LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
Ring finger domain/IQ calmodulin-binding motif containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IBG1_LEIIN
TriTrypDb:
LINF_350030400
Length:
396

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBG1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.529
CLV_NRD_NRD_1 130 132 PF00675 0.444
CLV_NRD_NRD_1 159 161 PF00675 0.535
CLV_NRD_NRD_1 230 232 PF00675 0.439
CLV_NRD_NRD_1 262 264 PF00675 0.645
CLV_NRD_NRD_1 287 289 PF00675 0.649
CLV_NRD_NRD_1 296 298 PF00675 0.610
CLV_NRD_NRD_1 364 366 PF00675 0.407
CLV_NRD_NRD_1 90 92 PF00675 0.241
CLV_PCSK_KEX2_1 130 132 PF00082 0.441
CLV_PCSK_KEX2_1 287 289 PF00082 0.626
CLV_PCSK_KEX2_1 296 298 PF00082 0.666
CLV_PCSK_KEX2_1 364 366 PF00082 0.407
CLV_PCSK_KEX2_1 62 64 PF00082 0.371
CLV_PCSK_KEX2_1 90 92 PF00082 0.241
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.365
CLV_PCSK_PC7_1 360 366 PF00082 0.388
CLV_PCSK_SKI1_1 146 150 PF00082 0.384
CLV_PCSK_SKI1_1 62 66 PF00082 0.361
CLV_PCSK_SKI1_1 85 89 PF00082 0.238
DEG_APCC_DBOX_1 363 371 PF00400 0.430
DEG_SPOP_SBC_1 166 170 PF00917 0.541
DOC_CKS1_1 268 273 PF01111 0.496
DOC_MAPK_gen_1 90 98 PF00069 0.494
DOC_MAPK_RevD_3 275 288 PF00069 0.509
DOC_MAPK_RevD_3 75 91 PF00069 0.441
DOC_PP2B_LxvP_1 175 178 PF13499 0.524
DOC_USP7_MATH_1 166 170 PF00917 0.579
DOC_USP7_MATH_1 233 237 PF00917 0.572
DOC_USP7_MATH_1 242 246 PF00917 0.608
DOC_USP7_MATH_1 253 257 PF00917 0.504
DOC_USP7_MATH_1 275 279 PF00917 0.551
DOC_USP7_MATH_1 318 322 PF00917 0.695
DOC_WW_Pin1_4 267 272 PF00397 0.521
LIG_14-3-3_CanoR_1 115 123 PF00244 0.364
LIG_14-3-3_CanoR_1 246 252 PF00244 0.614
LIG_14-3-3_CanoR_1 364 368 PF00244 0.462
LIG_14-3-3_CanoR_1 56 61 PF00244 0.464
LIG_BIR_II_1 1 5 PF00653 0.509
LIG_BIR_III_4 326 330 PF00653 0.520
LIG_BIR_III_4 39 43 PF00653 0.438
LIG_BRCT_BRCA1_1 16 20 PF00533 0.343
LIG_CaM_IQ_9 77 93 PF13499 0.429
LIG_deltaCOP1_diTrp_1 152 159 PF00928 0.501
LIG_eIF4E_1 93 99 PF01652 0.318
LIG_FHA_1 104 110 PF00498 0.436
LIG_FHA_1 42 48 PF00498 0.498
LIG_FHA_2 166 172 PF00498 0.698
LIG_FHA_2 214 220 PF00498 0.477
LIG_LIR_Gen_1 117 125 PF02991 0.481
LIG_LIR_Gen_1 152 163 PF02991 0.426
LIG_LIR_Gen_1 313 322 PF02991 0.567
LIG_LIR_Gen_1 356 363 PF02991 0.338
LIG_LIR_Nem_3 117 123 PF02991 0.367
LIG_LIR_Nem_3 152 158 PF02991 0.390
LIG_LIR_Nem_3 27 31 PF02991 0.369
LIG_LIR_Nem_3 313 319 PF02991 0.544
LIG_LIR_Nem_3 356 361 PF02991 0.360
LIG_LIR_Nem_3 59 64 PF02991 0.364
LIG_PCNA_yPIPBox_3 74 88 PF02747 0.524
LIG_PTB_Apo_2 98 105 PF02174 0.370
LIG_SH2_CRK 61 65 PF00017 0.451
LIG_SH2_CRK 93 97 PF00017 0.381
LIG_SH2_STAT5 108 111 PF00017 0.350
LIG_SH2_STAT5 31 34 PF00017 0.400
LIG_SH2_STAT5 349 352 PF00017 0.377
LIG_SH2_STAT5 391 394 PF00017 0.301
LIG_SH2_STAT5 93 96 PF00017 0.361
LIG_SH3_3 160 166 PF00018 0.485
LIG_SH3_3 182 188 PF00018 0.511
LIG_SH3_3 265 271 PF00018 0.676
LIG_SH3_3 332 338 PF00018 0.540
LIG_SH3_3 375 381 PF00018 0.446
LIG_SH3_3 43 49 PF00018 0.421
LIG_SUMO_SIM_anti_2 366 371 PF11976 0.393
LIG_TRAF2_1 125 128 PF00917 0.489
LIG_WRC_WIRS_1 25 30 PF05994 0.376
MOD_CDK_SPK_2 267 272 PF00069 0.496
MOD_CK1_1 167 173 PF00069 0.564
MOD_CK1_1 2 8 PF00069 0.619
MOD_CK1_1 236 242 PF00069 0.629
MOD_CK1_1 245 251 PF00069 0.541
MOD_CK2_1 165 171 PF00069 0.680
MOD_Cter_Amidation 294 297 PF01082 0.524
MOD_GlcNHglycan 116 119 PF01048 0.429
MOD_GlcNHglycan 247 250 PF01048 0.658
MOD_GlcNHglycan 255 258 PF01048 0.677
MOD_GlcNHglycan 320 323 PF01048 0.765
MOD_GlcNHglycan 339 342 PF01048 0.353
MOD_GlcNHglycan 388 391 PF01048 0.379
MOD_GSK3_1 167 174 PF00069 0.705
MOD_N-GLC_2 382 384 PF02516 0.355
MOD_NEK2_1 1 6 PF00069 0.579
MOD_NEK2_1 14 19 PF00069 0.284
MOD_NEK2_1 300 305 PF00069 0.713
MOD_NEK2_2 275 280 PF00069 0.557
MOD_PIKK_1 194 200 PF00454 0.522
MOD_PIKK_1 54 60 PF00454 0.478
MOD_PKA_2 114 120 PF00069 0.346
MOD_PKA_2 213 219 PF00069 0.468
MOD_PKA_2 245 251 PF00069 0.610
MOD_PKA_2 363 369 PF00069 0.449
MOD_Plk_1 275 281 PF00069 0.507
MOD_Plk_2-3 363 369 PF00069 0.397
MOD_Plk_4 56 62 PF00069 0.364
MOD_ProDKin_1 267 273 PF00069 0.523
MOD_SUMO_rev_2 236 245 PF00179 0.631
MOD_SUMO_rev_2 276 285 PF00179 0.531
TRG_DiLeu_BaLyEn_6 94 99 PF01217 0.318
TRG_ENDOCYTIC_2 358 361 PF00928 0.419
TRG_ENDOCYTIC_2 61 64 PF00928 0.452
TRG_ENDOCYTIC_2 93 96 PF00928 0.356
TRG_ER_diArg_1 104 107 PF00400 0.541

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8I6 Leptomonas seymouri 45% 72%
A0A1X0P5K1 Trypanosomatidae 33% 89%
A0A3Q8IGA8 Leishmania donovani 100% 100%
A0A3S5IR12 Trypanosoma rangeli 35% 92%
C9ZZA3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 75%
E9AF75 Leishmania major 84% 100%
E9AIW3 Leishmania braziliensis 71% 100%
E9B6D1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
V5B3S2 Trypanosoma cruzi 32% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS