SpoU_methylase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4IBH7_LEIIN

TriTrypDb:

Length:

607

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBH7

PDB structure(s): 7am2_BX , 7am2_BY

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	10
GO:0008173	RNA methyltransferase activity	4	9
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0097159	organic cyclic compound binding	2	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	315	319	PF00656	0.416
CLV_NRD_NRD_1	180	182	PF00675	0.505
CLV_NRD_NRD_1	19	21	PF00675	0.634
CLV_NRD_NRD_1	422	424	PF00675	0.423
CLV_NRD_NRD_1	425	427	PF00675	0.446
CLV_NRD_NRD_1	430	432	PF00675	0.427
CLV_NRD_NRD_1	525	527	PF00675	0.470
CLV_NRD_NRD_1	530	532	PF00675	0.483
CLV_NRD_NRD_1	544	546	PF00675	0.419
CLV_NRD_NRD_1	551	553	PF00675	0.438
CLV_NRD_NRD_1	556	558	PF00675	0.427
CLV_PCSK_FUR_1	178	182	PF00082	0.396
CLV_PCSK_FUR_1	523	527	PF00082	0.424
CLV_PCSK_FUR_1	554	558	PF00082	0.585
CLV_PCSK_KEX2_1	171	173	PF00082	0.596
CLV_PCSK_KEX2_1	180	182	PF00082	0.599
CLV_PCSK_KEX2_1	19	21	PF00082	0.634
CLV_PCSK_KEX2_1	2	4	PF00082	0.609
CLV_PCSK_KEX2_1	417	419	PF00082	0.417
CLV_PCSK_KEX2_1	422	424	PF00082	0.399
CLV_PCSK_KEX2_1	430	432	PF00082	0.403
CLV_PCSK_KEX2_1	475	477	PF00082	0.603
CLV_PCSK_KEX2_1	525	527	PF00082	0.424
CLV_PCSK_KEX2_1	529	531	PF00082	0.451
CLV_PCSK_KEX2_1	544	546	PF00082	0.435
CLV_PCSK_KEX2_1	551	553	PF00082	0.437
CLV_PCSK_KEX2_1	556	558	PF00082	0.428
CLV_PCSK_KEX2_1	95	97	PF00082	0.350
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.567
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.546
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.417
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.589
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.350
CLV_PCSK_PC7_1	418	424	PF00082	0.419
CLV_PCSK_PC7_1	426	432	PF00082	0.429
CLV_PCSK_PC7_1	525	531	PF00082	0.532
CLV_PCSK_PC7_1	552	558	PF00082	0.510
CLV_PCSK_SKI1_1	100	104	PF00082	0.393
CLV_PCSK_SKI1_1	141	145	PF00082	0.375
CLV_PCSK_SKI1_1	418	422	PF00082	0.595
CLV_PCSK_SKI1_1	434	438	PF00082	0.379
CLV_PCSK_SKI1_1	565	569	PF00082	0.719
CLV_PCSK_SKI1_1	589	593	PF00082	0.499
CLV_PCSK_SKI1_1	65	69	PF00082	0.517
CLV_Separin_Metazoa	520	524	PF03568	0.485
DEG_APCC_DBOX_1	19	27	PF00400	0.474
DEG_APCC_DBOX_1	304	312	PF00400	0.370
DEG_APCC_DBOX_1	417	425	PF00400	0.596
DEG_APCC_DBOX_1	433	441	PF00400	0.401
DEG_Nend_UBRbox_1	1	4	PF02207	0.763
DEG_ODPH_VHL_1	57	69	PF01847	0.467
DEG_SPOP_SBC_1	80	84	PF00917	0.624
DOC_CKS1_1	209	214	PF01111	0.517
DOC_CYCLIN_RxL_1	222	235	PF00134	0.398
DOC_MAPK_gen_1	136	145	PF00069	0.358
DOC_MAPK_gen_1	178	188	PF00069	0.405
DOC_MAPK_gen_1	19	26	PF00069	0.501
DOC_MAPK_gen_1	426	437	PF00069	0.462
DOC_MAPK_gen_1	475	483	PF00069	0.520
DOC_MAPK_gen_1	554	564	PF00069	0.473
DOC_MAPK_JIP1_4	161	167	PF00069	0.477
DOC_MAPK_MEF2A_6	486	494	PF00069	0.534
DOC_PP2B_LxvP_1	357	360	PF13499	0.573
DOC_PP4_FxxP_1	207	210	PF00568	0.375
DOC_PP4_FxxP_1	411	414	PF00568	0.474
DOC_USP7_MATH_1	360	364	PF00917	0.627
DOC_USP7_MATH_1	368	372	PF00917	0.590
DOC_USP7_MATH_1	376	380	PF00917	0.439
DOC_USP7_MATH_1	441	445	PF00917	0.550
DOC_USP7_MATH_1	46	50	PF00917	0.545
DOC_USP7_MATH_1	76	80	PF00917	0.550
DOC_USP7_MATH_2	443	449	PF00917	0.557
DOC_WW_Pin1_4	194	199	PF00397	0.458
DOC_WW_Pin1_4	208	213	PF00397	0.436
DOC_WW_Pin1_4	333	338	PF00397	0.704
DOC_WW_Pin1_4	439	444	PF00397	0.539
LIG_14-3-3_CanoR_1	180	188	PF00244	0.465
LIG_14-3-3_CanoR_1	190	198	PF00244	0.387
LIG_14-3-3_CanoR_1	3	9	PF00244	0.747
LIG_14-3-3_CanoR_1	346	350	PF00244	0.579
LIG_14-3-3_CanoR_1	361	367	PF00244	0.449
LIG_14-3-3_CanoR_1	430	437	PF00244	0.413
LIG_14-3-3_CanoR_1	47	57	PF00244	0.651
LIG_14-3-3_CanoR_1	496	506	PF00244	0.606
LIG_14-3-3_CanoR_1	584	588	PF00244	0.636
LIG_CSL_BTD_1	560	563	PF09270	0.688
LIG_FHA_1	181	187	PF00498	0.425
LIG_FHA_1	329	335	PF00498	0.652
LIG_FHA_1	431	437	PF00498	0.390
LIG_FHA_1	478	484	PF00498	0.521
LIG_FHA_1	66	72	PF00498	0.544
LIG_FHA_2	113	119	PF00498	0.393
LIG_FHA_2	284	290	PF00498	0.533
LIG_FHA_2	313	319	PF00498	0.453
LIG_FHA_2	472	478	PF00498	0.596
LIG_LIR_Apic_2	206	210	PF02991	0.371
LIG_LIR_Apic_2	51	56	PF02991	0.637
LIG_LIR_Apic_2	599	605	PF02991	0.596
LIG_LIR_Gen_1	406	414	PF02991	0.473
LIG_LIR_Nem_3	293	299	PF02991	0.363
LIG_LIR_Nem_3	406	411	PF02991	0.474
LIG_LIR_Nem_3	468	472	PF02991	0.467
LIG_NRBOX	239	245	PF00104	0.446
LIG_NRP_CendR_1	604	607	PF00754	0.601
LIG_PCNA_yPIPBox_3	543	557	PF02747	0.554
LIG_RPA_C_Fungi	540	552	PF08784	0.454
LIG_SH2_CRK	252	256	PF00017	0.282
LIG_SH2_CRK	296	300	PF00017	0.357
LIG_SH2_CRK	602	606	PF00017	0.713
LIG_SH2_SRC	4	7	PF00017	0.550
LIG_SH2_SRC	469	472	PF00017	0.543
LIG_SH2_STAP1	252	256	PF00017	0.282
LIG_SH2_STAP1	265	269	PF00017	0.282
LIG_SH2_STAP1	313	317	PF00017	0.388
LIG_SH2_STAP1	4	8	PF00017	0.554
LIG_SH2_STAT3	313	316	PF00017	0.441
LIG_SH2_STAT5	203	206	PF00017	0.414
LIG_SH2_STAT5	285	288	PF00017	0.369
LIG_SH2_STAT5	313	316	PF00017	0.462
LIG_SH2_STAT5	408	411	PF00017	0.468
LIG_SH2_STAT5	459	462	PF00017	0.400
LIG_SH2_STAT5	469	472	PF00017	0.388
LIG_SH3_1	53	59	PF00018	0.522
LIG_SH3_1	557	563	PF00018	0.492
LIG_SH3_2	210	215	PF14604	0.408
LIG_SH3_2	560	565	PF14604	0.522
LIG_SH3_3	207	213	PF00018	0.477
LIG_SH3_3	231	237	PF00018	0.254
LIG_SH3_3	331	337	PF00018	0.686
LIG_SH3_3	352	358	PF00018	0.654
LIG_SH3_3	53	59	PF00018	0.530
LIG_SH3_3	557	563	PF00018	0.613
LIG_SH3_3	64	70	PF00018	0.522
LIG_SH3_CIN85_PxpxPR_1	356	361	PF14604	0.624
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.469
LIG_SUMO_SIM_par_1	183	189	PF11976	0.389
LIG_SUMO_SIM_par_1	227	232	PF11976	0.320
LIG_TRAF2_1	381	384	PF00917	0.567
LIG_TRFH_1	459	463	PF08558	0.418
LIG_UBA3_1	420	427	PF00899	0.337
MOD_CDK_SPxxK_3	208	215	PF00069	0.462
MOD_CK1_1	363	369	PF00069	0.628
MOD_CK1_1	429	435	PF00069	0.419
MOD_CK1_1	439	445	PF00069	0.489
MOD_CK1_1	79	85	PF00069	0.604
MOD_CK2_1	129	135	PF00069	0.420
MOD_CK2_1	283	289	PF00069	0.400
MOD_CK2_1	332	338	PF00069	0.604
MOD_CK2_1	35	41	PF00069	0.616
MOD_CK2_1	395	401	PF00069	0.537
MOD_CK2_1	439	445	PF00069	0.569
MOD_CK2_1	471	477	PF00069	0.595
MOD_Cter_Amidation	169	172	PF01082	0.361
MOD_GlcNHglycan	192	195	PF01048	0.407
MOD_GlcNHglycan	247	250	PF01048	0.342
MOD_GlcNHglycan	26	29	PF01048	0.583
MOD_GlcNHglycan	398	401	PF01048	0.676
MOD_GlcNHglycan	405	408	PF01048	0.490
MOD_GlcNHglycan	499	502	PF01048	0.426
MOD_GlcNHglycan	50	53	PF01048	0.604
MOD_GlcNHglycan	78	81	PF01048	0.641
MOD_GlcNHglycan	83	86	PF01048	0.552
MOD_GlcNHglycan	89	92	PF01048	0.558
MOD_GSK3_1	190	197	PF00069	0.534
MOD_GSK3_1	239	246	PF00069	0.282
MOD_GSK3_1	24	31	PF00069	0.584
MOD_GSK3_1	328	335	PF00069	0.688
MOD_GSK3_1	363	370	PF00069	0.639
MOD_GSK3_1	392	399	PF00069	0.628
MOD_GSK3_1	426	433	PF00069	0.516
MOD_GSK3_1	441	448	PF00069	0.521
MOD_GSK3_1	76	83	PF00069	0.596
MOD_LATS_1	594	600	PF00433	0.576
MOD_N-GLC_1	65	70	PF02516	0.516
MOD_N-GLC_2	259	261	PF02516	0.282
MOD_NEK2_1	243	248	PF00069	0.315
MOD_NEK2_1	278	283	PF00069	0.316
MOD_NEK2_1	311	316	PF00069	0.317
MOD_NEK2_1	345	350	PF00069	0.642
MOD_NEK2_1	35	40	PF00069	0.718
MOD_NEK2_1	436	441	PF00069	0.546
MOD_NEK2_1	48	53	PF00069	0.563
MOD_NEK2_2	283	288	PF00069	0.391
MOD_NEK2_2	368	373	PF00069	0.551
MOD_PIKK_1	10	16	PF00454	0.712
MOD_PIKK_1	312	318	PF00454	0.328
MOD_PIKK_1	376	382	PF00454	0.670
MOD_PK_1	486	492	PF00069	0.474
MOD_PKA_1	180	186	PF00069	0.476
MOD_PKA_1	19	25	PF00069	0.648
MOD_PKA_1	426	432	PF00069	0.448
MOD_PKA_1	530	536	PF00069	0.491
MOD_PKA_2	180	186	PF00069	0.588
MOD_PKA_2	19	25	PF00069	0.538
MOD_PKA_2	345	351	PF00069	0.582
MOD_PKA_2	360	366	PF00069	0.448
MOD_PKA_2	392	398	PF00069	0.490
MOD_PKA_2	429	435	PF00069	0.434
MOD_PKA_2	46	52	PF00069	0.635
MOD_PKA_2	497	503	PF00069	0.555
MOD_PKA_2	530	536	PF00069	0.566
MOD_PKA_2	583	589	PF00069	0.636
MOD_PKA_2	71	77	PF00069	0.645
MOD_PKB_1	178	186	PF00069	0.354
MOD_Plk_1	188	194	PF00069	0.405
MOD_Plk_1	363	369	PF00069	0.587
MOD_Plk_1	476	482	PF00069	0.591
MOD_Plk_1	65	71	PF00069	0.517
MOD_Plk_2-3	477	483	PF00069	0.548
MOD_Plk_4	112	118	PF00069	0.373
MOD_Plk_4	19	25	PF00069	0.548
MOD_Plk_4	239	245	PF00069	0.282
MOD_Plk_4	345	351	PF00069	0.615
MOD_Plk_4	452	458	PF00069	0.442
MOD_ProDKin_1	194	200	PF00069	0.458
MOD_ProDKin_1	208	214	PF00069	0.439
MOD_ProDKin_1	333	339	PF00069	0.701
MOD_ProDKin_1	439	445	PF00069	0.544
MOD_SUMO_for_1	287	290	PF00179	0.412
TRG_DiLeu_BaEn_1	304	309	PF01217	0.469
TRG_DiLeu_BaEn_1	517	522	PF01217	0.349
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.499
TRG_ENDOCYTIC_2	252	255	PF00928	0.282
TRG_ENDOCYTIC_2	296	299	PF00928	0.357
TRG_ENDOCYTIC_2	408	411	PF00928	0.484
TRG_ENDOCYTIC_2	469	472	PF00928	0.461
TRG_ER_diArg_1	18	20	PF00400	0.642
TRG_ER_diArg_1	421	423	PF00400	0.426
TRG_ER_diArg_1	461	464	PF00400	0.472
TRG_ER_diArg_1	496	499	PF00400	0.503
TRG_ER_diArg_1	524	526	PF00400	0.451
TRG_ER_diArg_1	529	531	PF00400	0.475
TRG_ER_diArg_1	544	546	PF00400	0.308
TRG_ER_diArg_1	550	552	PF00400	0.436
TRG_ER_diArg_1	554	557	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE8	Leptomonas seymouri	68%	99%
A0A1X0P5S3	Trypanosomatidae	49%	100%
A0A3S7X9F7	Leishmania donovani	100%	100%
A0A422P2S4	Trypanosoma rangeli	50%	100%
A4HMV6	Leishmania braziliensis	82%	100%
C9ZZ65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AFB3	Leishmania major	94%	100%
E9B6G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%