Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF-hand domain pair - putative

Species:

Leishmania infantum

UniProt:

A4IBL2_LEIIN

TriTrypDb:

LINF_350037500

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4IBL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBL2

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0019208	phosphatase regulator activity	3	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.347
CLV_C14_Caspase3-7	567	571	PF00656	0.485
CLV_NRD_NRD_1	358	360	PF00675	0.236
CLV_NRD_NRD_1	596	598	PF00675	0.547
CLV_PCSK_KEX2_1	267	269	PF00082	0.526
CLV_PCSK_KEX2_1	358	360	PF00082	0.236
CLV_PCSK_KEX2_1	495	497	PF00082	0.251
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.560
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.251
CLV_PCSK_PC7_1	263	269	PF00082	0.320
CLV_PCSK_SKI1_1	254	258	PF00082	0.496
CLV_PCSK_SKI1_1	308	312	PF00082	0.300
CLV_PCSK_SKI1_1	317	321	PF00082	0.239
CLV_PCSK_SKI1_1	34	38	PF00082	0.565
CLV_PCSK_SKI1_1	39	43	PF00082	0.560
CLV_PCSK_SKI1_1	472	476	PF00082	0.381
CLV_PCSK_SKI1_1	624	628	PF00082	0.310
DEG_APCC_DBOX_1	33	41	PF00400	0.476
DOC_CKS1_1	165	170	PF01111	0.707
DOC_CYCLIN_RxL_1	561	571	PF00134	0.412
DOC_CYCLIN_RxL_1	621	632	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.575
DOC_MAPK_gen_1	267	275	PF00069	0.502
DOC_MAPK_gen_1	369	375	PF00069	0.492
DOC_MAPK_gen_1	595	603	PF00069	0.450
DOC_MAPK_MEF2A_6	268	277	PF00069	0.374
DOC_PP1_RVXF_1	421	427	PF00149	0.426
DOC_PP1_RVXF_1	562	569	PF00149	0.400
DOC_PP1_RVXF_1	622	629	PF00149	0.440
DOC_PP2B_LxvP_1	217	220	PF13499	0.582
DOC_PP4_FxxP_1	310	313	PF00568	0.259
DOC_USP7_MATH_1	116	120	PF00917	0.689
DOC_USP7_MATH_1	211	215	PF00917	0.569
DOC_USP7_MATH_1	231	235	PF00917	0.737
DOC_USP7_MATH_1	325	329	PF00917	0.327
DOC_USP7_MATH_1	504	508	PF00917	0.251
DOC_USP7_MATH_1	85	89	PF00917	0.727
DOC_WW_Pin1_4	107	112	PF00397	0.624
DOC_WW_Pin1_4	129	134	PF00397	0.633
DOC_WW_Pin1_4	138	143	PF00397	0.573
DOC_WW_Pin1_4	160	165	PF00397	0.580
DOC_WW_Pin1_4	167	172	PF00397	0.564
DOC_WW_Pin1_4	189	194	PF00397	0.627
DOC_WW_Pin1_4	198	203	PF00397	0.612
DOC_WW_Pin1_4	245	250	PF00397	0.536
DOC_WW_Pin1_4	568	573	PF00397	0.464
DOC_WW_Pin1_4	608	613	PF00397	0.314
LIG_14-3-3_CanoR_1	237	247	PF00244	0.515
LIG_14-3-3_CanoR_1	39	44	PF00244	0.650
LIG_14-3-3_CanoR_1	503	510	PF00244	0.270
LIG_14-3-3_CanoR_1	86	90	PF00244	0.720
LIG_AP2alpha_2	632	634	PF02296	0.364
LIG_APCC_ABBA_1	299	304	PF00400	0.471
LIG_APCC_ABBAyCdc20_2	317	323	PF00400	0.419
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	241	245	PF00533	0.496
LIG_BRCT_BRCA1_1	306	310	PF00533	0.410
LIG_Clathr_ClatBox_1	475	479	PF01394	0.270
LIG_deltaCOP1_diTrp_1	647	651	PF00928	0.296
LIG_FHA_1	19	25	PF00498	0.545
LIG_FHA_1	216	222	PF00498	0.595
LIG_FHA_1	234	240	PF00498	0.565
LIG_FHA_1	296	302	PF00498	0.385
LIG_FHA_1	40	46	PF00498	0.610
LIG_FHA_1	405	411	PF00498	0.401
LIG_FHA_1	489	495	PF00498	0.331
LIG_FHA_2	125	131	PF00498	0.502
LIG_FHA_2	255	261	PF00498	0.416
LIG_FHA_2	372	378	PF00498	0.425
LIG_FHA_2	468	474	PF00498	0.251
LIG_FHA_2	541	547	PF00498	0.381
LIG_FHA_2	600	606	PF00498	0.306
LIG_FHA_2	644	650	PF00498	0.316
LIG_FXI_DFP_1	426	430	PF00024	0.243
LIG_GBD_Chelix_1	408	416	PF00786	0.201
LIG_HCF-1_HBM_1	456	459	PF13415	0.247
LIG_LIR_Apic_2	307	313	PF02991	0.270
LIG_LIR_Apic_2	499	504	PF02991	0.381
LIG_LIR_Gen_1	345	354	PF02991	0.342
LIG_LIR_Gen_1	371	378	PF02991	0.427
LIG_LIR_Gen_1	402	413	PF02991	0.505
LIG_LIR_Gen_1	454	462	PF02991	0.236
LIG_LIR_Gen_1	514	523	PF02991	0.236
LIG_LIR_Gen_1	550	558	PF02991	0.289
LIG_LIR_Gen_1	623	633	PF02991	0.367
LIG_LIR_Gen_1	646	656	PF02991	0.298
LIG_LIR_Nem_3	318	324	PF02991	0.270
LIG_LIR_Nem_3	345	350	PF02991	0.319
LIG_LIR_Nem_3	371	375	PF02991	0.427
LIG_LIR_Nem_3	399	403	PF02991	0.412
LIG_LIR_Nem_3	451	455	PF02991	0.263
LIG_LIR_Nem_3	456	462	PF02991	0.224
LIG_LIR_Nem_3	514	518	PF02991	0.236
LIG_LIR_Nem_3	623	628	PF02991	0.340
LIG_LIR_Nem_3	646	651	PF02991	0.300
LIG_MAD2	496	504	PF02301	0.251
LIG_NRBOX	284	290	PF00104	0.487
LIG_PALB2_WD40_1	533	541	PF16756	0.236
LIG_Pex14_2	616	620	PF04695	0.245
LIG_PTAP_UEV_1	178	183	PF05743	0.622
LIG_PTB_Apo_2	345	352	PF02174	0.310
LIG_PTB_Apo_2	614	621	PF02174	0.265
LIG_PTB_Phospho_1	345	351	PF10480	0.315
LIG_SH2_CRK	351	355	PF00017	0.370
LIG_SH2_CRK	501	505	PF00017	0.381
LIG_SH2_GRB2like	20	23	PF00017	0.431
LIG_SH2_NCK_1	347	351	PF00017	0.336
LIG_SH2_STAP1	20	24	PF00017	0.509
LIG_SH2_STAP1	455	459	PF00017	0.246
LIG_SH2_STAP1	578	582	PF00017	0.383
LIG_SH2_STAP1	656	660	PF00017	0.305
LIG_SH2_STAT5	20	23	PF00017	0.469
LIG_SH2_STAT5	384	387	PF00017	0.414
LIG_SH2_STAT5	452	455	PF00017	0.244
LIG_SH2_STAT5	459	462	PF00017	0.236
LIG_SH2_STAT5	520	523	PF00017	0.236
LIG_SH3_2	113	118	PF14604	0.649
LIG_SH3_3	110	116	PF00018	0.577
LIG_SH3_3	132	138	PF00018	0.684
LIG_SH3_3	162	168	PF00018	0.637
LIG_SH3_3	176	182	PF00018	0.479
LIG_SH3_3	244	250	PF00018	0.513
LIG_SH3_3	347	353	PF00018	0.324
LIG_SUMO_SIM_par_1	352	357	PF11976	0.404
LIG_SUMO_SIM_par_1	39	44	PF11976	0.580
LIG_TYR_ITAM	348	364	PF00017	0.297
LIG_TYR_ITSM	343	350	PF00017	0.380
LIG_UBA3_1	438	444	PF00899	0.505
MOD_CDK_SPK_2	198	203	PF00069	0.697
MOD_CDK_SPxxK_3	111	118	PF00069	0.668
MOD_CDK_SPxxK_3	167	174	PF00069	0.699
MOD_CK1_1	119	125	PF00069	0.791
MOD_CK1_1	198	204	PF00069	0.623
MOD_CK1_1	225	231	PF00069	0.597
MOD_CK1_1	488	494	PF00069	0.336
MOD_CK1_1	59	65	PF00069	0.663
MOD_CK1_1	608	614	PF00069	0.431
MOD_CK2_1	22	28	PF00069	0.477
MOD_CK2_1	227	233	PF00069	0.645
MOD_CK2_1	263	269	PF00069	0.408
MOD_CK2_1	373	379	PF00069	0.462
MOD_CK2_1	547	553	PF00069	0.236
MOD_DYRK1A_RPxSP_1	107	111	PF00069	0.573
MOD_DYRK1A_RPxSP_1	160	164	PF00069	0.578
MOD_GlcNHglycan	1	4	PF01048	0.653
MOD_GlcNHglycan	121	124	PF01048	0.730
MOD_GlcNHglycan	178	182	PF01048	0.595
MOD_GlcNHglycan	187	190	PF01048	0.572
MOD_GlcNHglycan	213	216	PF01048	0.558
MOD_GlcNHglycan	229	232	PF01048	0.519
MOD_GlcNHglycan	241	244	PF01048	0.429
MOD_GlcNHglycan	327	330	PF01048	0.343
MOD_GlcNHglycan	506	509	PF01048	0.246
MOD_GlcNHglycan	549	552	PF01048	0.249
MOD_GlcNHglycan	97	100	PF01048	0.682
MOD_GSK3_1	107	114	PF00069	0.627
MOD_GSK3_1	136	143	PF00069	0.610
MOD_GSK3_1	160	167	PF00069	0.594
MOD_GSK3_1	18	25	PF00069	0.455
MOD_GSK3_1	185	192	PF00069	0.635
MOD_GSK3_1	211	218	PF00069	0.602
MOD_GSK3_1	221	228	PF00069	0.553
MOD_GSK3_1	241	248	PF00069	0.577
MOD_GSK3_1	263	270	PF00069	0.446
MOD_GSK3_1	39	46	PF00069	0.654
MOD_N-GLC_1	119	124	PF02516	0.555
MOD_N-GLC_1	620	625	PF02516	0.357
MOD_NEK2_1	204	209	PF00069	0.595
MOD_NEK2_1	221	226	PF00069	0.475
MOD_NEK2_1	227	232	PF00069	0.563
MOD_NEK2_1	238	243	PF00069	0.440
MOD_NEK2_1	354	359	PF00069	0.387
MOD_NEK2_1	363	368	PF00069	0.476
MOD_NEK2_1	41	46	PF00069	0.554
MOD_NEK2_1	620	625	PF00069	0.334
MOD_NEK2_1	94	99	PF00069	0.644
MOD_PIKK_1	6	12	PF00454	0.440
MOD_PKA_1	267	273	PF00069	0.464
MOD_PKA_2	231	237	PF00069	0.618
MOD_PKA_2	267	273	PF00069	0.458
MOD_PKA_2	85	91	PF00069	0.733
MOD_Plk_1	204	210	PF00069	0.568
MOD_Plk_1	215	221	PF00069	0.545
MOD_Plk_1	283	289	PF00069	0.363
MOD_Plk_1	578	584	PF00069	0.361
MOD_Plk_2-3	371	377	PF00069	0.443
MOD_Plk_2-3	451	457	PF00069	0.354
MOD_Plk_2-3	467	473	PF00069	0.160
MOD_Plk_4	140	146	PF00069	0.572
MOD_Plk_4	295	301	PF00069	0.505
MOD_Plk_4	485	491	PF00069	0.265
MOD_ProDKin_1	107	113	PF00069	0.624
MOD_ProDKin_1	129	135	PF00069	0.633
MOD_ProDKin_1	138	144	PF00069	0.572
MOD_ProDKin_1	160	166	PF00069	0.565
MOD_ProDKin_1	167	173	PF00069	0.561
MOD_ProDKin_1	189	195	PF00069	0.625
MOD_ProDKin_1	198	204	PF00069	0.611
MOD_ProDKin_1	245	251	PF00069	0.537
MOD_ProDKin_1	568	574	PF00069	0.460
MOD_ProDKin_1	608	614	PF00069	0.310
MOD_SUMO_for_1	368	371	PF00179	0.452
MOD_SUMO_rev_2	436	446	PF00179	0.412
MOD_SUMO_rev_2	524	530	PF00179	0.295
TRG_DiLeu_BaEn_1	284	289	PF01217	0.477
TRG_DiLeu_BaEn_4	280	286	PF01217	0.486
TRG_DiLeu_LyEn_5	284	289	PF01217	0.477
TRG_ENDOCYTIC_2	347	350	PF00928	0.331
TRG_ENDOCYTIC_2	351	354	PF00928	0.307
TRG_ENDOCYTIC_2	361	364	PF00928	0.412
TRG_ENDOCYTIC_2	455	458	PF00928	0.246
TRG_ENDOCYTIC_2	462	465	PF00928	0.236
TRG_ENDOCYTIC_2	520	523	PF00928	0.236
TRG_ENDOCYTIC_2	552	555	PF00928	0.340
TRG_ENDOCYTIC_2	656	659	PF00928	0.306
TRG_ER_diArg_1	358	360	PF00400	0.236
TRG_ER_diArg_1	639	642	PF00400	0.526
TRG_NES_CRM1_1	304	318	PF08389	0.336
TRG_NES_CRM1_1	31	47	PF08389	0.560
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Z7	Leptomonas seymouri	77%	100%
A0A0S4JHD9	Bodo saltans	41%	90%
A0A1X0P683	Trypanosomatidae	50%	100%
A0A3R7MAB5	Trypanosoma rangeli	52%	99%
A0A3S7X9I6	Leishmania donovani	100%	100%
A4HMY8	Leishmania braziliensis	84%	98%
C9ZZ28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9AFE5	Leishmania major	96%	100%
E9B6K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q5QIT3	Arabidopsis thaliana	34%	100%
Q8VZQ4	Arabidopsis thaliana	34%	100%
Q9SLI8	Arabidopsis thaliana	33%	100%
Q9XGR4	Arabidopsis thaliana	35%	100%
Q9Y5P8	Homo sapiens	30%	100%
V5BY37	Trypanosoma cruzi	51%	99%