PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IBD0_LEIIN

TriTrypDb:

LINF_350031500

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4IBD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBD0

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.503
CLV_C14_Caspase3-7	738	742	PF00656	0.661
CLV_NRD_NRD_1	237	239	PF00675	0.800
CLV_NRD_NRD_1	324	326	PF00675	0.460
CLV_NRD_NRD_1	336	338	PF00675	0.412
CLV_NRD_NRD_1	446	448	PF00675	0.650
CLV_NRD_NRD_1	525	527	PF00675	0.528
CLV_NRD_NRD_1	531	533	PF00675	0.479
CLV_NRD_NRD_1	586	588	PF00675	0.562
CLV_NRD_NRD_1	88	90	PF00675	0.522
CLV_PCSK_KEX2_1	237	239	PF00082	0.794
CLV_PCSK_KEX2_1	324	326	PF00082	0.476
CLV_PCSK_KEX2_1	336	338	PF00082	0.478
CLV_PCSK_KEX2_1	446	448	PF00082	0.649
CLV_PCSK_KEX2_1	531	533	PF00082	0.502
CLV_PCSK_KEX2_1	579	581	PF00082	0.502
CLV_PCSK_KEX2_1	585	587	PF00082	0.550
CLV_PCSK_KEX2_1	703	705	PF00082	0.604
CLV_PCSK_KEX2_1	88	90	PF00082	0.522
CLV_PCSK_KEX2_1	98	100	PF00082	0.615
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.548
CLV_PCSK_PC1ET2_1	703	705	PF00082	0.604
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.751
CLV_PCSK_PC7_1	84	90	PF00082	0.527
CLV_PCSK_PC7_1	94	100	PF00082	0.683
CLV_PCSK_SKI1_1	11	15	PF00082	0.525
CLV_PCSK_SKI1_1	257	261	PF00082	0.562
CLV_PCSK_SKI1_1	325	329	PF00082	0.504
CLV_PCSK_SKI1_1	89	93	PF00082	0.570
CLV_Separin_Metazoa	363	367	PF03568	0.508
DEG_APCC_DBOX_1	198	206	PF00400	0.690
DEG_SCF_TRCP1_1	408	413	PF00400	0.596
DEG_SPOP_SBC_1	435	439	PF00917	0.707
DOC_ANK_TNKS_1	585	592	PF00023	0.619
DOC_CKS1_1	279	284	PF01111	0.468
DOC_CKS1_1	368	373	PF01111	0.542
DOC_MAPK_gen_1	22	30	PF00069	0.317
DOC_MAPK_gen_1	280	288	PF00069	0.478
DOC_MAPK_gen_1	3	12	PF00069	0.438
DOC_MAPK_gen_1	321	330	PF00069	0.475
DOC_MAPK_gen_1	336	343	PF00069	0.464
DOC_MAPK_gen_1	355	364	PF00069	0.264
DOC_MAPK_gen_1	479	486	PF00069	0.630
DOC_MAPK_MEF2A_6	280	288	PF00069	0.492
DOC_MAPK_MEF2A_6	3	12	PF00069	0.415
DOC_MAPK_NFAT4_5	5	13	PF00069	0.421
DOC_PP1_RVXF_1	46	52	PF00149	0.408
DOC_PP1_RVXF_1	7	13	PF00149	0.433
DOC_PP4_FxxP_1	118	121	PF00568	0.634
DOC_PP4_FxxP_1	279	282	PF00568	0.481
DOC_PP4_FxxP_1	30	33	PF00568	0.512
DOC_USP7_MATH_1	434	438	PF00917	0.640
DOC_USP7_MATH_1	459	463	PF00917	0.693
DOC_USP7_MATH_1	624	628	PF00917	0.568
DOC_USP7_MATH_1	705	709	PF00917	0.749
DOC_USP7_MATH_1	723	727	PF00917	0.629
DOC_WW_Pin1_4	111	116	PF00397	0.730
DOC_WW_Pin1_4	187	192	PF00397	0.748
DOC_WW_Pin1_4	223	228	PF00397	0.689
DOC_WW_Pin1_4	278	283	PF00397	0.451
DOC_WW_Pin1_4	367	372	PF00397	0.508
LIG_14-3-3_CanoR_1	446	451	PF00244	0.620
LIG_14-3-3_CanoR_1	487	497	PF00244	0.529
LIG_14-3-3_CanoR_1	596	604	PF00244	0.493
LIG_14-3-3_CanoR_1	660	668	PF00244	0.512
LIG_14-3-3_CanoR_1	693	700	PF00244	0.603
LIG_AP2alpha_2	683	685	PF02296	0.585
LIG_Clathr_ClatBox_1	353	357	PF01394	0.456
LIG_FHA_1	298	304	PF00498	0.513
LIG_FHA_1	536	542	PF00498	0.444
LIG_FHA_1	593	599	PF00498	0.529
LIG_FHA_1	606	612	PF00498	0.398
LIG_FHA_1	693	699	PF00498	0.624
LIG_FHA_2	285	291	PF00498	0.472
LIG_FHA_2	380	386	PF00498	0.640
LIG_FHA_2	503	509	PF00498	0.570
LIG_FHA_2	99	105	PF00498	0.720
LIG_Integrin_RGD_1	321	323	PF01839	0.512
LIG_LIR_Apic_2	116	121	PF02991	0.627
LIG_LIR_Apic_2	29	33	PF02991	0.514
LIG_LIR_Apic_2	683	689	PF02991	0.576
LIG_LIR_Gen_1	307	316	PF02991	0.515
LIG_LIR_Gen_1	35	45	PF02991	0.432
LIG_LIR_Gen_1	57	64	PF02991	0.435
LIG_LIR_Gen_1	662	672	PF02991	0.424
LIG_LIR_Gen_1	673	684	PF02991	0.494
LIG_LIR_Gen_1	76	87	PF02991	0.540
LIG_LIR_Nem_3	21	27	PF02991	0.527
LIG_LIR_Nem_3	307	311	PF02991	0.524
LIG_LIR_Nem_3	35	41	PF02991	0.335
LIG_LIR_Nem_3	429	435	PF02991	0.750
LIG_LIR_Nem_3	57	62	PF02991	0.433
LIG_LIR_Nem_3	662	668	PF02991	0.423
LIG_LIR_Nem_3	673	679	PF02991	0.484
LIG_LIR_Nem_3	76	82	PF02991	0.392
LIG_LYPXL_yS_3	432	435	PF13949	0.702
LIG_PTB_Apo_2	117	124	PF02174	0.633
LIG_PTB_Phospho_1	117	123	PF10480	0.631
LIG_Rb_LxCxE_1	154	168	PF01857	0.527
LIG_SH2_GRB2like	676	679	PF00017	0.498
LIG_SH2_STAT5	269	272	PF00017	0.461
LIG_SH2_STAT5	334	337	PF00017	0.435
LIG_SH2_STAT5	676	679	PF00017	0.498
LIG_SH2_STAT5	78	81	PF00017	0.476
LIG_SH3_1	94	100	PF00018	0.659
LIG_SH3_3	10	16	PF00018	0.481
LIG_SH3_3	130	136	PF00018	0.563
LIG_SH3_3	493	499	PF00018	0.607
LIG_SH3_3	610	616	PF00018	0.497
LIG_SH3_3	681	687	PF00018	0.530
LIG_SH3_3	94	100	PF00018	0.659
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.651
LIG_SUMO_SIM_par_1	379	385	PF11976	0.675
LIG_SUMO_SIM_par_1	695	701	PF11976	0.554
LIG_TRAF2_1	480	483	PF00917	0.577
LIG_UBA3_1	352	361	PF00899	0.513
LIG_WRC_WIRS_1	27	32	PF05994	0.565
MOD_CDC14_SPxK_1	226	229	PF00782	0.685
MOD_CDK_SPK_2	278	283	PF00069	0.451
MOD_CDK_SPxK_1	223	229	PF00069	0.681
MOD_CK1_1	138	144	PF00069	0.711
MOD_CK1_1	165	171	PF00069	0.652
MOD_CK1_1	182	188	PF00069	0.575
MOD_CK1_1	437	443	PF00069	0.679
MOD_CK1_1	491	497	PF00069	0.598
MOD_CK1_1	548	554	PF00069	0.504
MOD_CK1_1	57	63	PF00069	0.462
MOD_CK2_1	26	32	PF00069	0.564
MOD_CK2_1	284	290	PF00069	0.447
MOD_CK2_1	304	310	PF00069	0.498
MOD_CK2_1	357	363	PF00069	0.439
MOD_CK2_1	379	385	PF00069	0.637
MOD_CK2_1	477	483	PF00069	0.611
MOD_CK2_1	624	630	PF00069	0.575
MOD_CK2_1	713	719	PF00069	0.608
MOD_CK2_1	98	104	PF00069	0.653
MOD_GlcNHglycan	128	131	PF01048	0.774
MOD_GlcNHglycan	184	187	PF01048	0.641
MOD_GlcNHglycan	215	218	PF01048	0.696
MOD_GlcNHglycan	221	224	PF01048	0.655
MOD_GlcNHglycan	376	379	PF01048	0.667
MOD_GlcNHglycan	388	391	PF01048	0.730
MOD_GlcNHglycan	408	411	PF01048	0.795
MOD_GlcNHglycan	412	415	PF01048	0.752
MOD_GlcNHglycan	424	427	PF01048	0.575
MOD_GlcNHglycan	428	431	PF01048	0.450
MOD_GlcNHglycan	442	445	PF01048	0.658
MOD_GlcNHglycan	455	458	PF01048	0.542
MOD_GlcNHglycan	461	464	PF01048	0.614
MOD_GlcNHglycan	490	493	PF01048	0.636
MOD_GlcNHglycan	549	553	PF01048	0.563
MOD_GlcNHglycan	605	608	PF01048	0.551
MOD_GlcNHglycan	622	625	PF01048	0.559
MOD_GlcNHglycan	626	629	PF01048	0.583
MOD_GlcNHglycan	673	676	PF01048	0.528
MOD_GlcNHglycan	79	82	PF01048	0.526
MOD_GSK3_1	131	138	PF00069	0.733
MOD_GSK3_1	219	226	PF00069	0.682
MOD_GSK3_1	297	304	PF00069	0.460
MOD_GSK3_1	406	413	PF00069	0.733
MOD_GSK3_1	422	429	PF00069	0.554
MOD_GSK3_1	434	441	PF00069	0.560
MOD_GSK3_1	448	455	PF00069	0.641
MOD_GSK3_1	599	606	PF00069	0.505
MOD_GSK3_1	620	627	PF00069	0.537
MOD_GSK3_1	73	80	PF00069	0.560
MOD_N-GLC_1	138	143	PF02516	0.672
MOD_N-GLC_2	642	644	PF02516	0.519
MOD_NEK2_1	163	168	PF00069	0.667
MOD_NEK2_1	180	185	PF00069	0.588
MOD_NEK2_1	213	218	PF00069	0.715
MOD_NEK2_1	356	361	PF00069	0.521
MOD_NEK2_1	452	457	PF00069	0.720
MOD_NEK2_1	52	57	PF00069	0.478
MOD_NEK2_1	561	566	PF00069	0.563
MOD_NEK2_1	597	602	PF00069	0.526
MOD_NEK2_1	603	608	PF00069	0.475
MOD_NEK2_1	671	676	PF00069	0.356
MOD_NEK2_2	379	384	PF00069	0.719
MOD_NEK2_2	607	612	PF00069	0.547
MOD_PIKK_1	297	303	PF00454	0.525
MOD_PIKK_1	535	541	PF00454	0.490
MOD_PIKK_1	692	698	PF00454	0.544
MOD_PKA_1	446	452	PF00069	0.723
MOD_PKA_1	98	104	PF00069	0.717
MOD_PKA_2	357	363	PF00069	0.472
MOD_PKA_2	445	451	PF00069	0.646
MOD_PKA_2	562	568	PF00069	0.630
MOD_PKA_2	659	665	PF00069	0.521
MOD_PKA_2	692	698	PF00069	0.578
MOD_PKA_2	98	104	PF00069	0.717
MOD_PKB_1	255	263	PF00069	0.498
MOD_PKB_1	404	412	PF00069	0.692
MOD_Plk_1	34	40	PF00069	0.477
MOD_Plk_1	57	63	PF00069	0.428
MOD_Plk_1	713	719	PF00069	0.610
MOD_Plk_2-3	26	32	PF00069	0.462
MOD_Plk_2-3	34	40	PF00069	0.477
MOD_Plk_4	599	605	PF00069	0.542
MOD_ProDKin_1	111	117	PF00069	0.727
MOD_ProDKin_1	187	193	PF00069	0.750
MOD_ProDKin_1	223	229	PF00069	0.691
MOD_ProDKin_1	278	284	PF00069	0.460
MOD_ProDKin_1	367	373	PF00069	0.510
MOD_SUMO_rev_2	40	49	PF00179	0.457
MOD_SUMO_rev_2	584	594	PF00179	0.615
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.452
TRG_ENDOCYTIC_2	38	41	PF00928	0.427
TRG_ENDOCYTIC_2	432	435	PF00928	0.702
TRG_ENDOCYTIC_2	676	679	PF00928	0.543
TRG_ER_diArg_1	2	5	PF00400	0.469
TRG_ER_diArg_1	236	238	PF00400	0.587
TRG_ER_diArg_1	254	257	PF00400	0.500
TRG_ER_diArg_1	335	337	PF00400	0.490
TRG_ER_diArg_1	445	447	PF00400	0.738
TRG_ER_diArg_1	478	481	PF00400	0.520
TRG_ER_diArg_1	530	532	PF00400	0.485
TRG_ER_diArg_1	585	587	PF00400	0.563
TRG_ER_diArg_1	8	11	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF9	Leptomonas seymouri	70%	100%
A0A3S7X9C0	Leishmania donovani	100%	100%
A4HMT2	Leishmania braziliensis	81%	100%
C9ZZ89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AF86	Leishmania major	92%	100%
E9B6E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DUV4	Trypanosoma cruzi	49%	100%