1-alkyl-2-acetylglycerophosphocholine esterase

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase A1 - putative

Species:

Leishmania infantum

UniProt:

A4IBJ0_LEIIN

TriTrypDb:

LINF_350035500

Length:

453

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, phospholipase A1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Phosphorylation

Amastigote: 445

Expansion

Sequence features

A4IBJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0016042	lipid catabolic process	4	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0052689	carboxylic ester hydrolase activity	4	13
GO:0004620	phospholipase activity	5	1
GO:0008970	phospholipase A1 activity	5	1
GO:0016298	lipase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.312
CLV_C14_Caspase3-7	279	283	PF00656	0.178
CLV_NRD_NRD_1	131	133	PF00675	0.415
CLV_NRD_NRD_1	305	307	PF00675	0.552
CLV_NRD_NRD_1	316	318	PF00675	0.385
CLV_PCSK_KEX2_1	131	133	PF00082	0.378
CLV_PCSK_KEX2_1	232	234	PF00082	0.470
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.465
CLV_PCSK_SKI1_1	307	311	PF00082	0.508
CLV_PCSK_SKI1_1	373	377	PF00082	0.478
DEG_APCC_DBOX_1	106	114	PF00400	0.248
DEG_APCC_DBOX_1	224	232	PF00400	0.215
DOC_CKS1_1	323	328	PF01111	0.236
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.308
DOC_MAPK_gen_1	232	241	PF00069	0.281
DOC_MAPK_gen_1	317	323	PF00069	0.313
DOC_MAPK_MEF2A_6	216	224	PF00069	0.312
DOC_MAPK_MEF2A_6	235	243	PF00069	0.217
DOC_MAPK_MEF2A_6	77	86	PF00069	0.278
DOC_PP4_FxxP_1	323	326	PF00568	0.312
DOC_PP4_MxPP_1	80	83	PF00568	0.312
DOC_USP7_MATH_1	15	19	PF00917	0.298
DOC_USP7_MATH_1	89	93	PF00917	0.248
DOC_WW_Pin1_4	322	327	PF00397	0.236
DOC_WW_Pin1_4	397	402	PF00397	0.262
DOC_WW_Pin1_4	409	414	PF00397	0.256
DOC_WW_Pin1_4	57	62	PF00397	0.370
DOC_WW_Pin1_4	91	96	PF00397	0.281
LIG_14-3-3_CanoR_1	202	206	PF00244	0.289
LIG_14-3-3_CanoR_1	286	296	PF00244	0.229
LIG_14-3-3_CanoR_1	306	310	PF00244	0.171
LIG_14-3-3_CanoR_1	357	365	PF00244	0.345
LIG_AP2alpha_2	299	301	PF02296	0.222
LIG_APCC_ABBA_1	328	333	PF00400	0.236
LIG_APCC_ABBAyCdc20_2	306	312	PF00400	0.178
LIG_BIR_III_2	137	141	PF00653	0.232
LIG_BIR_III_2	353	357	PF00653	0.295
LIG_BRCT_BRCA1_1	189	193	PF00533	0.196
LIG_FHA_1	323	329	PF00498	0.224
LIG_FHA_1	386	392	PF00498	0.288
LIG_FHA_1	437	443	PF00498	0.486
LIG_FHA_1	68	74	PF00498	0.326
LIG_FHA_2	210	216	PF00498	0.319
LIG_FHA_2	379	385	PF00498	0.350
LIG_FHA_2	390	396	PF00498	0.340
LIG_LIR_Apic_2	299	304	PF02991	0.211
LIG_LIR_Gen_1	115	124	PF02991	0.245
LIG_LIR_Gen_1	308	316	PF02991	0.248
LIG_LIR_Nem_3	115	119	PF02991	0.264
LIG_LIR_Nem_3	308	314	PF02991	0.312
LIG_LIR_Nem_3	377	382	PF02991	0.262
LIG_LIR_Nem_3	397	402	PF02991	0.175
LIG_Pex14_2	331	335	PF04695	0.278
LIG_SH2_CRK	116	120	PF00017	0.278
LIG_SH2_CRK	121	125	PF00017	0.278
LIG_SH2_CRK	167	171	PF00017	0.215
LIG_SH2_CRK	311	315	PF00017	0.284
LIG_SH2_NCK_1	116	120	PF00017	0.300
LIG_SH2_PTP2	52	55	PF00017	0.292
LIG_SH2_SRC	13	16	PF00017	0.360
LIG_SH2_STAP1	167	171	PF00017	0.222
LIG_SH2_STAT5	101	104	PF00017	0.210
LIG_SH2_STAT5	109	112	PF00017	0.190
LIG_SH2_STAT5	13	16	PF00017	0.309
LIG_SH2_STAT5	253	256	PF00017	0.236
LIG_SH2_STAT5	380	383	PF00017	0.348
LIG_SH2_STAT5	52	55	PF00017	0.391
LIG_SH2_STAT5	7	10	PF00017	0.304
LIG_SH3_3	294	300	PF00018	0.254
LIG_SH3_3	428	434	PF00018	0.289
LIG_SH3_5	3	7	PF00018	0.377
LIG_TRAF2_1	358	361	PF00917	0.336
LIG_TYR_ITIM	119	124	PF00017	0.312
LIG_UBA3_1	239	247	PF00899	0.300
LIG_UBA3_1	302	307	PF00899	0.243
MOD_CDK_SPK_2	409	414	PF00069	0.323
MOD_CDK_SPK_2	91	96	PF00069	0.314
MOD_CK1_1	204	210	PF00069	0.301
MOD_CK1_1	291	297	PF00069	0.276
MOD_CK1_1	378	384	PF00069	0.354
MOD_CK1_1	397	403	PF00069	0.194
MOD_CK1_1	44	50	PF00069	0.458
MOD_CK2_1	355	361	PF00069	0.327
MOD_GlcNHglycan	188	192	PF01048	0.419
MOD_GlcNHglycan	235	238	PF01048	0.504
MOD_GlcNHglycan	360	364	PF01048	0.537
MOD_GlcNHglycan	431	434	PF01048	0.576
MOD_GlcNHglycan	444	447	PF01048	0.567
MOD_GlcNHglycan	91	94	PF01048	0.448
MOD_GlcNHglycan	96	99	PF01048	0.521
MOD_GSK3_1	16	23	PF00069	0.347
MOD_GSK3_1	277	284	PF00069	0.277
MOD_GSK3_1	287	294	PF00069	0.241
MOD_GSK3_1	355	362	PF00069	0.310
MOD_GSK3_1	37	44	PF00069	0.425
MOD_GSK3_1	374	381	PF00069	0.189
MOD_GSK3_1	385	392	PF00069	0.240
MOD_GSK3_1	87	94	PF00069	0.279
MOD_N-GLC_1	277	282	PF02516	0.510
MOD_N-GLC_1	442	447	PF02516	0.614
MOD_NEK2_1	166	171	PF00069	0.270
MOD_NEK2_1	182	187	PF00069	0.265
MOD_NEK2_1	305	310	PF00069	0.347
MOD_NEK2_1	37	42	PF00069	0.298
MOD_NEK2_1	375	380	PF00069	0.310
MOD_NEK2_1	442	447	PF00069	0.399
MOD_NEK2_2	421	426	PF00069	0.224
MOD_NEK2_2	7	12	PF00069	0.319
MOD_OFUCOSY	36	41	PF10250	0.290
MOD_PIKK_1	204	210	PF00454	0.310
MOD_PIKK_1	277	283	PF00454	0.314
MOD_PKA_2	201	207	PF00069	0.258
MOD_PKA_2	224	230	PF00069	0.264
MOD_PKA_2	305	311	PF00069	0.237
MOD_PKA_2	356	362	PF00069	0.406
MOD_PKA_2	385	391	PF00069	0.347
MOD_Plk_1	359	365	PF00069	0.370
MOD_Plk_1	394	400	PF00069	0.301
MOD_Plk_1	442	448	PF00069	0.453
MOD_Plk_2-3	246	252	PF00069	0.248
MOD_Plk_4	16	22	PF00069	0.342
MOD_Plk_4	166	172	PF00069	0.274
MOD_Plk_4	249	255	PF00069	0.276
MOD_Plk_4	292	298	PF00069	0.233
MOD_Plk_4	305	311	PF00069	0.255
MOD_Plk_4	375	381	PF00069	0.303
MOD_Plk_4	394	400	PF00069	0.157
MOD_Plk_4	41	47	PF00069	0.407
MOD_Plk_4	82	88	PF00069	0.330
MOD_ProDKin_1	322	328	PF00069	0.236
MOD_ProDKin_1	397	403	PF00069	0.267
MOD_ProDKin_1	409	415	PF00069	0.258
MOD_ProDKin_1	57	63	PF00069	0.370
MOD_ProDKin_1	91	97	PF00069	0.281
MOD_SUMO_rev_2	312	320	PF00179	0.217
MOD_SUMO_rev_2	346	351	PF00179	0.401
MOD_SUMO_rev_2	432	442	PF00179	0.369
TRG_DiLeu_BaEn_1	106	111	PF01217	0.201
TRG_DiLeu_BaEn_1	360	365	PF01217	0.323
TRG_DiLeu_BaEn_3	346	352	PF01217	0.273
TRG_ENDOCYTIC_2	101	104	PF00928	0.234
TRG_ENDOCYTIC_2	116	119	PF00928	0.183
TRG_ENDOCYTIC_2	121	124	PF00928	0.236
TRG_ENDOCYTIC_2	167	170	PF00928	0.207
TRG_ENDOCYTIC_2	311	314	PF00928	0.284
TRG_ER_diArg_1	130	132	PF00400	0.208
TRG_ER_diArg_1	222	225	PF00400	0.317
TRG_NLS_MonoExtC_3	131	136	PF00514	0.199
TRG_NLS_MonoExtN_4	131	136	PF00514	0.217

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R1	Leptomonas seymouri	51%	100%
A0A0S4JLQ8	Bodo saltans	29%	95%
A0A1X0P5D8	Trypanosomatidae	36%	100%
A0A1X0P6A2	Trypanosomatidae	27%	100%
A0A3Q8IPQ3	Leishmania donovani	100%	100%
A0A3R7LD50	Trypanosoma rangeli	34%	100%
A0A3R7P367	Trypanosoma rangeli	26%	100%
A4HMW9	Leishmania braziliensis	77%	100%
C9ZZ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AFC6	Leishmania major	93%	100%
E9B6I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q13093	Homo sapiens	27%	100%
Q28017	Bos taurus	26%	100%
Q28262	Canis lupus familiaris	28%	100%
V5BD01	Trypanosoma cruzi	33%	100%
V5BTH3	Trypanosoma cruzi	28%	100%