Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase - putative

Species:

Leishmania infantum

UniProt:

A4IBH5_LEIIN

TriTrypDb:

LINF_350034000

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBH5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.415
CLV_C14_Caspase3-7	203	207	PF00656	0.424
CLV_C14_Caspase3-7	464	468	PF00656	0.763
CLV_C14_Caspase3-7	643	647	PF00656	0.419
CLV_NRD_NRD_1	102	104	PF00675	0.455
CLV_NRD_NRD_1	444	446	PF00675	0.507
CLV_NRD_NRD_1	682	684	PF00675	0.570
CLV_NRD_NRD_1	727	729	PF00675	0.527
CLV_NRD_NRD_1	730	732	PF00675	0.510
CLV_PCSK_FUR_1	100	104	PF00082	0.419
CLV_PCSK_KEX2_1	102	104	PF00082	0.425
CLV_PCSK_KEX2_1	405	407	PF00082	0.390
CLV_PCSK_KEX2_1	444	446	PF00082	0.507
CLV_PCSK_KEX2_1	682	684	PF00082	0.545
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.369
CLV_PCSK_SKI1_1	211	215	PF00082	0.475
CLV_PCSK_SKI1_1	422	426	PF00082	0.513
CLV_PCSK_SKI1_1	496	500	PF00082	0.564
CLV_PCSK_SKI1_1	545	549	PF00082	0.471
CLV_PCSK_SKI1_1	596	600	PF00082	0.590
CLV_PCSK_SKI1_1	733	737	PF00082	0.572
DEG_APCC_DBOX_1	405	413	PF00400	0.431
DEG_SPOP_SBC_1	126	130	PF00917	0.611
DEG_SPOP_SBC_1	293	297	PF00917	0.579
DEG_SPOP_SBC_1	571	575	PF00917	0.452
DEG_SPOP_SBC_1	716	720	PF00917	0.544
DEG_SPOP_SBC_1	75	79	PF00917	0.492
DOC_CKS1_1	489	494	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.462
DOC_MAPK_gen_1	211	220	PF00069	0.397
DOC_MAPK_gen_1	405	413	PF00069	0.442
DOC_MAPK_gen_1	555	563	PF00069	0.373
DOC_MAPK_MEF2A_6	260	269	PF00069	0.348
DOC_MAPK_RevD_3	90	103	PF00069	0.473
DOC_MIT_MIM_1	619	629	PF04212	0.546
DOC_PP1_RVXF_1	619	625	PF00149	0.484
DOC_USP7_MATH_1	163	167	PF00917	0.679
DOC_USP7_MATH_1	179	183	PF00917	0.516
DOC_USP7_MATH_1	316	320	PF00917	0.411
DOC_USP7_MATH_1	572	576	PF00917	0.525
DOC_USP7_MATH_1	716	720	PF00917	0.637
DOC_USP7_UBL2_3	729	733	PF12436	0.544
DOC_WW_Pin1_4	122	127	PF00397	0.616
DOC_WW_Pin1_4	142	147	PF00397	0.637
DOC_WW_Pin1_4	289	294	PF00397	0.561
DOC_WW_Pin1_4	399	404	PF00397	0.422
DOC_WW_Pin1_4	488	493	PF00397	0.561
DOC_WW_Pin1_4	502	507	PF00397	0.572
DOC_WW_Pin1_4	83	88	PF00397	0.439
LIG_14-3-3_CanoR_1	266	275	PF00244	0.387
LIG_14-3-3_CanoR_1	406	412	PF00244	0.396
LIG_14-3-3_CanoR_1	422	427	PF00244	0.421
LIG_14-3-3_CanoR_1	431	437	PF00244	0.377
LIG_14-3-3_CanoR_1	445	455	PF00244	0.531
LIG_14-3-3_CanoR_1	461	470	PF00244	0.576
LIG_14-3-3_CanoR_1	682	686	PF00244	0.568
LIG_14-3-3_CanoR_1	714	723	PF00244	0.524
LIG_AP2alpha_1	495	499	PF02296	0.627
LIG_APCC_ABBA_1	335	340	PF00400	0.391
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BRCT_BRCA1_1	302	306	PF00533	0.568
LIG_BRCT_BRCA1_1	414	418	PF00533	0.397
LIG_BRCT_BRCA1_2	414	420	PF00533	0.463
LIG_Clathr_ClatBox_1	189	193	PF01394	0.342
LIG_CtBP_PxDLS_1	537	541	PF00389	0.574
LIG_FHA_1	185	191	PF00498	0.409
LIG_FHA_1	293	299	PF00498	0.614
LIG_FHA_1	364	370	PF00498	0.595
LIG_FHA_1	390	396	PF00498	0.408
LIG_FHA_1	44	50	PF00498	0.649
LIG_FHA_1	589	595	PF00498	0.566
LIG_FHA_1	599	605	PF00498	0.463
LIG_FHA_1	607	613	PF00498	0.357
LIG_FHA_1	696	702	PF00498	0.622
LIG_FHA_1	716	722	PF00498	0.397
LIG_FHA_1	75	81	PF00498	0.522
LIG_FHA_2	110	116	PF00498	0.402
LIG_FHA_2	160	166	PF00498	0.628
LIG_FHA_2	423	429	PF00498	0.487
LIG_GBD_Chelix_1	227	235	PF00786	0.319
LIG_HCF-1_HBM_1	106	109	PF13415	0.426
LIG_LIR_Gen_1	322	331	PF02991	0.542
LIG_LIR_Gen_1	579	588	PF02991	0.424
LIG_LIR_LC3C_4	187	191	PF02991	0.387
LIG_LIR_Nem_3	25	29	PF02991	0.395
LIG_LIR_Nem_3	322	327	PF02991	0.549
LIG_LIR_Nem_3	494	498	PF02991	0.539
LIG_LIR_Nem_3	556	561	PF02991	0.497
LIG_LIR_Nem_3	579	584	PF02991	0.470
LIG_LIR_Nem_3	72	76	PF02991	0.379
LIG_NRBOX	408	414	PF00104	0.442
LIG_PCNA_PIPBox_1	605	614	PF02747	0.531
LIG_Pex14_2	495	499	PF04695	0.627
LIG_SH2_CRK	26	30	PF00017	0.398
LIG_SH2_GRB2like	118	121	PF00017	0.495
LIG_SH2_PTP2	73	76	PF00017	0.386
LIG_SH2_SRC	195	198	PF00017	0.414
LIG_SH2_SRC	204	207	PF00017	0.322
LIG_SH2_SRC	338	341	PF00017	0.343
LIG_SH2_STAP1	204	208	PF00017	0.365
LIG_SH2_STAP1	338	342	PF00017	0.341
LIG_SH2_STAP1	581	585	PF00017	0.442
LIG_SH2_STAT3	118	121	PF00017	0.473
LIG_SH2_STAT3	36	39	PF00017	0.459
LIG_SH2_STAT5	109	112	PF00017	0.408
LIG_SH2_STAT5	195	198	PF00017	0.431
LIG_SH2_STAT5	73	76	PF00017	0.386
LIG_SH3_1	700	706	PF00018	0.559
LIG_SH3_3	102	108	PF00018	0.384
LIG_SH3_3	120	126	PF00018	0.660
LIG_SH3_3	143	149	PF00018	0.609
LIG_SH3_3	262	268	PF00018	0.340
LIG_SH3_3	310	316	PF00018	0.520
LIG_SH3_3	452	458	PF00018	0.595
LIG_SH3_3	495	501	PF00018	0.543
LIG_SH3_3	700	706	PF00018	0.551
LIG_SUMO_SIM_anti_2	187	194	PF11976	0.352
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.431
LIG_SUMO_SIM_anti_2	366	374	PF11976	0.482
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.519
LIG_SUMO_SIM_par_1	187	194	PF11976	0.355
LIG_SUMO_SIM_par_1	273	279	PF11976	0.431
LIG_SUMO_SIM_par_1	366	374	PF11976	0.482
LIG_SUMO_SIM_par_1	432	438	PF11976	0.347
LIG_SUMO_SIM_par_1	476	483	PF11976	0.572
LIG_SUMO_SIM_par_1	500	505	PF11976	0.584
LIG_TRAF2_1	79	82	PF00917	0.618
LIG_TYR_ITIM	71	76	PF00017	0.375
LIG_WW_3	150	154	PF00397	0.662
MOD_CDC14_SPxK_1	150	153	PF00782	0.616
MOD_CDC14_SPxK_1	402	405	PF00782	0.428
MOD_CDK_SPK_2	289	294	PF00069	0.538
MOD_CDK_SPxK_1	147	153	PF00069	0.620
MOD_CDK_SPxK_1	399	405	PF00069	0.425
MOD_CDK_SPxxK_3	399	406	PF00069	0.417
MOD_CK1_1	124	130	PF00069	0.649
MOD_CK1_1	166	172	PF00069	0.710
MOD_CK1_1	184	190	PF00069	0.453
MOD_CK1_1	270	276	PF00069	0.368
MOD_CK1_1	281	287	PF00069	0.492
MOD_CK1_1	292	298	PF00069	0.578
MOD_CK1_1	319	325	PF00069	0.541
MOD_CK1_1	360	366	PF00069	0.514
MOD_CK1_1	478	484	PF00069	0.602
MOD_CK1_1	64	70	PF00069	0.551
MOD_CK1_1	83	89	PF00069	0.370
MOD_CK2_1	294	300	PF00069	0.590
MOD_CK2_1	394	400	PF00069	0.373
MOD_CK2_1	422	428	PF00069	0.494
MOD_CK2_1	432	438	PF00069	0.451
MOD_CK2_1	502	508	PF00069	0.528
MOD_CK2_1	681	687	PF00069	0.601
MOD_CK2_1	76	82	PF00069	0.538
MOD_GlcNHglycan	1	4	PF01048	0.563
MOD_GlcNHglycan	129	132	PF01048	0.624
MOD_GlcNHglycan	164	168	PF01048	0.687
MOD_GlcNHglycan	183	186	PF01048	0.586
MOD_GlcNHglycan	269	272	PF01048	0.375
MOD_GlcNHglycan	279	283	PF01048	0.531
MOD_GlcNHglycan	328	331	PF01048	0.524
MOD_GlcNHglycan	359	362	PF01048	0.460
MOD_GlcNHglycan	415	418	PF01048	0.378
MOD_GlcNHglycan	449	452	PF01048	0.603
MOD_GlcNHglycan	568	571	PF01048	0.539
MOD_GlcNHglycan	57	60	PF01048	0.623
MOD_GlcNHglycan	574	577	PF01048	0.515
MOD_GlcNHglycan	578	581	PF01048	0.467
MOD_GlcNHglycan	657	660	PF01048	0.529
MOD_GlcNHglycan	66	69	PF01048	0.420
MOD_GSK3_1	121	128	PF00069	0.576
MOD_GSK3_1	132	139	PF00069	0.772
MOD_GSK3_1	159	166	PF00069	0.762
MOD_GSK3_1	180	187	PF00069	0.561
MOD_GSK3_1	289	296	PF00069	0.598
MOD_GSK3_1	401	408	PF00069	0.392
MOD_GSK3_1	457	464	PF00069	0.688
MOD_GSK3_1	487	494	PF00069	0.627
MOD_GSK3_1	502	509	PF00069	0.508
MOD_GSK3_1	518	525	PF00069	0.541
MOD_GSK3_1	566	573	PF00069	0.571
MOD_GSK3_1	636	643	PF00069	0.488
MOD_GSK3_1	655	662	PF00069	0.468
MOD_GSK3_1	76	83	PF00069	0.543
MOD_LATS_1	459	465	PF00433	0.638
MOD_N-GLC_1	357	362	PF02516	0.467
MOD_N-GLC_1	363	368	PF02516	0.415
MOD_N-GLC_1	55	60	PF02516	0.608
MOD_N-GLC_1	716	721	PF02516	0.554
MOD_NEK2_1	180	185	PF00069	0.557
MOD_NEK2_1	394	399	PF00069	0.382
MOD_NEK2_1	412	417	PF00069	0.467
MOD_NEK2_1	487	492	PF00069	0.632
MOD_NEK2_1	5	10	PF00069	0.454
MOD_NEK2_1	650	655	PF00069	0.582
MOD_NEK2_1	722	727	PF00069	0.572
MOD_NEK2_1	76	81	PF00069	0.474
MOD_PIKK_1	136	142	PF00454	0.558
MOD_PIKK_1	527	533	PF00454	0.628
MOD_PIKK_1	563	569	PF00454	0.527
MOD_PK_1	294	300	PF00069	0.559
MOD_PKA_1	405	411	PF00069	0.402
MOD_PKA_2	22	28	PF00069	0.433
MOD_PKA_2	293	299	PF00069	0.552
MOD_PKA_2	405	411	PF00069	0.402
MOD_PKA_2	447	453	PF00069	0.614
MOD_PKA_2	655	661	PF00069	0.417
MOD_PKA_2	681	687	PF00069	0.539
MOD_Plk_1	475	481	PF00069	0.586
MOD_Plk_1	716	722	PF00069	0.553
MOD_Plk_2-3	197	203	PF00069	0.355
MOD_Plk_2-3	640	646	PF00069	0.462
MOD_Plk_4	132	138	PF00069	0.642
MOD_Plk_4	270	276	PF00069	0.368
MOD_Plk_4	407	413	PF00069	0.406
MOD_Plk_4	475	481	PF00069	0.579
MOD_Plk_4	650	656	PF00069	0.462
MOD_Plk_4	69	75	PF00069	0.377
MOD_Plk_4	717	723	PF00069	0.578
MOD_ProDKin_1	122	128	PF00069	0.622
MOD_ProDKin_1	142	148	PF00069	0.639
MOD_ProDKin_1	289	295	PF00069	0.563
MOD_ProDKin_1	399	405	PF00069	0.425
MOD_ProDKin_1	488	494	PF00069	0.558
MOD_ProDKin_1	502	508	PF00069	0.572
MOD_ProDKin_1	83	89	PF00069	0.430
MOD_SUMO_for_1	613	616	PF00179	0.495
MOD_SUMO_rev_2	303	312	PF00179	0.553
MOD_SUMO_rev_2	616	622	PF00179	0.492
MOD_SUMO_rev_2	684	691	PF00179	0.555
TRG_DiLeu_BaEn_2	307	313	PF01217	0.549
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.438
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.525
TRG_ENDOCYTIC_2	26	29	PF00928	0.401
TRG_ENDOCYTIC_2	338	341	PF00928	0.343
TRG_ENDOCYTIC_2	558	561	PF00928	0.482
TRG_ENDOCYTIC_2	581	584	PF00928	0.490
TRG_ENDOCYTIC_2	73	76	PF00928	0.386
TRG_ER_diArg_1	372	375	PF00400	0.336
TRG_ER_diArg_1	443	445	PF00400	0.483
TRG_ER_diArg_1	533	536	PF00400	0.643
TRG_ER_diArg_1	99	102	PF00400	0.394
TRG_NES_CRM1_1	640	652	PF08389	0.490
TRG_NLS_MonoExtC_3	727	732	PF00514	0.561
TRG_NLS_MonoExtN_4	728	735	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG5	Leptomonas seymouri	36%	98%
A0A3Q8IVC2	Leishmania donovani	99%	100%
A4HMV4	Leishmania braziliensis	62%	100%
E9AFB1	Leishmania major	88%	100%
E9B6G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%