LeishMANIAdb
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SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania infantum
UniProt:
A4IBE0_LEIIN
TriTrypDb:
LINF_350032500
Length:
770

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBE0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBE0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 283 287 PF00656 0.682
CLV_C14_Caspase3-7 345 349 PF00656 0.576
CLV_NRD_NRD_1 12 14 PF00675 0.627
CLV_NRD_NRD_1 173 175 PF00675 0.654
CLV_NRD_NRD_1 225 227 PF00675 0.689
CLV_NRD_NRD_1 298 300 PF00675 0.580
CLV_NRD_NRD_1 421 423 PF00675 0.518
CLV_NRD_NRD_1 446 448 PF00675 0.468
CLV_NRD_NRD_1 451 453 PF00675 0.473
CLV_NRD_NRD_1 584 586 PF00675 0.546
CLV_NRD_NRD_1 66 68 PF00675 0.651
CLV_PCSK_FUR_1 443 447 PF00082 0.486
CLV_PCSK_KEX2_1 224 226 PF00082 0.693
CLV_PCSK_KEX2_1 298 300 PF00082 0.580
CLV_PCSK_KEX2_1 421 423 PF00082 0.518
CLV_PCSK_KEX2_1 445 447 PF00082 0.481
CLV_PCSK_KEX2_1 714 716 PF00082 0.672
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.693
CLV_PCSK_PC1ET2_1 714 716 PF00082 0.672
CLV_PCSK_SKI1_1 144 148 PF00082 0.656
CLV_PCSK_SKI1_1 339 343 PF00082 0.517
CLV_PCSK_SKI1_1 379 383 PF00082 0.449
CLV_PCSK_SKI1_1 447 451 PF00082 0.489
CLV_PCSK_SKI1_1 453 457 PF00082 0.487
CLV_PCSK_SKI1_1 501 505 PF00082 0.774
CLV_PCSK_SKI1_1 57 61 PF00082 0.634
CLV_PCSK_SKI1_1 621 625 PF00082 0.709
CLV_PCSK_SKI1_1 635 639 PF00082 0.558
CLV_PCSK_SKI1_1 715 719 PF00082 0.641
DEG_APCC_KENBOX_2 109 113 PF00400 0.705
DEG_Nend_Nbox_1 1 3 PF02207 0.544
DEG_SCF_FBW7_1 180 187 PF00400 0.650
DEG_SPOP_SBC_1 128 132 PF00917 0.720
DEG_SPOP_SBC_1 371 375 PF00917 0.566
DOC_CKS1_1 488 493 PF01111 0.639
DOC_CYCLIN_yClb1_LxF_4 31 36 PF00134 0.499
DOC_CYCLIN_yCln2_LP_2 242 248 PF00134 0.537
DOC_CYCLIN_yCln2_LP_2 77 83 PF00134 0.625
DOC_MAPK_gen_1 33 40 PF00069 0.564
DOC_PP1_RVXF_1 31 37 PF00149 0.505
DOC_PP1_RVXF_1 577 584 PF00149 0.549
DOC_PP2B_LxvP_1 147 150 PF13499 0.633
DOC_PP2B_LxvP_1 38 41 PF13499 0.664
DOC_PP2B_LxvP_1 59 62 PF13499 0.615
DOC_PP2B_LxvP_1 637 640 PF13499 0.706
DOC_PP2B_LxvP_1 657 660 PF13499 0.354
DOC_PP2B_LxvP_1 77 80 PF13499 0.602
DOC_PP4_FxxP_1 404 407 PF00568 0.585
DOC_USP7_MATH_1 117 121 PF00917 0.727
DOC_USP7_MATH_1 126 130 PF00917 0.676
DOC_USP7_MATH_1 217 221 PF00917 0.688
DOC_USP7_MATH_1 275 279 PF00917 0.678
DOC_USP7_MATH_1 371 375 PF00917 0.615
DOC_USP7_MATH_1 62 66 PF00917 0.620
DOC_USP7_MATH_1 685 689 PF00917 0.480
DOC_USP7_MATH_1 752 756 PF00917 0.634
DOC_USP7_MATH_2 491 497 PF00917 0.646
DOC_USP7_UBL2_3 33 37 PF12436 0.518
DOC_WW_Pin1_4 121 126 PF00397 0.769
DOC_WW_Pin1_4 180 185 PF00397 0.709
DOC_WW_Pin1_4 487 492 PF00397 0.639
DOC_WW_Pin1_4 566 571 PF00397 0.614
DOC_WW_Pin1_4 621 626 PF00397 0.631
DOC_WW_Pin1_4 733 738 PF00397 0.804
DOC_WW_Pin1_4 765 770 PF00397 0.641
LIG_14-3-3_CanoR_1 119 128 PF00244 0.769
LIG_14-3-3_CanoR_1 144 150 PF00244 0.654
LIG_14-3-3_CanoR_1 16 23 PF00244 0.611
LIG_14-3-3_CanoR_1 57 62 PF00244 0.632
LIG_APCC_ABBA_1 380 385 PF00400 0.471
LIG_APCC_ABBAyCdc20_2 379 385 PF00400 0.448
LIG_APCC_ABBAyCdc20_2 540 546 PF00400 0.557
LIG_BIR_III_4 554 558 PF00653 0.539
LIG_BRCT_BRCA1_1 434 438 PF00533 0.547
LIG_CaM_IQ_9 608 623 PF13499 0.662
LIG_CtBP_PxDLS_1 218 224 PF00389 0.666
LIG_CtBP_PxDLS_1 239 243 PF00389 0.519
LIG_DCNL_PONY_1 1 4 PF03556 0.527
LIG_FHA_1 141 147 PF00498 0.698
LIG_FHA_1 175 181 PF00498 0.704
LIG_FHA_1 23 29 PF00498 0.671
LIG_FHA_1 49 55 PF00498 0.666
LIG_FHA_1 58 64 PF00498 0.567
LIG_FHA_1 612 618 PF00498 0.546
LIG_FHA_1 634 640 PF00498 0.606
LIG_FHA_2 40 46 PF00498 0.674
LIG_FHA_2 488 494 PF00498 0.641
LIG_FHA_2 554 560 PF00498 0.518
LIG_FHA_2 641 647 PF00498 0.679
LIG_FHA_2 685 691 PF00498 0.676
LIG_LIR_Apic_2 402 407 PF02991 0.556
LIG_LIR_Gen_1 435 444 PF02991 0.535
LIG_LIR_Gen_1 546 555 PF02991 0.575
LIG_LIR_Gen_1 671 681 PF02991 0.544
LIG_LIR_Nem_3 310 314 PF02991 0.523
LIG_LIR_Nem_3 435 441 PF02991 0.514
LIG_LIR_Nem_3 546 550 PF02991 0.555
LIG_LIR_Nem_3 669 673 PF02991 0.522
LIG_LIR_Nem_3 708 713 PF02991 0.699
LIG_LYPXL_yS_3 311 314 PF13949 0.529
LIG_NRBOX 435 441 PF00104 0.539
LIG_SH2_CRK 173 177 PF00017 0.700
LIG_SH2_NCK_1 97 101 PF00017 0.682
LIG_SH2_SRC 645 648 PF00017 0.547
LIG_SH2_STAP1 355 359 PF00017 0.456
LIG_SH2_STAP1 645 649 PF00017 0.542
LIG_SH2_STAP1 670 674 PF00017 0.517
LIG_SH2_STAT5 428 431 PF00017 0.482
LIG_SH2_STAT5 454 457 PF00017 0.485
LIG_SH2_STAT5 610 613 PF00017 0.571
LIG_SH2_STAT5 673 676 PF00017 0.524
LIG_SH3_1 729 735 PF00018 0.590
LIG_SH3_3 122 128 PF00018 0.754
LIG_SH3_3 152 158 PF00018 0.817
LIG_SH3_3 17 23 PF00018 0.567
LIG_SH3_3 243 249 PF00018 0.742
LIG_SH3_3 250 256 PF00018 0.809
LIG_SH3_3 725 731 PF00018 0.731
LIG_SH3_CIN85_PxpxPR_1 744 749 PF14604 0.645
LIG_Sin3_3 231 238 PF02671 0.608
LIG_TRAF2_1 736 739 PF00917 0.708
LIG_UBA3_1 580 586 PF00899 0.546
LIG_WW_3 124 128 PF00397 0.661
LIG_WW_3 248 252 PF00397 0.681
MOD_CDK_SPK_2 765 770 PF00069 0.641
MOD_CDK_SPxK_1 121 127 PF00069 0.664
MOD_CDK_SPxK_1 180 186 PF00069 0.652
MOD_CDK_SPxxK_3 487 494 PF00069 0.640
MOD_CDK_SPxxK_3 566 573 PF00069 0.534
MOD_CDK_SPxxK_3 621 628 PF00069 0.629
MOD_CK1_1 129 135 PF00069 0.782
MOD_CK1_1 140 146 PF00069 0.671
MOD_CK1_1 194 200 PF00069 0.745
MOD_CK1_1 39 45 PF00069 0.674
MOD_CK1_1 487 493 PF00069 0.639
MOD_CK1_1 589 595 PF00069 0.543
MOD_CK1_1 666 672 PF00069 0.529
MOD_CK1_1 757 763 PF00069 0.648
MOD_CK2_1 128 134 PF00069 0.721
MOD_CK2_1 371 377 PF00069 0.604
MOD_CK2_1 487 493 PF00069 0.639
MOD_CK2_1 553 559 PF00069 0.546
MOD_CK2_1 684 690 PF00069 0.670
MOD_CK2_1 733 739 PF00069 0.805
MOD_CK2_1 747 753 PF00069 0.586
MOD_CK2_1 83 89 PF00069 0.593
MOD_Cter_Amidation 11 14 PF01082 0.623
MOD_GlcNHglycan 147 150 PF01048 0.814
MOD_GlcNHglycan 17 20 PF01048 0.551
MOD_GlcNHglycan 273 276 PF01048 0.734
MOD_GlcNHglycan 315 318 PF01048 0.453
MOD_GlcNHglycan 495 498 PF01048 0.666
MOD_GlcNHglycan 526 529 PF01048 0.598
MOD_GlcNHglycan 660 663 PF01048 0.428
MOD_GlcNHglycan 687 690 PF01048 0.573
MOD_GlcNHglycan 70 73 PF01048 0.666
MOD_GlcNHglycan 85 88 PF01048 0.604
MOD_GlcNHglycan 9 12 PF01048 0.623
MOD_GlcNHglycan 96 100 PF01048 0.693
MOD_GSK3_1 115 122 PF00069 0.741
MOD_GSK3_1 145 152 PF00069 0.792
MOD_GSK3_1 180 187 PF00069 0.772
MOD_GSK3_1 271 278 PF00069 0.697
MOD_GSK3_1 357 364 PF00069 0.427
MOD_GSK3_1 385 392 PF00069 0.458
MOD_GSK3_1 463 470 PF00069 0.650
MOD_GSK3_1 471 478 PF00069 0.636
MOD_GSK3_1 57 64 PF00069 0.625
MOD_GSK3_1 754 761 PF00069 0.781
MOD_GSK3_1 83 90 PF00069 0.628
MOD_N-GLC_1 137 142 PF02516 0.726
MOD_N-GLC_1 371 376 PF02516 0.558
MOD_N-GLC_1 468 473 PF02516 0.695
MOD_N-GLC_1 504 509 PF02516 0.566
MOD_N-GLC_1 566 571 PF02516 0.589
MOD_N-GLC_2 203 205 PF02516 0.652
MOD_N-GLC_2 227 229 PF02516 0.603
MOD_NEK2_1 210 215 PF00069 0.758
MOD_NEK2_1 271 276 PF00069 0.684
MOD_NEK2_1 36 41 PF00069 0.624
MOD_NEK2_1 389 394 PF00069 0.483
MOD_NEK2_1 467 472 PF00069 0.709
MOD_NEK2_1 517 522 PF00069 0.627
MOD_NEK2_1 524 529 PF00069 0.515
MOD_NEK2_1 553 558 PF00069 0.605
MOD_NEK2_2 62 67 PF00069 0.627
MOD_NEK2_2 640 645 PF00069 0.583
MOD_PIKK_1 137 143 PF00454 0.815
MOD_PIKK_1 254 260 PF00454 0.682
MOD_PKA_1 174 180 PF00069 0.692
MOD_PKA_1 298 304 PF00069 0.588
MOD_PKA_2 126 132 PF00069 0.732
MOD_PKA_2 134 140 PF00069 0.746
MOD_PKA_2 15 21 PF00069 0.589
MOD_PKA_2 298 304 PF00069 0.588
MOD_PKA_2 389 395 PF00069 0.482
MOD_PKA_2 461 467 PF00069 0.524
MOD_Plk_1 184 190 PF00069 0.646
MOD_Plk_1 350 356 PF00069 0.473
MOD_Plk_1 384 390 PF00069 0.413
MOD_Plk_1 424 430 PF00069 0.479
MOD_Plk_1 515 521 PF00069 0.558
MOD_Plk_1 645 651 PF00069 0.543
MOD_Plk_1 752 758 PF00069 0.665
MOD_Plk_2-3 747 753 PF00069 0.646
MOD_Plk_4 217 223 PF00069 0.767
MOD_Plk_4 298 304 PF00069 0.585
MOD_Plk_4 310 316 PF00069 0.375
MOD_Plk_4 589 595 PF00069 0.568
MOD_Plk_4 633 639 PF00069 0.645
MOD_Plk_4 640 646 PF00069 0.581
MOD_Plk_4 669 675 PF00069 0.523
MOD_ProDKin_1 121 127 PF00069 0.772
MOD_ProDKin_1 180 186 PF00069 0.709
MOD_ProDKin_1 487 493 PF00069 0.639
MOD_ProDKin_1 566 572 PF00069 0.611
MOD_ProDKin_1 621 627 PF00069 0.628
MOD_ProDKin_1 733 739 PF00069 0.805
MOD_SUMO_rev_2 185 193 PF00179 0.779
MOD_SUMO_rev_2 316 322 PF00179 0.483
MOD_SUMO_rev_2 39 48 PF00179 0.672
MOD_SUMO_rev_2 487 496 PF00179 0.593
MOD_SUMO_rev_2 631 637 PF00179 0.571
TRG_Cilium_Arf4_1 766 770 PF00025 0.694
TRG_DiLeu_BaEn_4 424 430 PF01217 0.558
TRG_DiLeu_BaLyEn_6 576 581 PF01217 0.554
TRG_ENDOCYTIC_2 311 314 PF00928 0.529
TRG_ENDOCYTIC_2 383 386 PF00928 0.470
TRG_ENDOCYTIC_2 401 404 PF00928 0.524
TRG_ENDOCYTIC_2 673 676 PF00928 0.529
TRG_ER_diArg_1 420 422 PF00400 0.499
TRG_ER_diArg_1 445 447 PF00400 0.465
TRG_Pf-PMV_PEXEL_1 226 230 PF00026 0.659
TRG_Pf-PMV_PEXEL_1 447 451 PF00026 0.568
TRG_Pf-PMV_PEXEL_1 537 541 PF00026 0.584
TRG_Pf-PMV_PEXEL_1 701 705 PF00026 0.543
TRG_Pf-PMV_PEXEL_1 749 753 PF00026 0.648

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGC9 Leptomonas seymouri 55% 96%
A0A3Q8IIE1 Leishmania donovani 99% 100%
A4HMT9 Leishmania braziliensis 69% 98%
E9AF96 Leishmania major 56% 100%
E9B6F1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS