Putative ubiquitin hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase - putative

Species:

Leishmania infantum

UniProt:

A4IBF1_LEIIN

TriTrypDb:

LINF_350029400

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBF1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006511	ubiquitin-dependent protein catabolic process	7	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009057	macromolecule catabolic process	4	5
GO:0009987	cellular process	1	5
GO:0016579	protein deubiquitination	6	5
GO:0019538	protein metabolic process	3	5
GO:0019941	modification-dependent protein catabolic process	6	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0043632	modification-dependent macromolecule catabolic process	5	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044248	cellular catabolic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044265	obsolete cellular macromolecule catabolic process	4	5
GO:0051603	proteolysis involved in protein catabolic process	5	5
GO:0070646	protein modification by small protein removal	5	5
GO:0070647	protein modification by small protein conjugation or removal	5	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004843	cysteine-type deubiquitinase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0008234	cysteine-type peptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0019783	ubiquitin-like protein peptidase activity	4	5
GO:0101005	deubiquitinase activity	5	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.597
CLV_NRD_NRD_1	121	123	PF00675	0.435
CLV_NRD_NRD_1	126	128	PF00675	0.365
CLV_NRD_NRD_1	134	136	PF00675	0.235
CLV_NRD_NRD_1	417	419	PF00675	0.517
CLV_NRD_NRD_1	451	453	PF00675	0.528
CLV_NRD_NRD_1	535	537	PF00675	0.365
CLV_PCSK_FUR_1	338	342	PF00082	0.259
CLV_PCSK_KEX2_1	120	122	PF00082	0.435
CLV_PCSK_KEX2_1	126	128	PF00082	0.350
CLV_PCSK_KEX2_1	134	136	PF00082	0.217
CLV_PCSK_KEX2_1	340	342	PF00082	0.329
CLV_PCSK_KEX2_1	358	360	PF00082	0.203
CLV_PCSK_KEX2_1	451	453	PF00082	0.528
CLV_PCSK_KEX2_1	535	537	PF00082	0.365
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.248
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.319
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.203
CLV_PCSK_PC7_1	122	128	PF00082	0.365
CLV_PCSK_SKI1_1	19	23	PF00082	0.515
CLV_PCSK_SKI1_1	312	316	PF00082	0.248
CLV_PCSK_SKI1_1	381	385	PF00082	0.248
CLV_PCSK_SKI1_1	499	503	PF00082	0.474
CLV_PCSK_SKI1_1	512	516	PF00082	0.344
CLV_Separin_Metazoa	309	313	PF03568	0.248
DEG_SPOP_SBC_1	143	147	PF00917	0.248
DEG_SPOP_SBC_1	47	51	PF00917	0.698
DOC_CKS1_1	97	102	PF01111	0.248
DOC_CYCLIN_yCln2_LP_2	323	329	PF00134	0.248
DOC_MAPK_gen_1	448	457	PF00069	0.508
DOC_MAPK_MEF2A_6	264	273	PF00069	0.248
DOC_MAPK_RevD_3	520	536	PF00069	0.300
DOC_PP1_RVXF_1	226	233	PF00149	0.248
DOC_PP4_FxxP_1	430	433	PF00568	0.471
DOC_SPAK_OSR1_1	264	268	PF12202	0.248
DOC_USP7_MATH_1	143	147	PF00917	0.295
DOC_USP7_MATH_1	47	51	PF00917	0.555
DOC_USP7_MATH_1	473	477	PF00917	0.673
DOC_USP7_MATH_1	53	57	PF00917	0.528
DOC_USP7_UBL2_3	298	302	PF12436	0.248
DOC_WW_Pin1_4	442	447	PF00397	0.548
DOC_WW_Pin1_4	49	54	PF00397	0.558
DOC_WW_Pin1_4	96	101	PF00397	0.308
LIG_14-3-3_CanoR_1	228	233	PF00244	0.248
LIG_14-3-3_CanoR_1	341	347	PF00244	0.248
LIG_14-3-3_CanoR_1	394	402	PF00244	0.350
LIG_14-3-3_CanoR_1	474	480	PF00244	0.566
LIG_14-3-3_CanoR_1	55	65	PF00244	0.581
LIG_BRCT_BRCA1_1	261	265	PF00533	0.203
LIG_deltaCOP1_diTrp_1	116	123	PF00928	0.248
LIG_eIF4E_1	263	269	PF01652	0.248
LIG_eIF4E_1	348	354	PF01652	0.391
LIG_FHA_1	143	149	PF00498	0.235
LIG_FHA_1	367	373	PF00498	0.411
LIG_FHA_1	8	14	PF00498	0.564
LIG_FHA_1	84	90	PF00498	0.235
LIG_FHA_1	97	103	PF00498	0.235
LIG_FHA_2	1	7	PF00498	0.598
LIG_FHA_2	211	217	PF00498	0.408
LIG_FHA_2	238	244	PF00498	0.248
LIG_FHA_2	436	442	PF00498	0.521
LIG_Integrin_isoDGR_2	485	487	PF01839	0.569
LIG_IRF3_LxIS_1	265	272	PF10401	0.248
LIG_LIR_Apic_2	345	351	PF02991	0.248
LIG_LIR_Apic_2	428	433	PF02991	0.464
LIG_LIR_Gen_1	239	248	PF02991	0.227
LIG_LIR_Gen_1	262	273	PF02991	0.213
LIG_LIR_Gen_1	403	412	PF02991	0.295
LIG_LIR_Gen_1	528	537	PF02991	0.239
LIG_LIR_Nem_3	212	217	PF02991	0.431
LIG_LIR_Nem_3	239	245	PF02991	0.251
LIG_LIR_Nem_3	262	268	PF02991	0.225
LIG_LIR_Nem_3	347	352	PF02991	0.248
LIG_LIR_Nem_3	399	405	PF02991	0.235
LIG_LIR_Nem_3	528	533	PF02991	0.234
LIG_NRBOX	191	197	PF00104	0.235
LIG_PCNA_yPIPBox_3	90	104	PF02747	0.248
LIG_Pex14_2	373	377	PF04695	0.295
LIG_REV1ctd_RIR_1	313	323	PF16727	0.248
LIG_SH2_CRK	405	409	PF00017	0.416
LIG_SH2_GRB2like	88	91	PF00017	0.203
LIG_SH2_SRC	88	91	PF00017	0.235
LIG_SH2_STAP1	226	230	PF00017	0.248
LIG_SH2_STAP1	344	348	PF00017	0.248
LIG_SH2_STAT5	375	378	PF00017	0.248
LIG_SH2_STAT5	382	385	PF00017	0.230
LIG_SH2_STAT5	402	405	PF00017	0.203
LIG_SH2_STAT5	407	410	PF00017	0.351
LIG_SH2_STAT5	507	510	PF00017	0.269
LIG_SH2_STAT5	530	533	PF00017	0.330
LIG_SH2_STAT5	88	91	PF00017	0.235
LIG_SH3_1	28	34	PF00018	0.681
LIG_SH3_3	28	34	PF00018	0.693
LIG_SH3_3	368	374	PF00018	0.208
LIG_SH3_3	514	520	PF00018	0.341
LIG_SH3_4	207	214	PF00018	0.248
LIG_SUMO_SIM_par_1	145	153	PF11976	0.248
LIG_TYR_ITIM	532	537	PF00017	0.328
LIG_TYR_ITSM	401	408	PF00017	0.235
LIG_UBA3_1	165	170	PF00899	0.295
LIG_UBA3_1	192	201	PF00899	0.248
LIG_UBA3_1	352	358	PF00899	0.235
LIG_WRC_WIRS_1	13	18	PF05994	0.531
MOD_CDC14_SPxK_1	445	448	PF00782	0.439
MOD_CDK_SPxK_1	442	448	PF00069	0.445
MOD_CDK_SPxK_1	49	55	PF00069	0.601
MOD_CK1_1	276	282	PF00069	0.399
MOD_CK1_1	48	54	PF00069	0.554
MOD_CK1_1	56	62	PF00069	0.488
MOD_CK1_1	66	72	PF00069	0.527
MOD_CK1_1	9	15	PF00069	0.591
MOD_CK2_1	133	139	PF00069	0.258
MOD_CK2_1	253	259	PF00069	0.248
MOD_CMANNOS	229	232	PF00535	0.248
MOD_Cter_Amidation	118	121	PF01082	0.248
MOD_GlcNHglycan	38	41	PF01048	0.708
MOD_GlcNHglycan	398	401	PF01048	0.298
MOD_GlcNHglycan	495	498	PF01048	0.672
MOD_GlcNHglycan	516	520	PF01048	0.494
MOD_GlcNHglycan	56	59	PF01048	0.701
MOD_GlcNHglycan	65	68	PF01048	0.450
MOD_GSK3_1	249	256	PF00069	0.211
MOD_GSK3_1	269	276	PF00069	0.435
MOD_GSK3_1	32	39	PF00069	0.625
MOD_GSK3_1	396	403	PF00069	0.251
MOD_GSK3_1	42	49	PF00069	0.614
MOD_GSK3_1	431	438	PF00069	0.507
MOD_GSK3_1	474	481	PF00069	0.675
MOD_GSK3_1	493	500	PF00069	0.724
MOD_GSK3_1	53	60	PF00069	0.637
MOD_N-GLC_1	236	241	PF02516	0.248
MOD_N-GLC_1	366	371	PF02516	0.411
MOD_N-GLC_1	512	517	PF02516	0.339
MOD_NEK2_1	102	107	PF00069	0.394
MOD_NEK2_1	165	170	PF00069	0.248
MOD_NEK2_1	191	196	PF00069	0.259
MOD_NEK2_1	21	26	PF00069	0.657
MOD_NEK2_1	269	274	PF00069	0.203
MOD_NEK2_1	36	41	PF00069	0.565
MOD_NEK2_1	435	440	PF00069	0.506
MOD_NEK2_1	83	88	PF00069	0.250
MOD_NEK2_2	58	63	PF00069	0.510
MOD_OFUCOSY	251	258	PF10250	0.304
MOD_OFUCOSY	391	397	PF10250	0.248
MOD_PIKK_1	278	284	PF00454	0.313
MOD_PIKK_1	435	441	PF00454	0.510
MOD_PKA_1	7	13	PF00069	0.541
MOD_PKA_2	133	139	PF00069	0.435
MOD_PKA_2	393	399	PF00069	0.350
MOD_PKA_2	473	479	PF00069	0.743
MOD_PKA_2	54	60	PF00069	0.641
MOD_Plk_1	236	242	PF00069	0.225
MOD_Plk_1	258	264	PF00069	0.319
MOD_Plk_1	366	372	PF00069	0.384
MOD_Plk_4	144	150	PF00069	0.299
MOD_Plk_4	228	234	PF00069	0.279
MOD_Plk_4	237	243	PF00069	0.193
MOD_Plk_4	403	409	PF00069	0.243
MOD_Plk_4	88	94	PF00069	0.221
MOD_ProDKin_1	442	448	PF00069	0.545
MOD_ProDKin_1	49	55	PF00069	0.561
MOD_ProDKin_1	96	102	PF00069	0.308
MOD_SUMO_for_1	365	368	PF00179	0.295
MOD_SUMO_rev_2	136	143	PF00179	0.248
MOD_SUMO_rev_2	216	223	PF00179	0.272
MOD_SUMO_rev_2	294	299	PF00179	0.238
MOD_SUMO_rev_2	410	416	PF00179	0.453
TRG_ENDOCYTIC_2	242	245	PF00928	0.221
TRG_ENDOCYTIC_2	405	408	PF00928	0.342
TRG_ENDOCYTIC_2	530	533	PF00928	0.257
TRG_ENDOCYTIC_2	534	537	PF00928	0.274
TRG_ER_diArg_1	110	113	PF00400	0.248
TRG_ER_diArg_1	120	122	PF00400	0.422
TRG_ER_diArg_1	277	280	PF00400	0.248
TRG_ER_diArg_1	450	452	PF00400	0.531
TRG_ER_diArg_1	534	536	PF00400	0.351
TRG_NLS_MonoExtC_3	417	422	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KKZ6	Bodo saltans	29%	100%
A0A3Q8IB18	Leishmania donovani	24%	76%
A0A3Q8IGB5	Leishmania donovani	25%	95%
A0A3R7NR99	Trypanosoma rangeli	34%	100%
A4HZ39	Leishmania infantum	24%	76%
A4I2S8	Leishmania infantum	25%	95%
C9ZZB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADA6	Leishmania major	25%	95%
Q2KHV7	Bos taurus	27%	90%
Q4QCH5	Leishmania major	24%	82%
Q9QZL6	Mus musculus	28%	96%