LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
denn domain-containing protein
Species:
Leishmania infantum
UniProt:
A4IBI4_LEIIN
TriTrypDb:
LINF_350034900
Length:
559

Annotations

Annotations by Jardim et al.

Membrane associated proteins, denn domain-containing Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBI4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 409 413 PF00656 0.461
CLV_NRD_NRD_1 21 23 PF00675 0.649
CLV_NRD_NRD_1 504 506 PF00675 0.609
CLV_PCSK_FUR_1 370 374 PF00082 0.544
CLV_PCSK_KEX2_1 365 367 PF00082 0.616
CLV_PCSK_KEX2_1 372 374 PF00082 0.516
CLV_PCSK_KEX2_1 399 401 PF00082 0.473
CLV_PCSK_KEX2_1 504 506 PF00082 0.609
CLV_PCSK_PC1ET2_1 365 367 PF00082 0.542
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.462
CLV_PCSK_PC1ET2_1 399 401 PF00082 0.395
CLV_PCSK_SKI1_1 156 160 PF00082 0.415
CLV_PCSK_SKI1_1 399 403 PF00082 0.574
CLV_PCSK_SKI1_1 424 428 PF00082 0.544
DEG_APCC_DBOX_1 285 293 PF00400 0.462
DEG_APCC_DBOX_1 325 333 PF00400 0.498
DEG_SCF_FBW7_1 70 76 PF00400 0.528
DEG_SPOP_SBC_1 375 379 PF00917 0.274
DEG_SPOP_SBC_1 553 557 PF00917 0.616
DOC_CDC14_PxL_1 77 85 PF14671 0.499
DOC_CKS1_1 173 178 PF01111 0.420
DOC_CKS1_1 70 75 PF01111 0.495
DOC_MAPK_FxFP_2 203 206 PF00069 0.384
DOC_PP1_RVXF_1 62 68 PF00149 0.462
DOC_PP1_SILK_1 329 334 PF00149 0.554
DOC_PP2B_LxvP_1 244 247 PF13499 0.377
DOC_PP2B_LxvP_1 266 269 PF13499 0.321
DOC_PP4_FxxP_1 173 176 PF00568 0.348
DOC_PP4_FxxP_1 183 186 PF00568 0.297
DOC_PP4_FxxP_1 203 206 PF00568 0.384
DOC_USP7_MATH_1 27 31 PF00917 0.601
DOC_USP7_MATH_1 288 292 PF00917 0.377
DOC_USP7_MATH_1 553 557 PF00917 0.713
DOC_USP7_MATH_1 73 77 PF00917 0.489
DOC_USP7_UBL2_3 159 163 PF12436 0.420
DOC_WW_Pin1_4 128 133 PF00397 0.345
DOC_WW_Pin1_4 163 168 PF00397 0.325
DOC_WW_Pin1_4 172 177 PF00397 0.329
DOC_WW_Pin1_4 401 406 PF00397 0.595
DOC_WW_Pin1_4 554 559 PF00397 0.589
DOC_WW_Pin1_4 69 74 PF00397 0.490
LIG_14-3-3_CanoR_1 189 194 PF00244 0.321
LIG_14-3-3_CanoR_1 514 524 PF00244 0.693
LIG_APCC_ABBA_1 427 432 PF00400 0.465
LIG_BRCT_BRCA1_1 100 104 PF00533 0.378
LIG_BRCT_BRCA1_1 31 35 PF00533 0.637
LIG_BRCT_BRCA1_1 378 382 PF00533 0.463
LIG_BRCT_BRCA1_2 378 384 PF00533 0.446
LIG_CtBP_PxDLS_1 176 180 PF00389 0.420
LIG_deltaCOP1_diTrp_1 409 415 PF00928 0.463
LIG_eIF4E_1 140 146 PF01652 0.420
LIG_FHA_1 101 107 PF00498 0.391
LIG_FHA_1 117 123 PF00498 0.331
LIG_FHA_1 194 200 PF00498 0.304
LIG_FHA_1 258 264 PF00498 0.360
LIG_FHA_1 276 282 PF00498 0.201
LIG_FHA_1 460 466 PF00498 0.571
LIG_FHA_1 73 79 PF00498 0.507
LIG_FHA_2 1 7 PF00498 0.684
LIG_FHA_2 173 179 PF00498 0.418
LIG_FHA_2 339 345 PF00498 0.388
LIG_GBD_Chelix_1 273 281 PF00786 0.322
LIG_HOMEOBOX 248 251 PF00046 0.345
LIG_LIR_Apic_2 182 186 PF02991 0.381
LIG_LIR_Apic_2 200 206 PF02991 0.384
LIG_LIR_Apic_2 66 70 PF02991 0.415
LIG_LIR_Gen_1 101 106 PF02991 0.451
LIG_LIR_Gen_1 209 220 PF02991 0.321
LIG_LIR_Gen_1 249 258 PF02991 0.327
LIG_LIR_Gen_1 351 361 PF02991 0.360
LIG_LIR_Gen_1 379 386 PF02991 0.399
LIG_LIR_Gen_1 388 398 PF02991 0.322
LIG_LIR_Gen_1 9 19 PF02991 0.715
LIG_LIR_Nem_3 101 105 PF02991 0.448
LIG_LIR_Nem_3 16 21 PF02991 0.657
LIG_LIR_Nem_3 209 215 PF02991 0.340
LIG_LIR_Nem_3 249 253 PF02991 0.303
LIG_LIR_Nem_3 347 352 PF02991 0.361
LIG_LIR_Nem_3 355 360 PF02991 0.470
LIG_LIR_Nem_3 379 385 PF02991 0.375
LIG_LIR_Nem_3 388 394 PF02991 0.326
LIG_LIR_Nem_3 456 461 PF02991 0.577
LIG_LIR_Nem_3 9 14 PF02991 0.673
LIG_LYPXL_SIV_4 70 78 PF13949 0.533
LIG_LYPXL_yS_3 80 83 PF13949 0.418
LIG_MLH1_MIPbox_1 378 382 PF16413 0.439
LIG_Pex14_1 135 139 PF04695 0.321
LIG_Pex14_1 67 71 PF04695 0.517
LIG_REV1ctd_RIR_1 136 145 PF16727 0.377
LIG_REV1ctd_RIR_1 379 388 PF16727 0.475
LIG_SH2_CRK 102 106 PF00017 0.449
LIG_SH2_CRK 187 191 PF00017 0.301
LIG_SH2_CRK 353 357 PF00017 0.338
LIG_SH2_GRB2like 308 311 PF00017 0.489
LIG_SH2_NCK_1 71 75 PF00017 0.544
LIG_SH2_STAP1 102 106 PF00017 0.449
LIG_SH2_STAP1 353 357 PF00017 0.357
LIG_SH2_STAP1 431 435 PF00017 0.543
LIG_SH2_STAP1 448 452 PF00017 0.433
LIG_SH2_STAT5 102 105 PF00017 0.402
LIG_SH2_STAT5 144 147 PF00017 0.349
LIG_SH2_STAT5 272 275 PF00017 0.321
LIG_SH2_STAT5 71 74 PF00017 0.543
LIG_SH2_STAT5 95 98 PF00017 0.583
LIG_SH3_3 162 168 PF00018 0.280
LIG_SH3_3 253 259 PF00018 0.321
LIG_SH3_3 67 73 PF00018 0.480
LIG_SUMO_SIM_anti_2 260 267 PF11976 0.322
LIG_SUMO_SIM_anti_2 327 333 PF11976 0.502
LIG_SUMO_SIM_par_1 125 131 PF11976 0.345
LIG_SUMO_SIM_par_1 528 536 PF11976 0.543
LIG_TRAF2_1 58 61 PF00917 0.589
LIG_TYR_ITIM 100 105 PF00017 0.452
LIG_TYR_ITIM 142 147 PF00017 0.462
LIG_TYR_ITIM 78 83 PF00017 0.545
LIG_UBA3_1 331 338 PF00899 0.576
LIG_UBA3_1 356 365 PF00899 0.530
LIG_WRC_WIRS_1 190 195 PF05994 0.321
LIG_WW_1 269 272 PF00397 0.420
MOD_CK1_1 232 238 PF00069 0.408
MOD_CK1_1 404 410 PF00069 0.558
MOD_CK1_1 454 460 PF00069 0.587
MOD_CK1_1 490 496 PF00069 0.670
MOD_CK1_1 91 97 PF00069 0.458
MOD_CK2_1 27 33 PF00069 0.534
MOD_CK2_1 515 521 PF00069 0.745
MOD_CK2_1 536 542 PF00069 0.763
MOD_CK2_1 55 61 PF00069 0.559
MOD_Cter_Amidation 363 366 PF01082 0.526
MOD_Cter_Amidation 502 505 PF01082 0.638
MOD_GlcNHglycan 168 171 PF01048 0.321
MOD_GlcNHglycan 318 321 PF01048 0.454
MOD_GlcNHglycan 322 325 PF01048 0.396
MOD_GlcNHglycan 518 521 PF01048 0.687
MOD_GlcNHglycan 538 541 PF01048 0.659
MOD_GlcNHglycan 57 60 PF01048 0.609
MOD_GlcNHglycan 90 93 PF01048 0.413
MOD_GSK3_1 100 107 PF00069 0.399
MOD_GSK3_1 189 196 PF00069 0.311
MOD_GSK3_1 23 30 PF00069 0.617
MOD_GSK3_1 316 323 PF00069 0.433
MOD_GSK3_1 344 351 PF00069 0.364
MOD_GSK3_1 385 392 PF00069 0.382
MOD_GSK3_1 532 539 PF00069 0.726
MOD_GSK3_1 552 559 PF00069 0.677
MOD_GSK3_1 65 72 PF00069 0.426
MOD_LATS_1 336 342 PF00433 0.525
MOD_N-GLC_1 14 19 PF02516 0.641
MOD_N-GLC_1 229 234 PF02516 0.420
MOD_N-GLC_1 309 314 PF02516 0.532
MOD_NEK2_1 100 105 PF00069 0.365
MOD_NEK2_1 106 111 PF00069 0.438
MOD_NEK2_1 145 150 PF00069 0.322
MOD_NEK2_1 179 184 PF00069 0.368
MOD_NEK2_1 193 198 PF00069 0.236
MOD_NEK2_1 348 353 PF00069 0.337
MOD_NEK2_1 385 390 PF00069 0.337
MOD_NEK2_1 547 552 PF00069 0.696
MOD_NEK2_1 88 93 PF00069 0.417
MOD_NEK2_2 352 357 PF00069 0.455
MOD_NEK2_2 376 381 PF00069 0.467
MOD_PIKK_1 276 282 PF00454 0.321
MOD_PIKK_1 385 391 PF00454 0.364
MOD_PIKK_1 6 12 PF00454 0.667
MOD_PKA_1 23 29 PF00069 0.623
MOD_Plk_1 14 20 PF00069 0.623
MOD_Plk_1 229 235 PF00069 0.395
MOD_Plk_1 338 344 PF00069 0.462
MOD_Plk_1 40 46 PF00069 0.398
MOD_Plk_1 496 502 PF00069 0.618
MOD_Plk_1 547 553 PF00069 0.710
MOD_Plk_4 100 106 PF00069 0.355
MOD_Plk_4 14 20 PF00069 0.681
MOD_Plk_4 189 195 PF00069 0.321
MOD_Plk_4 258 264 PF00069 0.279
MOD_Plk_4 288 294 PF00069 0.462
MOD_Plk_4 327 333 PF00069 0.544
MOD_Plk_4 344 350 PF00069 0.362
MOD_Plk_4 352 358 PF00069 0.384
MOD_Plk_4 376 382 PF00069 0.456
MOD_Plk_4 496 502 PF00069 0.675
MOD_Plk_4 73 79 PF00069 0.533
MOD_ProDKin_1 128 134 PF00069 0.345
MOD_ProDKin_1 163 169 PF00069 0.325
MOD_ProDKin_1 172 178 PF00069 0.329
MOD_ProDKin_1 401 407 PF00069 0.600
MOD_ProDKin_1 69 75 PF00069 0.491
MOD_SUMO_rev_2 395 401 PF00179 0.504
TRG_ENDOCYTIC_2 102 105 PF00928 0.445
TRG_ENDOCYTIC_2 144 147 PF00928 0.462
TRG_ENDOCYTIC_2 187 190 PF00928 0.301
TRG_ENDOCYTIC_2 353 356 PF00928 0.356
TRG_ENDOCYTIC_2 431 434 PF00928 0.447
TRG_ENDOCYTIC_2 80 83 PF00928 0.418
TRG_ER_diArg_1 332 335 PF00400 0.564
TRG_ER_diArg_1 504 506 PF00400 0.609
TRG_NES_CRM1_1 209 221 PF08389 0.377
TRG_NES_CRM1_1 280 290 PF08389 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HV44 Leptomonas seymouri 74% 98%
A0A1X0P6A9 Trypanosomatidae 56% 98%
A0A3Q8IGE3 Leishmania donovani 100% 100%
A0A3R7NUK9 Trypanosoma rangeli 55% 100%
A4HMW3 Leishmania braziliensis 87% 100%
E9AFC0 Leishmania major 97% 100%
E9B6H5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q3U1T9 Mus musculus 26% 73%
Q6P3S1 Homo sapiens 24% 72%
Q8CFK6 Mus musculus 24% 71%
V5DUS4 Trypanosoma cruzi 54% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS