CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBG2_LEIIN

TriTrypDb:

LINF_350030500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.492
CLV_NRD_NRD_1	120	122	PF00675	0.735
CLV_NRD_NRD_1	253	255	PF00675	0.504
CLV_NRD_NRD_1	296	298	PF00675	0.579
CLV_NRD_NRD_1	299	301	PF00675	0.613
CLV_NRD_NRD_1	314	316	PF00675	0.464
CLV_NRD_NRD_1	327	329	PF00675	0.428
CLV_NRD_NRD_1	331	333	PF00675	0.403
CLV_PCSK_FUR_1	297	301	PF00082	0.533
CLV_PCSK_KEX2_1	120	122	PF00082	0.666
CLV_PCSK_KEX2_1	253	255	PF00082	0.528
CLV_PCSK_KEX2_1	298	300	PF00082	0.543
CLV_PCSK_KEX2_1	326	328	PF00082	0.454
CLV_PCSK_KEX2_1	333	335	PF00082	0.487
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.543
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.543
CLV_PCSK_SKI1_1	175	179	PF00082	0.525
DEG_APCC_DBOX_1	252	260	PF00400	0.472
DEG_SPOP_SBC_1	185	189	PF00917	0.494
DOC_CYCLIN_yCln2_LP_2	205	208	PF00134	0.475
DOC_MAPK_FxFP_2	231	234	PF00069	0.404
DOC_MAPK_gen_1	253	263	PF00069	0.390
DOC_MAPK_MEF2A_6	253	260	PF00069	0.384
DOC_MAPK_MEF2A_6	265	272	PF00069	0.391
DOC_MAPK_NFAT4_5	253	261	PF00069	0.516
DOC_PP2B_LxvP_1	205	208	PF13499	0.391
DOC_PP4_FxxP_1	166	169	PF00568	0.400
DOC_PP4_FxxP_1	231	234	PF00568	0.404
DOC_PP4_FxxP_1	264	267	PF00568	0.502
DOC_USP7_MATH_1	218	222	PF00917	0.575
DOC_USP7_MATH_1	64	68	PF00917	0.665
DOC_USP7_MATH_2	169	175	PF00917	0.344
DOC_WW_Pin1_4	301	306	PF00397	0.607
DOC_WW_Pin1_4	35	40	PF00397	0.536
DOC_WW_Pin1_4	66	71	PF00397	0.624
DOC_WW_Pin1_4	95	100	PF00397	0.567
LIG_14-3-3_CanoR_1	186	191	PF00244	0.559
LIG_14-3-3_CanoR_1	278	288	PF00244	0.453
LIG_14-3-3_CanoR_1	49	53	PF00244	0.557
LIG_APCC_ABBA_1	261	266	PF00400	0.444
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.504
LIG_FHA_1	159	165	PF00498	0.393
LIG_FHA_1	201	207	PF00498	0.455
LIG_FHA_1	282	288	PF00498	0.440
LIG_FHA_1	289	295	PF00498	0.433
LIG_FHA_2	128	134	PF00498	0.640
LIG_FHA_2	154	160	PF00498	0.583
LIG_FHA_2	187	193	PF00498	0.520
LIG_FHA_2	40	46	PF00498	0.618
LIG_LIR_Apic_2	163	169	PF02991	0.391
LIG_LIR_Gen_1	136	143	PF02991	0.586
LIG_LIR_Nem_3	136	142	PF02991	0.514
LIG_LIR_Nem_3	178	183	PF02991	0.585
LIG_LIR_Nem_3	312	317	PF02991	0.457
LIG_LIR_Nem_3	7	12	PF02991	0.550
LIG_Pex14_1	246	250	PF04695	0.494
LIG_Pex14_1	276	280	PF04695	0.356
LIG_Pex14_2	166	170	PF04695	0.522
LIG_Pex14_2	314	318	PF04695	0.498
LIG_SH2_STAP1	139	143	PF00017	0.580
LIG_SH3_5	2	6	PF00018	0.601
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.423
LIG_SUMO_SIM_par_1	158	165	PF11976	0.519
LIG_TRAF2_1	321	324	PF00917	0.458
LIG_TYR_ITIM	137	142	PF00017	0.588
MOD_CDK_SPxxK_3	301	308	PF00069	0.622
MOD_CK1_1	111	117	PF00069	0.778
MOD_CK1_1	15	21	PF00069	0.607
MOD_CK1_1	35	41	PF00069	0.650
MOD_CK1_1	48	54	PF00069	0.503
MOD_CK2_1	153	159	PF00069	0.513
MOD_CK2_1	16	22	PF00069	0.649
MOD_CK2_1	173	179	PF00069	0.530
MOD_CK2_1	186	192	PF00069	0.602
MOD_CK2_1	39	45	PF00069	0.644
MOD_CK2_1	95	101	PF00069	0.709
MOD_Cter_Amidation	118	121	PF01082	0.674
MOD_GlcNHglycan	14	17	PF01048	0.648
MOD_GlcNHglycan	18	21	PF01048	0.641
MOD_GlcNHglycan	212	215	PF01048	0.668
MOD_GlcNHglycan	218	221	PF01048	0.650
MOD_GlcNHglycan	66	69	PF01048	0.718
MOD_GSK3_1	10	17	PF00069	0.696
MOD_GSK3_1	107	114	PF00069	0.678
MOD_GSK3_1	158	165	PF00069	0.491
MOD_GSK3_1	169	176	PF00069	0.425
MOD_GSK3_1	186	193	PF00069	0.591
MOD_GSK3_1	212	219	PF00069	0.654
MOD_GSK3_1	279	286	PF00069	0.392
MOD_GSK3_1	35	42	PF00069	0.684
MOD_GSK3_1	78	85	PF00069	0.689
MOD_N-GLC_1	111	116	PF02516	0.682
MOD_N-GLC_1	82	87	PF02516	0.662
MOD_NEK2_1	12	17	PF00069	0.671
MOD_NEK2_1	138	143	PF00069	0.511
MOD_NEK2_1	200	205	PF00069	0.458
MOD_NEK2_1	212	217	PF00069	0.430
MOD_NEK2_1	270	275	PF00069	0.484
MOD_PIKK_1	153	159	PF00454	0.405
MOD_PIKK_1	288	294	PF00454	0.530
MOD_PK_1	173	179	PF00069	0.522
MOD_PKA_2	185	191	PF00069	0.536
MOD_PKA_2	48	54	PF00069	0.579
MOD_Plk_1	158	164	PF00069	0.446
MOD_Plk_1	200	206	PF00069	0.440
MOD_Plk_1	282	288	PF00069	0.433
MOD_Plk_4	162	168	PF00069	0.384
MOD_Plk_4	270	276	PF00069	0.427
MOD_Plk_4	283	289	PF00069	0.472
MOD_ProDKin_1	301	307	PF00069	0.600
MOD_ProDKin_1	35	41	PF00069	0.535
MOD_ProDKin_1	66	72	PF00069	0.627
MOD_ProDKin_1	95	101	PF00069	0.566
MOD_SUMO_for_1	93	96	PF00179	0.673
MOD_SUMO_rev_2	165	174	PF00179	0.330
TRG_DiLeu_BaEn_1	201	206	PF01217	0.423
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.386
TRG_ENDOCYTIC_2	139	142	PF00928	0.464
TRG_ER_diArg_1	252	254	PF00400	0.499
TRG_ER_diArg_1	297	300	PF00400	0.531
TRG_ER_diArg_1	325	328	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE56	Leptomonas seymouri	52%	100%
A0A0S4KNN3	Bodo saltans	31%	100%
A0A1X0P6G0	Trypanosomatidae	40%	100%
A0A3R7NBC1	Trypanosoma rangeli	42%	100%
A0A3S7X9A9	Leishmania donovani	99%	100%
A4HMS4	Leishmania braziliensis	73%	100%
C9ZZA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AF76	Leishmania major	90%	100%
E9B6D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BJ90	Trypanosoma cruzi	37%	100%