Paraflagellar rod component

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar Member 5

Species:

Leishmania infantum

UniProt:

A4IBF0_LEIIN

TriTrypDb:

LINF_350029300

Length:

1792

Annotations

Annotations by Jardim et al.

Flagella, Flagellar Member 5 (FLAM5Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005669	transcription factor TFIID complex	4	1
GO:0005929	cilium	4	12
GO:0005930	axoneme	2	1
GO:0016020	membrane	2	1
GO:0031514	motile cilium	5	2
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12

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Expansion

Sequence features

A4IBF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBF0

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1195	1199	PF00656	0.498
CLV_C14_Caspase3-7	122	126	PF00656	0.339
CLV_C14_Caspase3-7	1554	1558	PF00656	0.431
CLV_C14_Caspase3-7	1614	1618	PF00656	0.390
CLV_C14_Caspase3-7	1632	1636	PF00656	0.328
CLV_C14_Caspase3-7	1736	1740	PF00656	0.387
CLV_C14_Caspase3-7	519	523	PF00656	0.489
CLV_C14_Caspase3-7	911	915	PF00656	0.360
CLV_NRD_NRD_1	1099	1101	PF00675	0.770
CLV_NRD_NRD_1	1120	1122	PF00675	0.611

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3E2	Leptomonas seymouri	52%	98%
A0A0S4JDP4	Bodo saltans	26%	100%
A0A1X0P5L6	Trypanosomatidae	31%	100%
A0A3S7X9J3	Leishmania donovani	100%	100%
A0A422NM73	Trypanosoma rangeli	31%	100%
A4HMR4	Leishmania braziliensis	76%	100%
C9ZZB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AF64	Leishmania major	92%	100%
E9B6C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BNW7	Trypanosoma cruzi	29%	100%

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