LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBD3_LEIIN
TriTrypDb:
LINF_350031800
Length:
667

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBD3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBD3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 298 302 PF00656 0.621
CLV_C14_Caspase3-7 413 417 PF00656 0.740
CLV_NRD_NRD_1 209 211 PF00675 0.726
CLV_NRD_NRD_1 225 227 PF00675 0.475
CLV_NRD_NRD_1 228 230 PF00675 0.466
CLV_NRD_NRD_1 250 252 PF00675 0.546
CLV_NRD_NRD_1 456 458 PF00675 0.734
CLV_NRD_NRD_1 492 494 PF00675 0.697
CLV_NRD_NRD_1 515 517 PF00675 0.562
CLV_NRD_NRD_1 636 638 PF00675 0.583
CLV_PCSK_FUR_1 207 211 PF00082 0.698
CLV_PCSK_FUR_1 226 230 PF00082 0.554
CLV_PCSK_KEX2_1 206 208 PF00082 0.718
CLV_PCSK_KEX2_1 209 211 PF00082 0.715
CLV_PCSK_KEX2_1 227 229 PF00082 0.735
CLV_PCSK_KEX2_1 364 366 PF00082 0.514
CLV_PCSK_KEX2_1 456 458 PF00082 0.734
CLV_PCSK_KEX2_1 636 638 PF00082 0.583
CLV_PCSK_PC1ET2_1 206 208 PF00082 0.723
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.747
CLV_PCSK_PC1ET2_1 364 366 PF00082 0.675
CLV_PCSK_SKI1_1 252 256 PF00082 0.560
CLV_PCSK_SKI1_1 260 264 PF00082 0.510
CLV_PCSK_SKI1_1 374 378 PF00082 0.563
DEG_Nend_UBRbox_4 1 3 PF02207 0.667
DEG_SCF_FBW7_1 195 200 PF00400 0.575
DEG_SPOP_SBC_1 338 342 PF00917 0.791
DEG_SPOP_SBC_1 445 449 PF00917 0.754
DEG_SPOP_SBC_1 554 558 PF00917 0.623
DOC_CKS1_1 423 428 PF01111 0.717
DOC_CYCLIN_RxL_1 260 271 PF00134 0.630
DOC_CYCLIN_yCln2_LP_2 183 189 PF00134 0.579
DOC_CYCLIN_yCln2_LP_2 269 275 PF00134 0.640
DOC_CYCLIN_yCln2_LP_2 280 286 PF00134 0.632
DOC_MAPK_DCC_7 265 275 PF00069 0.532
DOC_MAPK_gen_1 526 536 PF00069 0.554
DOC_MAPK_RevD_3 193 207 PF00069 0.581
DOC_PP1_RVXF_1 646 653 PF00149 0.625
DOC_PP2B_LxvP_1 267 270 PF13499 0.643
DOC_PP4_FxxP_1 423 426 PF00568 0.696
DOC_USP7_MATH_1 133 137 PF00917 0.757
DOC_USP7_MATH_1 177 181 PF00917 0.702
DOC_USP7_MATH_1 197 201 PF00917 0.459
DOC_USP7_MATH_1 338 342 PF00917 0.711
DOC_USP7_MATH_1 44 48 PF00917 0.774
DOC_USP7_MATH_1 444 448 PF00917 0.730
DOC_USP7_MATH_1 474 478 PF00917 0.791
DOC_USP7_MATH_1 489 493 PF00917 0.588
DOC_USP7_MATH_1 554 558 PF00917 0.685
DOC_USP7_MATH_1 575 579 PF00917 0.713
DOC_USP7_MATH_1 618 622 PF00917 0.579
DOC_USP7_MATH_1 82 86 PF00917 0.812
DOC_USP7_UBL2_3 223 227 PF12436 0.681
DOC_WW_Pin1_4 111 116 PF00397 0.801
DOC_WW_Pin1_4 193 198 PF00397 0.576
DOC_WW_Pin1_4 2 7 PF00397 0.754
DOC_WW_Pin1_4 268 273 PF00397 0.629
DOC_WW_Pin1_4 305 310 PF00397 0.818
DOC_WW_Pin1_4 313 318 PF00397 0.692
DOC_WW_Pin1_4 321 326 PF00397 0.716
DOC_WW_Pin1_4 331 336 PF00397 0.584
DOC_WW_Pin1_4 342 347 PF00397 0.704
DOC_WW_Pin1_4 35 40 PF00397 0.780
DOC_WW_Pin1_4 407 412 PF00397 0.634
DOC_WW_Pin1_4 422 427 PF00397 0.634
DOC_WW_Pin1_4 446 451 PF00397 0.723
DOC_WW_Pin1_4 485 490 PF00397 0.694
DOC_WW_Pin1_4 72 77 PF00397 0.700
DOC_WW_Pin1_4 88 93 PF00397 0.523
LIG_14-3-3_CanoR_1 176 182 PF00244 0.694
LIG_14-3-3_CanoR_1 265 270 PF00244 0.603
LIG_14-3-3_CanoR_1 412 419 PF00244 0.817
LIG_14-3-3_CanoR_1 636 642 PF00244 0.647
LIG_BRCT_BRCA1_1 323 327 PF00533 0.684
LIG_BRCT_BRCA1_1 585 589 PF00533 0.700
LIG_CaM_IQ_9 357 372 PF13499 0.672
LIG_CSL_BTD_1 343 346 PF09270 0.738
LIG_deltaCOP1_diTrp_1 169 174 PF00928 0.642
LIG_EVH1_1 112 116 PF00568 0.684
LIG_EVH1_2 115 119 PF00568 0.735
LIG_FHA_1 194 200 PF00498 0.745
LIG_FHA_1 264 270 PF00498 0.730
LIG_FHA_1 275 281 PF00498 0.474
LIG_FHA_1 383 389 PF00498 0.777
LIG_FHA_1 547 553 PF00498 0.646
LIG_FHA_1 614 620 PF00498 0.770
LIG_FHA_1 644 650 PF00498 0.721
LIG_FHA_2 101 107 PF00498 0.550
LIG_FHA_2 411 417 PF00498 0.739
LIG_FHA_2 423 429 PF00498 0.565
LIG_FHA_2 463 469 PF00498 0.766
LIG_FHA_2 486 492 PF00498 0.793
LIG_FHA_2 51 57 PF00498 0.771
LIG_FHA_2 658 664 PF00498 0.687
LIG_Integrin_isoDGR_2 88 90 PF01839 0.561
LIG_Integrin_RGD_1 568 570 PF01839 0.798
LIG_LIR_Apic_2 422 426 PF02991 0.706
LIG_LIR_Nem_3 591 597 PF02991 0.763
LIG_Pex14_1 170 174 PF04695 0.643
LIG_Pex14_2 590 594 PF04695 0.765
LIG_PTAP_UEV_1 5 10 PF05743 0.746
LIG_SH2_STAT5 597 600 PF00017 0.553
LIG_SH3_3 110 116 PF00018 0.677
LIG_SH3_3 16 22 PF00018 0.602
LIG_SH3_3 3 9 PF00018 0.751
LIG_SH3_3 311 317 PF00018 0.747
LIG_SH3_3 386 392 PF00018 0.614
LIG_SH3_3 447 453 PF00018 0.689
LIG_SH3_3 559 565 PF00018 0.734
LIG_SUMO_SIM_anti_2 29 35 PF11976 0.655
LIG_SUMO_SIM_par_1 264 271 PF11976 0.644
LIG_TRAF2_1 495 498 PF00917 0.759
LIG_WRC_WIRS_1 482 487 PF05994 0.736
LIG_WRC_WIRS_1 638 643 PF05994 0.604
LIG_WW_2 19 22 PF00397 0.608
MOD_CDK_SPK_2 407 412 PF00069 0.600
MOD_CDK_SPxxK_3 449 456 PF00069 0.621
MOD_CK1_1 100 106 PF00069 0.612
MOD_CK1_1 134 140 PF00069 0.634
MOD_CK1_1 165 171 PF00069 0.586
MOD_CK1_1 268 274 PF00069 0.603
MOD_CK1_1 316 322 PF00069 0.653
MOD_CK1_1 328 334 PF00069 0.706
MOD_CK1_1 336 342 PF00069 0.591
MOD_CK1_1 35 41 PF00069 0.781
MOD_CK1_1 410 416 PF00069 0.694
MOD_CK1_1 448 454 PF00069 0.733
MOD_CK1_1 484 490 PF00069 0.687
MOD_CK1_1 548 554 PF00069 0.640
MOD_CK1_1 557 563 PF00069 0.554
MOD_CK1_1 583 589 PF00069 0.737
MOD_CK1_1 657 663 PF00069 0.683
MOD_CK1_1 7 13 PF00069 0.750
MOD_CK2_1 115 121 PF00069 0.746
MOD_CK2_1 133 139 PF00069 0.666
MOD_CK2_1 205 211 PF00069 0.599
MOD_CK2_1 462 468 PF00069 0.788
MOD_CK2_1 472 478 PF00069 0.660
MOD_CK2_1 485 491 PF00069 0.571
MOD_CK2_1 575 581 PF00069 0.745
MOD_CK2_1 657 663 PF00069 0.683
MOD_GlcNHglycan 133 136 PF01048 0.691
MOD_GlcNHglycan 199 202 PF01048 0.688
MOD_GlcNHglycan 336 339 PF01048 0.623
MOD_GlcNHglycan 34 37 PF01048 0.702
MOD_GlcNHglycan 341 344 PF01048 0.590
MOD_GlcNHglycan 416 419 PF01048 0.705
MOD_GlcNHglycan 572 575 PF01048 0.747
MOD_GlcNHglycan 577 580 PF01048 0.815
MOD_GlcNHglycan 581 585 PF01048 0.638
MOD_GlcNHglycan 6 9 PF01048 0.744
MOD_GlcNHglycan 620 623 PF01048 0.650
MOD_GlcNHglycan 627 630 PF01048 0.577
MOD_GSK3_1 111 118 PF00069 0.653
MOD_GSK3_1 193 200 PF00069 0.710
MOD_GSK3_1 261 268 PF00069 0.594
MOD_GSK3_1 282 289 PF00069 0.643
MOD_GSK3_1 292 299 PF00069 0.720
MOD_GSK3_1 305 312 PF00069 0.648
MOD_GSK3_1 321 328 PF00069 0.651
MOD_GSK3_1 333 340 PF00069 0.599
MOD_GSK3_1 35 42 PF00069 0.677
MOD_GSK3_1 370 377 PF00069 0.595
MOD_GSK3_1 380 387 PF00069 0.647
MOD_GSK3_1 410 417 PF00069 0.682
MOD_GSK3_1 444 451 PF00069 0.733
MOD_GSK3_1 481 488 PF00069 0.692
MOD_GSK3_1 553 560 PF00069 0.700
MOD_GSK3_1 570 577 PF00069 0.626
MOD_GSK3_1 637 644 PF00069 0.713
MOD_GSK3_1 657 664 PF00069 0.432
MOD_GSK3_1 96 103 PF00069 0.761
MOD_N-GLC_1 642 647 PF02516 0.711
MOD_NEK2_1 1 6 PF00069 0.743
MOD_NEK2_1 104 109 PF00069 0.790
MOD_NEK2_1 187 192 PF00069 0.767
MOD_NEK2_1 243 248 PF00069 0.560
MOD_NEK2_1 263 268 PF00069 0.375
MOD_NEK2_1 292 297 PF00069 0.695
MOD_NEK2_1 376 381 PF00069 0.601
MOD_NEK2_1 382 387 PF00069 0.659
MOD_NEK2_1 472 477 PF00069 0.709
MOD_NEK2_1 641 646 PF00069 0.620
MOD_PIKK_1 105 111 PF00454 0.705
MOD_PIKK_1 14 20 PF00454 0.720
MOD_PIKK_1 243 249 PF00454 0.549
MOD_PIKK_1 374 380 PF00454 0.600
MOD_PIKK_1 501 507 PF00454 0.726
MOD_PIKK_1 643 649 PF00454 0.721
MOD_PIKK_1 80 86 PF00454 0.711
MOD_PKA_1 205 211 PF00069 0.599
MOD_Plk_1 100 106 PF00069 0.584
MOD_Plk_1 29 35 PF00069 0.677
MOD_Plk_1 630 636 PF00069 0.591
MOD_Plk_4 177 183 PF00069 0.718
MOD_Plk_4 29 35 PF00069 0.677
MOD_Plk_4 328 334 PF00069 0.717
MOD_Plk_4 45 51 PF00069 0.696
MOD_ProDKin_1 111 117 PF00069 0.804
MOD_ProDKin_1 193 199 PF00069 0.575
MOD_ProDKin_1 2 8 PF00069 0.754
MOD_ProDKin_1 268 274 PF00069 0.633
MOD_ProDKin_1 305 311 PF00069 0.817
MOD_ProDKin_1 313 319 PF00069 0.689
MOD_ProDKin_1 321 327 PF00069 0.717
MOD_ProDKin_1 331 337 PF00069 0.583
MOD_ProDKin_1 342 348 PF00069 0.697
MOD_ProDKin_1 35 41 PF00069 0.781
MOD_ProDKin_1 407 413 PF00069 0.635
MOD_ProDKin_1 422 428 PF00069 0.631
MOD_ProDKin_1 446 452 PF00069 0.721
MOD_ProDKin_1 485 491 PF00069 0.692
MOD_ProDKin_1 72 78 PF00069 0.702
MOD_ProDKin_1 88 94 PF00069 0.521
MOD_SUMO_for_1 27 30 PF00179 0.566
MOD_SUMO_rev_2 54 59 PF00179 0.671
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.697
TRG_ER_diArg_1 207 210 PF00400 0.732
TRG_ER_diArg_1 226 229 PF00400 0.444
TRG_ER_diArg_1 320 323 PF00400 0.572
TRG_ER_diArg_1 456 458 PF00400 0.734
TRG_ER_diArg_1 635 637 PF00400 0.662
TRG_NLS_Bipartite_1 209 231 PF00514 0.668
TRG_NLS_MonoExtC_3 204 209 PF00514 0.804
TRG_NLS_MonoExtC_3 226 232 PF00514 0.650
TRG_NLS_MonoExtC_3 363 369 PF00514 0.674
TRG_NLS_MonoExtN_4 205 210 PF00514 0.813
TRG_NLS_MonoExtN_4 226 231 PF00514 0.732
TRG_Pf-PMV_PEXEL_1 248 253 PF00026 0.565
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.698
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.599
TRG_Pf-PMV_PEXEL_1 386 390 PF00026 0.692
TRG_Pf-PMV_PEXEL_1 526 531 PF00026 0.590

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDR5 Leptomonas seymouri 41% 100%
A0A3Q8IGC1 Leishmania donovani 99% 100%
A4HMT4 Leishmania braziliensis 63% 100%
E9AF89 Leishmania major 86% 100%
E9B6E4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS