TP_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrapyrrole (Corrin/Porphyrin) Methylases - putative

Species:

Leishmania infantum

UniProt:

A4IBM5_LEIIN

TriTrypDb:

LINF_350038900

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

A4IBM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBM5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.611
CLV_NRD_NRD_1	284	286	PF00675	0.256
CLV_NRD_NRD_1	365	367	PF00675	0.529
CLV_NRD_NRD_1	368	370	PF00675	0.501
CLV_NRD_NRD_1	414	416	PF00675	0.540
CLV_NRD_NRD_1	417	419	PF00675	0.497
CLV_NRD_NRD_1	425	427	PF00675	0.433
CLV_NRD_NRD_1	429	431	PF00675	0.390
CLV_NRD_NRD_1	59	61	PF00675	0.709
CLV_NRD_NRD_1	67	69	PF00675	0.645
CLV_PCSK_FUR_1	366	370	PF00082	0.495
CLV_PCSK_FUR_1	430	434	PF00082	0.503
CLV_PCSK_KEX2_1	16	18	PF00082	0.611
CLV_PCSK_KEX2_1	226	228	PF00082	0.384
CLV_PCSK_KEX2_1	284	286	PF00082	0.256
CLV_PCSK_KEX2_1	363	365	PF00082	0.490
CLV_PCSK_KEX2_1	368	370	PF00082	0.532
CLV_PCSK_KEX2_1	414	416	PF00082	0.540
CLV_PCSK_KEX2_1	425	427	PF00082	0.435
CLV_PCSK_KEX2_1	432	434	PF00082	0.351
CLV_PCSK_KEX2_1	59	61	PF00082	0.651
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.384
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.486
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.492
CLV_PCSK_PC7_1	364	370	PF00082	0.497
CLV_PCSK_PC7_1	421	427	PF00082	0.539
CLV_PCSK_PC7_1	428	434	PF00082	0.488
CLV_PCSK_SKI1_1	124	128	PF00082	0.277
CLV_PCSK_SKI1_1	448	452	PF00082	0.603
CLV_PCSK_SKI1_1	89	93	PF00082	0.488
CLV_Separin_Metazoa	281	285	PF03568	0.467
DEG_APCC_DBOX_1	153	161	PF00400	0.562
DEG_APCC_DBOX_1	420	428	PF00400	0.633
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	39	43	PF00917	0.717
DEG_SPOP_SBC_1	398	402	PF00917	0.771
DOC_CYCLIN_RxL_1	124	132	PF00134	0.475
DOC_MAPK_gen_1	284	290	PF00069	0.499
DOC_MAPK_gen_1	337	345	PF00069	0.414
DOC_MAPK_gen_1	446	453	PF00069	0.477
DOC_MAPK_MEF2A_6	337	345	PF00069	0.399
DOC_MAPK_MEF2A_6	446	453	PF00069	0.577
DOC_MAPK_NFAT4_5	338	346	PF00069	0.408
DOC_PP1_RVXF_1	320	327	PF00149	0.411
DOC_USP7_MATH_1	200	204	PF00917	0.536
DOC_USP7_MATH_1	218	222	PF00917	0.516
DOC_USP7_MATH_1	37	41	PF00917	0.737
DOC_USP7_MATH_1	380	384	PF00917	0.719
DOC_USP7_MATH_1	397	401	PF00917	0.754
DOC_USP7_MATH_1	439	443	PF00917	0.597
DOC_USP7_UBL2_3	359	363	PF12436	0.545
DOC_WW_Pin1_4	172	177	PF00397	0.475
DOC_WW_Pin1_4	18	23	PF00397	0.687
DOC_WW_Pin1_4	237	242	PF00397	0.524
DOC_WW_Pin1_4	70	75	PF00397	0.608
LIG_14-3-3_CanoR_1	147	157	PF00244	0.479
LIG_14-3-3_CanoR_1	16	20	PF00244	0.628
LIG_14-3-3_CanoR_1	366	372	PF00244	0.611
LIG_Actin_WH2_1	433	450	PF00022	0.541
LIG_BIR_III_2	377	381	PF00653	0.610
LIG_BRCT_BRCA1_1	247	251	PF00533	0.487
LIG_BRCT_BRCA1_1	61	65	PF00533	0.666
LIG_FHA_1	125	131	PF00498	0.487
LIG_FHA_1	173	179	PF00498	0.475
LIG_FHA_1	303	309	PF00498	0.536
LIG_FHA_2	127	133	PF00498	0.484
LIG_FHA_2	150	156	PF00498	0.536
LIG_FHA_2	241	247	PF00498	0.577
LIG_FHA_2	368	374	PF00498	0.660
LIG_FHA_2	71	77	PF00498	0.573
LIG_FHA_2	83	89	PF00498	0.504
LIG_IRF3_LxIS_1	205	212	PF10401	0.532
LIG_LIR_Nem_3	248	254	PF02991	0.536
LIG_LIR_Nem_3	274	278	PF02991	0.539
LIG_LIR_Nem_3	64	70	PF02991	0.655
LIG_MAD2	264	272	PF02301	0.579
LIG_MLH1_MIPbox_1	247	251	PF16413	0.487
LIG_NRBOX	156	162	PF00104	0.487
LIG_Pex14_2	275	279	PF04695	0.562
LIG_Pex14_2	61	65	PF04695	0.707
LIG_RPA_C_Fungi	450	462	PF08784	0.447
LIG_SH2_CRK	67	71	PF00017	0.651
LIG_SH2_STAT3	327	330	PF00017	0.456
LIG_SH2_STAT5	118	121	PF00017	0.328
LIG_SH2_STAT5	303	306	PF00017	0.448
LIG_SH2_STAT5	327	330	PF00017	0.542
LIG_SH3_3	131	137	PF00018	0.448
LIG_SH3_3	16	22	PF00018	0.662
LIG_SH3_3	92	98	PF00018	0.317
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.343
LIG_TRAF2_1	410	413	PF00917	0.641
LIG_TRAF2_1	442	445	PF00917	0.565
MOD_CK1_1	18	24	PF00069	0.687
MOD_CK1_1	212	218	PF00069	0.360
MOD_CK1_1	240	246	PF00069	0.448
MOD_CK1_1	40	46	PF00069	0.629
MOD_CK1_1	400	406	PF00069	0.702
MOD_CK2_1	149	155	PF00069	0.448
MOD_CK2_1	214	220	PF00069	0.328
MOD_CK2_1	381	387	PF00069	0.705
MOD_CK2_1	398	404	PF00069	0.780
MOD_CK2_1	439	445	PF00069	0.577
MOD_GlcNHglycan	172	175	PF01048	0.328
MOD_GlcNHglycan	191	194	PF01048	0.145
MOD_GlcNHglycan	202	205	PF01048	0.342
MOD_GlcNHglycan	206	209	PF01048	0.332
MOD_GlcNHglycan	211	214	PF01048	0.267
MOD_GlcNHglycan	216	219	PF01048	0.145
MOD_GlcNHglycan	220	223	PF01048	0.145
MOD_GlcNHglycan	23	26	PF01048	0.706
MOD_GlcNHglycan	387	390	PF01048	0.800
MOD_GlcNHglycan	4	7	PF01048	0.690
MOD_GlcNHglycan	54	57	PF01048	0.648
MOD_GlcNHglycan	61	64	PF01048	0.627
MOD_GSK3_1	168	175	PF00069	0.448
MOD_GSK3_1	200	207	PF00069	0.407
MOD_GSK3_1	209	216	PF00069	0.260
MOD_GSK3_1	302	309	PF00069	0.409
MOD_GSK3_1	381	388	PF00069	0.759
MOD_GSK3_1	398	405	PF00069	0.690
MOD_N-GLC_1	148	153	PF02516	0.343
MOD_N-GLC_1	311	316	PF02516	0.343
MOD_NEK2_1	15	20	PF00069	0.608
MOD_NEK2_1	169	174	PF00069	0.340
MOD_NEK2_1	189	194	PF00069	0.395
MOD_NEK2_1	2	7	PF00069	0.623
MOD_NEK2_1	209	214	PF00069	0.362
MOD_NEK2_1	311	316	PF00069	0.362
MOD_NEK2_1	367	372	PF00069	0.587
MOD_NEK2_1	54	59	PF00069	0.582
MOD_NEK2_1	61	66	PF00069	0.540
MOD_PIKK_1	24	30	PF00454	0.703
MOD_PKA_1	59	65	PF00069	0.644
MOD_PKA_2	149	155	PF00069	0.439
MOD_PKA_2	15	21	PF00069	0.690
MOD_PKA_2	194	200	PF00069	0.362
MOD_PKA_2	367	373	PF00069	0.587
MOD_PKA_2	392	398	PF00069	0.767
MOD_PKA_2	59	65	PF00069	0.610
MOD_Plk_1	103	109	PF00069	0.328
MOD_Plk_1	311	317	PF00069	0.343
MOD_Plk_1	403	409	PF00069	0.633
MOD_Plk_1	456	462	PF00069	0.662
MOD_Plk_4	126	132	PF00069	0.342
MOD_Plk_4	245	251	PF00069	0.343
MOD_Plk_4	292	298	PF00069	0.441
MOD_Plk_4	40	46	PF00069	0.662
MOD_ProDKin_1	172	178	PF00069	0.328
MOD_ProDKin_1	18	24	PF00069	0.689
MOD_ProDKin_1	237	243	PF00069	0.396
MOD_ProDKin_1	70	76	PF00069	0.607
MOD_SUMO_for_1	410	413	PF00179	0.613
TRG_DiLeu_BaEn_1	331	336	PF01217	0.464
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.343
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.531
TRG_ENDOCYTIC_2	67	70	PF00928	0.647
TRG_ER_diArg_1	15	17	PF00400	0.609
TRG_ER_diArg_1	262	265	PF00400	0.328
TRG_ER_diArg_1	283	285	PF00400	0.301
TRG_ER_diArg_1	364	366	PF00400	0.490
TRG_ER_diArg_1	367	369	PF00400	0.517
TRG_ER_diArg_1	424	426	PF00400	0.490
TRG_ER_diArg_1	427	430	PF00400	0.461
TRG_ER_diArg_1	446	449	PF00400	0.325
TRG_ER_diArg_1	59	61	PF00400	0.650
TRG_NLS_MonoCore_2	362	367	PF00514	0.614
TRG_NLS_MonoExtC_3	417	423	PF00514	0.615
TRG_NLS_MonoExtN_4	415	422	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G3	Leptomonas seymouri	67%	100%
A0A0S4IXW1	Bodo saltans	43%	100%
A0A1X0P5K8	Trypanosomatidae	56%	100%
A0A3R7N6Y9	Trypanosoma rangeli	55%	100%
A0A3S7X9K0	Leishmania donovani	100%	100%
A4HN02	Leishmania braziliensis	84%	100%
C9ZZ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AFF9	Leishmania major	96%	100%
E9B6L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BY28	Trypanosoma cruzi	57%	100%