WD domain, G-beta repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4IBM0_LEIIN

TriTrypDb:

LINF_350038400

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.762
CLV_NRD_NRD_1	302	304	PF00675	0.497
CLV_NRD_NRD_1	345	347	PF00675	0.552
CLV_NRD_NRD_1	385	387	PF00675	0.414
CLV_NRD_NRD_1	462	464	PF00675	0.574
CLV_NRD_NRD_1	485	487	PF00675	0.655
CLV_NRD_NRD_1	529	531	PF00675	0.572
CLV_PCSK_FUR_1	176	180	PF00082	0.768
CLV_PCSK_KEX2_1	178	180	PF00082	0.766
CLV_PCSK_KEX2_1	301	303	PF00082	0.505
CLV_PCSK_KEX2_1	384	386	PF00082	0.490
CLV_PCSK_KEX2_1	462	464	PF00082	0.574
CLV_PCSK_KEX2_1	485	487	PF00082	0.775
CLV_PCSK_KEX2_1	531	533	PF00082	0.571
CLV_PCSK_KEX2_1	584	586	PF00082	0.824
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.520
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.498
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.824
CLV_PCSK_PC7_1	381	387	PF00082	0.510
CLV_PCSK_SKI1_1	114	118	PF00082	0.446
CLV_PCSK_SKI1_1	292	296	PF00082	0.588
CLV_PCSK_SKI1_1	356	360	PF00082	0.719
CLV_PCSK_SKI1_1	385	389	PF00082	0.421
CLV_PCSK_SKI1_1	432	436	PF00082	0.401
CLV_PCSK_SKI1_1	463	467	PF00082	0.587
CLV_PCSK_SKI1_1	487	491	PF00082	0.775
CLV_PCSK_SKI1_1	532	536	PF00082	0.531
DEG_SPOP_SBC_1	574	578	PF00917	0.832
DOC_CKS1_1	235	240	PF01111	0.485
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.479
DOC_MAPK_MEF2A_6	421	430	PF00069	0.494
DOC_MAPK_NFAT4_5	421	429	PF00069	0.597
DOC_PP1_RVXF_1	430	437	PF00149	0.466
DOC_PP2B_LxvP_1	82	85	PF13499	0.771
DOC_USP7_MATH_1	163	167	PF00917	0.773
DOC_USP7_MATH_1	231	235	PF00917	0.500
DOC_USP7_MATH_1	334	338	PF00917	0.665
DOC_USP7_MATH_1	36	40	PF00917	0.552
DOC_USP7_MATH_1	396	400	PF00917	0.688
DOC_USP7_MATH_1	574	578	PF00917	0.832
DOC_USP7_MATH_1	590	594	PF00917	0.601
DOC_USP7_MATH_1	7	11	PF00917	0.604
DOC_USP7_MATH_1	75	79	PF00917	0.691
DOC_USP7_UBL2_3	466	470	PF12436	0.754
DOC_USP7_UBL2_3	627	631	PF12436	0.660
DOC_WW_Pin1_4	153	158	PF00397	0.593
DOC_WW_Pin1_4	234	239	PF00397	0.489
DOC_WW_Pin1_4	322	327	PF00397	0.600
DOC_WW_Pin1_4	390	395	PF00397	0.571
DOC_WW_Pin1_4	487	492	PF00397	0.773
DOC_WW_Pin1_4	500	505	PF00397	0.700
DOC_WW_Pin1_4	508	513	PF00397	0.588
DOC_WW_Pin1_4	553	558	PF00397	0.733
LIG_14-3-3_CanoR_1	143	153	PF00244	0.505
LIG_14-3-3_CanoR_1	203	211	PF00244	0.583
LIG_14-3-3_CanoR_1	292	298	PF00244	0.540
LIG_14-3-3_CanoR_1	385	394	PF00244	0.545
LIG_14-3-3_CanoR_1	591	599	PF00244	0.606
LIG_Actin_WH2_2	417	433	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	455	459	PF00533	0.579
LIG_FHA_1	235	241	PF00498	0.575
LIG_FHA_1	246	252	PF00498	0.455
LIG_FHA_1	409	415	PF00498	0.423
LIG_FHA_1	48	54	PF00498	0.522
LIG_FHA_1	505	511	PF00498	0.640
LIG_FHA_1	618	624	PF00498	0.551
LIG_FHA_2	116	122	PF00498	0.448
LIG_Integrin_isoDGR_2	569	571	PF01839	0.760
LIG_LIR_Apic_2	227	231	PF02991	0.571
LIG_LIR_Gen_1	6	15	PF02991	0.508
LIG_LIR_LC3C_4	106	109	PF02991	0.677
LIG_LIR_LC3C_4	237	242	PF02991	0.568
LIG_LIR_Nem_3	325	331	PF02991	0.633
LIG_LIR_Nem_3	6	11	PF02991	0.522
LIG_SH2_CRK	15	19	PF00017	0.461
LIG_SH2_PTP2	228	231	PF00017	0.575
LIG_SH2_PTP2	328	331	PF00017	0.597
LIG_SH2_SRC	404	407	PF00017	0.588
LIG_SH2_STAT3	133	136	PF00017	0.489
LIG_SH2_STAT3	215	218	PF00017	0.384
LIG_SH2_STAT5	200	203	PF00017	0.475
LIG_SH2_STAT5	228	231	PF00017	0.575
LIG_SH2_STAT5	328	331	PF00017	0.674
LIG_SH2_STAT5	404	407	PF00017	0.588
LIG_SH2_STAT5	526	529	PF00017	0.565
LIG_SH2_STAT5	604	607	PF00017	0.476
LIG_SH3_3	124	130	PF00018	0.429
LIG_SH3_3	280	286	PF00018	0.650
LIG_SH3_3	320	326	PF00018	0.515
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.554
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.574
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.603
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.609
LIG_SUMO_SIM_anti_2	620	629	PF11976	0.699
LIG_TRAF2_1	312	315	PF00917	0.651
LIG_UBA3_1	426	432	PF00899	0.445
LIG_UBA3_1	471	479	PF00899	0.667
LIG_WRC_WIRS_1	294	299	PF05994	0.465
LIG_WRC_WIRS_1	564	569	PF05994	0.746
LIG_WRC_WIRS_1	8	13	PF05994	0.651
MOD_CDK_SPxK_1	489	495	PF00069	0.732
MOD_CK1_1	234	240	PF00069	0.586
MOD_CK1_1	551	557	PF00069	0.665
MOD_CK1_1	583	589	PF00069	0.730
MOD_CK1_1	597	603	PF00069	0.610
MOD_CK1_1	74	80	PF00069	0.666
MOD_CK2_1	115	121	PF00069	0.487
MOD_CK2_1	163	169	PF00069	0.707
MOD_CK2_1	279	285	PF00069	0.560
MOD_CK2_1	470	476	PF00069	0.575
MOD_CK2_1	500	506	PF00069	0.752
MOD_CK2_1	508	514	PF00069	0.591
MOD_CK2_1	574	580	PF00069	0.719
MOD_GlcNHglycan	28	32	PF01048	0.545
MOD_GlcNHglycan	336	339	PF01048	0.614
MOD_GlcNHglycan	353	356	PF01048	0.597
MOD_GlcNHglycan	39	42	PF01048	0.447
MOD_GlcNHglycan	406	409	PF01048	0.501
MOD_GlcNHglycan	453	456	PF01048	0.653
MOD_GlcNHglycan	5	8	PF01048	0.556
MOD_GlcNHglycan	550	553	PF01048	0.625
MOD_GlcNHglycan	585	588	PF01048	0.751
MOD_GlcNHglycan	594	597	PF01048	0.666
MOD_GlcNHglycan	599	602	PF01048	0.565
MOD_GlcNHglycan	628	631	PF01048	0.761
MOD_GlcNHglycan	73	76	PF01048	0.746
MOD_GlcNHglycan	77	80	PF01048	0.714
MOD_GSK3_1	202	209	PF00069	0.528
MOD_GSK3_1	229	236	PF00069	0.579
MOD_GSK3_1	3	10	PF00069	0.583
MOD_GSK3_1	390	397	PF00069	0.569
MOD_GSK3_1	400	407	PF00069	0.487
MOD_GSK3_1	447	454	PF00069	0.657
MOD_GSK3_1	487	494	PF00069	0.777
MOD_GSK3_1	500	507	PF00069	0.629
MOD_GSK3_1	576	583	PF00069	0.712
MOD_GSK3_1	590	597	PF00069	0.772
MOD_GSK3_1	71	78	PF00069	0.655
MOD_N-GLC_1	163	168	PF02516	0.699
MOD_N-GLC_1	18	23	PF02516	0.471
MOD_N-GLC_2	444	446	PF02516	0.486
MOD_NEK2_1	202	207	PF00069	0.472
MOD_NEK2_1	233	238	PF00069	0.606
MOD_NEK2_1	416	421	PF00069	0.583
MOD_NEK2_1	451	456	PF00069	0.629
MOD_NEK2_1	505	510	PF00069	0.698
MOD_NEK2_1	625	630	PF00069	0.672
MOD_NEK2_1	71	76	PF00069	0.689
MOD_NEK2_2	192	197	PF00069	0.454
MOD_NEK2_2	447	452	PF00069	0.555
MOD_NEK2_2	7	12	PF00069	0.655
MOD_PIKK_1	453	459	PF00454	0.697
MOD_PIKK_1	47	53	PF00454	0.562
MOD_PK_1	134	140	PF00069	0.511
MOD_PKA_1	178	184	PF00069	0.665
MOD_PKA_1	385	391	PF00069	0.440
MOD_PKA_2	178	184	PF00069	0.700
MOD_PKA_2	202	208	PF00069	0.577
MOD_PKA_2	385	391	PF00069	0.485
MOD_PKA_2	590	596	PF00069	0.712
MOD_PKB_1	176	184	PF00069	0.710
MOD_Plk_1	18	24	PF00069	0.467
MOD_Plk_1	368	374	PF00069	0.622
MOD_Plk_1	505	511	PF00069	0.621
MOD_Plk_2-3	279	285	PF00069	0.662
MOD_Plk_4	224	230	PF00069	0.490
MOD_Plk_4	293	299	PF00069	0.584
MOD_Plk_4	400	406	PF00069	0.631
MOD_ProDKin_1	153	159	PF00069	0.600
MOD_ProDKin_1	234	240	PF00069	0.484
MOD_ProDKin_1	322	328	PF00069	0.598
MOD_ProDKin_1	390	396	PF00069	0.577
MOD_ProDKin_1	487	493	PF00069	0.772
MOD_ProDKin_1	500	506	PF00069	0.695
MOD_ProDKin_1	508	514	PF00069	0.576
MOD_ProDKin_1	553	559	PF00069	0.737
TRG_DiLeu_BaEn_1	423	428	PF01217	0.588
TRG_DiLeu_BaEn_1	621	626	PF01217	0.684
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.485
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.483
TRG_ENDOCYTIC_2	15	18	PF00928	0.546
TRG_ENDOCYTIC_2	328	331	PF00928	0.635
TRG_ENDOCYTIC_2	604	607	PF00928	0.418
TRG_ER_diArg_1	177	179	PF00400	0.766
TRG_ER_diArg_1	301	303	PF00400	0.484
TRG_ER_diArg_1	385	387	PF00400	0.433
TRG_ER_diArg_1	53	56	PF00400	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD2	Leptomonas seymouri	45%	100%
A0A3Q8IJ91	Leishmania donovani	99%	100%
A4HMZ7	Leishmania braziliensis	71%	100%
E9AFF4	Leishmania major	90%	100%
E9B6K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%