LeishMANIAdb
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MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
transporter - putative
Species:
Leishmania infantum
UniProt:
A4IBH0_LEIIN
TriTrypDb:
LINF_350033400
Length:
705

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4IBH0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBH0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0022857 transmembrane transporter activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 109 111 PF00675 0.302
CLV_NRD_NRD_1 212 214 PF00675 0.551
CLV_NRD_NRD_1 22 24 PF00675 0.476
CLV_NRD_NRD_1 27 29 PF00675 0.475
CLV_NRD_NRD_1 31 33 PF00675 0.434
CLV_PCSK_KEX2_1 109 111 PF00082 0.265
CLV_PCSK_KEX2_1 22 24 PF00082 0.459
CLV_PCSK_KEX2_1 31 33 PF00082 0.452
CLV_PCSK_KEX2_1 381 383 PF00082 0.425
CLV_PCSK_KEX2_1 461 463 PF00082 0.385
CLV_PCSK_PC1ET2_1 31 33 PF00082 0.463
CLV_PCSK_PC1ET2_1 381 383 PF00082 0.422
CLV_PCSK_PC1ET2_1 461 463 PF00082 0.383
CLV_PCSK_SKI1_1 214 218 PF00082 0.504
CLV_PCSK_SKI1_1 32 36 PF00082 0.392
CLV_PCSK_SKI1_1 421 425 PF00082 0.460
CLV_PCSK_SKI1_1 466 470 PF00082 0.354
CLV_PCSK_SKI1_1 471 475 PF00082 0.340
CLV_PCSK_SKI1_1 584 588 PF00082 0.286
DEG_MDM2_SWIB_1 586 594 PF02201 0.339
DOC_CKS1_1 629 634 PF01111 0.339
DOC_MAPK_DCC_7 213 223 PF00069 0.297
DOC_MAPK_FxFP_2 572 575 PF00069 0.284
DOC_MAPK_gen_1 511 520 PF00069 0.332
DOC_MAPK_gen_1 682 690 PF00069 0.532
DOC_MAPK_MEF2A_6 214 223 PF00069 0.297
DOC_MAPK_MEF2A_6 475 484 PF00069 0.540
DOC_MAPK_MEF2A_6 8 16 PF00069 0.662
DOC_MAPK_NFAT4_5 475 483 PF00069 0.465
DOC_PP4_FxxP_1 266 269 PF00568 0.543
DOC_PP4_FxxP_1 385 388 PF00568 0.666
DOC_PP4_FxxP_1 469 472 PF00568 0.590
DOC_PP4_FxxP_1 572 575 PF00568 0.315
DOC_USP7_MATH_1 171 175 PF00917 0.322
DOC_USP7_MATH_1 194 198 PF00917 0.270
DOC_USP7_MATH_1 436 440 PF00917 0.775
DOC_USP7_MATH_1 441 445 PF00917 0.723
DOC_USP7_MATH_1 562 566 PF00917 0.309
DOC_USP7_UBL2_3 29 33 PF12436 0.707
DOC_WW_Pin1_4 32 37 PF00397 0.587
DOC_WW_Pin1_4 324 329 PF00397 0.672
DOC_WW_Pin1_4 359 364 PF00397 0.686
DOC_WW_Pin1_4 384 389 PF00397 0.627
DOC_WW_Pin1_4 628 633 PF00397 0.339
LIG_14-3-3_CanoR_1 382 388 PF00244 0.712
LIG_14-3-3_CanoR_1 548 553 PF00244 0.459
LIG_14-3-3_CanoR_1 584 594 PF00244 0.269
LIG_14-3-3_CterR_2 702 705 PF00244 0.593
LIG_Actin_WH2_2 58 73 PF00022 0.339
LIG_BRCT_BRCA1_1 114 118 PF00533 0.328
LIG_BRCT_BRCA1_1 361 365 PF00533 0.654
LIG_BRCT_BRCA1_1 568 572 PF00533 0.432
LIG_deltaCOP1_diTrp_1 681 686 PF00928 0.587
LIG_DLG_GKlike_1 548 556 PF00625 0.459
LIG_EH1_1 176 184 PF00400 0.322
LIG_eIF4E_1 177 183 PF01652 0.322
LIG_eIF4E_1 80 86 PF01652 0.303
LIG_FHA_1 117 123 PF00498 0.286
LIG_FHA_1 233 239 PF00498 0.382
LIG_FHA_1 272 278 PF00498 0.647
LIG_FHA_1 315 321 PF00498 0.630
LIG_FHA_1 324 330 PF00498 0.609
LIG_FHA_1 397 403 PF00498 0.647
LIG_FHA_1 420 426 PF00498 0.691
LIG_FHA_1 44 50 PF00498 0.337
LIG_FHA_1 472 478 PF00498 0.564
LIG_FHA_1 519 525 PF00498 0.304
LIG_FHA_1 55 61 PF00498 0.356
LIG_FHA_2 282 288 PF00498 0.679
LIG_FHA_2 365 371 PF00498 0.703
LIG_FHA_2 488 494 PF00498 0.304
LIG_FHA_2 669 675 PF00498 0.534
LIG_LIR_Apic_2 569 575 PF02991 0.327
LIG_LIR_Gen_1 321 330 PF02991 0.638
LIG_LIR_Gen_1 46 54 PF02991 0.374
LIG_LIR_Nem_3 321 325 PF02991 0.635
LIG_LIR_Nem_3 46 50 PF02991 0.304
LIG_LIR_Nem_3 551 556 PF02991 0.492
LIG_LIR_Nem_3 569 574 PF02991 0.268
LIG_LIR_Nem_3 696 701 PF02991 0.518
LIG_LYPXL_S_1 255 259 PF13949 0.317
LIG_MLH1_MIPbox_1 568 572 PF16413 0.347
LIG_MYND_1 215 219 PF01753 0.374
LIG_NRBOX 479 485 PF00104 0.260
LIG_NRBOX 649 655 PF00104 0.304
LIG_PCNA_yPIPBox_3 308 320 PF02747 0.610
LIG_Pex14_1 134 138 PF04695 0.272
LIG_Pex14_2 586 590 PF04695 0.357
LIG_REV1ctd_RIR_1 136 144 PF16727 0.304
LIG_SH2_CRK 226 230 PF00017 0.295
LIG_SH2_GRB2like 226 229 PF00017 0.295
LIG_SH2_GRB2like 540 543 PF00017 0.556
LIG_SH2_NCK_1 192 196 PF00017 0.252
LIG_SH2_PTP2 254 257 PF00017 0.537
LIG_SH2_PTP2 481 484 PF00017 0.260
LIG_SH2_PTP2 517 520 PF00017 0.286
LIG_SH2_SRC 192 195 PF00017 0.252
LIG_SH2_SRC 254 257 PF00017 0.537
LIG_SH2_SRC 663 666 PF00017 0.357
LIG_SH2_STAP1 419 423 PF00017 0.618
LIG_SH2_STAP1 665 669 PF00017 0.503
LIG_SH2_STAT5 226 229 PF00017 0.295
LIG_SH2_STAT5 254 257 PF00017 0.510
LIG_SH2_STAT5 481 484 PF00017 0.278
LIG_SH2_STAT5 517 520 PF00017 0.320
LIG_SH2_STAT5 540 543 PF00017 0.545
LIG_SH2_STAT5 566 569 PF00017 0.356
LIG_SH2_STAT5 571 574 PF00017 0.344
LIG_SH2_STAT5 663 666 PF00017 0.392
LIG_SH3_3 322 328 PF00018 0.625
LIG_SH3_3 6 12 PF00018 0.738
LIG_SH3_3 626 632 PF00018 0.307
LIG_SUMO_SIM_anti_2 352 357 PF11976 0.642
LIG_SUMO_SIM_anti_2 391 401 PF11976 0.639
LIG_SUMO_SIM_anti_2 476 481 PF11976 0.322
LIG_SUMO_SIM_anti_2 557 562 PF11976 0.292
LIG_SUMO_SIM_par_1 391 401 PF11976 0.639
LIG_TRAF2_1 490 493 PF00917 0.389
LIG_TRFH_1 571 575 PF08558 0.324
LIG_TYR_ITIM 479 484 PF00017 0.479
LIG_TYR_ITIM 515 520 PF00017 0.286
LIG_UBA3_1 156 163 PF00899 0.440
LIG_WRC_WIRS_1 233 238 PF05994 0.363
MOD_CDK_SPxxK_3 324 331 PF00069 0.599
MOD_CK1_1 206 212 PF00069 0.366
MOD_CK1_1 270 276 PF00069 0.609
MOD_CK1_1 283 289 PF00069 0.621
MOD_CK1_1 346 352 PF00069 0.757
MOD_CK1_1 53 59 PF00069 0.360
MOD_CK1_1 655 661 PF00069 0.229
MOD_CK1_1 693 699 PF00069 0.506
MOD_CK2_1 281 287 PF00069 0.664
MOD_CK2_1 289 295 PF00069 0.707
MOD_CK2_1 368 374 PF00069 0.677
MOD_CK2_1 487 493 PF00069 0.304
MOD_CK2_1 71 77 PF00069 0.297
MOD_Cter_Amidation 107 110 PF01082 0.303
MOD_GlcNHglycan 114 117 PF01048 0.251
MOD_GlcNHglycan 119 122 PF01048 0.295
MOD_GlcNHglycan 197 200 PF01048 0.569
MOD_GlcNHglycan 438 441 PF01048 0.487
MOD_GlcNHglycan 484 487 PF01048 0.328
MOD_GlcNHglycan 601 604 PF01048 0.335
MOD_GlcNHglycan 654 657 PF01048 0.407
MOD_GlcNHglycan 660 663 PF01048 0.295
MOD_GlcNHglycan 81 84 PF01048 0.349
MOD_GlcNHglycan 95 98 PF01048 0.349
MOD_GSK3_1 112 119 PF00069 0.286
MOD_GSK3_1 267 274 PF00069 0.661
MOD_GSK3_1 277 284 PF00069 0.638
MOD_GSK3_1 364 371 PF00069 0.744
MOD_GSK3_1 413 420 PF00069 0.669
MOD_GSK3_1 436 443 PF00069 0.673
MOD_GSK3_1 50 57 PF00069 0.404
MOD_GSK3_1 562 569 PF00069 0.382
MOD_GSK3_1 599 606 PF00069 0.573
MOD_GSK3_1 636 643 PF00069 0.346
MOD_LATS_1 69 75 PF00433 0.297
MOD_N-GLC_1 16 21 PF02516 0.465
MOD_N-GLC_1 195 200 PF02516 0.555
MOD_N-GLC_1 289 294 PF02516 0.488
MOD_N-GLC_1 346 351 PF02516 0.465
MOD_N-GLC_1 50 55 PF02516 0.295
MOD_NEK2_1 117 122 PF00069 0.301
MOD_NEK2_1 127 132 PF00069 0.295
MOD_NEK2_1 224 229 PF00069 0.426
MOD_NEK2_1 232 237 PF00069 0.474
MOD_NEK2_1 277 282 PF00069 0.662
MOD_NEK2_1 341 346 PF00069 0.675
MOD_NEK2_1 364 369 PF00069 0.707
MOD_NEK2_1 50 55 PF00069 0.334
MOD_NEK2_1 520 525 PF00069 0.406
MOD_NEK2_1 578 583 PF00069 0.359
MOD_NEK2_1 586 591 PF00069 0.484
MOD_NEK2_1 612 617 PF00069 0.511
MOD_NEK2_1 634 639 PF00069 0.333
MOD_NEK2_1 652 657 PF00069 0.346
MOD_NEK2_2 419 424 PF00069 0.644
MOD_OFUCOSY 301 307 PF10250 0.415
MOD_PIKK_1 314 320 PF00454 0.629
MOD_PIKK_1 612 618 PF00454 0.486
MOD_PK_1 71 77 PF00069 0.297
MOD_PKA_2 403 409 PF00069 0.688
MOD_Plk_1 195 201 PF00069 0.361
MOD_Plk_1 277 283 PF00069 0.615
MOD_Plk_1 351 357 PF00069 0.626
MOD_Plk_1 487 493 PF00069 0.304
MOD_Plk_1 50 56 PF00069 0.295
MOD_Plk_1 680 686 PF00069 0.579
MOD_Plk_2-3 374 380 PF00069 0.635
MOD_Plk_4 129 135 PF00069 0.355
MOD_Plk_4 152 158 PF00069 0.502
MOD_Plk_4 206 212 PF00069 0.377
MOD_Plk_4 217 223 PF00069 0.246
MOD_Plk_4 232 238 PF00069 0.370
MOD_Plk_4 351 357 PF00069 0.663
MOD_Plk_4 43 49 PF00069 0.317
MOD_Plk_4 54 60 PF00069 0.364
MOD_Plk_4 542 548 PF00069 0.558
MOD_Plk_4 562 568 PF00069 0.430
MOD_Plk_4 593 599 PF00069 0.348
MOD_Plk_4 607 613 PF00069 0.502
MOD_ProDKin_1 32 38 PF00069 0.577
MOD_ProDKin_1 324 330 PF00069 0.671
MOD_ProDKin_1 359 365 PF00069 0.686
MOD_ProDKin_1 384 390 PF00069 0.629
MOD_ProDKin_1 628 634 PF00069 0.339
MOD_SUMO_rev_2 373 383 PF00179 0.631
MOD_SUMO_rev_2 439 448 PF00179 0.676
MOD_SUMO_rev_2 457 463 PF00179 0.611
TRG_DiLeu_BaEn_2 261 267 PF01217 0.551
TRG_DiLeu_BaLyEn_6 325 330 PF01217 0.657
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.661
TRG_ENDOCYTIC_2 226 229 PF00928 0.295
TRG_ENDOCYTIC_2 256 259 PF00928 0.512
TRG_ENDOCYTIC_2 481 484 PF00928 0.393
TRG_ENDOCYTIC_2 517 520 PF00928 0.318
TRG_ENDOCYTIC_2 571 574 PF00928 0.310
TRG_ENDOCYTIC_2 592 595 PF00928 0.490
TRG_ENDOCYTIC_2 698 701 PF00928 0.582
TRG_ER_diArg_1 109 111 PF00400 0.465
TRG_NES_CRM1_1 41 52 PF08389 0.497
TRG_NLS_MonoExtC_3 27 32 PF00514 0.687
TRG_NLS_MonoExtN_4 28 35 PF00514 0.654

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMM8 Leptomonas seymouri 46% 100%
A0A3Q8II42 Leishmania donovani 31% 99%
A0A3Q8IPN7 Leishmania donovani 100% 100%
A4HMU7 Leishmania braziliensis 64% 100%
A4HMU9 Leishmania braziliensis 30% 97%
A4IBH1 Leishmania infantum 31% 99%
E8NHI2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9AFA5 Leishmania major 89% 100%
E9AFA6 Leishmania major 31% 98%
E9B6G0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS