MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Major Facilitator Superfamily/Sugar (and other) transporter - putative

Species:

Leishmania infantum

UniProt:

A4IBH1_LEIIN

TriTrypDb:

LINF_350033500

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4IBH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBH1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	14
GO:0022857	transmembrane transporter activity	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.392
CLV_MEL_PAP_1	641	647	PF00089	0.348
CLV_NRD_NRD_1	238	240	PF00675	0.439
CLV_NRD_NRD_1	80	82	PF00675	0.305
CLV_PCSK_FUR_1	236	240	PF00082	0.427
CLV_PCSK_KEX2_1	238	240	PF00082	0.442
CLV_PCSK_PC7_1	234	240	PF00082	0.402
CLV_PCSK_SKI1_1	175	179	PF00082	0.687
CLV_PCSK_SKI1_1	436	440	PF00082	0.410
CLV_PCSK_SKI1_1	505	509	PF00082	0.361
CLV_PCSK_SKI1_1	594	598	PF00082	0.310
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DEG_SCF_TRCP1_1	420	425	PF00400	0.636
DEG_SPOP_SBC_1	550	554	PF00917	0.291
DOC_CDC14_PxL_1	626	634	PF14671	0.340
DOC_CKS1_1	530	535	PF01111	0.340
DOC_MAPK_gen_1	401	410	PF00069	0.612
DOC_MAPK_gen_1	473	480	PF00069	0.405
DOC_MAPK_gen_1	81	89	PF00069	0.503
DOC_MAPK_MEF2A_6	445	452	PF00069	0.558
DOC_MAPK_MEF2A_6	78	87	PF00069	0.502
DOC_PP2B_LxvP_1	297	300	PF13499	0.705
DOC_PP2B_LxvP_1	30	33	PF13499	0.349
DOC_PP2B_LxvP_1	439	442	PF13499	0.519
DOC_USP7_MATH_1	216	220	PF00917	0.600
DOC_USP7_MATH_1	225	229	PF00917	0.756
DOC_USP7_MATH_1	250	254	PF00917	0.632
DOC_USP7_MATH_1	323	327	PF00917	0.636
DOC_USP7_MATH_1	418	422	PF00917	0.676
DOC_USP7_MATH_1	93	97	PF00917	0.301
DOC_WW_Pin1_4	332	337	PF00397	0.722
DOC_WW_Pin1_4	387	392	PF00397	0.714
DOC_WW_Pin1_4	529	534	PF00397	0.347
DOC_WW_Pin1_4	99	104	PF00397	0.349
LIG_14-3-3_CanoR_1	352	360	PF00244	0.753
LIG_14-3-3_CanoR_1	426	430	PF00244	0.802
LIG_14-3-3_CanoR_1	594	599	PF00244	0.340
LIG_14-3-3_CanoR_1	6	11	PF00244	0.517
LIG_14-3-3_CterR_2	644	647	PF00244	0.552
LIG_BIR_III_4	376	380	PF00653	0.661
LIG_BRCT_BRCA1_1	499	503	PF00533	0.349
LIG_BRCT_BRCA1_1	541	545	PF00533	0.417
LIG_BRCT_BRCA1_1	563	567	PF00533	0.355
LIG_BRCT_BRCA1_1	95	99	PF00533	0.369
LIG_DLG_GKlike_1	356	364	PF00625	0.577
LIG_eIF4E_1	52	58	PF01652	0.354
LIG_FHA_1	109	115	PF00498	0.310
LIG_FHA_1	135	141	PF00498	0.474
LIG_FHA_1	17	23	PF00498	0.351
LIG_FHA_1	205	211	PF00498	0.419
LIG_FHA_1	512	518	PF00498	0.523
LIG_FHA_1	525	531	PF00498	0.303
LIG_FHA_1	552	558	PF00498	0.359
LIG_FHA_1	595	601	PF00498	0.291
LIG_FHA_1	66	72	PF00498	0.349
LIG_FHA_2	131	137	PF00498	0.505
LIG_FHA_2	72	78	PF00498	0.502
LIG_IRF3_LxIS_1	206	212	PF10401	0.277
LIG_IRF3_LxIS_1	485	492	PF10401	0.349
LIG_IRF3_LxIS_1	53	59	PF10401	0.301
LIG_LIR_Gen_1	201	211	PF02991	0.310
LIG_LIR_Gen_1	276	285	PF02991	0.697
LIG_LIR_Gen_1	493	503	PF02991	0.329
LIG_LIR_Gen_1	519	524	PF02991	0.309
LIG_LIR_Gen_1	560	571	PF02991	0.351
LIG_LIR_Gen_1	591	600	PF02991	0.303
LIG_LIR_Gen_1	9	17	PF02991	0.555
LIG_LIR_Nem_3	146	151	PF02991	0.286
LIG_LIR_Nem_3	201	206	PF02991	0.310
LIG_LIR_Nem_3	276	282	PF02991	0.700
LIG_LIR_Nem_3	493	499	PF02991	0.329
LIG_LIR_Nem_3	500	506	PF02991	0.362
LIG_LIR_Nem_3	519	523	PF02991	0.293
LIG_LIR_Nem_3	564	570	PF02991	0.517
LIG_LIR_Nem_3	96	101	PF02991	0.340
LIG_MLH1_MIPbox_1	95	99	PF16413	0.349
LIG_MYND_1	170	174	PF01753	0.362
LIG_MYND_1	192	196	PF01753	0.341
LIG_Pex14_2	226	230	PF04695	0.666
LIG_Pex14_2	34	38	PF04695	0.278
LIG_Pex14_2	618	622	PF04695	0.372
LIG_PTAP_UEV_1	311	316	PF05743	0.606
LIG_SH2_CRK	451	455	PF00017	0.331
LIG_SH2_CRK	620	624	PF00017	0.295
LIG_SH2_GRB2like	11	14	PF00017	0.467
LIG_SH2_PTP2	496	499	PF00017	0.400
LIG_SH2_STAP1	11	15	PF00017	0.502
LIG_SH2_STAP1	360	364	PF00017	0.593
LIG_SH2_STAP1	546	550	PF00017	0.341
LIG_SH2_STAP1	563	567	PF00017	0.384
LIG_SH2_STAT5	11	14	PF00017	0.502
LIG_SH2_STAT5	162	165	PF00017	0.310
LIG_SH2_STAT5	496	499	PF00017	0.430
LIG_SH2_STAT5	52	55	PF00017	0.388
LIG_SH2_STAT5	537	540	PF00017	0.399
LIG_SH2_STAT5	569	572	PF00017	0.495
LIG_SH3_3	151	157	PF00018	0.349
LIG_SH3_3	168	174	PF00018	0.408
LIG_SH3_3	186	192	PF00018	0.253
LIG_SH3_3	219	225	PF00018	0.625
LIG_SH3_3	309	315	PF00018	0.620
LIG_SH3_3	385	391	PF00018	0.694
LIG_SH3_3	597	603	PF00018	0.313
LIG_SH3_3	609	615	PF00018	0.373
LIG_SH3_4	82	89	PF00018	0.502
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.343
LIG_SUMO_SIM_anti_2	259	270	PF11976	0.703
LIG_SUMO_SIM_par_1	18	25	PF11976	0.346
LIG_SUMO_SIM_par_1	206	212	PF11976	0.277
LIG_SUMO_SIM_par_1	629	634	PF11976	0.340
LIG_SxIP_EBH_1	594	607	PF03271	0.310
LIG_TRFH_1	188	192	PF08558	0.373
LIG_TRFH_1	99	103	PF08558	0.310
LIG_TYR_ITIM	449	454	PF00017	0.461
LIG_TYR_ITIM	494	499	PF00017	0.400
LIG_UBA3_1	97	106	PF00899	0.349
LIG_WRC_WIRS_1	200	205	PF05994	0.424
LIG_WRC_WIRS_1	589	594	PF05994	0.262
LIG_WRC_WIRS_1	632	637	PF05994	0.340
MOD_CDK_SPxxK_3	99	106	PF00069	0.349
MOD_CK1_1	201	207	PF00069	0.495
MOD_CK1_1	302	308	PF00069	0.620
MOD_CK1_1	359	365	PF00069	0.525
MOD_CK1_1	421	427	PF00069	0.631
MOD_CK1_1	456	462	PF00069	0.275
MOD_CK1_1	529	535	PF00069	0.359
MOD_CK1_1	588	594	PF00069	0.329
MOD_CK1_1	9	15	PF00069	0.374
MOD_CK2_1	310	316	PF00069	0.623
MOD_CK2_1	550	556	PF00069	0.340
MOD_Cter_Amidation	79	82	PF01082	0.354
MOD_GlcNHglycan	203	206	PF01048	0.375
MOD_GlcNHglycan	231	234	PF01048	0.522
MOD_GlcNHglycan	26	29	PF01048	0.349
MOD_GlcNHglycan	288	291	PF01048	0.649
MOD_GlcNHglycan	293	296	PF01048	0.642
MOD_GlcNHglycan	312	315	PF01048	0.435
MOD_GlcNHglycan	368	371	PF01048	0.557
MOD_GlcNHglycan	420	423	PF01048	0.631
MOD_GlcNHglycan	458	461	PF01048	0.413
MOD_GlcNHglycan	53	56	PF01048	0.371
MOD_GlcNHglycan	572	575	PF01048	0.463
MOD_GSK3_1	130	137	PF00069	0.439
MOD_GSK3_1	16	23	PF00069	0.392
MOD_GSK3_1	2	9	PF00069	0.545
MOD_GSK3_1	225	232	PF00069	0.589
MOD_GSK3_1	286	293	PF00069	0.619
MOD_GSK3_1	302	309	PF00069	0.615
MOD_GSK3_1	347	354	PF00069	0.628
MOD_GSK3_1	356	363	PF00069	0.506
MOD_GSK3_1	418	425	PF00069	0.684
MOD_GSK3_1	497	504	PF00069	0.391
MOD_GSK3_1	525	532	PF00069	0.387
MOD_GSK3_1	536	543	PF00069	0.390
MOD_GSK3_1	557	564	PF00069	0.329
MOD_GSK3_1	590	597	PF00069	0.363
MOD_GSK3_1	631	638	PF00069	0.379
MOD_N-GLC_1	286	291	PF02516	0.558
MOD_NEK2_1	209	214	PF00069	0.553
MOD_NEK2_1	229	234	PF00069	0.569
MOD_NEK2_1	26	31	PF00069	0.373
MOD_NEK2_1	366	371	PF00069	0.594
MOD_NEK2_1	478	483	PF00069	0.398
MOD_NEK2_1	489	494	PF00069	0.400
MOD_NEK2_1	501	506	PF00069	0.421
MOD_NEK2_1	524	529	PF00069	0.358
MOD_NEK2_1	56	61	PF00069	0.401
MOD_NEK2_1	596	601	PF00069	0.374
MOD_NEK2_1	605	610	PF00069	0.456
MOD_NEK2_1	624	629	PF00069	0.351
MOD_NEK2_1	631	636	PF00069	0.351
MOD_NEK2_1	71	76	PF00069	0.479
MOD_NEK2_2	143	148	PF00069	0.310
MOD_NEK2_2	225	230	PF00069	0.576
MOD_NEK2_2	93	98	PF00069	0.413
MOD_PIKK_1	330	336	PF00454	0.559
MOD_PIKK_1	395	401	PF00454	0.562
MOD_PKA_1	238	244	PF00069	0.498
MOD_PKA_2	238	244	PF00069	0.589
MOD_PKA_2	351	357	PF00069	0.652
MOD_PKA_2	425	431	PF00069	0.519
MOD_PKB_1	236	244	PF00069	0.492
MOD_Plk_1	518	524	PF00069	0.340
MOD_Plk_1	539	545	PF00069	0.421
MOD_Plk_4	124	130	PF00069	0.516
MOD_Plk_4	150	156	PF00069	0.371
MOD_Plk_4	16	22	PF00069	0.344
MOD_Plk_4	225	231	PF00069	0.725
MOD_Plk_4	26	32	PF00069	0.328
MOD_Plk_4	490	496	PF00069	0.516
MOD_Plk_4	526	532	PF00069	0.358
MOD_Plk_4	540	546	PF00069	0.504
MOD_Plk_4	561	567	PF00069	0.393
MOD_Plk_4	596	602	PF00069	0.336
MOD_Plk_4	6	12	PF00069	0.543
MOD_Plk_4	631	637	PF00069	0.371
MOD_Plk_4	93	99	PF00069	0.399
MOD_ProDKin_1	332	338	PF00069	0.657
MOD_ProDKin_1	387	393	PF00069	0.643
MOD_ProDKin_1	529	535	PF00069	0.347
MOD_ProDKin_1	99	105	PF00069	0.349
MOD_SUMO_rev_2	428	433	PF00179	0.511
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.522
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.340
TRG_ENDOCYTIC_2	11	14	PF00928	0.349
TRG_ENDOCYTIC_2	451	454	PF00928	0.373
TRG_ENDOCYTIC_2	496	499	PF00928	0.419
TRG_ENDOCYTIC_2	563	566	PF00928	0.510
TRG_ENDOCYTIC_2	620	623	PF00928	0.353
TRG_ER_diArg_1	238	240	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	31%	98%
A0A0S4KJ45	Bodo saltans	28%	100%
A0A3Q8II42	Leishmania donovani	99%	100%
A0A3Q8IPN7	Leishmania donovani	31%	92%
A4HMU7	Leishmania braziliensis	30%	100%
A4HMU9	Leishmania braziliensis	71%	100%
A4IBH0	Leishmania infantum	31%	92%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9AFA5	Leishmania major	31%	92%
E9AFA6	Leishmania major	88%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%