Present in the outer mitochondrial membrane proteome 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBD2_LEIIN

TriTrypDb:

LINF_350031700

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	7
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4IBD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.675
CLV_C14_Caspase3-7	26	30	PF00656	0.698
CLV_NRD_NRD_1	147	149	PF00675	0.550
CLV_NRD_NRD_1	158	160	PF00675	0.569
CLV_NRD_NRD_1	234	236	PF00675	0.398
CLV_NRD_NRD_1	260	262	PF00675	0.598
CLV_NRD_NRD_1	36	38	PF00675	0.495
CLV_PCSK_FUR_1	42	46	PF00082	0.324
CLV_PCSK_KEX2_1	158	160	PF00082	0.569
CLV_PCSK_KEX2_1	234	236	PF00082	0.398
CLV_PCSK_KEX2_1	36	38	PF00082	0.428
CLV_PCSK_KEX2_1	41	43	PF00082	0.407
CLV_PCSK_KEX2_1	44	46	PF00082	0.380
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.373
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.357
CLV_PCSK_PC7_1	37	43	PF00082	0.419
CLV_PCSK_SKI1_1	180	184	PF00082	0.664
DEG_APCC_DBOX_1	147	155	PF00400	0.321
DEG_APCC_DBOX_1	234	242	PF00400	0.647
DEG_APCC_DBOX_1	44	52	PF00400	0.479
DOC_CYCLIN_RxL_1	33	43	PF00134	0.682
DOC_USP7_MATH_1	165	169	PF00917	0.364
DOC_USP7_MATH_1	242	246	PF00917	0.662
LIG_14-3-3_CanoR_1	174	183	PF00244	0.408
LIG_14-3-3_CanoR_1	79	85	PF00244	0.404
LIG_14-3-3_CanoR_1	89	97	PF00244	0.382
LIG_APCC_ABBA_1	72	77	PF00400	0.374
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BRCT_BRCA1_1	178	182	PF00533	0.466
LIG_deltaCOP1_diTrp_1	111	121	PF00928	0.571
LIG_FHA_1	124	130	PF00498	0.606
LIG_FHA_1	135	141	PF00498	0.307
LIG_FHA_1	187	193	PF00498	0.391
LIG_FHA_1	89	95	PF00498	0.382
LIG_FHA_2	12	18	PF00498	0.689
LIG_LIR_Gen_1	91	101	PF02991	0.440
LIG_LIR_Nem_3	91	96	PF02991	0.440
LIG_SH2_CRK	53	57	PF00017	0.394
LIG_SH2_STAT5	107	110	PF00017	0.408
LIG_SH2_STAT5	216	219	PF00017	0.555
LIG_SH2_STAT5	82	85	PF00017	0.391
LIG_SH3_1	164	170	PF00018	0.384
LIG_SH3_3	164	170	PF00018	0.384
LIG_SH3_3	248	254	PF00018	0.805
LIG_SH3_4	253	260	PF00018	0.814
LIG_SUMO_SIM_anti_2	6	14	PF11976	0.632
LIG_TRAF2_1	255	258	PF00917	0.727
LIG_TYR_ITIM	51	56	PF00017	0.437
MOD_CK1_1	6	12	PF00069	0.577
MOD_CK2_1	175	181	PF00069	0.531
MOD_Cter_Amidation	156	159	PF01082	0.439
MOD_GlcNHglycan	154	157	PF01048	0.450
MOD_GlcNHglycan	192	195	PF01048	0.337
MOD_GlcNHglycan	196	199	PF01048	0.337
MOD_GlcNHglycan	210	213	PF01048	0.450
MOD_GlcNHglycan	246	249	PF01048	0.681
MOD_GSK3_1	113	120	PF00069	0.557
MOD_GSK3_1	181	188	PF00069	0.452
MOD_GSK3_1	190	197	PF00069	0.309
MOD_GSK3_1	20	27	PF00069	0.595
MOD_GSK3_1	204	211	PF00069	0.391
MOD_GSK3_1	6	13	PF00069	0.570
MOD_GSK3_1	63	70	PF00069	0.405
MOD_N-GLC_1	80	85	PF02516	0.488
MOD_NEK2_1	11	16	PF00069	0.505
MOD_NEK2_1	113	118	PF00069	0.542
MOD_NEK2_1	175	180	PF00069	0.554
MOD_NEK2_1	186	191	PF00069	0.379
MOD_NEK2_1	208	213	PF00069	0.575
MOD_NEK2_1	3	8	PF00069	0.530
MOD_NEK2_1	56	61	PF00069	0.331
MOD_NEK2_1	63	68	PF00069	0.318
MOD_NEK2_1	75	80	PF00069	0.338
MOD_NEK2_1	88	93	PF00069	0.416
MOD_NEK2_2	101	106	PF00069	0.437
MOD_PK_1	20	26	PF00069	0.621
MOD_PKA_2	176	182	PF00069	0.600
MOD_PKA_2	6	12	PF00069	0.608
MOD_PKA_2	88	94	PF00069	0.468
MOD_Plk_1	3	9	PF00069	0.642
MOD_Plk_1	80	86	PF00069	0.478
MOD_Plk_4	186	192	PF00069	0.534
MOD_Plk_4	27	33	PF00069	0.601
MOD_Plk_4	70	76	PF00069	0.567
MOD_SUMO_for_1	40	43	PF00179	0.545
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.482
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.581
TRG_ENDOCYTIC_2	216	219	PF00928	0.422
TRG_ENDOCYTIC_2	227	230	PF00928	0.442
TRG_ENDOCYTIC_2	53	56	PF00928	0.394
TRG_ER_diArg_1	158	160	PF00400	0.456
TRG_ER_diArg_1	233	235	PF00400	0.435
TRG_ER_diArg_1	36	38	PF00400	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R5	Leptomonas seymouri	77%	100%
A0A1X0P5Q2	Trypanosomatidae	58%	100%
A0A3Q8IJ41	Leishmania donovani	100%	100%
C9ZZ87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AF88	Leishmania major	94%	100%
E9B6E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C312	Trypanosoma cruzi	58%	100%