Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBG7_LEIIN

TriTrypDb:

LINF_350031000

Length:

190

Annotations

LeishMANIAdb annotations

Might be an organellar (mitochondrial) protein with transit signal. Localization: Mitochondrial (by feature)

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4IBG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.773
CLV_NRD_NRD_1	35	37	PF00675	0.822
CLV_PCSK_KEX2_1	10	12	PF00082	0.773
CLV_PCSK_KEX2_1	125	127	PF00082	0.365
CLV_PCSK_KEX2_1	35	37	PF00082	0.822
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.365
CLV_PCSK_SKI1_1	176	180	PF00082	0.358
CLV_PCSK_SKI1_1	98	102	PF00082	0.478
DEG_APCC_DBOX_1	2	10	PF00400	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.505
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.467
DOC_PP1_RVXF_1	157	164	PF00149	0.576
DOC_PP1_RVXF_1	95	102	PF00149	0.363
DOC_PP2B_LxvP_1	20	23	PF13499	0.467
DOC_PP2B_LxvP_1	31	34	PF13499	0.525
DOC_USP7_MATH_1	180	184	PF00917	0.568
DOC_USP7_MATH_1	45	49	PF00917	0.588
DOC_USP7_MATH_1	56	60	PF00917	0.471
DOC_WW_Pin1_4	25	30	PF00397	0.508
DOC_WW_Pin1_4	40	45	PF00397	0.454
DOC_WW_Pin1_4	51	56	PF00397	0.526
LIG_14-3-3_CanoR_1	10	17	PF00244	0.521
LIG_BIR_III_2	131	135	PF00653	0.671
LIG_FHA_1	91	97	PF00498	0.377
LIG_FHA_2	165	171	PF00498	0.562
LIG_LIR_Gen_1	171	181	PF02991	0.532
LIG_LIR_LC3C_4	28	33	PF02991	0.474
LIG_LIR_Nem_3	171	177	PF02991	0.536
LIG_SH2_NCK_1	174	178	PF00017	0.538
LIG_SH2_STAP1	174	178	PF00017	0.538
LIG_SH2_STAT5	154	157	PF00017	0.581
LIG_SH3_3	133	139	PF00018	0.705
LIG_SH3_3	52	58	PF00018	0.588
LIG_TRAF2_1	167	170	PF00917	0.562
LIG_TYR_ITIM	172	177	PF00017	0.536
MOD_CDC14_SPxK_1	54	57	PF00782	0.511
MOD_CDK_SPxK_1	51	57	PF00069	0.511
MOD_CK1_1	25	31	PF00069	0.468
MOD_CK1_1	40	46	PF00069	0.440
MOD_CK1_1	90	96	PF00069	0.399
MOD_CK2_1	164	170	PF00069	0.562
MOD_CK2_1	36	42	PF00069	0.610
MOD_GlcNHglycan	12	15	PF01048	0.624
MOD_GlcNHglycan	47	50	PF01048	0.709
MOD_GlcNHglycan	58	61	PF01048	0.721
MOD_GlcNHglycan	6	9	PF01048	0.677
MOD_GSK3_1	36	43	PF00069	0.521
MOD_GSK3_1	45	52	PF00069	0.529
MOD_NEK2_1	4	9	PF00069	0.472
MOD_PIKK_1	148	154	PF00454	0.616
MOD_PIKK_1	180	186	PF00454	0.593
MOD_PIKK_1	61	67	PF00454	0.519
MOD_PKA_1	10	16	PF00069	0.503
MOD_PKA_2	9	15	PF00069	0.488
MOD_Plk_1	36	42	PF00069	0.588
MOD_Plk_2-3	164	170	PF00069	0.561
MOD_Plk_2-3	37	43	PF00069	0.459
MOD_ProDKin_1	25	31	PF00069	0.511
MOD_ProDKin_1	40	46	PF00069	0.455
MOD_ProDKin_1	51	57	PF00069	0.527
TRG_ENDOCYTIC_2	174	177	PF00928	0.540
TRG_ER_diArg_1	34	36	PF00400	0.599
TRG_ER_diArg_1	9	11	PF00400	0.577
TRG_NLS_MonoCore_2	121	126	PF00514	0.572
TRG_NLS_MonoExtC_3	121	126	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R4	Leptomonas seymouri	57%	100%
A0A3Q8IMC4	Leishmania donovani	100%	100%
E9AF81	Leishmania major	94%	100%
E9AIW4	Leishmania braziliensis	65%	100%
E9B6D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%