LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
SET domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IBE7_LEIIN
TriTrypDb:
LINF_350029000
Length:
825

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBE7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBE7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.666
CLV_C14_Caspase3-7 295 299 PF00656 0.528
CLV_C14_Caspase3-7 422 426 PF00656 0.674
CLV_C14_Caspase3-7 591 595 PF00656 0.736
CLV_C14_Caspase3-7 772 776 PF00656 0.561
CLV_NRD_NRD_1 13 15 PF00675 0.545
CLV_NRD_NRD_1 136 138 PF00675 0.465
CLV_NRD_NRD_1 646 648 PF00675 0.467
CLV_NRD_NRD_1 653 655 PF00675 0.460
CLV_NRD_NRD_1 703 705 PF00675 0.371
CLV_PCSK_FUR_1 416 420 PF00082 0.751
CLV_PCSK_FUR_1 502 506 PF00082 0.585
CLV_PCSK_FUR_1 700 704 PF00082 0.360
CLV_PCSK_KEX2_1 13 15 PF00082 0.545
CLV_PCSK_KEX2_1 136 138 PF00082 0.465
CLV_PCSK_KEX2_1 418 420 PF00082 0.641
CLV_PCSK_KEX2_1 504 506 PF00082 0.721
CLV_PCSK_KEX2_1 645 647 PF00082 0.471
CLV_PCSK_KEX2_1 653 655 PF00082 0.460
CLV_PCSK_KEX2_1 702 704 PF00082 0.367
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.759
CLV_PCSK_PC1ET2_1 504 506 PF00082 0.618
CLV_PCSK_SKI1_1 13 17 PF00082 0.548
CLV_PCSK_SKI1_1 33 37 PF00082 0.312
CLV_PCSK_SKI1_1 403 407 PF00082 0.575
CLV_PCSK_SKI1_1 421 425 PF00082 0.656
CLV_PCSK_SKI1_1 451 455 PF00082 0.624
CLV_PCSK_SKI1_1 505 509 PF00082 0.690
CLV_PCSK_SKI1_1 653 657 PF00082 0.452
CLV_PCSK_SKI1_1 694 698 PF00082 0.373
DEG_APCC_DBOX_1 169 177 PF00400 0.735
DEG_APCC_DBOX_1 601 609 PF00400 0.712
DEG_APCC_DBOX_1 644 652 PF00400 0.465
DEG_Nend_UBRbox_2 1 3 PF02207 0.495
DEG_SPOP_SBC_1 343 347 PF00917 0.747
DEG_SPOP_SBC_1 358 362 PF00917 0.575
DOC_CDC14_PxL_1 527 535 PF14671 0.732
DOC_CKS1_1 522 527 PF01111 0.623
DOC_CKS1_1 59 64 PF01111 0.436
DOC_CYCLIN_RxL_1 647 657 PF00134 0.462
DOC_CYCLIN_yClb1_LxF_4 552 557 PF00134 0.740
DOC_CYCLIN_yCln2_LP_2 689 695 PF00134 0.387
DOC_MAPK_gen_1 170 179 PF00069 0.620
DOC_MAPK_gen_1 733 741 PF00069 0.506
DOC_MAPK_MEF2A_6 733 741 PF00069 0.388
DOC_MAPK_RevD_3 1 14 PF00069 0.468
DOC_PP2B_LxvP_1 689 692 PF13499 0.392
DOC_PP4_FxxP_1 695 698 PF00568 0.368
DOC_USP7_MATH_1 132 136 PF00917 0.548
DOC_USP7_MATH_1 178 182 PF00917 0.681
DOC_USP7_MATH_1 190 194 PF00917 0.579
DOC_USP7_MATH_1 205 209 PF00917 0.741
DOC_USP7_MATH_1 214 218 PF00917 0.509
DOC_USP7_MATH_1 226 230 PF00917 0.650
DOC_USP7_MATH_1 232 236 PF00917 0.801
DOC_USP7_MATH_1 237 241 PF00917 0.651
DOC_USP7_MATH_1 242 246 PF00917 0.625
DOC_USP7_MATH_1 344 348 PF00917 0.748
DOC_USP7_MATH_1 358 362 PF00917 0.535
DOC_USP7_MATH_1 394 398 PF00917 0.584
DOC_USP7_MATH_1 426 430 PF00917 0.703
DOC_USP7_MATH_1 444 448 PF00917 0.618
DOC_USP7_MATH_1 497 501 PF00917 0.714
DOC_USP7_MATH_1 545 549 PF00917 0.640
DOC_USP7_MATH_1 562 566 PF00917 0.576
DOC_USP7_MATH_1 586 590 PF00917 0.646
DOC_USP7_MATH_1 624 628 PF00917 0.605
DOC_USP7_MATH_1 633 637 PF00917 0.438
DOC_USP7_MATH_1 684 688 PF00917 0.450
DOC_USP7_MATH_1 773 777 PF00917 0.684
DOC_USP7_MATH_1 786 790 PF00917 0.385
DOC_WW_Pin1_4 155 160 PF00397 0.592
DOC_WW_Pin1_4 305 310 PF00397 0.501
DOC_WW_Pin1_4 319 324 PF00397 0.501
DOC_WW_Pin1_4 345 350 PF00397 0.677
DOC_WW_Pin1_4 521 526 PF00397 0.642
DOC_WW_Pin1_4 538 543 PF00397 0.530
DOC_WW_Pin1_4 548 553 PF00397 0.556
DOC_WW_Pin1_4 58 63 PF00397 0.430
DOC_WW_Pin1_4 627 632 PF00397 0.644
DOC_WW_Pin1_4 635 640 PF00397 0.436
DOC_WW_Pin1_4 714 719 PF00397 0.481
DOC_WW_Pin1_4 800 805 PF00397 0.550
LIG_14-3-3_CanoR_1 154 161 PF00244 0.574
LIG_14-3-3_CanoR_1 252 258 PF00244 0.597
LIG_14-3-3_CanoR_1 315 320 PF00244 0.483
LIG_14-3-3_CanoR_1 33 38 PF00244 0.461
LIG_14-3-3_CanoR_1 419 424 PF00244 0.771
LIG_14-3-3_CanoR_1 602 608 PF00244 0.618
LIG_14-3-3_CanoR_1 683 693 PF00244 0.437
LIG_14-3-3_CanoR_1 736 740 PF00244 0.508
LIG_14-3-3_CanoR_1 77 82 PF00244 0.469
LIG_BIR_III_4 425 429 PF00653 0.678
LIG_BIR_III_4 799 803 PF00653 0.520
LIG_BRCT_BRCA1_1 361 365 PF00533 0.749
LIG_CaM_IQ_9 609 625 PF13499 0.627
LIG_deltaCOP1_diTrp_1 371 378 PF00928 0.605
LIG_DLG_GKlike_1 126 133 PF00625 0.475
LIG_eIF4E_1 24 30 PF01652 0.416
LIG_eIF4E_1 43 49 PF01652 0.436
LIG_FHA_1 129 135 PF00498 0.440
LIG_FHA_1 182 188 PF00498 0.685
LIG_FHA_1 306 312 PF00498 0.506
LIG_FHA_1 522 528 PF00498 0.785
LIG_FHA_1 610 616 PF00498 0.669
LIG_FHA_1 650 656 PF00498 0.464
LIG_FHA_2 568 574 PF00498 0.582
LIG_FHA_2 609 615 PF00498 0.721
LIG_FHA_2 727 733 PF00498 0.502
LIG_Integrin_RGD_1 677 679 PF01839 0.443
LIG_LIR_Apic_2 256 260 PF02991 0.584
LIG_LIR_Gen_1 128 134 PF02991 0.452
LIG_LIR_Gen_1 158 168 PF02991 0.584
LIG_LIR_Gen_1 583 588 PF02991 0.636
LIG_LIR_Gen_1 64 71 PF02991 0.465
LIG_LIR_LC3C_4 616 620 PF02991 0.495
LIG_LIR_LC3C_4 738 741 PF02991 0.370
LIG_LIR_Nem_3 128 133 PF02991 0.458
LIG_LIR_Nem_3 158 163 PF02991 0.588
LIG_LIR_Nem_3 583 587 PF02991 0.606
LIG_LIR_Nem_3 61 66 PF02991 0.433
LIG_LIR_Nem_3 80 86 PF02991 0.532
LIG_MYND_3 555 559 PF01753 0.682
LIG_NRBOX 315 321 PF00104 0.479
LIG_Pex14_2 66 70 PF04695 0.465
LIG_SH2_STAP1 779 783 PF00017 0.533
LIG_SH2_STAP1 90 94 PF00017 0.415
LIG_SH2_STAT3 637 640 PF00017 0.614
LIG_SH2_STAT5 408 411 PF00017 0.582
LIG_SH2_STAT5 607 610 PF00017 0.711
LIG_SH2_STAT5 669 672 PF00017 0.432
LIG_SH2_STAT5 747 750 PF00017 0.376
LIG_SH2_STAT5 79 82 PF00017 0.451
LIG_SH3_3 174 180 PF00018 0.593
LIG_SH3_3 35 41 PF00018 0.471
LIG_SH3_3 374 380 PF00018 0.601
LIG_SH3_3 430 436 PF00018 0.711
LIG_SH3_CIN85_PxpxPR_1 265 270 PF14604 0.573
LIG_SUMO_SIM_anti_2 516 524 PF11976 0.709
LIG_SUMO_SIM_anti_2 616 622 PF11976 0.516
LIG_SUMO_SIM_anti_2 735 742 PF11976 0.394
LIG_SUMO_SIM_par_1 315 322 PF11976 0.486
LIG_SUMO_SIM_par_1 751 756 PF11976 0.471
LIG_SUMO_SIM_par_1 794 799 PF11976 0.344
LIG_SxIP_EBH_1 51 60 PF03271 0.417
LIG_TRAF2_1 141 144 PF00917 0.548
LIG_TRAF2_1 25 28 PF00917 0.426
LIG_TRAF2_1 611 614 PF00917 0.569
LIG_TRAF2_2 380 385 PF00917 0.591
LIG_TRFH_1 695 699 PF08558 0.432
LIG_WRC_WIRS_1 179 184 PF05994 0.742
LIG_WRC_WIRS_1 581 586 PF05994 0.565
LIG_WRC_WIRS_1 727 732 PF05994 0.511
LIG_WW_3 697 701 PF00397 0.447
MOD_CDC14_SPxK_1 551 554 PF00782 0.736
MOD_CDK_SPK_2 305 310 PF00069 0.483
MOD_CDK_SPxK_1 548 554 PF00069 0.738
MOD_CK1_1 181 187 PF00069 0.681
MOD_CK1_1 188 194 PF00069 0.623
MOD_CK1_1 208 214 PF00069 0.694
MOD_CK1_1 235 241 PF00069 0.624
MOD_CK1_1 318 324 PF00069 0.485
MOD_CK1_1 342 348 PF00069 0.662
MOD_CK1_1 367 373 PF00069 0.713
MOD_CK1_1 429 435 PF00069 0.670
MOD_CK1_1 500 506 PF00069 0.713
MOD_CK1_1 535 541 PF00069 0.633
MOD_CK1_1 548 554 PF00069 0.593
MOD_CK1_1 569 575 PF00069 0.690
MOD_CK1_1 589 595 PF00069 0.678
MOD_CK1_1 627 633 PF00069 0.592
MOD_CK1_1 714 720 PF00069 0.616
MOD_CK1_1 73 79 PF00069 0.496
MOD_CK2_1 235 241 PF00069 0.688
MOD_CK2_1 287 293 PF00069 0.456
MOD_CK2_1 394 400 PF00069 0.587
MOD_CK2_1 568 574 PF00069 0.623
MOD_CK2_1 608 614 PF00069 0.696
MOD_CK2_1 684 690 PF00069 0.479
MOD_CMANNOS 381 384 PF00535 0.587
MOD_GlcNHglycan 117 120 PF01048 0.455
MOD_GlcNHglycan 155 158 PF01048 0.580
MOD_GlcNHglycan 187 190 PF01048 0.760
MOD_GlcNHglycan 194 197 PF01048 0.664
MOD_GlcNHglycan 207 210 PF01048 0.739
MOD_GlcNHglycan 228 231 PF01048 0.789
MOD_GlcNHglycan 235 238 PF01048 0.612
MOD_GlcNHglycan 245 248 PF01048 0.555
MOD_GlcNHglycan 257 260 PF01048 0.597
MOD_GlcNHglycan 311 314 PF01048 0.522
MOD_GlcNHglycan 341 344 PF01048 0.678
MOD_GlcNHglycan 354 357 PF01048 0.769
MOD_GlcNHglycan 428 431 PF01048 0.656
MOD_GlcNHglycan 494 497 PF01048 0.696
MOD_GlcNHglycan 499 502 PF01048 0.736
MOD_GlcNHglycan 537 540 PF01048 0.695
MOD_GlcNHglycan 547 550 PF01048 0.646
MOD_GlcNHglycan 562 565 PF01048 0.601
MOD_GlcNHglycan 626 629 PF01048 0.601
MOD_GlcNHglycan 63 66 PF01048 0.431
MOD_GlcNHglycan 713 716 PF01048 0.659
MOD_GlcNHglycan 768 772 PF01048 0.711
MOD_GSK3_1 128 135 PF00069 0.478
MOD_GSK3_1 181 188 PF00069 0.705
MOD_GSK3_1 226 233 PF00069 0.767
MOD_GSK3_1 255 262 PF00069 0.627
MOD_GSK3_1 305 312 PF00069 0.518
MOD_GSK3_1 315 322 PF00069 0.558
MOD_GSK3_1 335 342 PF00069 0.455
MOD_GSK3_1 345 352 PF00069 0.654
MOD_GSK3_1 359 366 PF00069 0.751
MOD_GSK3_1 394 401 PF00069 0.586
MOD_GSK3_1 453 460 PF00069 0.667
MOD_GSK3_1 49 56 PF00069 0.447
MOD_GSK3_1 531 538 PF00069 0.619
MOD_GSK3_1 558 565 PF00069 0.754
MOD_GSK3_1 582 589 PF00069 0.713
MOD_GSK3_1 603 610 PF00069 0.603
MOD_GSK3_1 635 642 PF00069 0.526
MOD_GSK3_1 69 76 PF00069 0.509
MOD_GSK3_1 735 742 PF00069 0.394
MOD_GSK3_1 767 774 PF00069 0.641
MOD_LATS_1 396 402 PF00433 0.584
MOD_N-GLC_1 115 120 PF02516 0.447
MOD_N-GLC_1 363 368 PF02516 0.574
MOD_N-GLC_1 426 431 PF02516 0.601
MOD_N-GLC_1 485 490 PF02516 0.641
MOD_N-GLC_2 686 688 PF02516 0.607
MOD_NEK2_1 200 205 PF00069 0.723
MOD_NEK2_1 359 364 PF00069 0.675
MOD_NEK2_1 453 458 PF00069 0.599
MOD_NEK2_1 49 54 PF00069 0.527
MOD_NEK2_1 532 537 PF00069 0.592
MOD_NEK2_1 558 563 PF00069 0.690
MOD_NEK2_1 608 613 PF00069 0.723
MOD_NEK2_1 70 75 PF00069 0.511
MOD_OFUCOSY 682 688 PF10250 0.514
MOD_PIKK_1 281 287 PF00454 0.469
MOD_PIKK_1 323 329 PF00454 0.468
MOD_PIKK_1 335 341 PF00454 0.600
MOD_PIKK_1 349 355 PF00454 0.654
MOD_PIKK_1 398 404 PF00454 0.599
MOD_PIKK_1 444 450 PF00454 0.724
MOD_PIKK_1 609 615 PF00454 0.563
MOD_PK_1 183 189 PF00069 0.606
MOD_PK_1 419 425 PF00069 0.770
MOD_PKA_2 153 159 PF00069 0.592
MOD_PKA_2 589 595 PF00069 0.598
MOD_PKA_2 682 688 PF00069 0.485
MOD_PKA_2 735 741 PF00069 0.527
MOD_PKB_1 490 498 PF00069 0.687
MOD_PKB_1 675 683 PF00069 0.463
MOD_Plk_1 466 472 PF00069 0.722
MOD_Plk_1 633 639 PF00069 0.564
MOD_Plk_1 753 759 PF00069 0.506
MOD_Plk_2-3 514 520 PF00069 0.654
MOD_Plk_4 315 321 PF00069 0.534
MOD_Plk_4 326 332 PF00069 0.417
MOD_Plk_4 388 394 PF00069 0.584
MOD_Plk_4 55 61 PF00069 0.443
MOD_Plk_4 603 609 PF00069 0.593
MOD_Plk_4 639 645 PF00069 0.553
MOD_Plk_4 665 671 PF00069 0.428
MOD_Plk_4 735 741 PF00069 0.386
MOD_ProDKin_1 155 161 PF00069 0.592
MOD_ProDKin_1 305 311 PF00069 0.501
MOD_ProDKin_1 319 325 PF00069 0.496
MOD_ProDKin_1 345 351 PF00069 0.677
MOD_ProDKin_1 521 527 PF00069 0.643
MOD_ProDKin_1 538 544 PF00069 0.533
MOD_ProDKin_1 548 554 PF00069 0.556
MOD_ProDKin_1 58 64 PF00069 0.436
MOD_ProDKin_1 627 633 PF00069 0.648
MOD_ProDKin_1 635 641 PF00069 0.425
MOD_ProDKin_1 714 720 PF00069 0.473
MOD_ProDKin_1 800 806 PF00069 0.542
MOD_SUMO_for_1 212 215 PF00179 0.649
TRG_AP2beta_CARGO_1 128 137 PF09066 0.451
TRG_DiLeu_BaEn_1 518 523 PF01217 0.715
TRG_DiLeu_BaEn_1 614 619 PF01217 0.477
TRG_DiLeu_BaEn_4 518 524 PF01217 0.716
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.731
TRG_DiLeu_BaLyEn_6 816 821 PF01217 0.406
TRG_ENDOCYTIC_2 100 103 PF00928 0.536
TRG_ENDOCYTIC_2 63 66 PF00928 0.431
TRG_ER_diArg_1 13 15 PF00400 0.545
TRG_ER_diArg_1 169 172 PF00400 0.608
TRG_ER_diArg_1 473 476 PF00400 0.705
TRG_ER_diArg_1 644 647 PF00400 0.458
TRG_ER_diArg_1 653 655 PF00400 0.460
TRG_ER_diArg_1 674 677 PF00400 0.423
TRG_ER_diArg_1 699 702 PF00400 0.545
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.461
TRG_Pf-PMV_PEXEL_1 270 274 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 33 37 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P946 Leptomonas seymouri 52% 89%
A0A3Q8IMA4 Leishmania donovani 99% 100%
A4HMR1 Leishmania braziliensis 78% 98%
E9AF61 Leishmania major 90% 100%
E9B6B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS