Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1) - putative

Species:

Leishmania infantum

UniProt:

A4IBL0_LEIIN

TriTrypDb:

LINF_350037300

Length:

897

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4IBL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.557
CLV_C14_Caspase3-7	228	232	PF00656	0.394
CLV_C14_Caspase3-7	23	27	PF00656	0.363
CLV_C14_Caspase3-7	280	284	PF00656	0.461
CLV_C14_Caspase3-7	325	329	PF00656	0.482
CLV_C14_Caspase3-7	587	591	PF00656	0.542
CLV_C14_Caspase3-7	888	892	PF00656	0.575
CLV_NRD_NRD_1	189	191	PF00675	0.734
CLV_NRD_NRD_1	24	26	PF00675	0.563
CLV_NRD_NRD_1	258	260	PF00675	0.558
CLV_NRD_NRD_1	358	360	PF00675	0.705
CLV_NRD_NRD_1	668	670	PF00675	0.454
CLV_NRD_NRD_1	737	739	PF00675	0.468
CLV_PCSK_FUR_1	735	739	PF00082	0.471
CLV_PCSK_KEX2_1	24	26	PF00082	0.563
CLV_PCSK_KEX2_1	258	260	PF00082	0.558
CLV_PCSK_KEX2_1	353	355	PF00082	0.698
CLV_PCSK_KEX2_1	358	360	PF00082	0.685
CLV_PCSK_KEX2_1	668	670	PF00082	0.454
CLV_PCSK_KEX2_1	737	739	PF00082	0.468
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.698
CLV_PCSK_PC7_1	20	26	PF00082	0.563
CLV_PCSK_PC7_1	354	360	PF00082	0.697
CLV_PCSK_SKI1_1	162	166	PF00082	0.662
CLV_PCSK_SKI1_1	443	447	PF00082	0.694
DEG_SCF_FBW7_1	472	479	PF00400	0.576
DEG_SPOP_SBC_1	197	201	PF00917	0.466
DEG_SPOP_SBC_1	3	7	PF00917	0.486
DEG_SPOP_SBC_1	360	364	PF00917	0.482
DEG_SPOP_SBC_1	477	481	PF00917	0.527
DOC_ANK_TNKS_1	297	304	PF00023	0.440
DOC_CKS1_1	408	413	PF01111	0.561
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.517
DOC_MAPK_gen_1	110	119	PF00069	0.315
DOC_MAPK_HePTP_8	107	119	PF00069	0.276
DOC_MAPK_MEF2A_6	110	119	PF00069	0.315
DOC_MAPK_MEF2A_6	287	294	PF00069	0.414
DOC_MAPK_MEF2A_6	825	834	PF00069	0.348
DOC_MAPK_MEF2A_6	866	873	PF00069	0.253
DOC_MAPK_NFAT4_5	866	874	PF00069	0.253
DOC_PP2B_LxvP_1	117	120	PF13499	0.363
DOC_PP2B_LxvP_1	571	574	PF13499	0.522
DOC_PP4_FxxP_1	380	383	PF00568	0.479
DOC_USP7_MATH_1	10	14	PF00917	0.407
DOC_USP7_MATH_1	118	122	PF00917	0.324
DOC_USP7_MATH_1	160	164	PF00917	0.523
DOC_USP7_MATH_1	232	236	PF00917	0.383
DOC_USP7_MATH_1	3	7	PF00917	0.529
DOC_USP7_MATH_1	344	348	PF00917	0.519
DOC_USP7_MATH_1	391	395	PF00917	0.526
DOC_USP7_MATH_1	397	401	PF00917	0.514
DOC_USP7_MATH_1	445	449	PF00917	0.597
DOC_USP7_MATH_1	450	454	PF00917	0.561
DOC_USP7_MATH_1	476	480	PF00917	0.538
DOC_USP7_MATH_1	502	506	PF00917	0.501
DOC_USP7_MATH_1	553	557	PF00917	0.490
DOC_USP7_MATH_1	62	66	PF00917	0.332
DOC_USP7_MATH_1	621	625	PF00917	0.750
DOC_USP7_MATH_1	638	642	PF00917	0.619
DOC_USP7_MATH_1	680	684	PF00917	0.428
DOC_USP7_MATH_1	759	763	PF00917	0.651
DOC_USP7_MATH_1	893	897	PF00917	0.614
DOC_USP7_MATH_1	90	94	PF00917	0.324
DOC_WW_Pin1_4	172	177	PF00397	0.532
DOC_WW_Pin1_4	369	374	PF00397	0.566
DOC_WW_Pin1_4	407	412	PF00397	0.591
DOC_WW_Pin1_4	472	477	PF00397	0.576
DOC_WW_Pin1_4	589	594	PF00397	0.533
DOC_WW_Pin1_4	68	73	PF00397	0.363
DOC_WW_Pin1_4	804	809	PF00397	0.700
LIG_14-3-3_CanoR_1	142	148	PF00244	0.359
LIG_14-3-3_CanoR_1	169	176	PF00244	0.448
LIG_14-3-3_CanoR_1	198	205	PF00244	0.547
LIG_14-3-3_CanoR_1	359	368	PF00244	0.550
LIG_14-3-3_CanoR_1	398	405	PF00244	0.531
LIG_14-3-3_CanoR_1	443	450	PF00244	0.494
LIG_14-3-3_CanoR_1	566	572	PF00244	0.566
LIG_14-3-3_CanoR_1	642	648	PF00244	0.743
LIG_14-3-3_CanoR_1	672	677	PF00244	0.660
LIG_14-3-3_CanoR_1	703	709	PF00244	0.312
LIG_14-3-3_CanoR_1	737	746	PF00244	0.657
LIG_14-3-3_CanoR_1	75	83	PF00244	0.361
LIG_Actin_WH2_2	150	167	PF00022	0.439
LIG_Actin_WH2_2	506	522	PF00022	0.486
LIG_BIR_III_2	283	287	PF00653	0.453
LIG_BIR_III_4	231	235	PF00653	0.305
LIG_BRCT_BRCA1_1	840	844	PF00533	0.401
LIG_Clathr_ClatBox_1	291	295	PF01394	0.452
LIG_EH_1	377	381	PF12763	0.477
LIG_FHA_1	159	165	PF00498	0.504
LIG_FHA_1	247	253	PF00498	0.366
LIG_FHA_1	498	504	PF00498	0.552
LIG_FHA_1	661	667	PF00498	0.718
LIG_FHA_1	807	813	PF00498	0.702
LIG_FHA_2	168	174	PF00498	0.543
LIG_FHA_2	226	232	PF00498	0.362
LIG_FHA_2	886	892	PF00498	0.568
LIG_FHA_2	97	103	PF00498	0.363
LIG_GBD_Chelix_1	50	58	PF00786	0.563
LIG_LIR_Gen_1	248	257	PF02991	0.360
LIG_LIR_Gen_1	718	727	PF02991	0.428
LIG_LIR_Gen_1	841	852	PF02991	0.473
LIG_LIR_LC3C_4	65	70	PF02991	0.305
LIG_LIR_Nem_3	102	107	PF02991	0.322
LIG_LIR_Nem_3	152	157	PF02991	0.435
LIG_LIR_Nem_3	248	254	PF02991	0.397
LIG_LIR_Nem_3	707	713	PF02991	0.407
LIG_LIR_Nem_3	718	724	PF02991	0.302
LIG_LIR_Nem_3	841	847	PF02991	0.401
LIG_LIR_Nem_3	874	878	PF02991	0.313
LIG_NRBOX	868	874	PF00104	0.401
LIG_PDZ_Class_3	892	897	PF00595	0.653
LIG_Pex14_1	709	713	PF04695	0.428
LIG_Pex14_1	717	721	PF04695	0.337
LIG_Pex14_2	692	696	PF04695	0.408
LIG_Pex14_2	713	717	PF04695	0.428
LIG_Pex14_2	844	848	PF04695	0.396
LIG_PTB_Apo_2	261	268	PF02174	0.417
LIG_PTB_Phospho_1	261	267	PF10480	0.418
LIG_RPA_C_Fungi	820	832	PF08784	0.280
LIG_SH2_CRK	154	158	PF00017	0.499
LIG_SH2_CRK	875	879	PF00017	0.428
LIG_SH2_GRB2like	309	312	PF00017	0.582
LIG_SH2_SRC	309	312	PF00017	0.582
LIG_SH2_STAP1	247	251	PF00017	0.541
LIG_SH2_STAT3	11	14	PF00017	0.520
LIG_SH2_STAT5	143	146	PF00017	0.443
LIG_SH2_STAT5	309	312	PF00017	0.582
LIG_SH2_STAT5	789	792	PF00017	0.551
LIG_SH3_3	100	106	PF00018	0.428
LIG_SH3_3	112	118	PF00018	0.291
LIG_SH3_3	283	289	PF00018	0.548
LIG_SH3_3	376	382	PF00018	0.621
LIG_SH3_3	413	419	PF00018	0.649
LIG_SH3_3	571	577	PF00018	0.698
LIG_SH3_3	590	596	PF00018	0.528
LIG_SH3_3	66	72	PF00018	0.375
LIG_SH3_3	859	865	PF00018	0.421
LIG_SUMO_SIM_anti_2	223	228	PF11976	0.474
LIG_SUMO_SIM_anti_2	288	295	PF11976	0.494
LIG_SUMO_SIM_par_1	223	228	PF11976	0.474
LIG_SUMO_SIM_par_1	288	295	PF11976	0.494
LIG_SUMO_SIM_par_1	769	774	PF11976	0.540
LIG_SUMO_SIM_par_1	868	874	PF11976	0.359
LIG_TRAF2_1	170	173	PF00917	0.618
LIG_TYR_ITIM	873	878	PF00017	0.428
LIG_UBA3_1	290	296	PF00899	0.559
LIG_UBA3_1	617	623	PF00899	0.605
LIG_UBA3_1	826	833	PF00899	0.375
LIG_WRC_WIRS_1	144	149	PF05994	0.431
LIG_WRC_WIRS_1	251	256	PF05994	0.374
LIG_WW_3	195	199	PF00397	0.723
LIG_WW_3	219	223	PF00397	0.447
MOD_CDK_SPxxK_3	68	75	PF00069	0.428
MOD_CDK_SPxxK_3	804	811	PF00069	0.617
MOD_CK1_1	168	174	PF00069	0.627
MOD_CK1_1	199	205	PF00069	0.689
MOD_CK1_1	214	220	PF00069	0.532
MOD_CK1_1	235	241	PF00069	0.401
MOD_CK1_1	439	445	PF00069	0.702
MOD_CK1_1	480	486	PF00069	0.755
MOD_CK1_1	592	598	PF00069	0.622
MOD_CK1_1	612	618	PF00069	0.569
MOD_CK1_1	838	844	PF00069	0.428
MOD_CK2_1	167	173	PF00069	0.706
MOD_CK2_1	359	365	PF00069	0.691
MOD_CK2_1	389	395	PF00069	0.630
MOD_CK2_1	738	744	PF00069	0.564
MOD_CK2_1	788	794	PF00069	0.592
MOD_CK2_1	96	102	PF00069	0.428
MOD_GlcNHglycan	304	307	PF01048	0.687
MOD_GlcNHglycan	346	349	PF01048	0.668
MOD_GlcNHglycan	401	404	PF01048	0.661
MOD_GlcNHglycan	420	423	PF01048	0.710
MOD_GlcNHglycan	431	434	PF01048	0.615
MOD_GlcNHglycan	438	441	PF01048	0.564
MOD_GlcNHglycan	447	450	PF01048	0.587
MOD_GlcNHglycan	504	507	PF01048	0.644
MOD_GlcNHglycan	525	528	PF01048	0.668
MOD_GlcNHglycan	614	617	PF01048	0.544
MOD_GlcNHglycan	64	67	PF01048	0.375
MOD_GlcNHglycan	658	661	PF01048	0.665
MOD_GlcNHglycan	683	686	PF01048	0.348
MOD_GlcNHglycan	740	743	PF01048	0.531
MOD_GlcNHglycan	782	785	PF01048	0.665
MOD_GlcNHglycan	790	793	PF01048	0.563
MOD_GlcNHglycan	837	840	PF01048	0.375
MOD_GSK3_1	156	163	PF00069	0.602
MOD_GSK3_1	168	175	PF00069	0.591
MOD_GSK3_1	197	204	PF00069	0.695
MOD_GSK3_1	210	217	PF00069	0.580
MOD_GSK3_1	246	253	PF00069	0.503
MOD_GSK3_1	359	366	PF00069	0.691
MOD_GSK3_1	399	406	PF00069	0.664
MOD_GSK3_1	431	438	PF00069	0.691
MOD_GSK3_1	439	446	PF00069	0.688
MOD_GSK3_1	472	479	PF00069	0.727
MOD_GSK3_1	502	509	PF00069	0.651
MOD_GSK3_1	656	663	PF00069	0.673
MOD_N-GLC_1	435	440	PF02516	0.750
MOD_N-GLC_1	506	511	PF02516	0.715
MOD_N-GLC_1	567	572	PF02516	0.679
MOD_NEK2_1	158	163	PF00069	0.682
MOD_NEK2_1	554	559	PF00069	0.695
MOD_NEK2_1	598	603	PF00069	0.358
MOD_NEK2_1	662	667	PF00069	0.590
MOD_NEK2_1	681	686	PF00069	0.208
MOD_NEK2_1	73	78	PF00069	0.428
MOD_NEK2_1	779	784	PF00069	0.652
MOD_NEK2_1	835	840	PF00069	0.375
MOD_NEK2_1	847	852	PF00069	0.363
MOD_NEK2_1	871	876	PF00069	0.358
MOD_NEK2_2	160	165	PF00069	0.626
MOD_NEK2_2	506	511	PF00069	0.599
MOD_PIKK_1	10	16	PF00454	0.524
MOD_PIKK_1	403	409	PF00454	0.698
MOD_PIKK_1	431	437	PF00454	0.642
MOD_PIKK_1	450	456	PF00454	0.636
MOD_PIKK_1	759	765	PF00454	0.551
MOD_PK_1	672	678	PF00069	0.562
MOD_PKA_1	190	196	PF00069	0.645
MOD_PKA_1	24	30	PF00069	0.428
MOD_PKA_2	168	174	PF00069	0.575
MOD_PKA_2	197	203	PF00069	0.719
MOD_PKA_2	24	30	PF00069	0.428
MOD_PKA_2	344	350	PF00069	0.671
MOD_PKA_2	397	403	PF00069	0.684
MOD_PKB_1	468	476	PF00069	0.745
MOD_Plk_1	567	573	PF00069	0.652
MOD_Plk_1	598	604	PF00069	0.280
MOD_Plk_1	631	637	PF00069	0.674
MOD_Plk_1	96	102	PF00069	0.428
MOD_Plk_2-3	316	322	PF00069	0.696
MOD_Plk_4	143	149	PF00069	0.428
MOD_Plk_4	211	217	PF00069	0.576
MOD_Plk_4	232	238	PF00069	0.420
MOD_Plk_4	250	256	PF00069	0.296
MOD_Plk_4	576	582	PF00069	0.648
MOD_Plk_4	704	710	PF00069	0.407
MOD_Plk_4	838	844	PF00069	0.399
MOD_Plk_4	90	96	PF00069	0.375
MOD_ProDKin_1	172	178	PF00069	0.664
MOD_ProDKin_1	369	375	PF00069	0.713
MOD_ProDKin_1	407	413	PF00069	0.748
MOD_ProDKin_1	472	478	PF00069	0.729
MOD_ProDKin_1	589	595	PF00069	0.666
MOD_ProDKin_1	68	74	PF00069	0.428
MOD_ProDKin_1	804	810	PF00069	0.619
MOD_SUMO_rev_2	886	890	PF00179	0.455
TRG_AP2beta_CARGO_1	248	258	PF09066	0.414
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.431
TRG_ENDOCYTIC_2	154	157	PF00928	0.483
TRG_ENDOCYTIC_2	875	878	PF00928	0.428
TRG_ER_diArg_1	257	259	PF00400	0.408
TRG_ER_diArg_1	358	360	PF00400	0.637
TRG_ER_diArg_1	468	471	PF00400	0.755
TRG_ER_diArg_1	668	670	PF00400	0.556
TRG_ER_diArg_1	671	674	PF00400	0.514
TRG_ER_diArg_1	734	737	PF00400	0.576
TRG_ER_FFAT_2	783	794	PF00635	0.553
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	882	886	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II65	Leishmania donovani	99%	100%
A4HMY6	Leishmania braziliensis	53%	98%
E9AFE3	Leishmania major	83%	99%
E9B6J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%