LeishMANIAdb
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Putative cytochrome P450 reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cytochrome P450 reductase
Gene product:
cytochrome P450 reductase - putative
Species:
Leishmania infantum
UniProt:
A4IBG5_LEIIN
TriTrypDb:
LINF_350030800
Length:
832

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Annotations by Jardim et al.

Oxidoreductase, cytochrome P450 reductase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0005829 cytosol 2 2

Expansion

Sequence features

A4IBG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBG5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0005488 binding 1 19
GO:0010181 FMN binding 4 19
GO:0016491 oxidoreductase activity 2 19
GO:0032553 ribonucleotide binding 3 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0003958 NADPH-hemoprotein reductase activity 5 6
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 6
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 6
GO:0050660 flavin adenine dinucleotide binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.765
CLV_NRD_NRD_1 150 152 PF00675 0.440
CLV_NRD_NRD_1 194 196 PF00675 0.321
CLV_NRD_NRD_1 33 35 PF00675 0.355
CLV_NRD_NRD_1 662 664 PF00675 0.267
CLV_NRD_NRD_1 668 670 PF00675 0.292
CLV_NRD_NRD_1 687 689 PF00675 0.289
CLV_NRD_NRD_1 725 727 PF00675 0.343
CLV_NRD_NRD_1 819 821 PF00675 0.323
CLV_PCSK_FUR_1 31 35 PF00082 0.328
CLV_PCSK_KEX2_1 127 129 PF00082 0.338
CLV_PCSK_KEX2_1 194 196 PF00082 0.321
CLV_PCSK_KEX2_1 33 35 PF00082 0.436
CLV_PCSK_KEX2_1 4 6 PF00082 0.560
CLV_PCSK_KEX2_1 642 644 PF00082 0.311
CLV_PCSK_KEX2_1 687 689 PF00082 0.332
CLV_PCSK_KEX2_1 725 727 PF00082 0.343
CLV_PCSK_KEX2_1 754 756 PF00082 0.287
CLV_PCSK_KEX2_1 819 821 PF00082 0.333
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.338
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.526
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.263
CLV_PCSK_PC1ET2_1 754 756 PF00082 0.287
CLV_PCSK_PC7_1 638 644 PF00082 0.273
CLV_PCSK_SKI1_1 194 198 PF00082 0.331
CLV_PCSK_SKI1_1 243 247 PF00082 0.263
CLV_PCSK_SKI1_1 283 287 PF00082 0.385
CLV_PCSK_SKI1_1 355 359 PF00082 0.432
CLV_PCSK_SKI1_1 360 364 PF00082 0.408
CLV_PCSK_SKI1_1 39 43 PF00082 0.496
CLV_PCSK_SKI1_1 400 404 PF00082 0.318
CLV_PCSK_SKI1_1 451 455 PF00082 0.231
CLV_PCSK_SKI1_1 476 480 PF00082 0.291
CLV_PCSK_SKI1_1 490 494 PF00082 0.189
CLV_PCSK_SKI1_1 603 607 PF00082 0.318
CLV_PCSK_SKI1_1 643 647 PF00082 0.297
CLV_PCSK_SKI1_1 664 668 PF00082 0.256
CLV_PCSK_SKI1_1 755 759 PF00082 0.407
CLV_PCSK_SKI1_1 826 830 PF00082 0.277
CLV_Separin_Metazoa 526 530 PF03568 0.481
DEG_APCC_DBOX_1 160 168 PF00400 0.585
DEG_APCC_DBOX_1 485 493 PF00400 0.424
DEG_SPOP_SBC_1 321 325 PF00917 0.636
DEG_SPOP_SBC_1 341 345 PF00917 0.561
DEG_SPOP_SBC_1 370 374 PF00917 0.635
DOC_CKS1_1 463 468 PF01111 0.466
DOC_CYCLIN_yCln2_LP_2 132 138 PF00134 0.611
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.476
DOC_MAPK_gen_1 253 260 PF00069 0.425
DOC_MAPK_gen_1 502 510 PF00069 0.439
DOC_MAPK_gen_1 642 648 PF00069 0.569
DOC_MAPK_MEF2A_6 161 169 PF00069 0.502
DOC_MAPK_MEF2A_6 301 310 PF00069 0.627
DOC_MAPK_MEF2A_6 486 493 PF00069 0.404
DOC_MAPK_MEF2A_6 597 604 PF00069 0.535
DOC_PP1_RVXF_1 260 266 PF00149 0.521
DOC_PP2B_LxvP_1 407 410 PF13499 0.393
DOC_PP2B_LxvP_1 456 459 PF13499 0.483
DOC_PP2B_LxvP_1 528 531 PF13499 0.581
DOC_PP4_FxxP_1 382 385 PF00568 0.629
DOC_PP4_FxxP_1 633 636 PF00568 0.479
DOC_USP7_MATH_1 202 206 PF00917 0.525
DOC_USP7_MATH_1 212 216 PF00917 0.546
DOC_USP7_MATH_1 322 326 PF00917 0.734
DOC_USP7_MATH_1 340 344 PF00917 0.774
DOC_USP7_MATH_1 353 357 PF00917 0.700
DOC_USP7_MATH_1 362 366 PF00917 0.763
DOC_USP7_MATH_1 369 373 PF00917 0.679
DOC_USP7_MATH_1 410 414 PF00917 0.539
DOC_USP7_MATH_1 503 507 PF00917 0.454
DOC_USP7_MATH_1 540 544 PF00917 0.539
DOC_USP7_MATH_1 724 728 PF00917 0.625
DOC_USP7_UBL2_3 148 152 PF12436 0.660
DOC_WW_Pin1_4 156 161 PF00397 0.647
DOC_WW_Pin1_4 360 365 PF00397 0.790
DOC_WW_Pin1_4 405 410 PF00397 0.490
DOC_WW_Pin1_4 441 446 PF00397 0.388
DOC_WW_Pin1_4 462 467 PF00397 0.469
DOC_WW_Pin1_4 58 63 PF00397 0.762
LIG_14-3-3_CanoR_1 194 202 PF00244 0.425
LIG_14-3-3_CanoR_1 243 252 PF00244 0.511
LIG_14-3-3_CanoR_1 502 511 PF00244 0.463
LIG_14-3-3_CanoR_1 591 598 PF00244 0.533
LIG_14-3-3_CanoR_1 629 634 PF00244 0.503
LIG_14-3-3_CanoR_1 687 694 PF00244 0.469
LIG_14-3-3_CanoR_1 725 735 PF00244 0.662
LIG_14-3-3_CanoR_1 755 761 PF00244 0.457
LIG_Actin_WH2_2 475 492 PF00022 0.536
LIG_Actin_WH2_2 814 831 PF00022 0.519
LIG_APCC_ABBA_1 183 188 PF00400 0.457
LIG_BIR_II_1 1 5 PF00653 0.457
LIG_BRCT_BRCA1_1 378 382 PF00533 0.568
LIG_CtBP_PxDLS_1 445 449 PF00389 0.521
LIG_eIF4E_1 662 668 PF01652 0.447
LIG_EVH1_1 380 384 PF00568 0.590
LIG_FHA_1 16 22 PF00498 0.307
LIG_FHA_1 196 202 PF00498 0.514
LIG_FHA_1 246 252 PF00498 0.469
LIG_FHA_1 322 328 PF00498 0.620
LIG_FHA_1 342 348 PF00498 0.563
LIG_FHA_1 505 511 PF00498 0.546
LIG_FHA_1 514 520 PF00498 0.504
LIG_FHA_1 604 610 PF00498 0.516
LIG_FHA_1 630 636 PF00498 0.496
LIG_FHA_1 677 683 PF00498 0.515
LIG_FHA_1 756 762 PF00498 0.477
LIG_FHA_2 151 157 PF00498 0.757
LIG_FHA_2 170 176 PF00498 0.414
LIG_FHA_2 463 469 PF00498 0.471
LIG_FHA_2 552 558 PF00498 0.426
LIG_FHA_2 594 600 PF00498 0.440
LIG_FHA_2 739 745 PF00498 0.504
LIG_FHA_2 98 104 PF00498 0.474
LIG_GBD_Chelix_1 601 609 PF00786 0.321
LIG_HCF-1_HBM_1 824 827 PF13415 0.564
LIG_LIR_Apic_2 379 385 PF02991 0.595
LIG_LIR_Apic_2 631 636 PF02991 0.491
LIG_LIR_Gen_1 114 124 PF02991 0.518
LIG_LIR_Gen_1 179 189 PF02991 0.484
LIG_LIR_Gen_1 522 532 PF02991 0.481
LIG_LIR_Gen_1 622 633 PF02991 0.496
LIG_LIR_Gen_1 766 776 PF02991 0.561
LIG_LIR_Nem_3 179 185 PF02991 0.481
LIG_LIR_Nem_3 220 226 PF02991 0.434
LIG_LIR_Nem_3 235 241 PF02991 0.445
LIG_LIR_Nem_3 307 313 PF02991 0.586
LIG_LIR_Nem_3 522 527 PF02991 0.475
LIG_LIR_Nem_3 622 628 PF02991 0.565
LIG_LIR_Nem_3 729 735 PF02991 0.511
LIG_LIR_Nem_3 766 772 PF02991 0.504
LIG_NRBOX 798 804 PF00104 0.498
LIG_Pex14_2 182 186 PF04695 0.457
LIG_PTB_Apo_2 222 229 PF02174 0.499
LIG_PTB_Phospho_1 222 228 PF10480 0.499
LIG_SH2_GRB2like 124 127 PF00017 0.523
LIG_SH2_NCK_1 585 589 PF00017 0.442
LIG_SH2_PTP2 166 169 PF00017 0.521
LIG_SH2_PTP2 496 499 PF00017 0.483
LIG_SH2_PTP2 6 9 PF00017 0.420
LIG_SH2_PTP2 627 630 PF00017 0.576
LIG_SH2_SRC 122 125 PF00017 0.516
LIG_SH2_STAP1 40 44 PF00017 0.559
LIG_SH2_STAT3 40 43 PF00017 0.664
LIG_SH2_STAT5 122 125 PF00017 0.544
LIG_SH2_STAT5 166 169 PF00017 0.514
LIG_SH2_STAT5 241 244 PF00017 0.450
LIG_SH2_STAT5 496 499 PF00017 0.440
LIG_SH2_STAT5 514 517 PF00017 0.440
LIG_SH2_STAT5 558 561 PF00017 0.478
LIG_SH2_STAT5 6 9 PF00017 0.446
LIG_SH2_STAT5 613 616 PF00017 0.496
LIG_SH2_STAT5 627 630 PF00017 0.552
LIG_SH2_STAT5 692 695 PF00017 0.493
LIG_SH2_STAT5 756 759 PF00017 0.503
LIG_SH2_STAT5 827 830 PF00017 0.504
LIG_SH3_3 157 163 PF00018 0.731
LIG_SH3_3 300 306 PF00018 0.553
LIG_SH3_3 378 384 PF00018 0.574
LIG_SH3_3 439 445 PF00018 0.461
LIG_SH3_4 305 312 PF00018 0.619
LIG_SUMO_SIM_anti_2 18 25 PF11976 0.266
LIG_SUMO_SIM_anti_2 596 602 PF11976 0.496
LIG_SUMO_SIM_par_1 284 290 PF11976 0.488
LIG_SUMO_SIM_par_1 385 390 PF11976 0.645
LIG_SUMO_SIM_par_1 464 471 PF11976 0.416
LIG_TRAF2_1 153 156 PF00917 0.620
LIG_TRAF2_1 217 220 PF00917 0.543
LIG_TRAF2_1 287 290 PF00917 0.557
LIG_TYR_ITIM 164 169 PF00017 0.466
LIG_TYR_ITIM 767 772 PF00017 0.464
LIG_UBA3_1 132 137 PF00899 0.561
LIG_UBA3_1 285 291 PF00899 0.496
LIG_UBA3_1 527 534 PF00899 0.399
LIG_WRC_WIRS_1 630 635 PF05994 0.563
LIG_WW_3 408 412 PF00397 0.393
MOD_CDC14_SPxK_1 408 411 PF00782 0.498
MOD_CDK_SPK_2 156 161 PF00069 0.579
MOD_CDK_SPxK_1 405 411 PF00069 0.498
MOD_CK1_1 140 146 PF00069 0.734
MOD_CK1_1 150 156 PF00069 0.720
MOD_CK1_1 206 212 PF00069 0.576
MOD_CK1_1 215 221 PF00069 0.516
MOD_CK1_1 343 349 PF00069 0.740
MOD_CK1_1 413 419 PF00069 0.491
MOD_CK1_1 586 592 PF00069 0.440
MOD_CK1_1 593 599 PF00069 0.440
MOD_CK1_1 61 67 PF00069 0.691
MOD_CK1_1 738 744 PF00069 0.551
MOD_CK2_1 141 147 PF00069 0.725
MOD_CK2_1 150 156 PF00069 0.758
MOD_CK2_1 169 175 PF00069 0.421
MOD_CK2_1 213 219 PF00069 0.404
MOD_CK2_1 441 447 PF00069 0.494
MOD_CK2_1 462 468 PF00069 0.499
MOD_CK2_1 593 599 PF00069 0.440
MOD_GlcNHglycan 144 147 PF01048 0.492
MOD_GlcNHglycan 18 21 PF01048 0.259
MOD_GlcNHglycan 190 193 PF01048 0.268
MOD_GlcNHglycan 205 208 PF01048 0.212
MOD_GlcNHglycan 215 218 PF01048 0.282
MOD_GlcNHglycan 243 246 PF01048 0.225
MOD_GlcNHglycan 365 368 PF01048 0.563
MOD_GlcNHglycan 373 376 PF01048 0.525
MOD_GlcNHglycan 58 61 PF01048 0.525
MOD_GlcNHglycan 63 66 PF01048 0.546
MOD_GlcNHglycan 784 787 PF01048 0.277
MOD_GlcNHglycan 86 89 PF01048 0.310
MOD_GSK3_1 137 144 PF00069 0.696
MOD_GSK3_1 202 209 PF00069 0.567
MOD_GSK3_1 241 248 PF00069 0.489
MOD_GSK3_1 312 319 PF00069 0.639
MOD_GSK3_1 336 343 PF00069 0.761
MOD_GSK3_1 358 365 PF00069 0.649
MOD_GSK3_1 410 417 PF00069 0.472
MOD_GSK3_1 586 593 PF00069 0.440
MOD_GSK3_1 61 68 PF00069 0.682
MOD_GSK3_1 724 731 PF00069 0.667
MOD_GSK3_1 735 742 PF00069 0.532
MOD_GSK3_1 782 789 PF00069 0.477
MOD_N-GLC_1 141 146 PF02516 0.385
MOD_N-GLC_1 353 358 PF02516 0.427
MOD_NEK2_1 15 20 PF00069 0.285
MOD_NEK2_1 233 238 PF00069 0.434
MOD_NEK2_1 294 299 PF00069 0.644
MOD_NEK2_1 312 317 PF00069 0.659
MOD_NEK2_1 358 363 PF00069 0.652
MOD_NEK2_1 609 614 PF00069 0.532
MOD_NEK2_1 771 776 PF00069 0.512
MOD_NEK2_1 97 102 PF00069 0.549
MOD_PIKK_1 402 408 PF00454 0.499
MOD_PIKK_1 577 583 PF00454 0.425
MOD_PK_1 454 460 PF00069 0.425
MOD_PK_1 583 589 PF00069 0.440
MOD_PKA_1 194 200 PF00069 0.425
MOD_PKA_1 504 510 PF00069 0.490
MOD_PKA_1 687 693 PF00069 0.493
MOD_PKA_2 150 156 PF00069 0.602
MOD_PKA_2 194 200 PF00069 0.425
MOD_PKA_2 410 416 PF00069 0.471
MOD_PKA_2 590 596 PF00069 0.521
MOD_PKA_2 628 634 PF00069 0.499
MOD_PKA_2 687 693 PF00069 0.479
MOD_PKA_2 724 730 PF00069 0.674
MOD_PKB_1 398 406 PF00069 0.503
MOD_Plk_1 234 240 PF00069 0.433
MOD_Plk_1 353 359 PF00069 0.628
MOD_Plk_1 786 792 PF00069 0.500
MOD_Plk_4 247 253 PF00069 0.483
MOD_Plk_4 389 395 PF00069 0.552
MOD_Plk_4 414 420 PF00069 0.441
MOD_Plk_4 609 615 PF00069 0.497
MOD_Plk_4 676 682 PF00069 0.549
MOD_Plk_4 735 741 PF00069 0.473
MOD_Plk_4 756 762 PF00069 0.612
MOD_Plk_4 786 792 PF00069 0.524
MOD_ProDKin_1 156 162 PF00069 0.638
MOD_ProDKin_1 360 366 PF00069 0.788
MOD_ProDKin_1 405 411 PF00069 0.490
MOD_ProDKin_1 441 447 PF00069 0.388
MOD_ProDKin_1 462 468 PF00069 0.469
MOD_ProDKin_1 58 64 PF00069 0.761
MOD_SUMO_for_1 304 307 PF00179 0.608
TRG_DiLeu_BaEn_4 289 295 PF01217 0.523
TRG_ENDOCYTIC_2 166 169 PF00928 0.481
TRG_ENDOCYTIC_2 227 230 PF00928 0.441
TRG_ENDOCYTIC_2 496 499 PF00928 0.440
TRG_ENDOCYTIC_2 584 587 PF00928 0.469
TRG_ENDOCYTIC_2 6 9 PF00928 0.433
TRG_ENDOCYTIC_2 627 630 PF00928 0.584
TRG_ENDOCYTIC_2 769 772 PF00928 0.562
TRG_ER_diArg_1 193 195 PF00400 0.521
TRG_ER_diArg_1 398 401 PF00400 0.503
TRG_ER_diArg_1 818 820 PF00400 0.534
TRG_NLS_MonoExtN_4 548 554 PF00514 0.520
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.240
TRG_Pf-PMV_PEXEL_1 826 830 PF00026 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X2 Leptomonas seymouri 30% 100%
A0A0N1IBR8 Leptomonas seymouri 67% 100%
A0A1X0P5U2 Trypanosomatidae 41% 100%
A0A2U1KZS6 Artemisia annua 24% 100%
A0A3Q8II21 Leishmania donovani 100% 100%
A0A3R7K908 Trypanosoma rangeli 43% 100%
A0A3S7X1H9 Leishmania donovani 31% 100%
A0A422N1R6 Trypanosoma rangeli 29% 100%
A1JJS2 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) 23% 100%
A2AI05 Mus musculus 23% 100%
A4HGH1 Leishmania braziliensis 29% 100%
A4HMS7 Leishmania braziliensis 85% 100%
A4I3K3 Leishmania infantum 30% 100%
C9ZZA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A835 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AF79 Leishmania major 96% 100%
E9AZU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 86%
E9B6D5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O62699 Canis lupus familiaris 24% 72%
P04175 Sus scrofa 23% 100%
P29477 Mus musculus 23% 73%
P35228 Homo sapiens 23% 72%
P37116 Vigna radiata var. radiata 24% 100%
Q05001 Catharanthus roseus 26% 100%
Q17574 Caenorhabditis elegans 20% 100%
Q1JPJ0 Bos taurus 24% 100%
Q27995 Bos taurus 24% 72%
Q3SYT8 Bos taurus 23% 100%
Q4HZQ1 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 23% 100%
Q4JIJ2 Bos taurus 25% 100%
Q4Q8E2 Leishmania major 38% 100%
Q5BB41 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 100%
Q6NRG5 Xenopus laevis 23% 100%
Q6PFP6 Danio rerio 23% 100%
Q7X7K8 Oryza sativa subsp. japonica 25% 100%
Q90703 Gallus gallus 22% 73%
Q9HDG2 Phanerodontia chrysosporium 22% 100%
Q9SB48 Arabidopsis thaliana 23% 100%
Q9UBK8 Homo sapiens 23% 100%
Q9UHB4 Homo sapiens 24% 100%
Q9US28 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
V5DK85 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS