LeishMANIAdb
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Putative ribonuclease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ribonuclease
Gene product:
poly(A)-specific ribonuclease PARN - putative
Species:
Leishmania infantum
UniProt:
A4IBC6_LEIIN
TriTrypDb:
LINF_350028700
Length:
677

Annotations

Annotations by Jardim et al.

Nucleases, ribonuclease

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4IBC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBC6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 16
GO:0005488 binding 1 16
GO:0097159 organic cyclic compound binding 2 16
GO:1901363 heterocyclic compound binding 2 16
GO:0000175 3'-5'-RNA exonuclease activity 7 2
GO:0003723 RNA binding 4 2
GO:0003824 catalytic activity 1 2
GO:0004518 nuclease activity 4 2
GO:0004527 exonuclease activity 5 2
GO:0004532 RNA exonuclease activity 5 2
GO:0004540 RNA nuclease activity 4 2
GO:0008408 3'-5' exonuclease activity 6 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 2
GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6 2
GO:0140098 catalytic activity, acting on RNA 3 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 388 392 PF00656 0.431
CLV_NRD_NRD_1 111 113 PF00675 0.312
CLV_NRD_NRD_1 211 213 PF00675 0.376
CLV_NRD_NRD_1 315 317 PF00675 0.388
CLV_NRD_NRD_1 402 404 PF00675 0.264
CLV_NRD_NRD_1 442 444 PF00675 0.304
CLV_NRD_NRD_1 480 482 PF00675 0.234
CLV_NRD_NRD_1 54 56 PF00675 0.251
CLV_PCSK_KEX2_1 211 213 PF00082 0.321
CLV_PCSK_KEX2_1 480 482 PF00082 0.281
CLV_PCSK_SKI1_1 138 142 PF00082 0.196
CLV_PCSK_SKI1_1 155 159 PF00082 0.277
CLV_PCSK_SKI1_1 212 216 PF00082 0.317
CLV_PCSK_SKI1_1 268 272 PF00082 0.355
CLV_PCSK_SKI1_1 384 388 PF00082 0.264
CLV_PCSK_SKI1_1 537 541 PF00082 0.231
CLV_PCSK_SKI1_1 621 625 PF00082 0.402
CLV_PCSK_SKI1_1 659 663 PF00082 0.548
DEG_Nend_UBRbox_2 1 3 PF02207 0.401
DEG_SPOP_SBC_1 130 134 PF00917 0.421
DEG_SPOP_SBC_1 409 413 PF00917 0.431
DOC_CDC14_PxL_1 187 195 PF14671 0.406
DOC_CYCLIN_yClb3_PxF_3 469 475 PF00134 0.396
DOC_MAPK_gen_1 268 276 PF00069 0.523
DOC_MAPK_gen_1 316 324 PF00069 0.580
DOC_MAPK_gen_1 665 672 PF00069 0.365
DOC_MAPK_MEF2A_6 69 78 PF00069 0.505
DOC_PP1_RVXF_1 442 449 PF00149 0.593
DOC_PP2B_LxvP_1 101 104 PF13499 0.447
DOC_PP4_FxxP_1 222 225 PF00568 0.396
DOC_SPAK_OSR1_1 333 337 PF12202 0.431
DOC_USP7_MATH_1 172 176 PF00917 0.547
DOC_USP7_MATH_1 186 190 PF00917 0.420
DOC_USP7_MATH_1 206 210 PF00917 0.421
DOC_USP7_MATH_1 242 246 PF00917 0.406
DOC_USP7_MATH_1 409 413 PF00917 0.483
DOC_USP7_MATH_1 49 53 PF00917 0.451
DOC_USP7_MATH_1 523 527 PF00917 0.521
DOC_USP7_MATH_1 531 535 PF00917 0.417
DOC_USP7_MATH_1 569 573 PF00917 0.359
DOC_USP7_UBL2_3 400 404 PF12436 0.514
DOC_WW_Pin1_4 322 327 PF00397 0.431
DOC_WW_Pin1_4 42 47 PF00397 0.496
LIG_14-3-3_CanoR_1 126 130 PF00244 0.396
LIG_14-3-3_CanoR_1 178 186 PF00244 0.526
LIG_14-3-3_CanoR_1 205 211 PF00244 0.582
LIG_14-3-3_CanoR_1 360 366 PF00244 0.431
LIG_14-3-3_CanoR_1 417 423 PF00244 0.469
LIG_14-3-3_CanoR_1 490 498 PF00244 0.532
LIG_14-3-3_CanoR_1 665 673 PF00244 0.491
LIG_APCC_ABBA_1 78 83 PF00400 0.451
LIG_APCC_ABBAyCdc20_2 382 388 PF00400 0.431
LIG_BIR_III_4 88 92 PF00653 0.543
LIG_BRCT_BRCA1_1 401 405 PF00533 0.431
LIG_BRCT_BRCA1_1 525 529 PF00533 0.523
LIG_eIF4E_1 380 386 PF01652 0.431
LIG_FHA_1 130 136 PF00498 0.451
LIG_FHA_1 248 254 PF00498 0.529
LIG_FHA_1 265 271 PF00498 0.575
LIG_FHA_1 487 493 PF00498 0.465
LIG_FHA_1 503 509 PF00498 0.425
LIG_FHA_1 538 544 PF00498 0.512
LIG_FHA_1 553 559 PF00498 0.460
LIG_FHA_1 601 607 PF00498 0.383
LIG_FHA_1 628 634 PF00498 0.377
LIG_FHA_1 80 86 PF00498 0.414
LIG_FHA_2 126 132 PF00498 0.557
LIG_FHA_2 617 623 PF00498 0.315
LIG_LIR_Gen_1 233 242 PF02991 0.451
LIG_LIR_Gen_1 454 465 PF02991 0.591
LIG_LIR_Gen_1 582 591 PF02991 0.415
LIG_LIR_Gen_1 79 89 PF02991 0.577
LIG_LIR_Nem_3 151 157 PF02991 0.450
LIG_LIR_Nem_3 21 27 PF02991 0.474
LIG_LIR_Nem_3 233 237 PF02991 0.476
LIG_LIR_Nem_3 28 34 PF02991 0.462
LIG_LIR_Nem_3 454 460 PF02991 0.557
LIG_LIR_Nem_3 474 478 PF02991 0.425
LIG_LIR_Nem_3 526 532 PF02991 0.531
LIG_LIR_Nem_3 582 586 PF02991 0.408
LIG_LIR_Nem_3 79 84 PF02991 0.578
LIG_NRBOX 431 437 PF00104 0.451
LIG_PCNA_PIPBox_1 456 465 PF02747 0.431
LIG_PDZ_Class_2 672 677 PF00595 0.441
LIG_Pex14_2 150 154 PF04695 0.451
LIG_Pex14_2 483 487 PF04695 0.568
LIG_SH2_CRK 583 587 PF00017 0.384
LIG_SH2_CRK 71 75 PF00017 0.553
LIG_SH2_GRB2like 576 579 PF00017 0.413
LIG_SH2_NCK_1 71 75 PF00017 0.553
LIG_SH2_STAP1 437 441 PF00017 0.555
LIG_SH2_STAP1 452 456 PF00017 0.411
LIG_SH2_STAP1 576 580 PF00017 0.363
LIG_SH2_STAP1 583 587 PF00017 0.402
LIG_SH2_STAT3 463 466 PF00017 0.507
LIG_SH2_STAT3 640 643 PF00017 0.416
LIG_SH2_STAT5 14 17 PF00017 0.531
LIG_SH2_STAT5 156 159 PF00017 0.481
LIG_SH2_STAT5 355 358 PF00017 0.523
LIG_SH2_STAT5 380 383 PF00017 0.471
LIG_SH2_STAT5 452 455 PF00017 0.451
LIG_SH2_STAT5 583 586 PF00017 0.485
LIG_SH2_STAT5 608 611 PF00017 0.384
LIG_SH2_STAT5 640 643 PF00017 0.363
LIG_SH3_3 180 186 PF00018 0.423
LIG_SH3_3 320 326 PF00018 0.451
LIG_SH3_3 467 473 PF00018 0.396
LIG_SUMO_SIM_anti_2 167 172 PF11976 0.566
LIG_SUMO_SIM_par_1 334 340 PF11976 0.584
LIG_WRC_WIRS_1 231 236 PF05994 0.523
LIG_WRC_WIRS_1 362 367 PF05994 0.523
LIG_WRC_WIRS_1 472 477 PF05994 0.451
MOD_CK1_1 235 241 PF00069 0.586
MOD_CK1_1 378 384 PF00069 0.582
MOD_CK1_1 413 419 PF00069 0.513
MOD_CK1_1 421 427 PF00069 0.451
MOD_CK1_1 474 480 PF00069 0.451
MOD_CK1_1 516 522 PF00069 0.525
MOD_CK1_1 594 600 PF00069 0.405
MOD_CK1_1 638 644 PF00069 0.501
MOD_CK1_1 79 85 PF00069 0.487
MOD_CK2_1 125 131 PF00069 0.514
MOD_CK2_1 322 328 PF00069 0.471
MOD_CK2_1 616 622 PF00069 0.330
MOD_CK2_1 665 671 PF00069 0.339
MOD_Cter_Amidation 314 317 PF01082 0.226
MOD_GlcNHglycan 105 108 PF01048 0.251
MOD_GlcNHglycan 141 144 PF01048 0.284
MOD_GlcNHglycan 151 154 PF01048 0.228
MOD_GlcNHglycan 234 237 PF01048 0.325
MOD_GlcNHglycan 244 247 PF01048 0.313
MOD_GlcNHglycan 30 34 PF01048 0.355
MOD_GlcNHglycan 342 345 PF01048 0.340
MOD_GlcNHglycan 372 375 PF01048 0.404
MOD_GlcNHglycan 428 431 PF01048 0.323
MOD_GlcNHglycan 533 536 PF01048 0.348
MOD_GlcNHglycan 612 615 PF01048 0.476
MOD_GlcNHglycan 637 640 PF01048 0.305
MOD_GlcNHglycan 93 96 PF01048 0.310
MOD_GSK3_1 125 132 PF00069 0.542
MOD_GSK3_1 409 416 PF00069 0.482
MOD_GSK3_1 417 424 PF00069 0.472
MOD_GSK3_1 482 489 PF00069 0.477
MOD_GSK3_1 502 509 PF00069 0.585
MOD_GSK3_1 51 58 PF00069 0.409
MOD_GSK3_1 513 520 PF00069 0.521
MOD_GSK3_1 581 588 PF00069 0.396
MOD_GSK3_1 93 100 PF00069 0.510
MOD_N-GLC_1 124 129 PF02516 0.241
MOD_N-GLC_1 502 507 PF02516 0.283
MOD_N-GLC_1 569 574 PF02516 0.361
MOD_N-GLC_1 610 615 PF02516 0.581
MOD_NEK2_1 1 6 PF00069 0.386
MOD_NEK2_1 139 144 PF00069 0.431
MOD_NEK2_1 264 269 PF00069 0.596
MOD_NEK2_1 29 34 PF00069 0.446
MOD_NEK2_1 431 436 PF00069 0.539
MOD_NEK2_1 486 491 PF00069 0.482
MOD_NEK2_1 579 584 PF00069 0.413
MOD_NEK2_2 569 574 PF00069 0.551
MOD_PIKK_1 537 543 PF00454 0.451
MOD_PIKK_1 665 671 PF00454 0.444
MOD_PK_1 507 513 PF00069 0.576
MOD_PK_1 517 523 PF00069 0.507
MOD_PKA_1 55 61 PF00069 0.451
MOD_PKA_2 125 131 PF00069 0.580
MOD_PKA_2 172 178 PF00069 0.512
MOD_PKA_2 635 641 PF00069 0.476
MOD_Plk_1 124 130 PF00069 0.457
MOD_Plk_1 20 26 PF00069 0.481
MOD_Plk_1 247 253 PF00069 0.501
MOD_Plk_1 264 270 PF00069 0.506
MOD_Plk_1 569 575 PF00069 0.364
MOD_Plk_2-3 131 137 PF00069 0.421
MOD_Plk_4 131 137 PF00069 0.546
MOD_Plk_4 14 20 PF00069 0.480
MOD_Plk_4 302 308 PF00069 0.548
MOD_Plk_4 375 381 PF00069 0.448
MOD_Plk_4 418 424 PF00069 0.467
MOD_Plk_4 431 437 PF00069 0.508
MOD_Plk_4 474 480 PF00069 0.587
MOD_Plk_4 482 488 PF00069 0.606
MOD_Plk_4 507 513 PF00069 0.532
MOD_Plk_4 523 529 PF00069 0.474
MOD_Plk_4 582 588 PF00069 0.380
MOD_Plk_4 594 600 PF00069 0.444
MOD_Plk_4 69 75 PF00069 0.567
MOD_ProDKin_1 322 328 PF00069 0.431
MOD_ProDKin_1 42 48 PF00069 0.496
MOD_SUMO_for_1 386 389 PF00179 0.431
MOD_SUMO_rev_2 289 294 PF00179 0.521
TRG_DiLeu_BaEn_2 113 119 PF01217 0.451
TRG_DiLeu_BaLyEn_6 358 363 PF01217 0.431
TRG_ENDOCYTIC_2 197 200 PF00928 0.464
TRG_ENDOCYTIC_2 452 455 PF00928 0.523
TRG_ENDOCYTIC_2 576 579 PF00928 0.347
TRG_ENDOCYTIC_2 583 586 PF00928 0.358
TRG_ENDOCYTIC_2 71 74 PF00928 0.513
TRG_ER_diArg_1 210 212 PF00400 0.496
TRG_ER_diArg_1 479 481 PF00400 0.431
TRG_NES_CRM1_1 312 328 PF08389 0.590
TRG_Pf-PMV_PEXEL_1 316 320 PF00026 0.206

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGE9 Leptomonas seymouri 42% 96%
A0A0S4J225 Bodo saltans 22% 93%
A0A1X0P5M9 Trypanosomatidae 26% 100%
A0A3Q8ICI3 Leishmania donovani 27% 100%
A0A3R7LZW8 Trypanosoma rangeli 25% 100%
A0A3S7X9D8 Leishmania donovani 100% 100%
A4HCS6 Leishmania braziliensis 26% 100%
A4HMQ8 Leishmania braziliensis 67% 100%
A4I0A0 Leishmania infantum 27% 100%
C9ZZC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AF58 Leishmania major 92% 100%
E9AW65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6B4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QBB3 Leishmania major 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS