Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBD8_LEIIN

TriTrypDb:

LINF_350032300

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.600
CLV_NRD_NRD_1	492	494	PF00675	0.531
CLV_NRD_NRD_1	7	9	PF00675	0.574
CLV_PCSK_KEX2_1	444	446	PF00082	0.732
CLV_PCSK_KEX2_1	491	493	PF00082	0.551
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.732
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.551
CLV_PCSK_SKI1_1	139	143	PF00082	0.558
CLV_PCSK_SKI1_1	221	225	PF00082	0.644
CLV_PCSK_SKI1_1	29	33	PF00082	0.508
CLV_PCSK_SKI1_1	294	298	PF00082	0.508
CLV_PCSK_SKI1_1	482	486	PF00082	0.505
CLV_PCSK_SKI1_1	8	12	PF00082	0.442
DEG_APCC_DBOX_1	293	301	PF00400	0.566
DEG_APCC_DBOX_1	349	357	PF00400	0.558
DEG_APCC_DBOX_1	7	15	PF00400	0.434
DEG_Nend_UBRbox_1	1	4	PF02207	0.640
DEG_SCF_FBW7_1	59	66	PF00400	0.633
DEG_SPOP_SBC_1	208	212	PF00917	0.682
DEG_SPOP_SBC_1	48	52	PF00917	0.788
DEG_SPOP_SBC_1	74	78	PF00917	0.697
DOC_CYCLIN_RxL_1	136	146	PF00134	0.522
DOC_MAPK_gen_1	137	144	PF00069	0.522
DOC_MAPK_RevD_3	479	493	PF00069	0.468
DOC_PP1_RVXF_1	137	144	PF00149	0.445
DOC_PP1_RVXF_1	346	352	PF00149	0.508
DOC_PP4_FxxP_1	427	430	PF00568	0.632
DOC_USP7_MATH_1	208	212	PF00917	0.779
DOC_USP7_MATH_1	223	227	PF00917	0.572
DOC_USP7_MATH_1	314	318	PF00917	0.543
DOC_USP7_MATH_1	358	362	PF00917	0.628
DOC_USP7_MATH_1	438	442	PF00917	0.743
DOC_USP7_MATH_1	461	465	PF00917	0.567
DOC_USP7_MATH_1	68	72	PF00917	0.826
DOC_USP7_MATH_1	74	78	PF00917	0.714
DOC_USP7_UBL2_3	12	16	PF12436	0.509
DOC_WW_Pin1_4	354	359	PF00397	0.537
DOC_WW_Pin1_4	451	456	PF00397	0.734
DOC_WW_Pin1_4	59	64	PF00397	0.723
DOC_WW_Pin1_4	70	75	PF00397	0.687
LIG_14-3-3_CanoR_1	150	159	PF00244	0.609
LIG_14-3-3_CanoR_1	29	35	PF00244	0.517
LIG_14-3-3_CanoR_1	348	354	PF00244	0.450
LIG_14-3-3_CanoR_1	465	470	PF00244	0.484
LIG_14-3-3_CanoR_1	93	101	PF00244	0.653
LIG_BRCT_BRCA1_1	463	467	PF00533	0.519
LIG_FHA_1	101	107	PF00498	0.530
LIG_FHA_1	154	160	PF00498	0.537
LIG_FHA_1	222	228	PF00498	0.636
LIG_FHA_1	296	302	PF00498	0.498
LIG_FHA_2	281	287	PF00498	0.542
LIG_FHA_2	308	314	PF00498	0.558
LIG_FHA_2	328	334	PF00498	0.286
LIG_FHA_2	37	43	PF00498	0.730
LIG_FHA_2	438	444	PF00498	0.748
LIG_FHA_2	457	463	PF00498	0.617
LIG_FHA_2	64	70	PF00498	0.735
LIG_FHA_2	80	86	PF00498	0.500
LIG_IRF3_LxIS_1	160	167	PF10401	0.678
LIG_LIR_Apic_2	424	430	PF02991	0.624
LIG_LIR_Gen_1	373	383	PF02991	0.404
LIG_LIR_Gen_1	408	418	PF02991	0.653
LIG_LIR_LC3C_4	367	371	PF02991	0.510
LIG_LIR_Nem_3	373	378	PF02991	0.396
LIG_LIR_Nem_3	408	413	PF02991	0.603
LIG_LIR_Nem_3	464	470	PF02991	0.516
LIG_MLH1_MIPbox_1	467	471	PF16413	0.507
LIG_NRBOX	480	486	PF00104	0.499
LIG_PCNA_yPIPBox_3	139	152	PF02747	0.582
LIG_Pex14_2	275	279	PF04695	0.532
LIG_Pex14_2	30	34	PF04695	0.614
LIG_Pex14_2	347	351	PF04695	0.388
LIG_Pex14_2	467	471	PF04695	0.399
LIG_PTB_Apo_2	369	376	PF02174	0.412
LIG_SH2_CRK	138	142	PF00017	0.563
LIG_SH2_CRK	19	23	PF00017	0.461
LIG_SH2_CRK	7	11	PF00017	0.433
LIG_SH2_SRC	391	394	PF00017	0.473
LIG_SH2_STAP1	325	329	PF00017	0.617
LIG_SH2_STAT3	325	328	PF00017	0.548
LIG_SH2_STAT5	111	114	PF00017	0.522
LIG_SH2_STAT5	180	183	PF00017	0.596
LIG_SH2_STAT5	19	22	PF00017	0.611
LIG_SH2_STAT5	24	27	PF00017	0.540
LIG_SH2_STAT5	329	332	PF00017	0.564
LIG_SH2_STAT5	339	342	PF00017	0.505
LIG_SH2_STAT5	374	377	PF00017	0.375
LIG_SH2_STAT5	391	394	PF00017	0.473
LIG_SH2_STAT5	470	473	PF00017	0.477
LIG_SH3_3	352	358	PF00018	0.454
LIG_SH3_3	449	455	PF00018	0.562
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.497
LIG_SUMO_SIM_par_1	367	373	PF11976	0.510
LIG_TRAF2_1	117	120	PF00917	0.434
LIG_TRAF2_1	239	242	PF00917	0.531
LIG_TRFH_1	351	355	PF08558	0.422
LIG_TYR_ITIM	136	141	PF00017	0.565
LIG_TYR_ITIM	484	489	PF00017	0.509
MOD_CDK_SPK_2	70	75	PF00069	0.701
MOD_CK1_1	153	159	PF00069	0.507
MOD_CK1_1	194	200	PF00069	0.750
MOD_CK1_1	211	217	PF00069	0.764
MOD_CK1_1	41	47	PF00069	0.734
MOD_CK1_1	450	456	PF00069	0.720
MOD_CK1_1	53	59	PF00069	0.790
MOD_CK1_1	73	79	PF00069	0.502
MOD_CK2_1	280	286	PF00069	0.560
MOD_CK2_1	327	333	PF00069	0.593
MOD_CK2_1	358	364	PF00069	0.643
MOD_CK2_1	36	42	PF00069	0.683
MOD_CK2_1	443	449	PF00069	0.731
MOD_CK2_1	456	462	PF00069	0.570
MOD_Cter_Amidation	489	492	PF01082	0.519
MOD_GlcNHglycan	120	123	PF01048	0.636
MOD_GlcNHglycan	189	192	PF01048	0.741
MOD_GlcNHglycan	193	196	PF01048	0.750
MOD_GlcNHglycan	215	218	PF01048	0.801
MOD_GlcNHglycan	249	252	PF01048	0.544
MOD_GlcNHglycan	359	363	PF01048	0.533
MOD_GlcNHglycan	415	418	PF01048	0.624
MOD_GlcNHglycan	440	443	PF01048	0.653
MOD_GlcNHglycan	77	80	PF01048	0.719
MOD_GSK3_1	160	167	PF00069	0.679
MOD_GSK3_1	187	194	PF00069	0.720
MOD_GSK3_1	204	211	PF00069	0.717
MOD_GSK3_1	213	220	PF00069	0.687
MOD_GSK3_1	314	321	PF00069	0.425
MOD_GSK3_1	354	361	PF00069	0.615
MOD_GSK3_1	38	45	PF00069	0.666
MOD_GSK3_1	443	450	PF00069	0.745
MOD_GSK3_1	461	468	PF00069	0.515
MOD_GSK3_1	47	54	PF00069	0.684
MOD_GSK3_1	59	66	PF00069	0.732
MOD_GSK3_1	70	77	PF00069	0.651
MOD_N-GLC_1	187	192	PF02516	0.687
MOD_N-GLC_1	314	319	PF02516	0.519
MOD_N-GLC_1	472	477	PF02516	0.540
MOD_NEK2_1	159	164	PF00069	0.607
MOD_NEK2_1	193	198	PF00069	0.745
MOD_NEK2_1	30	35	PF00069	0.519
MOD_NEK2_1	36	41	PF00069	0.593
MOD_NEK2_1	413	418	PF00069	0.682
MOD_PIKK_1	153	159	PF00454	0.541
MOD_PIKK_1	182	188	PF00454	0.673
MOD_PIKK_1	196	202	PF00454	0.697
MOD_PIKK_1	295	301	PF00454	0.499
MOD_PKA_2	212	218	PF00069	0.761
MOD_PKA_2	265	271	PF00069	0.550
MOD_PKA_2	349	355	PF00069	0.512
MOD_PKA_2	92	98	PF00069	0.699
MOD_Plk_1	101	107	PF00069	0.602
MOD_Plk_1	314	320	PF00069	0.411
MOD_Plk_1	448	454	PF00069	0.563
MOD_Plk_4	102	108	PF00069	0.596
MOD_Plk_4	370	376	PF00069	0.396
MOD_ProDKin_1	354	360	PF00069	0.543
MOD_ProDKin_1	451	457	PF00069	0.728
MOD_ProDKin_1	59	65	PF00069	0.724
MOD_ProDKin_1	70	76	PF00069	0.685
MOD_SUMO_rev_2	178	185	PF00179	0.641
TRG_DiLeu_BaEn_1	381	386	PF01217	0.518
TRG_DiLeu_BaEn_4	387	393	PF01217	0.534
TRG_ENDOCYTIC_2	111	114	PF00928	0.566
TRG_ENDOCYTIC_2	138	141	PF00928	0.560
TRG_ENDOCYTIC_2	486	489	PF00928	0.398
TRG_ENDOCYTIC_2	7	10	PF00928	0.440
TRG_ER_diArg_1	263	266	PF00400	0.525
TRG_ER_diArg_1	347	350	PF00400	0.534
TRG_NLS_MonoExtN_4	488	495	PF00514	0.496
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBR0	Leptomonas seymouri	51%	97%
A0A1X0P6J4	Trypanosomatidae	24%	100%
A0A3S7X9M3	Leishmania donovani	99%	100%
A0A422P2R2	Trypanosoma rangeli	27%	100%
A4HMT7	Leishmania braziliensis	75%	100%
C9ZZ79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF94	Leishmania major	93%	100%
E9B6E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BTJ6	Trypanosoma cruzi	30%	100%