Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBF3_LEIIN

TriTrypDb:

LINF_350029600

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IBF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.682
CLV_C14_Caspase3-7	274	278	PF00656	0.806
CLV_C14_Caspase3-7	370	374	PF00656	0.811
CLV_NRD_NRD_1	143	145	PF00675	0.615
CLV_NRD_NRD_1	303	305	PF00675	0.666
CLV_NRD_NRD_1	306	308	PF00675	0.658
CLV_NRD_NRD_1	37	39	PF00675	0.785
CLV_PCSK_FUR_1	304	308	PF00082	0.638
CLV_PCSK_FUR_1	35	39	PF00082	0.641
CLV_PCSK_KEX2_1	143	145	PF00082	0.611
CLV_PCSK_KEX2_1	305	307	PF00082	0.625
CLV_PCSK_KEX2_1	37	39	PF00082	0.785
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.625
CLV_PCSK_SKI1_1	165	169	PF00082	0.625
CLV_PCSK_SKI1_1	251	255	PF00082	0.799
CLV_PCSK_SKI1_1	396	400	PF00082	0.681
CLV_PCSK_SKI1_1	484	488	PF00082	0.680
CLV_PCSK_SKI1_1	494	498	PF00082	0.554
CLV_PCSK_SKI1_1	502	506	PF00082	0.564
CLV_PCSK_SKI1_1	55	59	PF00082	0.660
DEG_APCC_DBOX_1	108	116	PF00400	0.683
DEG_APCC_DBOX_1	164	172	PF00400	0.625
DEG_Nend_UBRbox_3	1	3	PF02207	0.778
DEG_SCF_FBW7_1	431	437	PF00400	0.814
DEG_SCF_FBW7_2	398	403	PF00400	0.828
DEG_SPOP_SBC_1	341	345	PF00917	0.592
DOC_CKS1_1	286	291	PF01111	0.651
DOC_CKS1_1	322	327	PF01111	0.729
DOC_CKS1_1	431	436	PF01111	0.812
DOC_PP2B_LxvP_1	222	225	PF13499	0.654
DOC_PP2B_LxvP_1	242	245	PF13499	0.595
DOC_PP2B_LxvP_1	339	342	PF13499	0.797
DOC_USP7_MATH_1	102	106	PF00917	0.683
DOC_USP7_MATH_1	342	346	PF00917	0.738
DOC_USP7_MATH_1	418	422	PF00917	0.805
DOC_USP7_MATH_1	423	427	PF00917	0.705
DOC_USP7_MATH_2	225	231	PF00917	0.665
DOC_WW_Pin1_4	128	133	PF00397	0.766
DOC_WW_Pin1_4	232	237	PF00397	0.747
DOC_WW_Pin1_4	245	250	PF00397	0.696
DOC_WW_Pin1_4	285	290	PF00397	0.653
DOC_WW_Pin1_4	321	326	PF00397	0.741
DOC_WW_Pin1_4	337	342	PF00397	0.553
DOC_WW_Pin1_4	396	401	PF00397	0.716
DOC_WW_Pin1_4	408	413	PF00397	0.750
DOC_WW_Pin1_4	430	435	PF00397	0.692
DOC_WW_Pin1_4	443	448	PF00397	0.668
DOC_WW_Pin1_4	474	479	PF00397	0.680
DOC_WW_Pin1_4	65	70	PF00397	0.635
LIG_14-3-3_CanoR_1	143	152	PF00244	0.619
LIG_14-3-3_CanoR_1	304	314	PF00244	0.656
LIG_BIR_III_4	122	126	PF00653	0.694
LIG_BRCT_BRCA1_1	194	198	PF00533	0.516
LIG_BRCT_BRCA1_1	383	387	PF00533	0.797
LIG_CtBP_PxDLS_1	300	304	PF00389	0.646
LIG_FHA_1	248	254	PF00498	0.776
LIG_FHA_1	255	261	PF00498	0.502
LIG_FHA_1	286	292	PF00498	0.653
LIG_FHA_1	322	328	PF00498	0.697
LIG_FHA_1	354	360	PF00498	0.811
LIG_FHA_1	409	415	PF00498	0.736
LIG_FHA_1	431	437	PF00498	0.814
LIG_FHA_1	493	499	PF00498	0.703
LIG_FHA_1	509	515	PF00498	0.609
LIG_FHA_1	76	82	PF00498	0.675
LIG_FHA_2	117	123	PF00498	0.825
LIG_FHA_2	15	21	PF00498	0.688
LIG_Integrin_RGD_1	73	75	PF01839	0.771
LIG_LIR_Apic_2	218	224	PF02991	0.682
LIG_LIR_Apic_2	308	314	PF02991	0.641
LIG_LIR_Apic_2	500	506	PF02991	0.730
LIG_LIR_Nem_3	313	318	PF02991	0.583
LIG_MYND_1	317	321	PF01753	0.643
LIG_Pex14_2	83	87	PF04695	0.772
LIG_SH2_CRK	322	326	PF00017	0.626
LIG_SH2_STAT5	215	218	PF00017	0.627
LIG_SH2_STAT5	221	224	PF00017	0.606
LIG_SH2_STAT5	311	314	PF00017	0.750
LIG_SH3_1	311	317	PF00018	0.639
LIG_SH3_3	129	135	PF00018	0.819
LIG_SH3_3	163	169	PF00018	0.602
LIG_SH3_3	197	203	PF00018	0.771
LIG_SH3_3	243	249	PF00018	0.677
LIG_SH3_3	283	289	PF00018	0.797
LIG_SH3_3	311	317	PF00018	0.639
LIG_SH3_3	428	434	PF00018	0.682
LIG_SH3_3	435	441	PF00018	0.702
LIG_SH3_3	477	483	PF00018	0.770
LIG_SUMO_SIM_par_1	492	500	PF11976	0.617
LIG_TRAF2_1	271	274	PF00917	0.651
LIG_TRAF2_1	404	407	PF00917	0.846
LIG_TRAF2_1	490	493	PF00917	0.596
MOD_CDC14_SPxK_1	248	251	PF00782	0.653
MOD_CDK_SPxK_1	245	251	PF00069	0.650
MOD_CDK_SPxxK_3	285	292	PF00069	0.654
MOD_CDK_SPxxK_3	408	415	PF00069	0.687
MOD_CK1_1	118	124	PF00069	0.719
MOD_CK1_1	128	134	PF00069	0.675
MOD_CK1_1	139	145	PF00069	0.646
MOD_CK1_1	14	20	PF00069	0.728
MOD_CK1_1	214	220	PF00069	0.733
MOD_CK1_1	29	35	PF00069	0.667
MOD_CK1_1	337	343	PF00069	0.801
MOD_CK1_1	374	380	PF00069	0.763
MOD_CK1_1	381	387	PF00069	0.682
MOD_CK1_1	388	394	PF00069	0.575
MOD_CK1_1	40	46	PF00069	0.607
MOD_CK2_1	214	220	PF00069	0.733
MOD_CK2_1	223	229	PF00069	0.642
MOD_CK2_1	25	31	PF00069	0.806
MOD_CK2_1	268	274	PF00069	0.669
MOD_CK2_1	401	407	PF00069	0.741
MOD_CK2_1	487	493	PF00069	0.602
MOD_CK2_1	93	99	PF00069	0.780
MOD_DYRK1A_RPxSP_1	396	400	PF00069	0.681
MOD_GlcNHglycan	122	126	PF01048	0.630
MOD_GlcNHglycan	145	148	PF01048	0.703
MOD_GlcNHglycan	194	197	PF01048	0.562
MOD_GlcNHglycan	373	376	PF01048	0.697
MOD_GlcNHglycan	387	390	PF01048	0.678
MOD_GlcNHglycan	489	492	PF01048	0.585
MOD_GlcNHglycan	54	58	PF01048	0.542
MOD_GSK3_1	121	128	PF00069	0.750
MOD_GSK3_1	139	146	PF00069	0.662
MOD_GSK3_1	198	205	PF00069	0.674
MOD_GSK3_1	207	214	PF00069	0.601
MOD_GSK3_1	223	230	PF00069	0.683
MOD_GSK3_1	245	252	PF00069	0.779
MOD_GSK3_1	25	32	PF00069	0.764
MOD_GSK3_1	254	261	PF00069	0.610
MOD_GSK3_1	281	288	PF00069	0.658
MOD_GSK3_1	337	344	PF00069	0.689
MOD_GSK3_1	374	381	PF00069	0.739
MOD_GSK3_1	387	394	PF00069	0.611
MOD_GSK3_1	430	437	PF00069	0.758
MOD_N-GLC_1	381	386	PF02516	0.771
MOD_N-GLC_1	423	428	PF02516	0.792
MOD_N-GLC_1	487	492	PF02516	0.598
MOD_N-GLC_1	83	88	PF02516	0.753
MOD_NEK2_1	158	163	PF00069	0.726
MOD_NEK2_1	192	197	PF00069	0.517
MOD_NEK2_1	208	213	PF00069	0.788
MOD_NEK2_1	281	286	PF00069	0.666
MOD_NEK2_1	387	392	PF00069	0.793
MOD_NEK2_1	497	502	PF00069	0.707
MOD_NEK2_2	342	347	PF00069	0.671
MOD_PIKK_1	102	108	PF00454	0.687
MOD_PIKK_1	198	204	PF00454	0.786
MOD_PKA_1	143	149	PF00069	0.680
MOD_PKA_1	305	311	PF00069	0.615
MOD_PKA_1	37	43	PF00069	0.792
MOD_PKA_2	116	122	PF00069	0.824
MOD_PKA_2	142	148	PF00069	0.636
MOD_PKA_2	305	311	PF00069	0.715
MOD_PKA_2	37	43	PF00069	0.792
MOD_PKA_2	6	12	PF00069	0.660
MOD_PKB_1	35	43	PF00069	0.648
MOD_Plk_1	184	190	PF00069	0.790
MOD_Plk_1	268	274	PF00069	0.669
MOD_Plk_1	423	429	PF00069	0.704
MOD_Plk_1	492	498	PF00069	0.587
MOD_Plk_1	53	59	PF00069	0.541
MOD_Plk_1	83	89	PF00069	0.769
MOD_Plk_2-3	268	274	PF00069	0.782
MOD_Plk_4	211	217	PF00069	0.779
MOD_Plk_4	249	255	PF00069	0.657
MOD_Plk_4	334	340	PF00069	0.678
MOD_Plk_4	388	394	PF00069	0.794
MOD_Plk_4	458	464	PF00069	0.666
MOD_ProDKin_1	128	134	PF00069	0.765
MOD_ProDKin_1	232	238	PF00069	0.745
MOD_ProDKin_1	245	251	PF00069	0.698
MOD_ProDKin_1	285	291	PF00069	0.653
MOD_ProDKin_1	321	327	PF00069	0.742
MOD_ProDKin_1	337	343	PF00069	0.555
MOD_ProDKin_1	396	402	PF00069	0.720
MOD_ProDKin_1	408	414	PF00069	0.749
MOD_ProDKin_1	430	436	PF00069	0.695
MOD_ProDKin_1	443	449	PF00069	0.673
MOD_ProDKin_1	474	480	PF00069	0.676
MOD_ProDKin_1	65	71	PF00069	0.635
MOD_SUMO_rev_2	262	272	PF00179	0.663
MOD_SUMO_rev_2	426	434	PF00179	0.793
TRG_DiLeu_BaEn_1	492	497	PF01217	0.586
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.625
TRG_ER_diArg_1	303	306	PF00400	0.626
TRG_ER_diArg_1	346	349	PF00400	0.699
TRG_NLS_MonoCore_2	303	308	PF00514	0.639
TRG_NLS_MonoExtC_3	303	309	PF00514	0.777
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.792

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH2	Leptomonas seymouri	29%	69%
E9B6C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%