Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBH2_LEIIN

TriTrypDb:

LINF_350033600

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.444
CLV_C14_Caspase3-7	485	489	PF00656	0.737
CLV_NRD_NRD_1	191	193	PF00675	0.485
CLV_NRD_NRD_1	347	349	PF00675	0.648
CLV_NRD_NRD_1	452	454	PF00675	0.581
CLV_PCSK_FUR_1	450	454	PF00082	0.579
CLV_PCSK_KEX2_1	144	146	PF00082	0.598
CLV_PCSK_KEX2_1	191	193	PF00082	0.485
CLV_PCSK_KEX2_1	23	25	PF00082	0.483
CLV_PCSK_KEX2_1	347	349	PF00082	0.642
CLV_PCSK_KEX2_1	364	366	PF00082	0.563
CLV_PCSK_KEX2_1	435	437	PF00082	0.703
CLV_PCSK_KEX2_1	452	454	PF00082	0.581
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.529
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.483
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.653
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.703
CLV_PCSK_SKI1_1	114	118	PF00082	0.417
CLV_PCSK_SKI1_1	145	149	PF00082	0.603
CLV_PCSK_SKI1_1	191	195	PF00082	0.573
CLV_PCSK_SKI1_1	255	259	PF00082	0.543
CLV_PCSK_SKI1_1	365	369	PF00082	0.614
CLV_PCSK_SKI1_1	436	440	PF00082	0.740
CLV_PCSK_SKI1_1	552	556	PF00082	0.607
CLV_PCSK_SKI1_1	564	568	PF00082	0.521
DEG_SCF_FBW7_1	566	571	PF00400	0.623
DOC_ANK_TNKS_1	503	510	PF00023	0.733
DOC_CYCLIN_RxL_1	287	298	PF00134	0.580
DOC_CYCLIN_yClb1_LxF_4	385	390	PF00134	0.320
DOC_MAPK_gen_1	288	296	PF00069	0.577
DOC_MAPK_gen_1	44	51	PF00069	0.474
DOC_MAPK_gen_1	450	460	PF00069	0.589
DOC_MAPK_JIP1_4	290	296	PF00069	0.558
DOC_MAPK_MEF2A_6	109	117	PF00069	0.346
DOC_MAPK_MEF2A_6	23	32	PF00069	0.468
DOC_MAPK_MEF2A_6	255	264	PF00069	0.535
DOC_MAPK_MEF2A_6	288	296	PF00069	0.464
DOC_PP1_RVXF_1	385	391	PF00149	0.322
DOC_PP2B_LxvP_1	500	503	PF13499	0.723
DOC_USP7_MATH_1	135	139	PF00917	0.450
DOC_USP7_MATH_1	158	162	PF00917	0.573
DOC_USP7_MATH_1	279	283	PF00917	0.537
DOC_USP7_MATH_1	295	299	PF00917	0.434
DOC_USP7_MATH_1	377	381	PF00917	0.518
DOC_USP7_MATH_1	568	572	PF00917	0.630
DOC_USP7_MATH_1	603	607	PF00917	0.560
DOC_WD40_RPTOR_TOS_1	90	96	PF00400	0.464
DOC_WW_Pin1_4	301	306	PF00397	0.552
DOC_WW_Pin1_4	319	324	PF00397	0.423
DOC_WW_Pin1_4	371	376	PF00397	0.696
DOC_WW_Pin1_4	494	499	PF00397	0.688
DOC_WW_Pin1_4	564	569	PF00397	0.701
DOC_WW_Pin1_4	84	89	PF00397	0.617
LIG_14-3-3_CanoR_1	221	231	PF00244	0.586
LIG_14-3-3_CanoR_1	24	28	PF00244	0.469
LIG_14-3-3_CanoR_1	335	339	PF00244	0.658
LIG_14-3-3_CanoR_1	387	391	PF00244	0.322
LIG_14-3-3_CanoR_1	405	411	PF00244	0.574
LIG_14-3-3_CanoR_1	44	51	PF00244	0.423
LIG_Actin_WH2_2	590	607	PF00022	0.523
LIG_APCC_ABBA_1	162	167	PF00400	0.450
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_BIR_III_2	275	279	PF00653	0.660
LIG_BRCT_BRCA1_1	208	212	PF00533	0.431
LIG_BRCT_BRCA1_1	55	59	PF00533	0.509
LIG_BRCT_BRCA1_1	86	90	PF00533	0.513
LIG_deltaCOP1_diTrp_1	315	324	PF00928	0.424
LIG_eIF4E_1	189	195	PF01652	0.527
LIG_FHA_1	529	535	PF00498	0.500
LIG_FHA_2	144	150	PF00498	0.531
LIG_FHA_2	177	183	PF00498	0.532
LIG_FHA_2	247	253	PF00498	0.589
LIG_FHA_2	474	480	PF00498	0.704
LIG_FHA_2	594	600	PF00498	0.527
LIG_IRF3_LxIS_1	27	33	PF10401	0.458
LIG_LIR_Gen_1	209	220	PF02991	0.407
LIG_LIR_Gen_1	322	331	PF02991	0.432
LIG_LIR_Gen_1	544	554	PF02991	0.654
LIG_LIR_Nem_3	209	215	PF02991	0.426
LIG_LIR_Nem_3	25	30	PF02991	0.465
LIG_LIR_Nem_3	256	261	PF02991	0.429
LIG_LIR_Nem_3	322	327	PF02991	0.385
LIG_LIR_Nem_3	544	550	PF02991	0.581
LIG_LIR_Nem_3	56	62	PF02991	0.506
LIG_MYND_1	523	527	PF01753	0.679
LIG_NRBOX	456	462	PF00104	0.559
LIG_Pex14_1	317	321	PF04695	0.382
LIG_Pex14_2	99	103	PF04695	0.365
LIG_SH2_SRC	273	276	PF00017	0.433
LIG_SH2_STAP1	100	104	PF00017	0.413
LIG_SH2_STAP1	165	169	PF00017	0.510
LIG_SH2_STAP1	189	193	PF00017	0.504
LIG_SH2_STAP1	397	401	PF00017	0.503
LIG_SH2_STAT3	177	180	PF00017	0.623
LIG_SH2_STAT5	165	168	PF00017	0.475
LIG_SH2_STAT5	214	217	PF00017	0.393
LIG_SH2_STAT5	273	276	PF00017	0.433
LIG_SH2_STAT5	321	324	PF00017	0.433
LIG_SH3_3	182	188	PF00018	0.484
LIG_SH3_3	299	305	PF00018	0.505
LIG_SH3_3	492	498	PF00018	0.691
LIG_Sin3_3	258	265	PF02671	0.521
LIG_SUMO_SIM_anti_2	462	470	PF11976	0.644
LIG_SUMO_SIM_par_1	292	298	PF11976	0.442
LIG_SUMO_SIM_par_1	585	593	PF11976	0.535
LIG_TRAF2_1	124	127	PF00917	0.597
LIG_TRAF2_1	179	182	PF00917	0.487
LIG_TRAF2_1	441	444	PF00917	0.700
LIG_UBA3_1	457	464	PF00899	0.612
MOD_CDK_SPxxK_3	494	501	PF00069	0.735
MOD_CK1_1	163	169	PF00069	0.522
MOD_CK1_1	225	231	PF00069	0.630
MOD_CK1_1	242	248	PF00069	0.638
MOD_CK1_1	282	288	PF00069	0.670
MOD_CK1_1	360	366	PF00069	0.670
MOD_CK1_1	473	479	PF00069	0.667
MOD_CK1_1	491	497	PF00069	0.673
MOD_CK1_1	52	58	PF00069	0.491
MOD_CK1_1	528	534	PF00069	0.628
MOD_CK1_1	593	599	PF00069	0.592
MOD_CK2_1	121	127	PF00069	0.589
MOD_CK2_1	135	141	PF00069	0.511
MOD_CK2_1	143	149	PF00069	0.510
MOD_CK2_1	176	182	PF00069	0.514
MOD_CK2_1	303	309	PF00069	0.751
MOD_CK2_1	473	479	PF00069	0.658
MOD_DYRK1A_RPxSP_1	605	609	PF00069	0.590
MOD_GlcNHglycan	123	126	PF01048	0.524
MOD_GlcNHglycan	137	140	PF01048	0.443
MOD_GlcNHglycan	216	219	PF01048	0.486
MOD_GlcNHglycan	281	284	PF01048	0.697
MOD_GlcNHglycan	359	362	PF01048	0.673
MOD_GlcNHglycan	365	368	PF01048	0.610
MOD_GlcNHglycan	379	382	PF01048	0.554
MOD_GlcNHglycan	485	488	PF01048	0.688
MOD_GlcNHglycan	570	573	PF01048	0.594
MOD_GSK3_1	143	150	PF00069	0.528
MOD_GSK3_1	242	249	PF00069	0.641
MOD_GSK3_1	28	35	PF00069	0.520
MOD_GSK3_1	406	413	PF00069	0.544
MOD_GSK3_1	444	451	PF00069	0.597
MOD_GSK3_1	466	473	PF00069	0.684
MOD_GSK3_1	49	56	PF00069	0.563
MOD_GSK3_1	564	571	PF00069	0.668
MOD_GSK3_1	589	596	PF00069	0.525
MOD_GSK3_1	84	91	PF00069	0.536
MOD_N-GLC_1	28	33	PF02516	0.458
MOD_N-GLC_1	482	487	PF02516	0.608
MOD_N-GLC_2	582	584	PF02516	0.479
MOD_NEK2_1	143	148	PF00069	0.565
MOD_NEK2_1	176	181	PF00069	0.580
MOD_NEK2_1	222	227	PF00069	0.458
MOD_NEK2_1	30	35	PF00069	0.456
MOD_NEK2_1	339	344	PF00069	0.514
MOD_NEK2_1	386	391	PF00069	0.507
MOD_NEK2_1	418	423	PF00069	0.618
MOD_NEK2_1	482	487	PF00069	0.696
MOD_NEK2_2	160	165	PF00069	0.537
MOD_OFUCOSY	48	53	PF10250	0.502
MOD_PIKK_1	176	182	PF00454	0.584
MOD_PIKK_1	282	288	PF00454	0.670
MOD_PIKK_1	392	398	PF00454	0.502
MOD_PIKK_1	62	68	PF00454	0.418
MOD_PKA_1	23	29	PF00069	0.472
MOD_PKA_2	16	22	PF00069	0.488
MOD_PKA_2	23	29	PF00069	0.466
MOD_PKA_2	239	245	PF00069	0.692
MOD_PKA_2	334	340	PF00069	0.430
MOD_PKA_2	386	392	PF00069	0.369
MOD_PKA_2	473	479	PF00069	0.658
MOD_PKA_2	491	497	PF00069	0.661
MOD_Plk_1	148	154	PF00069	0.695
MOD_Plk_1	158	164	PF00069	0.419
MOD_Plk_1	28	34	PF00069	0.458
MOD_Plk_1	589	595	PF00069	0.640
MOD_Plk_4	160	166	PF00069	0.476
MOD_Plk_4	334	340	PF00069	0.533
MOD_Plk_4	386	392	PF00069	0.410
MOD_Plk_4	53	59	PF00069	0.510
MOD_Plk_4	555	561	PF00069	0.584
MOD_ProDKin_1	301	307	PF00069	0.559
MOD_ProDKin_1	319	325	PF00069	0.426
MOD_ProDKin_1	371	377	PF00069	0.695
MOD_ProDKin_1	494	500	PF00069	0.689
MOD_ProDKin_1	564	570	PF00069	0.698
MOD_ProDKin_1	84	90	PF00069	0.599
MOD_SUMO_rev_2	91	99	PF00179	0.523
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.563
TRG_ENDOCYTIC_2	100	103	PF00928	0.405
TRG_ENDOCYTIC_2	15	18	PF00928	0.500
TRG_ENDOCYTIC_2	321	324	PF00928	0.408
TRG_ENDOCYTIC_2	40	43	PF00928	0.516
TRG_ER_diArg_1	346	348	PF00400	0.624
TRG_ER_diArg_1	43	46	PF00400	0.446
TRG_ER_diArg_1	450	453	PF00400	0.581
TRG_ER_diArg_1	561	564	PF00400	0.519
TRG_NES_CRM1_1	167	182	PF08389	0.409
TRG_NES_CRM1_1	456	470	PF08389	0.628
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q6	Leptomonas seymouri	40%	97%
A0A3S7X9F0	Leishmania donovani	100%	100%
A4HMV0	Leishmania braziliensis	71%	100%
E9AFA7	Leishmania major	85%	100%
E9B6G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%