Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein - putative

Species:

Leishmania infantum

UniProt:

A4IBL1_LEIIN

TriTrypDb:

LINF_350037400

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 578

Expansion

Sequence features

A4IBL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBL1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.531
CLV_C14_Caspase3-7	624	628	PF00656	0.658
CLV_NRD_NRD_1	120	122	PF00675	0.554
CLV_NRD_NRD_1	287	289	PF00675	0.581
CLV_NRD_NRD_1	350	352	PF00675	0.351
CLV_NRD_NRD_1	362	364	PF00675	0.260
CLV_NRD_NRD_1	391	393	PF00675	0.561
CLV_NRD_NRD_1	46	48	PF00675	0.574
CLV_NRD_NRD_1	60	62	PF00675	0.367
CLV_PCSK_KEX2_1	349	351	PF00082	0.349
CLV_PCSK_KEX2_1	391	393	PF00082	0.561
CLV_PCSK_KEX2_1	46	48	PF00082	0.574
CLV_PCSK_KEX2_1	571	573	PF00082	0.788
CLV_PCSK_KEX2_1	69	71	PF00082	0.512
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.651
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.450
CLV_PCSK_SKI1_1	106	110	PF00082	0.629
CLV_PCSK_SKI1_1	27	31	PF00082	0.551
CLV_PCSK_SKI1_1	350	354	PF00082	0.351
CLV_PCSK_SKI1_1	363	367	PF00082	0.253
CLV_PCSK_SKI1_1	61	65	PF00082	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.611
DEG_SPOP_SBC_1	491	495	PF00917	0.566
DOC_CDC14_PxL_1	276	284	PF14671	0.610
DOC_CDC14_PxL_1	619	627	PF14671	0.556
DOC_CYCLIN_RxL_1	58	65	PF00134	0.517
DOC_CYCLIN_yClb1_LxF_4	48	53	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	677	683	PF00134	0.702
DOC_MAPK_gen_1	349	356	PF00069	0.549
DOC_MAPK_gen_1	371	380	PF00069	0.551
DOC_MAPK_gen_1	46	53	PF00069	0.586
DOC_MAPK_JIP1_4	47	53	PF00069	0.534
DOC_MAPK_MEF2A_6	271	279	PF00069	0.589
DOC_MAPK_MEF2A_6	374	382	PF00069	0.551
DOC_PP1_RVXF_1	48	54	PF00149	0.535
DOC_PP2B_LxvP_1	20	23	PF13499	0.573
DOC_PP2B_LxvP_1	677	680	PF13499	0.702
DOC_PP2B_LxvP_1	697	700	PF13499	0.650
DOC_PP4_FxxP_1	329	332	PF00568	0.576
DOC_PP4_FxxP_1	631	634	PF00568	0.633
DOC_PP4_FxxP_1	692	695	PF00568	0.646
DOC_PP4_MxPP_1	691	694	PF00568	0.702
DOC_USP7_MATH_1	131	135	PF00917	0.690
DOC_USP7_MATH_1	150	154	PF00917	0.666
DOC_USP7_MATH_1	191	195	PF00917	0.535
DOC_USP7_MATH_1	278	282	PF00917	0.646
DOC_USP7_MATH_1	334	338	PF00917	0.566
DOC_USP7_MATH_1	405	409	PF00917	0.667
DOC_USP7_MATH_1	417	421	PF00917	0.693
DOC_USP7_MATH_1	423	427	PF00917	0.638
DOC_USP7_MATH_1	516	520	PF00917	0.638
DOC_USP7_MATH_1	543	547	PF00917	0.696
DOC_USP7_MATH_1	562	566	PF00917	0.517
DOC_USP7_MATH_1	579	583	PF00917	0.643
DOC_USP7_MATH_1	658	662	PF00917	0.770
DOC_USP7_MATH_1	668	672	PF00917	0.682
DOC_WW_Pin1_4	122	127	PF00397	0.683
DOC_WW_Pin1_4	271	276	PF00397	0.569
DOC_WW_Pin1_4	380	385	PF00397	0.637
DOC_WW_Pin1_4	428	433	PF00397	0.784
DOC_WW_Pin1_4	492	497	PF00397	0.722
DOC_WW_Pin1_4	548	553	PF00397	0.685
DOC_WW_Pin1_4	575	580	PF00397	0.724
DOC_WW_Pin1_4	598	603	PF00397	0.680
DOC_WW_Pin1_4	604	609	PF00397	0.628
DOC_WW_Pin1_4	646	651	PF00397	0.721
DOC_WW_Pin1_4	666	671	PF00397	0.710
LIG_14-3-3_CanoR_1	351	357	PF00244	0.551
LIG_14-3-3_CanoR_1	374	379	PF00244	0.624
LIG_14-3-3_CanoR_1	490	496	PF00244	0.735
LIG_14-3-3_CanoR_1	61	67	PF00244	0.507
LIG_14-3-3_CanoR_1	662	670	PF00244	0.667
LIG_BRCT_BRCA1_1	152	156	PF00533	0.634
LIG_BRCT_BRCA1_1	24	28	PF00533	0.558
LIG_BRCT_BRCA1_1	336	340	PF00533	0.551
LIG_Clathr_ClatBox_1	29	33	PF01394	0.557
LIG_Clathr_ClatBox_1	438	442	PF01394	0.597
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.556
LIG_EVH1_1	631	635	PF00568	0.704
LIG_EVH1_1	692	696	PF00568	0.692
LIG_FHA_1	309	315	PF00498	0.412
LIG_FHA_1	375	381	PF00498	0.551
LIG_FHA_1	443	449	PF00498	0.695
LIG_FHA_1	464	470	PF00498	0.728
LIG_FHA_1	484	490	PF00498	0.614
LIG_FHA_2	1	7	PF00498	0.636
LIG_FHA_2	150	156	PF00498	0.633
LIG_FHA_2	320	326	PF00498	0.551
LIG_FHA_2	396	402	PF00498	0.597
LIG_LIR_Apic_2	328	332	PF02991	0.551
LIG_LIR_Apic_2	383	389	PF02991	0.562
LIG_LIR_Apic_2	690	695	PF02991	0.645
LIG_LIR_Gen_1	13	22	PF02991	0.580
LIG_LIR_Gen_1	162	169	PF02991	0.656
LIG_LIR_Gen_1	218	227	PF02991	0.504
LIG_LIR_Gen_1	33	40	PF02991	0.588
LIG_LIR_Gen_1	355	361	PF02991	0.551
LIG_LIR_Nem_3	13	17	PF02991	0.557
LIG_LIR_Nem_3	157	163	PF02991	0.646
LIG_LIR_Nem_3	213	217	PF02991	0.496
LIG_LIR_Nem_3	218	223	PF02991	0.455
LIG_LIR_Nem_3	292	298	PF02991	0.550
LIG_LIR_Nem_3	328	333	PF02991	0.551
LIG_LIR_Nem_3	33	37	PF02991	0.642
LIG_LIR_Nem_3	355	359	PF02991	0.551
LIG_LIR_Nem_3	519	524	PF02991	0.610
LIG_LIR_Nem_3	613	619	PF02991	0.811
LIG_MYND_1	670	674	PF01753	0.645
LIG_MYND_1	695	699	PF01753	0.672
LIG_MYND_3	279	283	PF01753	0.609
LIG_NRBOX	25	31	PF00104	0.548
LIG_NRBOX	59	65	PF00104	0.436
LIG_PAM2_1	62	74	PF00658	0.522
LIG_Pex14_2	156	160	PF04695	0.632
LIG_Pex14_2	201	205	PF04695	0.535
LIG_Pex14_2	49	53	PF04695	0.521
LIG_Pex14_2	591	595	PF04695	0.797
LIG_PROFILIN_1	632	638	PF00235	0.644
LIG_RPA_C_Fungi	533	545	PF08784	0.630
LIG_SH2_CRK	34	38	PF00017	0.592
LIG_SH2_CRK	619	623	PF00017	0.688
LIG_SH2_CRK	675	679	PF00017	0.703
LIG_SH2_NCK_1	675	679	PF00017	0.703
LIG_SH2_PTP2	386	389	PF00017	0.586
LIG_SH2_SRC	644	647	PF00017	0.729
LIG_SH2_SRC	98	101	PF00017	0.619
LIG_SH2_STAP1	34	38	PF00017	0.592
LIG_SH2_STAP1	95	99	PF00017	0.594
LIG_SH2_STAT3	500	503	PF00017	0.642
LIG_SH2_STAT5	181	184	PF00017	0.611
LIG_SH2_STAT5	386	389	PF00017	0.586
LIG_SH2_STAT5	500	503	PF00017	0.692
LIG_SH2_STAT5	644	647	PF00017	0.729
LIG_SH2_STAT5	681	684	PF00017	0.694
LIG_SH2_STAT5	701	704	PF00017	0.652
LIG_SH2_STAT5	98	101	PF00017	0.675
LIG_SH3_2	549	554	PF14604	0.700
LIG_SH3_2	606	611	PF14604	0.669
LIG_SH3_3	127	133	PF00018	0.631
LIG_SH3_3	269	275	PF00018	0.549
LIG_SH3_3	379	385	PF00018	0.621
LIG_SH3_3	52	58	PF00018	0.473
LIG_SH3_3	546	552	PF00018	0.684
LIG_SH3_3	603	609	PF00018	0.667
LIG_SH3_3	626	632	PF00018	0.716
LIG_SH3_3	633	639	PF00018	0.618
LIG_SH3_3	667	673	PF00018	0.702
LIG_SH3_3	690	696	PF00018	0.680
LIG_SUMO_SIM_par_1	437	442	PF11976	0.595
LIG_TRFH_1	268	272	PF08558	0.522
LIG_TRFH_1	675	679	PF08558	0.703
LIG_TYR_ITIM	32	37	PF00017	0.583
LIG_UBA3_1	63	69	PF00899	0.392
LIG_WRC_WIRS_1	326	331	PF05994	0.412
LIG_WRC_WIRS_1	353	358	PF05994	0.412
LIG_WW_1	641	644	PF00397	0.721
LIG_WW_1	678	681	PF00397	0.703
LIG_WW_1	698	701	PF00397	0.669
LIG_WW_2	695	698	PF00397	0.677
MOD_CDC14_SPxK_1	388	391	PF00782	0.603
MOD_CDC14_SPxK_1	551	554	PF00782	0.701
MOD_CDK_SPxK_1	385	391	PF00069	0.587
MOD_CDK_SPxK_1	548	554	PF00069	0.696
MOD_CDK_SPxxK_3	385	392	PF00069	0.581
MOD_CDK_SPxxK_3	598	605	PF00069	0.667
MOD_CK1_1	136	142	PF00069	0.674
MOD_CK1_1	164	170	PF00069	0.688
MOD_CK1_1	189	195	PF00069	0.543
MOD_CK1_1	21	27	PF00069	0.566
MOD_CK1_1	218	224	PF00069	0.457
MOD_CK1_1	426	432	PF00069	0.713
MOD_CK1_1	434	440	PF00069	0.703
MOD_CK1_1	478	484	PF00069	0.705
MOD_CK1_1	506	512	PF00069	0.691
MOD_CK1_1	577	583	PF00069	0.582
MOD_CK1_1	661	667	PF00069	0.720
MOD_CK1_1	82	88	PF00069	0.513
MOD_CK2_1	149	155	PF00069	0.675
MOD_CK2_1	256	262	PF00069	0.604
MOD_CK2_1	319	325	PF00069	0.457
MOD_CK2_1	562	568	PF00069	0.670
MOD_CK2_1	640	646	PF00069	0.715
MOD_DYRK1A_RPxSP_1	271	275	PF00069	0.566
MOD_GlcNHglycan	133	136	PF01048	0.695
MOD_GlcNHglycan	216	220	PF01048	0.493
MOD_GlcNHglycan	337	340	PF01048	0.386
MOD_GlcNHglycan	413	416	PF01048	0.640
MOD_GlcNHglycan	508	511	PF01048	0.675
MOD_GlcNHglycan	545	548	PF01048	0.671
MOD_GlcNHglycan	564	567	PF01048	0.626
MOD_GlcNHglycan	579	582	PF01048	0.530
MOD_GSK3_1	122	129	PF00069	0.580
MOD_GSK3_1	136	143	PF00069	0.636
MOD_GSK3_1	146	153	PF00069	0.607
MOD_GSK3_1	161	168	PF00069	0.623
MOD_GSK3_1	18	25	PF00069	0.574
MOD_GSK3_1	370	377	PF00069	0.508
MOD_GSK3_1	405	412	PF00069	0.699
MOD_GSK3_1	423	430	PF00069	0.648
MOD_GSK3_1	437	444	PF00069	0.714
MOD_GSK3_1	490	497	PF00069	0.569
MOD_GSK3_1	575	582	PF00069	0.744
MOD_GSK3_1	657	664	PF00069	0.727
MOD_N-GLC_1	442	447	PF02516	0.637
MOD_N-GLC_1	516	521	PF02516	0.663
MOD_N-GLC_2	425	427	PF02516	0.650
MOD_NEK2_1	156	161	PF00069	0.677
MOD_NEK2_1	359	364	PF00069	0.412
MOD_NEK2_1	409	414	PF00069	0.677
MOD_NEK2_1	84	89	PF00069	0.496
MOD_PIKK_1	241	247	PF00454	0.510
MOD_PK_1	18	24	PF00069	0.576
MOD_PKA_2	658	664	PF00069	0.789
MOD_Plk_1	156	162	PF00069	0.639
MOD_Plk_1	168	174	PF00069	0.520
MOD_Plk_1	283	289	PF00069	0.527
MOD_Plk_1	464	470	PF00069	0.645
MOD_Plk_1	484	490	PF00069	0.741
MOD_Plk_1	516	522	PF00069	0.664
MOD_Plk_2-3	256	262	PF00069	0.665
MOD_Plk_2-3	319	325	PF00069	0.412
MOD_Plk_4	156	162	PF00069	0.684
MOD_Plk_4	308	314	PF00069	0.475
MOD_Plk_4	325	331	PF00069	0.231
MOD_Plk_4	434	440	PF00069	0.611
MOD_Plk_4	484	490	PF00069	0.665
MOD_Plk_4	640	646	PF00069	0.702
MOD_Plk_4	79	85	PF00069	0.587
MOD_ProDKin_1	122	128	PF00069	0.680
MOD_ProDKin_1	271	277	PF00069	0.577
MOD_ProDKin_1	380	386	PF00069	0.638
MOD_ProDKin_1	428	434	PF00069	0.783
MOD_ProDKin_1	492	498	PF00069	0.721
MOD_ProDKin_1	548	554	PF00069	0.688
MOD_ProDKin_1	575	581	PF00069	0.722
MOD_ProDKin_1	598	604	PF00069	0.679
MOD_ProDKin_1	646	652	PF00069	0.719
MOD_ProDKin_1	666	672	PF00069	0.710
MOD_SUMO_for_1	396	399	PF00179	0.640
MOD_SUMO_for_1	610	613	PF00179	0.698
MOD_SUMO_rev_2	13	20	PF00179	0.580
MOD_SUMO_rev_2	337	346	PF00179	0.412
MOD_SUMO_rev_2	367	373	PF00179	0.412
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.589
TRG_ENDOCYTIC_2	163	166	PF00928	0.656
TRG_ENDOCYTIC_2	181	184	PF00928	0.611
TRG_ENDOCYTIC_2	34	37	PF00928	0.586
TRG_ENDOCYTIC_2	619	622	PF00928	0.690
TRG_ER_diArg_1	349	351	PF00400	0.409
TRG_ER_diArg_1	46	48	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMJ6	Leishmania donovani	100%	100%
A4HMY7	Leishmania braziliensis	81%	100%
E9AFE4	Leishmania major	94%	100%
E9B6J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%