LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Probable eukaryotic initiation factor 4A

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable eukaryotic initiation factor 4A
Gene product:
ATP-dependent RNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4IBK1_LEIIN
TriTrypDb:
LINF_350036300
Length:
924

Annotations

Annotations by Jardim et al.

Helicases, ATP-dependent RNA helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 6
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 2
Pissara et al. yes yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0034399 nuclear periphery 2 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097165 nuclear stress granule 4 1
GO:0099080 supramolecular complex 2 1
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Promastigote: 408
Promastigote/Amastigote: 10, 108, 409

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBK1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 11
GO:0003724 RNA helicase activity 3 11
GO:0003743 translation initiation factor activity 4 11
GO:0003824 catalytic activity 1 11
GO:0004386 helicase activity 2 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0008186 ATP-dependent activity, acting on RNA 2 11
GO:0016787 hydrolase activity 2 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140098 catalytic activity, acting on RNA 3 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11
GO:0140657 ATP-dependent activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003723 RNA binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 900 904 PF00656 0.651
CLV_NRD_NRD_1 177 179 PF00675 0.640
CLV_NRD_NRD_1 221 223 PF00675 0.674
CLV_NRD_NRD_1 236 238 PF00675 0.600
CLV_NRD_NRD_1 263 265 PF00675 0.675
CLV_NRD_NRD_1 276 278 PF00675 0.548
CLV_NRD_NRD_1 311 313 PF00675 0.631
CLV_NRD_NRD_1 318 320 PF00675 0.645
CLV_NRD_NRD_1 340 342 PF00675 0.741
CLV_NRD_NRD_1 42 44 PF00675 0.642
CLV_NRD_NRD_1 420 422 PF00675 0.703
CLV_NRD_NRD_1 429 431 PF00675 0.492
CLV_NRD_NRD_1 544 546 PF00675 0.288
CLV_NRD_NRD_1 568 570 PF00675 0.326
CLV_NRD_NRD_1 677 679 PF00675 0.435
CLV_NRD_NRD_1 739 741 PF00675 0.363
CLV_NRD_NRD_1 755 757 PF00675 0.206
CLV_NRD_NRD_1 830 832 PF00675 0.447
CLV_NRD_NRD_1 874 876 PF00675 0.652
CLV_NRD_NRD_1 914 916 PF00675 0.680
CLV_PCSK_FUR_1 316 320 PF00082 0.608
CLV_PCSK_FUR_1 40 44 PF00082 0.661
CLV_PCSK_KEX2_1 177 179 PF00082 0.640
CLV_PCSK_KEX2_1 221 223 PF00082 0.674
CLV_PCSK_KEX2_1 235 237 PF00082 0.617
CLV_PCSK_KEX2_1 263 265 PF00082 0.675
CLV_PCSK_KEX2_1 276 278 PF00082 0.548
CLV_PCSK_KEX2_1 311 313 PF00082 0.631
CLV_PCSK_KEX2_1 318 320 PF00082 0.645
CLV_PCSK_KEX2_1 340 342 PF00082 0.741
CLV_PCSK_KEX2_1 42 44 PF00082 0.642
CLV_PCSK_KEX2_1 420 422 PF00082 0.703
CLV_PCSK_KEX2_1 429 431 PF00082 0.492
CLV_PCSK_KEX2_1 673 675 PF00082 0.425
CLV_PCSK_KEX2_1 677 679 PF00082 0.415
CLV_PCSK_KEX2_1 739 741 PF00082 0.348
CLV_PCSK_KEX2_1 755 757 PF00082 0.263
CLV_PCSK_KEX2_1 830 832 PF00082 0.501
CLV_PCSK_KEX2_1 873 875 PF00082 0.648
CLV_PCSK_KEX2_1 914 916 PF00082 0.680
CLV_PCSK_PC1ET2_1 673 675 PF00082 0.406
CLV_PCSK_SKI1_1 420 424 PF00082 0.641
CLV_PCSK_SKI1_1 466 470 PF00082 0.475
CLV_PCSK_SKI1_1 569 573 PF00082 0.398
CLV_PCSK_SKI1_1 605 609 PF00082 0.252
CLV_PCSK_SKI1_1 693 697 PF00082 0.475
CLV_PCSK_SKI1_1 831 835 PF00082 0.448
DEG_Nend_UBRbox_2 1 3 PF02207 0.629
DEG_SPOP_SBC_1 688 692 PF00917 0.552
DOC_ANK_TNKS_1 886 893 PF00023 0.595
DOC_CYCLIN_RxL_1 616 627 PF00134 0.488
DOC_CYCLIN_yCln2_LP_2 478 484 PF00134 0.429
DOC_MAPK_DCC_7 768 776 PF00069 0.488
DOC_MAPK_gen_1 445 453 PF00069 0.505
DOC_MAPK_gen_1 543 552 PF00069 0.491
DOC_MAPK_gen_1 677 685 PF00069 0.405
DOC_MAPK_gen_1 768 776 PF00069 0.502
DOC_MAPK_gen_1 827 836 PF00069 0.502
DOC_MAPK_MEF2A_6 500 507 PF00069 0.488
DOC_MAPK_MEF2A_6 545 554 PF00069 0.488
DOC_MAPK_MEF2A_6 827 836 PF00069 0.448
DOC_PP1_RVXF_1 567 574 PF00149 0.488
DOC_PP2B_LxvP_1 785 788 PF13499 0.508
DOC_PP4_FxxP_1 170 173 PF00568 0.653
DOC_PP4_FxxP_1 526 529 PF00568 0.488
DOC_PP4_FxxP_1 796 799 PF00568 0.488
DOC_USP7_MATH_1 119 123 PF00917 0.591
DOC_USP7_MATH_1 363 367 PF00917 0.667
DOC_USP7_MATH_1 377 381 PF00917 0.532
DOC_USP7_MATH_1 392 396 PF00917 0.475
DOC_USP7_MATH_1 46 50 PF00917 0.651
DOC_WW_Pin1_4 105 110 PF00397 0.633
DOC_WW_Pin1_4 144 149 PF00397 0.596
DOC_WW_Pin1_4 364 369 PF00397 0.649
DOC_WW_Pin1_4 406 411 PF00397 0.643
DOC_WW_Pin1_4 493 498 PF00397 0.476
DOC_WW_Pin1_4 537 542 PF00397 0.495
DOC_WW_Pin1_4 769 774 PF00397 0.488
LIG_14-3-3_CanoR_1 543 549 PF00244 0.494
LIG_14-3-3_CanoR_1 569 574 PF00244 0.598
LIG_14-3-3_CanoR_1 645 652 PF00244 0.548
LIG_14-3-3_CanoR_1 655 659 PF00244 0.508
LIG_14-3-3_CanoR_1 687 695 PF00244 0.535
LIG_APCC_ABBA_1 562 567 PF00400 0.526
LIG_APCC_ABBA_1 724 729 PF00400 0.504
LIG_BIR_III_4 113 117 PF00653 0.596
LIG_BRCT_BRCA1_1 660 664 PF00533 0.526
LIG_Clathr_ClatBox_1 725 729 PF01394 0.526
LIG_CtBP_PxDLS_1 460 464 PF00389 0.463
LIG_EH1_1 717 725 PF00400 0.488
LIG_FHA_1 555 561 PF00498 0.526
LIG_FHA_1 690 696 PF00498 0.481
LIG_FHA_1 770 776 PF00498 0.488
LIG_FHA_1 804 810 PF00498 0.449
LIG_FHA_2 25 31 PF00498 0.643
LIG_FHA_2 293 299 PF00498 0.615
LIG_FHA_2 649 655 PF00498 0.488
LIG_FHA_2 95 101 PF00498 0.656
LIG_LIR_Apic_2 167 173 PF02991 0.658
LIG_LIR_Apic_2 325 331 PF02991 0.735
LIG_LIR_Apic_2 523 529 PF02991 0.526
LIG_LIR_Gen_1 454 464 PF02991 0.502
LIG_LIR_Gen_1 472 482 PF02991 0.497
LIG_LIR_Gen_1 576 583 PF02991 0.491
LIG_LIR_Gen_1 610 620 PF02991 0.581
LIG_LIR_Gen_1 644 652 PF02991 0.488
LIG_LIR_Nem_3 304 310 PF02991 0.597
LIG_LIR_Nem_3 342 346 PF02991 0.651
LIG_LIR_Nem_3 454 459 PF02991 0.535
LIG_LIR_Nem_3 472 477 PF02991 0.303
LIG_LIR_Nem_3 575 581 PF02991 0.504
LIG_LIR_Nem_3 610 615 PF02991 0.592
LIG_Pex14_2 660 664 PF04695 0.488
LIG_PTAP_UEV_1 905 910 PF05743 0.639
LIG_PTB_Apo_2 606 613 PF02174 0.488
LIG_PTB_Phospho_1 606 612 PF10480 0.488
LIG_SH2_CRK 328 332 PF00017 0.740
LIG_SH2_CRK 456 460 PF00017 0.510
LIG_SH2_CRK 492 496 PF00017 0.482
LIG_SH2_CRK 501 505 PF00017 0.484
LIG_SH2_CRK 533 537 PF00017 0.488
LIG_SH2_CRK 579 583 PF00017 0.488
LIG_SH2_GRB2like 3 6 PF00017 0.572
LIG_SH2_NCK_1 456 460 PF00017 0.510
LIG_SH2_NCK_1 579 583 PF00017 0.488
LIG_SH2_SRC 239 242 PF00017 0.583
LIG_SH2_SRC 302 305 PF00017 0.607
LIG_SH2_STAP1 249 253 PF00017 0.620
LIG_SH2_STAP1 579 583 PF00017 0.488
LIG_SH2_STAP1 805 809 PF00017 0.488
LIG_SH2_STAT5 3 6 PF00017 0.614
LIG_SH2_STAT5 612 615 PF00017 0.598
LIG_SH2_STAT5 646 649 PF00017 0.510
LIG_SH2_STAT5 675 678 PF00017 0.402
LIG_SH2_STAT5 681 684 PF00017 0.397
LIG_SH2_STAT5 805 808 PF00017 0.526
LIG_SH2_STAT5 839 842 PF00017 0.458
LIG_SH3_3 150 156 PF00018 0.604
LIG_SH3_3 178 184 PF00018 0.557
LIG_SH3_3 394 400 PF00018 0.538
LIG_SH3_3 404 410 PF00018 0.703
LIG_SH3_3 550 556 PF00018 0.548
LIG_SH3_3 595 601 PF00018 0.526
LIG_SH3_3 903 909 PF00018 0.644
LIG_Sin3_3 475 482 PF02671 0.444
LIG_SUMO_SIM_par_1 503 508 PF11976 0.458
LIG_SUMO_SIM_par_1 772 779 PF11976 0.449
LIG_TRAF2_1 226 229 PF00917 0.645
LIG_TRAF2_1 376 379 PF00917 0.626
LIG_TYR_ITIM 531 536 PF00017 0.488
LIG_TYR_ITIM 577 582 PF00017 0.488
LIG_UBA3_1 668 673 PF00899 0.392
LIG_WRC_WIRS_1 25 30 PF05994 0.642
LIG_WRC_WIRS_1 343 348 PF05994 0.650
LIG_WRC_WIRS_1 612 617 PF05994 0.488
MOD_CDC14_SPxK_1 540 543 PF00782 0.504
MOD_CDK_SPxK_1 537 543 PF00069 0.504
MOD_CDK_SPxxK_3 493 500 PF00069 0.391
MOD_CK1_1 122 128 PF00069 0.612
MOD_CK1_1 520 526 PF00069 0.526
MOD_CK1_1 54 60 PF00069 0.614
MOD_CK1_1 644 650 PF00069 0.488
MOD_CK1_1 747 753 PF00069 0.488
MOD_CK1_1 904 910 PF00069 0.639
MOD_CK2_1 151 157 PF00069 0.604
MOD_CK2_1 292 298 PF00069 0.616
MOD_CK2_1 648 654 PF00069 0.421
MOD_CK2_1 7 13 PF00069 0.682
MOD_CK2_1 94 100 PF00069 0.656
MOD_Cter_Amidation 219 222 PF01082 0.648
MOD_Cter_Amidation 274 277 PF01082 0.641
MOD_Cter_Amidation 338 341 PF01082 0.655
MOD_Cter_Amidation 40 43 PF01082 0.663
MOD_Cter_Amidation 871 874 PF01082 0.632
MOD_Cter_Amidation 912 915 PF01082 0.653
MOD_GlcNHglycan 131 134 PF01048 0.593
MOD_GlcNHglycan 149 152 PF01048 0.504
MOD_GlcNHglycan 153 156 PF01048 0.603
MOD_GlcNHglycan 202 205 PF01048 0.613
MOD_GlcNHglycan 254 257 PF01048 0.626
MOD_GlcNHglycan 354 358 PF01048 0.655
MOD_GlcNHglycan 379 382 PF01048 0.625
MOD_GlcNHglycan 394 397 PF01048 0.554
MOD_GlcNHglycan 416 419 PF01048 0.652
MOD_GlcNHglycan 507 510 PF01048 0.350
MOD_GlcNHglycan 519 522 PF01048 0.280
MOD_GlcNHglycan 55 59 PF01048 0.654
MOD_GlcNHglycan 615 618 PF01048 0.288
MOD_GlcNHglycan 660 663 PF01048 0.326
MOD_GlcNHglycan 887 890 PF01048 0.649
MOD_GlcNHglycan 906 909 PF01048 0.742
MOD_GSK3_1 119 126 PF00069 0.600
MOD_GSK3_1 147 154 PF00069 0.610
MOD_GSK3_1 179 186 PF00069 0.537
MOD_GSK3_1 364 371 PF00069 0.643
MOD_GSK3_1 644 651 PF00069 0.548
MOD_GSK3_1 654 661 PF00069 0.508
MOD_GSK3_1 689 696 PF00069 0.544
MOD_GSK3_1 775 782 PF00069 0.526
MOD_GSK3_1 897 904 PF00069 0.653
MOD_GSK3_1 94 101 PF00069 0.643
MOD_N-GLC_1 105 110 PF02516 0.615
MOD_N-GLC_1 122 127 PF02516 0.499
MOD_N-GLC_1 693 698 PF02516 0.529
MOD_NEK2_1 353 358 PF00069 0.631
MOD_NEK2_1 613 618 PF00069 0.488
MOD_NEK2_1 641 646 PF00069 0.495
MOD_NEK2_1 658 663 PF00069 0.581
MOD_NEK2_1 727 732 PF00069 0.498
MOD_PIKK_1 412 418 PF00454 0.610
MOD_PIKK_1 693 699 PF00454 0.523
MOD_PKA_1 420 426 PF00069 0.632
MOD_PKA_1 569 575 PF00069 0.598
MOD_PKA_1 7 13 PF00069 0.638
MOD_PKA_2 420 426 PF00069 0.632
MOD_PKA_2 446 452 PF00069 0.698
MOD_PKA_2 544 550 PF00069 0.446
MOD_PKA_2 644 650 PF00069 0.548
MOD_PKA_2 654 660 PF00069 0.508
MOD_PKA_2 89 95 PF00069 0.645
MOD_PKA_2 904 910 PF00069 0.639
MOD_PKA_2 98 104 PF00069 0.562
MOD_Plk_2-3 24 30 PF00069 0.643
MOD_Plk_2-3 648 654 PF00069 0.488
MOD_Plk_4 654 660 PF00069 0.526
MOD_ProDKin_1 105 111 PF00069 0.633
MOD_ProDKin_1 144 150 PF00069 0.593
MOD_ProDKin_1 364 370 PF00069 0.646
MOD_ProDKin_1 406 412 PF00069 0.642
MOD_ProDKin_1 493 499 PF00069 0.387
MOD_ProDKin_1 537 543 PF00069 0.495
MOD_ProDKin_1 769 775 PF00069 0.488
MOD_SUMO_rev_2 2 10 PF00179 0.622
MOD_SUMO_rev_2 434 439 PF00179 0.503
MOD_SUMO_rev_2 462 471 PF00179 0.545
TRG_DiLeu_BaEn_1 593 598 PF01217 0.488
TRG_DiLeu_BaEn_1 859 864 PF01217 0.506
TRG_DiLeu_BaEn_2 653 659 PF01217 0.421
TRG_DiLeu_BaLyEn_6 707 712 PF01217 0.488
TRG_ENDOCYTIC_2 456 459 PF00928 0.563
TRG_ENDOCYTIC_2 533 536 PF00928 0.488
TRG_ENDOCYTIC_2 579 582 PF00928 0.488
TRG_ENDOCYTIC_2 612 615 PF00928 0.581
TRG_ENDOCYTIC_2 646 649 PF00928 0.488
TRG_ENDOCYTIC_2 680 683 PF00928 0.381
TRG_ER_diArg_1 221 223 PF00400 0.655
TRG_ER_diArg_1 234 237 PF00400 0.545
TRG_ER_diArg_1 262 264 PF00400 0.637
TRG_ER_diArg_1 276 278 PF00400 0.500
TRG_ER_diArg_1 310 312 PF00400 0.662
TRG_ER_diArg_1 317 319 PF00400 0.599
TRG_ER_diArg_1 331 334 PF00400 0.685
TRG_ER_diArg_1 40 43 PF00400 0.663
TRG_ER_diArg_1 419 421 PF00400 0.701
TRG_ER_diArg_1 428 430 PF00400 0.531
TRG_ER_diArg_1 676 678 PF00400 0.404
TRG_ER_diArg_1 739 741 PF00400 0.488
TRG_ER_diArg_1 830 832 PF00400 0.447
TRG_ER_diArg_1 873 875 PF00400 0.733
TRG_Pf-PMV_PEXEL_1 558 563 PF00026 0.326
TRG_Pf-PMV_PEXEL_1 739 744 PF00026 0.398
TRG_Pf-PMV_PEXEL_1 830 835 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JDN6 Bodo saltans 52% 100%
A0A3Q8IF94 Leishmania donovani 51% 100%
A0A3Q8IJ79 Leishmania donovani 99% 100%
A4HMX7 Leishmania braziliensis 79% 94%
A4I7K4 Leishmania infantum 51% 100%
E9AFD4 Leishmania major 94% 100%
E9B2G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B6I9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q5P5 Leishmania major 49% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS