeishMANIAdb
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ATP-dependent RNA helicase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-dependent RNA helicase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBM7_LEIIN
TriTrypDb:
LINF_350039100
Length:
1084

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBM7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2
GO:0003824 catalytic activity 1 3
GO:0004386 helicase activity 2 3
GO:0140640 catalytic activity, acting on a nucleic acid 2 3
GO:0140657 ATP-dependent activity 1 3
GO:0000166 nucleotide binding 3 1
GO:0005524 ATP binding 5 1
GO:0017076 purine nucleotide binding 4 1
GO:0030554 adenyl nucleotide binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032559 adenyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0097367 carbohydrate derivative binding 2 1
GO:1901265 nucleoside phosphate binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.504
CLV_C14_Caspase3-7 995 999 PF00656 0.537
CLV_NRD_NRD_1 1005 1007 PF00675 0.411
CLV_NRD_NRD_1 229 231 PF00675 0.510
CLV_NRD_NRD_1 405 407 PF00675 0.527
CLV_NRD_NRD_1 505 507 PF00675 0.447
CLV_NRD_NRD_1 533 535 PF00675 0.445
CLV_NRD_NRD_1 63 65 PF00675 0.694
CLV_NRD_NRD_1 786 788 PF00675 0.322
CLV_NRD_NRD_1 8 10 PF00675 0.619
CLV_PCSK_KEX2_1 505 507 PF00082 0.429
CLV_PCSK_KEX2_1 533 535 PF00082 0.494
CLV_PCSK_KEX2_1 62 64 PF00082 0.727
CLV_PCSK_KEX2_1 679 681 PF00082 0.456
CLV_PCSK_KEX2_1 786 788 PF00082 0.337
CLV_PCSK_KEX2_1 896 898 PF00082 0.347
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.727
CLV_PCSK_PC1ET2_1 679 681 PF00082 0.456
CLV_PCSK_PC1ET2_1 896 898 PF00082 0.347
CLV_PCSK_SKI1_1 786 790 PF00082 0.341
CLV_PCSK_SKI1_1 893 897 PF00082 0.393
CLV_PCSK_SKI1_1 926 930 PF00082 0.491
DEG_MDM2_SWIB_1 911 919 PF02201 0.422
DEG_SPOP_SBC_1 1039 1043 PF00917 0.517
DOC_CKS1_1 124 129 PF01111 0.729
DOC_CKS1_1 363 368 PF01111 0.548
DOC_CYCLIN_RxL_1 783 793 PF00134 0.449
DOC_CYCLIN_yCln2_LP_2 1048 1054 PF00134 0.636
DOC_CYCLIN_yCln2_LP_2 215 221 PF00134 0.512
DOC_MAPK_gen_1 230 240 PF00069 0.488
DOC_MAPK_gen_1 800 809 PF00069 0.362
DOC_MAPK_gen_1 893 902 PF00069 0.369
DOC_MAPK_HePTP_8 214 226 PF00069 0.444
DOC_MAPK_HePTP_8 228 240 PF00069 0.431
DOC_MAPK_MEF2A_6 217 226 PF00069 0.445
DOC_MAPK_MEF2A_6 231 240 PF00069 0.431
DOC_MAPK_MEF2A_6 630 637 PF00069 0.354
DOC_PIKK_1 1063 1071 PF02985 0.628
DOC_PP1_RVXF_1 784 791 PF00149 0.435
DOC_PP1_RVXF_1 881 888 PF00149 0.430
DOC_PP2B_LxvP_1 303 306 PF13499 0.419
DOC_PP2B_LxvP_1 548 551 PF13499 0.478
DOC_SPAK_OSR1_1 897 901 PF12202 0.368
DOC_USP7_MATH_1 103 107 PF00917 0.748
DOC_USP7_MATH_1 1030 1034 PF00917 0.705
DOC_USP7_MATH_1 120 124 PF00917 0.697
DOC_USP7_MATH_1 169 173 PF00917 0.500
DOC_USP7_MATH_1 19 23 PF00917 0.727
DOC_USP7_MATH_1 313 317 PF00917 0.478
DOC_USP7_MATH_1 35 39 PF00917 0.746
DOC_USP7_MATH_1 471 475 PF00917 0.614
DOC_USP7_MATH_1 57 61 PF00917 0.685
DOC_USP7_MATH_1 694 698 PF00917 0.371
DOC_USP7_MATH_1 75 79 PF00917 0.457
DOC_USP7_MATH_1 80 84 PF00917 0.631
DOC_USP7_MATH_1 820 824 PF00917 0.507
DOC_USP7_MATH_1 848 852 PF00917 0.421
DOC_USP7_MATH_2 594 600 PF00917 0.558
DOC_USP7_MATH_2 874 880 PF00917 0.565
DOC_USP7_UBL2_3 725 729 PF12436 0.504
DOC_WW_Pin1_4 1021 1026 PF00397 0.609
DOC_WW_Pin1_4 123 128 PF00397 0.685
DOC_WW_Pin1_4 14 19 PF00397 0.615
DOC_WW_Pin1_4 22 27 PF00397 0.619
DOC_WW_Pin1_4 254 259 PF00397 0.572
DOC_WW_Pin1_4 362 367 PF00397 0.524
DOC_WW_Pin1_4 469 474 PF00397 0.670
DOC_WW_Pin1_4 62 67 PF00397 0.692
DOC_WW_Pin1_4 818 823 PF00397 0.515
LIG_14-3-3_CanoR_1 422 431 PF00244 0.487
LIG_14-3-3_CanoR_1 737 743 PF00244 0.437
LIG_14-3-3_CanoR_1 744 753 PF00244 0.391
LIG_14-3-3_CanoR_1 849 857 PF00244 0.458
LIG_Actin_WH2_2 208 225 PF00022 0.484
LIG_Actin_WH2_2 697 715 PF00022 0.378
LIG_APCC_ABBA_1 703 708 PF00400 0.430
LIG_BRCT_BRCA1_1 1004 1008 PF00533 0.445
LIG_BRCT_BRCA1_1 131 135 PF00533 0.622
LIG_BRCT_BRCA1_1 512 516 PF00533 0.429
LIG_BRCT_BRCA1_1 619 623 PF00533 0.466
LIG_Clathr_ClatBox_1 704 708 PF01394 0.350
LIG_Clathr_ClatBox_1 833 837 PF01394 0.440
LIG_deltaCOP1_diTrp_1 1012 1018 PF00928 0.545
LIG_EH1_1 52 60 PF00400 0.701
LIG_eIF4E_1 857 863 PF01652 0.340
LIG_FHA_1 284 290 PF00498 0.395
LIG_FHA_1 299 305 PF00498 0.347
LIG_FHA_1 366 372 PF00498 0.532
LIG_FHA_1 494 500 PF00498 0.367
LIG_FHA_1 502 508 PF00498 0.410
LIG_FHA_1 622 628 PF00498 0.404
LIG_FHA_1 84 90 PF00498 0.615
LIG_FHA_1 977 983 PF00498 0.515
LIG_FHA_2 280 286 PF00498 0.364
LIG_FHA_2 392 398 PF00498 0.579
LIG_FHA_2 564 570 PF00498 0.522
LIG_FHA_2 683 689 PF00498 0.506
LIG_FHA_2 775 781 PF00498 0.432
LIG_FHA_2 964 970 PF00498 0.484
LIG_LIR_Apic_2 398 404 PF02991 0.471
LIG_LIR_Apic_2 870 874 PF02991 0.365
LIG_LIR_Gen_1 741 750 PF02991 0.378
LIG_LIR_Gen_1 774 784 PF02991 0.379
LIG_LIR_Gen_1 856 867 PF02991 0.441
LIG_LIR_LC3C_4 234 239 PF02991 0.456
LIG_LIR_Nem_3 486 490 PF02991 0.566
LIG_LIR_Nem_3 708 712 PF02991 0.350
LIG_LIR_Nem_3 741 745 PF02991 0.377
LIG_LIR_Nem_3 748 753 PF02991 0.361
LIG_LIR_Nem_3 774 779 PF02991 0.440
LIG_LIR_Nem_3 856 862 PF02991 0.422
LIG_LYPXL_S_1 865 869 PF13949 0.338
LIG_LYPXL_yS_3 866 869 PF13949 0.341
LIG_MAD2 814 822 PF02301 0.470
LIG_NBox_RRM_1 778 788 PF00076 0.453
LIG_PCNA_PIPBox_1 311 320 PF02747 0.446
LIG_PCNA_yPIPBox_3 52 64 PF02747 0.708
LIG_PCNA_yPIPBox_3 770 779 PF02747 0.449
LIG_PCNA_yPIPBox_3 954 965 PF02747 0.490
LIG_Pex14_1 1014 1018 PF04695 0.647
LIG_Pex14_2 619 623 PF04695 0.477
LIG_Pex14_2 706 710 PF04695 0.394
LIG_Pex14_2 911 915 PF04695 0.420
LIG_REV1ctd_RIR_1 355 364 PF16727 0.523
LIG_REV1ctd_RIR_1 787 796 PF16727 0.470
LIG_SH2_CRK 219 223 PF00017 0.495
LIG_SH2_CRK 664 668 PF00017 0.502
LIG_SH2_CRK 871 875 PF00017 0.374
LIG_SH2_NCK_1 243 247 PF00017 0.486
LIG_SH2_NCK_1 379 383 PF00017 0.443
LIG_SH2_PTP2 545 548 PF00017 0.416
LIG_SH2_SRC 379 382 PF00017 0.447
LIG_SH2_STAT5 1072 1075 PF00017 0.568
LIG_SH2_STAT5 185 188 PF00017 0.517
LIG_SH2_STAT5 290 293 PF00017 0.393
LIG_SH2_STAT5 317 320 PF00017 0.433
LIG_SH2_STAT5 435 438 PF00017 0.421
LIG_SH2_STAT5 545 548 PF00017 0.322
LIG_SH2_STAT5 742 745 PF00017 0.388
LIG_SH2_STAT5 857 860 PF00017 0.349
LIG_SH2_STAT5 886 889 PF00017 0.351
LIG_SH2_STAT5 921 924 PF00017 0.469
LIG_SH3_3 122 128 PF00018 0.671
LIG_SH3_3 235 241 PF00018 0.365
LIG_SH3_3 360 366 PF00018 0.522
LIG_SH3_3 367 373 PF00018 0.513
LIG_SH3_3 41 47 PF00018 0.650
LIG_SH3_3 872 878 PF00018 0.512
LIG_SUMO_SIM_anti_2 1058 1070 PF11976 0.606
LIG_SUMO_SIM_anti_2 234 240 PF11976 0.418
LIG_SUMO_SIM_par_1 342 347 PF11976 0.499
LIG_SUMO_SIM_par_1 389 394 PF11976 0.543
LIG_SUMO_SIM_par_1 631 636 PF11976 0.362
LIG_SUMO_SIM_par_1 832 837 PF11976 0.439
LIG_SUMO_SIM_par_1 872 879 PF11976 0.505
LIG_TRAF2_1 587 590 PF00917 0.506
LIG_TRAF2_1 685 688 PF00917 0.423
LIG_TYR_ITIM 740 745 PF00017 0.440
LIG_TYR_ITIM 864 869 PF00017 0.321
LIG_TYR_ITIM 884 889 PF00017 0.144
LIG_TYR_ITIM 919 924 PF00017 0.488
LIG_UBA3_1 444 450 PF00899 0.517
LIG_WRC_WIRS_1 484 489 PF05994 0.551
LIG_WRC_WIRS_1 775 780 PF05994 0.432
MOD_CDC14_SPxK_1 257 260 PF00782 0.491
MOD_CDC14_SPxK_1 65 68 PF00782 0.729
MOD_CDK_SPxK_1 254 260 PF00069 0.572
MOD_CDK_SPxK_1 469 475 PF00069 0.660
MOD_CDK_SPxK_1 62 68 PF00069 0.727
MOD_CK1_1 1017 1023 PF00069 0.650
MOD_CK1_1 1046 1052 PF00069 0.652
MOD_CK1_1 123 129 PF00069 0.660
MOD_CK1_1 22 28 PF00069 0.696
MOD_CK1_1 229 235 PF00069 0.476
MOD_CK1_1 244 250 PF00069 0.361
MOD_CK1_1 267 273 PF00069 0.477
MOD_CK1_1 30 36 PF00069 0.638
MOD_CK1_1 42 48 PF00069 0.635
MOD_CK1_1 483 489 PF00069 0.569
MOD_CK1_1 519 525 PF00069 0.475
MOD_CK1_1 617 623 PF00069 0.437
MOD_CK1_1 715 721 PF00069 0.410
MOD_CK1_1 768 774 PF00069 0.446
MOD_CK1_1 78 84 PF00069 0.667
MOD_CK1_1 821 827 PF00069 0.470
MOD_CK1_1 843 849 PF00069 0.415
MOD_CK1_1 976 982 PF00069 0.437
MOD_CK2_1 375 381 PF00069 0.388
MOD_CK2_1 391 397 PF00069 0.495
MOD_CK2_1 517 523 PF00069 0.430
MOD_CK2_1 563 569 PF00069 0.526
MOD_CK2_1 603 609 PF00069 0.428
MOD_CK2_1 682 688 PF00069 0.438
MOD_CK2_1 774 780 PF00069 0.399
MOD_CK2_1 81 87 PF00069 0.698
MOD_CK2_1 898 904 PF00069 0.445
MOD_CK2_1 963 969 PF00069 0.490
MOD_Cter_Amidation 7 10 PF01082 0.623
MOD_DYRK1A_RPxSP_1 254 258 PF00069 0.565
MOD_GlcNHglycan 1045 1048 PF01048 0.683
MOD_GlcNHglycan 105 108 PF01048 0.692
MOD_GlcNHglycan 109 112 PF01048 0.710
MOD_GlcNHglycan 171 174 PF01048 0.467
MOD_GlcNHglycan 265 269 PF01048 0.465
MOD_GlcNHglycan 329 332 PF01048 0.569
MOD_GlcNHglycan 346 349 PF01048 0.261
MOD_GlcNHglycan 35 38 PF01048 0.668
MOD_GlcNHglycan 396 400 PF01048 0.540
MOD_GlcNHglycan 426 429 PF01048 0.437
MOD_GlcNHglycan 519 522 PF01048 0.514
MOD_GlcNHglycan 670 673 PF01048 0.550
MOD_GlcNHglycan 714 717 PF01048 0.361
MOD_GlcNHglycan 762 765 PF01048 0.442
MOD_GlcNHglycan 77 81 PF01048 0.651
MOD_GlcNHglycan 828 831 PF01048 0.465
MOD_GlcNHglycan 83 86 PF01048 0.655
MOD_GlcNHglycan 850 853 PF01048 0.429
MOD_GlcNHglycan 870 874 PF01048 0.464
MOD_GlcNHglycan 92 95 PF01048 0.704
MOD_GSK3_1 1013 1020 PF00069 0.526
MOD_GSK3_1 103 110 PF00069 0.721
MOD_GSK3_1 1038 1045 PF00069 0.702
MOD_GSK3_1 20 27 PF00069 0.661
MOD_GSK3_1 279 286 PF00069 0.355
MOD_GSK3_1 344 351 PF00069 0.402
MOD_GSK3_1 35 42 PF00069 0.585
MOD_GSK3_1 391 398 PF00069 0.557
MOD_GSK3_1 519 526 PF00069 0.394
MOD_GSK3_1 617 624 PF00069 0.415
MOD_GSK3_1 712 719 PF00069 0.376
MOD_GSK3_1 76 83 PF00069 0.661
MOD_GSK3_1 816 823 PF00069 0.419
MOD_GSK3_1 92 99 PF00069 0.718
MOD_GSK3_1 993 1000 PF00069 0.512
MOD_N-GLC_1 153 158 PF02516 0.628
MOD_N-GLC_1 306 311 PF02516 0.443
MOD_N-GLC_1 47 52 PF02516 0.691
MOD_N-GLC_1 510 515 PF02516 0.547
MOD_N-GLC_1 614 619 PF02516 0.510
MOD_N-GLC_1 694 699 PF02516 0.469
MOD_N-GLC_1 75 80 PF02516 0.654
MOD_N-GLC_1 771 776 PF02516 0.380
MOD_N-GLC_1 843 848 PF02516 0.398
MOD_N-GLC_1 853 858 PF02516 0.448
MOD_N-GLC_2 643 645 PF02516 0.456
MOD_NEK2_1 1013 1018 PF00069 0.591
MOD_NEK2_1 1040 1045 PF00069 0.746
MOD_NEK2_1 333 338 PF00069 0.549
MOD_NEK2_1 415 420 PF00069 0.426
MOD_NEK2_1 424 429 PF00069 0.429
MOD_NEK2_1 453 458 PF00069 0.547
MOD_NEK2_1 501 506 PF00069 0.428
MOD_NEK2_1 516 521 PF00069 0.307
MOD_NEK2_1 575 580 PF00069 0.395
MOD_NEK2_1 619 624 PF00069 0.380
MOD_NEK2_1 712 717 PF00069 0.359
MOD_NEK2_1 808 813 PF00069 0.383
MOD_NEK2_1 887 892 PF00069 0.373
MOD_NEK2_1 898 903 PF00069 0.391
MOD_NEK2_2 153 158 PF00069 0.669
MOD_PIKK_1 1040 1046 PF00454 0.699
MOD_PIKK_1 178 184 PF00454 0.446
MOD_PIKK_1 290 296 PF00454 0.456
MOD_PKA_2 229 235 PF00069 0.487
MOD_PKA_2 327 333 PF00069 0.517
MOD_PKA_2 809 815 PF00069 0.403
MOD_PKA_2 848 854 PF00069 0.445
MOD_PKA_2 898 904 PF00069 0.448
MOD_Plk_1 153 159 PF00069 0.625
MOD_Plk_1 306 312 PF00069 0.450
MOD_Plk_1 375 381 PF00069 0.377
MOD_Plk_1 391 397 PF00069 0.460
MOD_Plk_1 409 415 PF00069 0.271
MOD_Plk_1 454 460 PF00069 0.490
MOD_Plk_1 47 53 PF00069 0.704
MOD_Plk_1 493 499 PF00069 0.391
MOD_Plk_1 617 623 PF00069 0.441
MOD_Plk_1 758 764 PF00069 0.404
MOD_Plk_1 771 777 PF00069 0.303
MOD_Plk_1 853 859 PF00069 0.444
MOD_Plk_2-3 195 201 PF00069 0.650
MOD_Plk_2-3 596 602 PF00069 0.531
MOD_Plk_4 120 126 PF00069 0.747
MOD_Plk_4 24 30 PF00069 0.581
MOD_Plk_4 267 273 PF00069 0.528
MOD_Plk_4 313 319 PF00069 0.405
MOD_Plk_4 415 421 PF00069 0.438
MOD_Plk_4 454 460 PF00069 0.490
MOD_Plk_4 480 486 PF00069 0.498
MOD_Plk_4 493 499 PF00069 0.373
MOD_Plk_4 563 569 PF00069 0.541
MOD_Plk_4 771 777 PF00069 0.353
MOD_Plk_4 821 827 PF00069 0.430
MOD_Plk_4 853 859 PF00069 0.408
MOD_ProDKin_1 1021 1027 PF00069 0.605
MOD_ProDKin_1 123 129 PF00069 0.678
MOD_ProDKin_1 14 20 PF00069 0.617
MOD_ProDKin_1 22 28 PF00069 0.620
MOD_ProDKin_1 254 260 PF00069 0.583
MOD_ProDKin_1 362 368 PF00069 0.530
MOD_ProDKin_1 469 475 PF00069 0.660
MOD_ProDKin_1 62 68 PF00069 0.694
MOD_ProDKin_1 818 824 PF00069 0.509
MOD_SUMO_for_1 941 944 PF00179 0.547
TRG_DiLeu_BaEn_1 960 965 PF01217 0.495
TRG_DiLeu_BaEn_2 492 498 PF01217 0.492
TRG_DiLeu_BaEn_4 531 537 PF01217 0.471
TRG_DiLeu_BaLyEn_6 449 454 PF01217 0.580
TRG_ENDOCYTIC_2 1072 1075 PF00928 0.596
TRG_ENDOCYTIC_2 219 222 PF00928 0.490
TRG_ENDOCYTIC_2 243 246 PF00928 0.359
TRG_ENDOCYTIC_2 545 548 PF00928 0.322
TRG_ENDOCYTIC_2 742 745 PF00928 0.363
TRG_ENDOCYTIC_2 750 753 PF00928 0.302
TRG_ENDOCYTIC_2 866 869 PF00928 0.316
TRG_ENDOCYTIC_2 886 889 PF00928 0.141
TRG_ENDOCYTIC_2 921 924 PF00928 0.452
TRG_ER_diArg_1 505 507 PF00400 0.450
TRG_ER_diArg_1 786 788 PF00400 0.435
TRG_NLS_MonoCore_2 60 65 PF00514 0.719
TRG_NLS_MonoExtC_3 61 66 PF00514 0.743
TRG_NLS_MonoExtN_4 61 66 PF00514 0.743
TRG_NLS_MonoExtN_4 893 900 PF00514 0.473
TRG_Pf-PMV_PEXEL_1 406 410 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 505 510 PF00026 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWI4 Leptomonas seymouri 73% 99%
A0A0S4JM26 Bodo saltans 27% 100%
A0A1X0P5G8 Trypanosomatidae 38% 100%
A0A3S5IQN1 Trypanosoma rangeli 36% 100%
A0A3S7X9K2 Leishmania donovani 100% 100%
A4HN04 Leishmania braziliensis 87% 100%
C9ZN47 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 20% 99%
C9ZZ06 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AFG1 Leishmania major 96% 100%
E9B6L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BCW9 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS