PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IBD0_LEIIN

TriTrypDb:

LINF_350031500

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A4IBD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBD0

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.503
CLV_C14_Caspase3-7	738	742	PF00656	0.661
CLV_NRD_NRD_1	237	239	PF00675	0.800
CLV_NRD_NRD_1	324	326	PF00675	0.460
CLV_NRD_NRD_1	336	338	PF00675	0.412
CLV_NRD_NRD_1	446	448	PF00675	0.650
CLV_NRD_NRD_1	525	527	PF00675	0.528
CLV_NRD_NRD_1	531	533	PF00675	0.479
CLV_NRD_NRD_1	586	588	PF00675	0.562
CLV_NRD_NRD_1	88	90	PF00675	0.522

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF9	Leptomonas seymouri	70%	100%
A0A3S7X9C0	Leishmania donovani	100%	100%
A4HMT2	Leishmania braziliensis	81%	100%
C9ZZ89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AF86	Leishmania major	92%	100%
E9B6E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DUV4	Trypanosoma cruzi	49%	100%

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