LeishMANIAdb
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Importin N-terminal domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Importin N-terminal domain-containing protein
Gene product:
Importin 1
Species:
Leishmania infantum
UniProt:
A4IBC5_LEIIN
TriTrypDb:
LINF_350028600
Length:
919

Annotations

Annotations by Jardim et al.

Nuclear proteins, Importin 1 (IMP1) Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

A4IBC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBC5

Function

Biological processes
Term Name Level Count
GO:0006606 protein import into nucleus 5 12
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0006913 nucleocytoplasmic transport 5 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0033365 protein localization to organelle 5 12
GO:0034504 protein localization to nucleus 6 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051169 nuclear transport 4 12
GO:0051170 import into nucleus 6 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0072594 establishment of protein localization to organelle 4 12
GO:0006405 RNA export from nucleus 5 1
GO:0006406 mRNA export from nucleus 6 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0050657 nucleic acid transport 6 1
GO:0050658 RNA transport 4 1
GO:0051028 mRNA transport 5 1
GO:0051168 nuclear export 6 1
GO:0051236 establishment of RNA localization 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0005048 signal sequence binding 4 1
GO:0005488 binding 1 2
GO:0008139 nuclear localization sequence binding 5 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1
GO:0061608 nuclear import signal receptor activity 3 1
GO:0140104 molecular carrier activity 1 1
GO:0140142 nucleocytoplasmic carrier activity 2 1
GO:0003824 catalytic activity 1 1
GO:0005515 protein binding 2 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1
GO:0019899 enzyme binding 3 1
GO:0031267 small GTPase binding 5 1
GO:0051020 GTPase binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.484
CLV_C14_Caspase3-7 343 347 PF00656 0.566
CLV_NRD_NRD_1 384 386 PF00675 0.337
CLV_NRD_NRD_1 496 498 PF00675 0.520
CLV_NRD_NRD_1 851 853 PF00675 0.567
CLV_NRD_NRD_1 908 910 PF00675 0.514
CLV_PCSK_KEX2_1 384 386 PF00082 0.337
CLV_PCSK_SKI1_1 161 165 PF00082 0.358
CLV_PCSK_SKI1_1 242 246 PF00082 0.265
CLV_PCSK_SKI1_1 295 299 PF00082 0.345
CLV_PCSK_SKI1_1 515 519 PF00082 0.488
CLV_PCSK_SKI1_1 549 553 PF00082 0.305
CLV_PCSK_SKI1_1 883 887 PF00082 0.448
CLV_PCSK_SKI1_1 898 902 PF00082 0.502
DOC_CDC14_PxL_1 165 173 PF14671 0.468
DOC_CDC14_PxL_1 401 409 PF14671 0.505
DOC_CYCLIN_RxL_1 546 554 PF00134 0.310
DOC_CYCLIN_yCln2_LP_2 159 165 PF00134 0.447
DOC_CYCLIN_yCln2_LP_2 69 75 PF00134 0.444
DOC_MAPK_gen_1 187 196 PF00069 0.369
DOC_MAPK_gen_1 384 391 PF00069 0.332
DOC_MAPK_gen_1 56 63 PF00069 0.424
DOC_MAPK_MEF2A_6 189 198 PF00069 0.324
DOC_MAPK_MEF2A_6 242 250 PF00069 0.302
DOC_PP2B_LxvP_1 228 231 PF13499 0.501
DOC_PP2B_LxvP_1 402 405 PF13499 0.343
DOC_PP2B_LxvP_1 577 580 PF13499 0.426
DOC_USP7_MATH_1 13 17 PF00917 0.456
DOC_USP7_MATH_1 513 517 PF00917 0.421
DOC_USP7_MATH_1 555 559 PF00917 0.441
DOC_USP7_MATH_1 638 642 PF00917 0.489
DOC_USP7_MATH_1 664 668 PF00917 0.416
DOC_USP7_MATH_1 732 736 PF00917 0.529
DOC_USP7_MATH_1 738 742 PF00917 0.480
DOC_USP7_MATH_1 767 771 PF00917 0.360
DOC_USP7_MATH_1 814 818 PF00917 0.470
DOC_USP7_MATH_1 856 860 PF00917 0.474
DOC_WW_Pin1_4 14 19 PF00397 0.524
DOC_WW_Pin1_4 585 590 PF00397 0.389
DOC_WW_Pin1_4 689 694 PF00397 0.558
DOC_WW_Pin1_4 763 768 PF00397 0.474
LIG_14-3-3_CanoR_1 141 146 PF00244 0.451
LIG_14-3-3_CanoR_1 242 247 PF00244 0.352
LIG_14-3-3_CanoR_1 384 391 PF00244 0.317
LIG_14-3-3_CanoR_1 535 544 PF00244 0.395
LIG_14-3-3_CanoR_1 623 628 PF00244 0.466
LIG_Actin_WH2_2 341 359 PF00022 0.414
LIG_APCC_ABBA_1 802 807 PF00400 0.366
LIG_APCC_ABBA_1 861 866 PF00400 0.305
LIG_APCC_ABBAyCdc20_2 320 326 PF00400 0.383
LIG_BIR_III_2 149 153 PF00653 0.302
LIG_BIR_III_2 690 694 PF00653 0.483
LIG_BIR_III_4 155 159 PF00653 0.466
LIG_BIR_III_4 663 667 PF00653 0.354
LIG_BRCT_BRCA1_1 172 176 PF00533 0.434
LIG_BRCT_BRCA1_1 246 250 PF00533 0.388
LIG_BRCT_BRCA1_1 658 662 PF00533 0.295
LIG_BRCT_BRCA1_1 769 773 PF00533 0.394
LIG_deltaCOP1_diTrp_1 292 300 PF00928 0.331
LIG_eIF4E_1 397 403 PF01652 0.393
LIG_FHA_1 158 164 PF00498 0.374
LIG_FHA_1 170 176 PF00498 0.355
LIG_FHA_1 216 222 PF00498 0.330
LIG_FHA_1 236 242 PF00498 0.232
LIG_FHA_1 243 249 PF00498 0.295
LIG_FHA_1 460 466 PF00498 0.387
LIG_FHA_1 615 621 PF00498 0.412
LIG_FHA_1 651 657 PF00498 0.450
LIG_FHA_2 177 183 PF00498 0.510
LIG_FHA_2 388 394 PF00498 0.367
LIG_FHA_2 586 592 PF00498 0.375
LIG_FHA_2 728 734 PF00498 0.427
LIG_GBD_Chelix_1 118 126 PF00786 0.454
LIG_GBD_Chelix_1 4 12 PF00786 0.364
LIG_LIR_Apic_2 337 342 PF02991 0.415
LIG_LIR_Gen_1 249 259 PF02991 0.381
LIG_LIR_Gen_1 321 332 PF02991 0.380
LIG_LIR_Gen_1 436 447 PF02991 0.401
LIG_LIR_Gen_1 461 471 PF02991 0.364
LIG_LIR_Gen_1 597 607 PF02991 0.359
LIG_LIR_Gen_1 624 632 PF02991 0.423
LIG_LIR_Gen_1 659 669 PF02991 0.391
LIG_LIR_Gen_1 677 688 PF02991 0.476
LIG_LIR_Gen_1 734 744 PF02991 0.368
LIG_LIR_Gen_1 770 780 PF02991 0.448
LIG_LIR_LC3C_4 462 467 PF02991 0.362
LIG_LIR_Nem_3 207 213 PF02991 0.362
LIG_LIR_Nem_3 249 254 PF02991 0.379
LIG_LIR_Nem_3 256 262 PF02991 0.367
LIG_LIR_Nem_3 291 297 PF02991 0.333
LIG_LIR_Nem_3 395 401 PF02991 0.405
LIG_LIR_Nem_3 436 442 PF02991 0.478
LIG_LIR_Nem_3 461 467 PF02991 0.402
LIG_LIR_Nem_3 539 544 PF02991 0.469
LIG_LIR_Nem_3 624 628 PF02991 0.335
LIG_LIR_Nem_3 677 683 PF02991 0.482
LIG_LIR_Nem_3 734 740 PF02991 0.366
LIG_LIR_Nem_3 770 776 PF02991 0.449
LIG_NRBOX 452 458 PF00104 0.308
LIG_PCNA_PIPBox_1 769 778 PF02747 0.434
LIG_PCNA_yPIPBox_3 211 221 PF02747 0.352
LIG_Pex14_2 621 625 PF04695 0.466
LIG_Pex14_2 821 825 PF04695 0.290
LIG_PTB_Apo_2 619 626 PF02174 0.474
LIG_Rb_pABgroove_1 593 601 PF01858 0.446
LIG_Rb_pABgroove_1 656 664 PF01858 0.307
LIG_SH2_CRK 210 214 PF00017 0.400
LIG_SH2_CRK 439 443 PF00017 0.462
LIG_SH2_CRK 737 741 PF00017 0.337
LIG_SH2_NCK_1 737 741 PF00017 0.354
LIG_SH2_SRC 251 254 PF00017 0.365
LIG_SH2_SRC 805 808 PF00017 0.388
LIG_SH2_STAP1 439 443 PF00017 0.359
LIG_SH2_STAT3 916 919 PF00017 0.378
LIG_SH2_STAT5 145 148 PF00017 0.448
LIG_SH2_STAT5 170 173 PF00017 0.378
LIG_SH2_STAT5 353 356 PF00017 0.513
LIG_SH2_STAT5 40 43 PF00017 0.444
LIG_SH2_STAT5 480 483 PF00017 0.374
LIG_SH2_STAT5 805 808 PF00017 0.396
LIG_SH3_3 86 92 PF00018 0.417
LIG_SUMO_SIM_anti_2 192 199 PF11976 0.331
LIG_SUMO_SIM_anti_2 400 405 PF11976 0.411
LIG_SUMO_SIM_par_1 244 249 PF11976 0.298
LIG_SUMO_SIM_par_1 315 321 PF11976 0.317
LIG_SUMO_SIM_par_1 465 470 PF11976 0.329
LIG_SUMO_SIM_par_1 549 554 PF11976 0.402
LIG_TRAF2_1 281 284 PF00917 0.464
LIG_TRAF2_1 646 649 PF00917 0.505
LIG_TYR_ITSM 247 254 PF00017 0.456
LIG_UBA3_1 491 498 PF00899 0.431
LIG_UBA3_1 772 778 PF00899 0.379
MOD_CDK_SPxxK_3 689 696 PF00069 0.412
MOD_CK1_1 102 108 PF00069 0.385
MOD_CK1_1 209 215 PF00069 0.387
MOD_CK1_1 3 9 PF00069 0.496
MOD_CK1_1 387 393 PF00069 0.309
MOD_CK1_1 470 476 PF00069 0.325
MOD_CK1_1 536 542 PF00069 0.447
MOD_CK1_1 686 692 PF00069 0.449
MOD_CK1_1 887 893 PF00069 0.477
MOD_CK2_1 322 328 PF00069 0.333
MOD_CK2_1 387 393 PF00069 0.369
MOD_CK2_1 40 46 PF00069 0.342
MOD_CK2_1 405 411 PF00069 0.430
MOD_CK2_1 513 519 PF00069 0.436
MOD_CK2_1 664 670 PF00069 0.382
MOD_CK2_1 834 840 PF00069 0.513
MOD_GlcNHglycan 334 337 PF01048 0.464
MOD_GlcNHglycan 386 389 PF01048 0.316
MOD_GlcNHglycan 415 418 PF01048 0.455
MOD_GlcNHglycan 507 510 PF01048 0.395
MOD_GlcNHglycan 640 643 PF01048 0.586
MOD_GlcNHglycan 658 661 PF01048 0.200
MOD_GlcNHglycan 666 669 PF01048 0.439
MOD_GlcNHglycan 81 84 PF01048 0.505
MOD_GlcNHglycan 854 857 PF01048 0.460
MOD_GSK3_1 171 178 PF00069 0.496
MOD_GSK3_1 242 249 PF00069 0.313
MOD_GSK3_1 318 325 PF00069 0.359
MOD_GSK3_1 35 42 PF00069 0.464
MOD_GSK3_1 472 479 PF00069 0.463
MOD_GSK3_1 555 562 PF00069 0.371
MOD_GSK3_1 585 592 PF00069 0.396
MOD_GSK3_1 601 608 PF00069 0.314
MOD_GSK3_1 648 655 PF00069 0.490
MOD_GSK3_1 755 762 PF00069 0.559
MOD_GSK3_1 763 770 PF00069 0.492
MOD_GSK3_1 780 787 PF00069 0.490
MOD_GSK3_1 852 859 PF00069 0.541
MOD_N-GLC_1 35 40 PF02516 0.446
MOD_N-GLC_1 500 505 PF02516 0.294
MOD_N-GLC_1 589 594 PF02516 0.381
MOD_N-GLC_1 621 626 PF02516 0.403
MOD_N-GLC_1 727 732 PF02516 0.468
MOD_N-GLC_1 794 799 PF02516 0.414
MOD_N-GLC_1 887 892 PF02516 0.553
MOD_NEK2_1 171 176 PF00069 0.490
MOD_NEK2_1 246 251 PF00069 0.353
MOD_NEK2_1 35 40 PF00069 0.435
MOD_NEK2_1 413 418 PF00069 0.486
MOD_NEK2_1 465 470 PF00069 0.350
MOD_NEK2_1 505 510 PF00069 0.406
MOD_NEK2_1 573 578 PF00069 0.421
MOD_NEK2_1 594 599 PF00069 0.323
MOD_NEK2_1 621 626 PF00069 0.362
MOD_NEK2_1 65 70 PF00069 0.491
MOD_NEK2_1 650 655 PF00069 0.354
MOD_NEK2_1 681 686 PF00069 0.352
MOD_NEK2_1 867 872 PF00069 0.351
MOD_NEK2_2 732 737 PF00069 0.430
MOD_PIKK_1 124 130 PF00454 0.493
MOD_PIKK_1 230 236 PF00454 0.436
MOD_PIKK_1 3 9 PF00454 0.377
MOD_PIKK_1 392 398 PF00454 0.390
MOD_PIKK_1 47 53 PF00454 0.479
MOD_PIKK_1 583 589 PF00454 0.508
MOD_PIKK_1 767 773 PF00454 0.347
MOD_PK_1 344 350 PF00069 0.493
MOD_PKA_1 384 390 PF00069 0.322
MOD_PKA_1 852 858 PF00069 0.280
MOD_PKA_2 384 390 PF00069 0.322
MOD_PKA_2 567 573 PF00069 0.427
MOD_PKA_2 832 838 PF00069 0.539
MOD_PKB_1 349 357 PF00069 0.578
MOD_Plk_1 282 288 PF00069 0.509
MOD_Plk_1 35 41 PF00069 0.455
MOD_Plk_1 392 398 PF00069 0.401
MOD_Plk_1 621 627 PF00069 0.383
MOD_Plk_1 648 654 PF00069 0.345
MOD_Plk_1 727 733 PF00069 0.389
MOD_Plk_1 794 800 PF00069 0.445
MOD_Plk_1 833 839 PF00069 0.524
MOD_Plk_1 876 882 PF00069 0.561
MOD_Plk_2-3 834 840 PF00069 0.513
MOD_Plk_4 121 127 PF00069 0.498
MOD_Plk_4 141 147 PF00069 0.433
MOD_Plk_4 171 177 PF00069 0.293
MOD_Plk_4 216 222 PF00069 0.441
MOD_Plk_4 246 252 PF00069 0.463
MOD_Plk_4 307 313 PF00069 0.363
MOD_Plk_4 438 444 PF00069 0.413
MOD_Plk_4 476 482 PF00069 0.504
MOD_Plk_4 573 579 PF00069 0.422
MOD_Plk_4 652 658 PF00069 0.488
MOD_Plk_4 683 689 PF00069 0.356
MOD_Plk_4 834 840 PF00069 0.517
MOD_Plk_4 99 105 PF00069 0.387
MOD_ProDKin_1 14 20 PF00069 0.528
MOD_ProDKin_1 585 591 PF00069 0.395
MOD_ProDKin_1 689 695 PF00069 0.552
MOD_ProDKin_1 763 769 PF00069 0.464
MOD_SUMO_rev_2 807 814 PF00179 0.473
TRG_DiLeu_BaEn_1 192 197 PF01217 0.434
TRG_DiLeu_BaEn_1 834 839 PF01217 0.513
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.295
TRG_DiLeu_BaLyEn_6 590 595 PF01217 0.335
TRG_ENDOCYTIC_2 210 213 PF00928 0.337
TRG_ENDOCYTIC_2 251 254 PF00928 0.415
TRG_ENDOCYTIC_2 324 327 PF00928 0.351
TRG_ENDOCYTIC_2 353 356 PF00928 0.513
TRG_ENDOCYTIC_2 398 401 PF00928 0.405
TRG_ENDOCYTIC_2 439 442 PF00928 0.494
TRG_ENDOCYTIC_2 737 740 PF00928 0.342
TRG_ER_diArg_1 348 351 PF00400 0.416
TRG_ER_diArg_1 383 385 PF00400 0.343
TRG_ER_diArg_1 55 58 PF00400 0.429
TRG_NLS_MonoExtC_3 908 914 PF00514 0.438
TRG_NLS_MonoExtN_4 907 913 PF00514 0.436
TRG_Pf-PMV_PEXEL_1 549 554 PF00026 0.308
TRG_Pf-PMV_PEXEL_1 880 884 PF00026 0.470
TRG_Pf-PMV_PEXEL_1 910 914 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1U2 Leptomonas seymouri 74% 100%
A0A0S4J991 Bodo saltans 37% 100%
A0A1X0P5L5 Trypanosomatidae 47% 100%
A0A3S7X9A3 Leishmania donovani 99% 100%
A0A422NM11 Trypanosoma rangeli 48% 100%
A4HMQ7 Leishmania braziliensis 91% 100%
B8ARW2 Oryza sativa subsp. indica 25% 100%
B9FDR3 Oryza sativa subsp. japonica 26% 100%
C9ZZC4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 98%
E9AF57 Leishmania major 97% 100%
E9B6B3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O14089 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
O14787 Homo sapiens 25% 100%
P38217 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q3SYU7 Bos taurus 24% 100%
Q8BFY9 Mus musculus 24% 100%
Q8H0U4 Arabidopsis thaliana 27% 100%
Q92973 Homo sapiens 24% 100%
Q99LG2 Mus musculus 25% 100%
V5BTG7 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS