Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBC8_LEIIN

TriTrypDb:

LINF_350031300

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.767
CLV_NRD_NRD_1	188	190	PF00675	0.819
CLV_NRD_NRD_1	206	208	PF00675	0.505
CLV_NRD_NRD_1	266	268	PF00675	0.610
CLV_NRD_NRD_1	36	38	PF00675	0.728
CLV_NRD_NRD_1	8	10	PF00675	0.764
CLV_PCSK_FUR_1	33	37	PF00082	0.710
CLV_PCSK_FUR_1	6	10	PF00082	0.765
CLV_PCSK_KEX2_1	103	105	PF00082	0.797
CLV_PCSK_KEX2_1	205	207	PF00082	0.709
CLV_PCSK_KEX2_1	265	267	PF00082	0.613
CLV_PCSK_KEX2_1	35	37	PF00082	0.779
CLV_PCSK_KEX2_1	41	43	PF00082	0.747
CLV_PCSK_KEX2_1	8	10	PF00082	0.764
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.843
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.613
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.779
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.747
CLV_PCSK_PC7_1	37	43	PF00082	0.677
CLV_PCSK_SKI1_1	131	135	PF00082	0.756
CLV_PCSK_SKI1_1	138	142	PF00082	0.653
CLV_PCSK_SKI1_1	190	194	PF00082	0.632
CLV_PCSK_SKI1_1	198	202	PF00082	0.596
CLV_PCSK_SKI1_1	266	270	PF00082	0.611
CLV_PCSK_SKI1_1	41	45	PF00082	0.821
CLV_PCSK_SKI1_1	93	97	PF00082	0.663
DEG_APCC_DBOX_1	265	273	PF00400	0.617
DEG_Nend_UBRbox_1	1	4	PF02207	0.814
DEG_SCF_FBW7_1	184	191	PF00400	0.698
DOC_CDC14_PxL_1	284	292	PF14671	0.562
DOC_CKS1_1	180	185	PF01111	0.701
DOC_CKS1_1	220	225	PF01111	0.772
DOC_CKS1_1	83	88	PF01111	0.768
DOC_MAPK_gen_1	265	271	PF00069	0.611
DOC_MAPK_MEF2A_6	236	243	PF00069	0.430
DOC_MAPK_MEF2A_6	265	273	PF00069	0.617
DOC_PP4_FxxP_1	318	321	PF00568	0.658
DOC_USP7_MATH_1	118	122	PF00917	0.720
DOC_USP7_MATH_1	171	175	PF00917	0.723
DOC_USP7_MATH_1	254	258	PF00917	0.546
DOC_USP7_MATH_1	68	72	PF00917	0.724
DOC_USP7_UBL2_3	134	138	PF12436	0.839
DOC_USP7_UBL2_3	35	39	PF12436	0.801
DOC_USP7_UBL2_3	57	61	PF12436	0.754
DOC_WW_Pin1_4	111	116	PF00397	0.684
DOC_WW_Pin1_4	179	184	PF00397	0.701
DOC_WW_Pin1_4	219	224	PF00397	0.768
DOC_WW_Pin1_4	277	282	PF00397	0.691
DOC_WW_Pin1_4	41	46	PF00397	0.820
DOC_WW_Pin1_4	69	74	PF00397	0.681
DOC_WW_Pin1_4	82	87	PF00397	0.724
LIG_14-3-3_CanoR_1	110	115	PF00244	0.808
LIG_14-3-3_CanoR_1	189	195	PF00244	0.825
LIG_14-3-3_CanoR_1	252	262	PF00244	0.535
LIG_14-3-3_CanoR_1	308	316	PF00244	0.541
LIG_14-3-3_CanoR_1	8	16	PF00244	0.669
LIG_FHA_1	189	195	PF00498	0.816
LIG_FHA_1	220	226	PF00498	0.778
LIG_FHA_1	238	244	PF00498	0.321
LIG_FHA_1	299	305	PF00498	0.631
LIG_FHA_1	85	91	PF00498	0.704
LIG_FHA_2	258	264	PF00498	0.561
LIG_Integrin_isoDGR_2	293	295	PF01839	0.675
LIG_Integrin_RGD_1	236	238	PF01839	0.491
LIG_LIR_Apic_2	313	319	PF02991	0.590
LIG_RPA_C_Fungi	200	212	PF08784	0.641
LIG_SH2_STAT5	14	17	PF00017	0.726
LIG_SH2_STAT5	28	31	PF00017	0.464
LIG_SH2_STAT5	316	319	PF00017	0.456
LIG_SH3_1	211	217	PF00018	0.714
LIG_SH3_1	80	86	PF00018	0.707
LIG_SH3_1	88	94	PF00018	0.674
LIG_SH3_2	185	190	PF14604	0.798
LIG_SH3_2	83	88	PF14604	0.834
LIG_SH3_3	177	183	PF00018	0.820
LIG_SH3_3	211	217	PF00018	0.792
LIG_SH3_3	268	274	PF00018	0.552
LIG_SH3_3	282	288	PF00018	0.690
LIG_SH3_3	45	51	PF00018	0.781
LIG_SH3_3	80	86	PF00018	0.804
LIG_SH3_3	88	94	PF00018	0.733
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.565
LIG_SUMO_SIM_par_1	238	245	PF11976	0.489
MOD_CDK_SPK_2	184	189	PF00069	0.700
MOD_CDK_SPxK_1	184	190	PF00069	0.698
MOD_CDK_SPxK_1	82	88	PF00069	0.766
MOD_CK1_1	157	163	PF00069	0.708
MOD_CK1_1	257	263	PF00069	0.491
MOD_CK1_1	280	286	PF00069	0.609
MOD_CK1_1	310	316	PF00069	0.521
MOD_CK1_1	72	78	PF00069	0.698
MOD_GlcNHglycan	173	176	PF01048	0.730
MOD_GlcNHglycan	277	280	PF01048	0.728
MOD_GlcNHglycan	309	312	PF01048	0.562
MOD_GSK3_1	184	191	PF00069	0.698
MOD_GSK3_1	242	249	PF00069	0.577
MOD_GSK3_1	253	260	PF00069	0.387
MOD_GSK3_1	273	280	PF00069	0.588
MOD_GSK3_1	307	314	PF00069	0.549
MOD_GSK3_1	31	38	PF00069	0.716
MOD_GSK3_1	56	63	PF00069	0.707
MOD_GSK3_1	68	75	PF00069	0.599
MOD_GSK3_1	78	85	PF00069	0.642
MOD_GSK3_1	89	96	PF00069	0.567
MOD_N-GLC_1	246	251	PF02516	0.541
MOD_NEK2_1	242	247	PF00069	0.616
MOD_NEK2_2	311	316	PF00069	0.533
MOD_PKA_1	110	116	PF00069	0.714
MOD_PKA_1	35	41	PF00069	0.728
MOD_PKA_1	61	67	PF00069	0.648
MOD_PKA_2	109	115	PF00069	0.827
MOD_PKA_2	141	147	PF00069	0.708
MOD_PKA_2	188	194	PF00069	0.824
MOD_PKA_2	307	313	PF00069	0.553
MOD_PKA_2	35	41	PF00069	0.728
MOD_PKB_1	108	116	PF00069	0.715
MOD_Plk_1	237	243	PF00069	0.615
MOD_Plk_1	257	263	PF00069	0.277
MOD_Plk_1	311	317	PF00069	0.528
MOD_Plk_4	196	202	PF00069	0.817
MOD_Plk_4	237	243	PF00069	0.495
MOD_Plk_4	257	263	PF00069	0.358
MOD_Plk_4	280	286	PF00069	0.648
MOD_Plk_4	311	317	PF00069	0.606
MOD_ProDKin_1	111	117	PF00069	0.686
MOD_ProDKin_1	179	185	PF00069	0.702
MOD_ProDKin_1	219	225	PF00069	0.771
MOD_ProDKin_1	277	283	PF00069	0.694
MOD_ProDKin_1	41	47	PF00069	0.821
MOD_ProDKin_1	69	75	PF00069	0.681
MOD_ProDKin_1	82	88	PF00069	0.726
MOD_SUMO_for_1	1	4	PF00179	0.697
TRG_ER_diArg_1	105	108	PF00400	0.745
TRG_ER_diArg_1	129	132	PF00400	0.740
TRG_ER_diArg_1	205	207	PF00400	0.674
TRG_ER_diArg_1	266	268	PF00400	0.610
TRG_ER_diArg_1	8	11	PF00400	0.690
TRG_NLS_MonoExtC_3	264	270	PF00514	0.599
TRG_NLS_MonoExtC_3	34	39	PF00514	0.720
TRG_NLS_MonoExtN_4	33	39	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF70	Leishmania donovani	97%	99%
A4HMT0	Leishmania braziliensis	60%	90%
E9AF84	Leishmania major	88%	100%
E9B6D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%