LeishMANIAdb
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Hydrolase_4 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hydrolase_4 domain-containing protein
Gene product:
Chlamydia CHLPS protein (DUF818)/Alpha/beta hydrolase family - putative
Species:
Leishmania infantum
UniProt:
A4IBE6_LEIIN
TriTrypDb:
LINF_350033300
Length:
400

Annotations

LeishMANIAdb annotations

A catalytically active hydrolase 4 domain associated with a multi-pass membrane domain. Probably recognizes membrane-associated substrates.. Distant Eukaryotic relatives typically have signal-anchors and are luminal

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4IBE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBE6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.517
CLV_C14_Caspase3-7 291 295 PF00656 0.462
CLV_C14_Caspase3-7 359 363 PF00656 0.518
CLV_NRD_NRD_1 141 143 PF00675 0.378
CLV_NRD_NRD_1 151 153 PF00675 0.217
CLV_NRD_NRD_1 307 309 PF00675 0.327
CLV_NRD_NRD_1 330 332 PF00675 0.344
CLV_PCSK_FUR_1 139 143 PF00082 0.348
CLV_PCSK_KEX2_1 141 143 PF00082 0.330
CLV_PCSK_SKI1_1 308 312 PF00082 0.307
CLV_PCSK_SKI1_1 332 336 PF00082 0.304
CLV_PCSK_SKI1_1 396 400 PF00082 0.342
CLV_PCSK_SKI1_1 93 97 PF00082 0.608
DEG_COP1_1 157 166 PF00400 0.599
DEG_MDM2_SWIB_1 109 116 PF02201 0.217
DEG_Nend_Nbox_1 1 3 PF02207 0.656
DEG_ODPH_VHL_1 29 42 PF01847 0.265
DEG_SCF_FBW7_1 302 307 PF00400 0.539
DOC_CKS1_1 301 306 PF01111 0.457
DOC_CYCLIN_RxL_1 328 337 PF00134 0.570
DOC_CYCLIN_yClb1_LxF_4 255 261 PF00134 0.396
DOC_MAPK_DCC_7 93 101 PF00069 0.263
DOC_MAPK_gen_1 152 160 PF00069 0.559
DOC_MAPK_HePTP_8 150 162 PF00069 0.512
DOC_MAPK_MEF2A_6 153 162 PF00069 0.599
DOC_MAPK_MEF2A_6 93 101 PF00069 0.263
DOC_PP1_RVXF_1 219 226 PF00149 0.457
DOC_PP2B_LxvP_1 28 31 PF13499 0.350
DOC_PP4_FxxP_1 370 373 PF00568 0.470
DOC_USP7_MATH_1 13 17 PF00917 0.623
DOC_USP7_MATH_1 279 283 PF00917 0.510
DOC_USP7_UBL2_3 305 309 PF12436 0.518
DOC_WW_Pin1_4 300 305 PF00397 0.466
LIG_14-3-3_CanoR_1 287 293 PF00244 0.443
LIG_BRCT_BRCA1_1 394 398 PF00533 0.515
LIG_eIF4E_1 278 284 PF01652 0.539
LIG_FHA_1 102 108 PF00498 0.396
LIG_FHA_1 172 178 PF00498 0.535
LIG_FHA_1 225 231 PF00498 0.501
LIG_FHA_1 301 307 PF00498 0.484
LIG_LIR_Apic_2 300 304 PF02991 0.457
LIG_LIR_Apic_2 368 373 PF02991 0.462
LIG_LIR_Gen_1 108 116 PF02991 0.476
LIG_LIR_Gen_1 286 297 PF02991 0.469
LIG_LIR_Gen_1 385 394 PF02991 0.576
LIG_LIR_Gen_1 62 70 PF02991 0.350
LIG_LIR_LC3C_4 174 177 PF02991 0.543
LIG_LIR_Nem_3 108 112 PF02991 0.442
LIG_LIR_Nem_3 183 189 PF02991 0.466
LIG_LIR_Nem_3 382 387 PF02991 0.586
LIG_LIR_Nem_3 62 68 PF02991 0.368
LIG_PDZ_Class_2 395 400 PF00595 0.452
LIG_Pex14_2 109 113 PF04695 0.217
LIG_SH2_GRB2like 376 379 PF00017 0.509
LIG_SH2_SRC 21 24 PF00017 0.627
LIG_SH2_SRC 387 390 PF00017 0.529
LIG_SH2_STAT3 229 232 PF00017 0.582
LIG_SH2_STAT3 336 339 PF00017 0.491
LIG_SH2_STAT5 189 192 PF00017 0.477
LIG_SH2_STAT5 21 24 PF00017 0.596
LIG_SH2_STAT5 229 232 PF00017 0.491
LIG_SH2_STAT5 247 250 PF00017 0.400
LIG_SH2_STAT5 301 304 PF00017 0.556
LIG_SH2_STAT5 50 53 PF00017 0.346
LIG_SH3_3 76 82 PF00018 0.302
LIG_SUMO_SIM_anti_2 5 11 PF11976 0.602
LIG_SUMO_SIM_anti_2 76 82 PF11976 0.396
LIG_SUMO_SIM_par_1 103 108 PF11976 0.299
LIG_UBA3_1 63 71 PF00899 0.302
LIG_WW_1 373 376 PF00397 0.517
MOD_CDK_SPK_2 300 305 PF00069 0.518
MOD_CK1_1 290 296 PF00069 0.464
MOD_CK1_1 300 306 PF00069 0.463
MOD_CK1_1 379 385 PF00069 0.521
MOD_GlcNHglycan 16 19 PF01048 0.301
MOD_GlcNHglycan 381 384 PF01048 0.324
MOD_GlcNHglycan 4 7 PF01048 0.344
MOD_GSK3_1 101 108 PF00069 0.406
MOD_GSK3_1 167 174 PF00069 0.560
MOD_GSK3_1 224 231 PF00069 0.506
MOD_GSK3_1 300 307 PF00069 0.504
MOD_GSK3_1 372 379 PF00069 0.502
MOD_GSK3_1 392 399 PF00069 0.588
MOD_GSK3_1 69 76 PF00069 0.469
MOD_N-GLC_1 14 19 PF02516 0.348
MOD_NEK2_1 14 19 PF00069 0.545
MOD_NEK2_1 197 202 PF00069 0.535
MOD_NEK2_1 261 266 PF00069 0.528
MOD_NEK2_1 285 290 PF00069 0.465
MOD_NEK2_1 345 350 PF00069 0.535
MOD_NEK2_1 59 64 PF00069 0.341
MOD_NEK2_1 83 88 PF00069 0.342
MOD_PIKK_1 228 234 PF00454 0.582
MOD_PK_1 154 160 PF00069 0.513
MOD_PKA_2 392 398 PF00069 0.531
MOD_Plk_1 154 160 PF00069 0.508
MOD_Plk_1 181 187 PF00069 0.549
MOD_Plk_1 197 203 PF00069 0.455
MOD_Plk_1 285 291 PF00069 0.437
MOD_Plk_1 345 351 PF00069 0.507
MOD_Plk_4 105 111 PF00069 0.240
MOD_Plk_4 171 177 PF00069 0.553
MOD_Plk_4 279 285 PF00069 0.554
MOD_Plk_4 376 382 PF00069 0.562
MOD_Plk_4 59 65 PF00069 0.364
MOD_ProDKin_1 300 306 PF00069 0.466
MOD_SUMO_rev_2 165 170 PF00179 0.625
TRG_DiLeu_BaEn_1 171 176 PF01217 0.447
TRG_ENDOCYTIC_2 387 390 PF00928 0.577
TRG_ER_diArg_1 139 142 PF00400 0.574

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Q9 Leptomonas seymouri 63% 100%
A0A0S4JC83 Bodo saltans 32% 93%
A0A1X0P6X8 Trypanosomatidae 35% 99%
A0A3S5H7Z7 Leishmania donovani 100% 100%
A0A422P2Q7 Trypanosoma rangeli 35% 99%
A4HMU6 Leishmania braziliensis 77% 100%
C9ZZ74 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 95%
E9AFA4 Leishmania major 94% 100%
E9B6F9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BD21 Trypanosoma cruzi 34% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS