Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBC3_LEIIN

TriTrypDb:

LINF_350028400

Length:

248

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4IBC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBC3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.512
CLV_C14_Caspase3-7	227	231	PF00656	0.536
CLV_NRD_NRD_1	149	151	PF00675	0.540
CLV_NRD_NRD_1	180	182	PF00675	0.641
CLV_NRD_NRD_1	3	5	PF00675	0.534
CLV_NRD_NRD_1	48	50	PF00675	0.480
CLV_PCSK_KEX2_1	149	151	PF00082	0.624
CLV_PCSK_KEX2_1	180	182	PF00082	0.594
CLV_PCSK_KEX2_1	3	5	PF00082	0.534
CLV_PCSK_KEX2_1	48	50	PF00082	0.494
CLV_PCSK_SKI1_1	49	53	PF00082	0.548
DEG_ODPH_VHL_1	174	187	PF01847	0.329
DEG_SPOP_SBC_1	163	167	PF00917	0.495
DOC_CKS1_1	6	11	PF01111	0.730
DOC_MAPK_gen_1	180	187	PF00069	0.316
DOC_SPAK_OSR1_1	87	91	PF12202	0.429
DOC_USP7_MATH_1	120	124	PF00917	0.558
DOC_WW_Pin1_4	5	10	PF00397	0.726
DOC_WW_Pin1_4	53	58	PF00397	0.741
DOC_WW_Pin1_4	66	71	PF00397	0.699
LIG_14-3-3_CanoR_1	134	142	PF00244	0.442
LIG_14-3-3_CanoR_1	164	174	PF00244	0.484
LIG_14-3-3_CanoR_1	3	7	PF00244	0.734
LIG_FHA_1	166	172	PF00498	0.467
LIG_FHA_1	234	240	PF00498	0.583
LIG_FHA_1	27	33	PF00498	0.741
LIG_FHA_1	6	12	PF00498	0.731
LIG_LIR_Gen_1	153	163	PF02991	0.491
LIG_LIR_Gen_1	22	32	PF02991	0.702
LIG_LIR_Nem_3	148	154	PF02991	0.445
LIG_LIR_Nem_3	22	28	PF02991	0.736
LIG_Pex14_2	187	191	PF04695	0.369
LIG_SH2_CRK	155	159	PF00017	0.439
LIG_SH2_CRK	25	29	PF00017	0.775
LIG_SH2_NCK_1	155	159	PF00017	0.439
LIG_SH2_STAT5	155	158	PF00017	0.478
LIG_SH2_STAT5	25	28	PF00017	0.777
LIG_SH3_3	170	176	PF00018	0.447
LIG_SH3_3	3	9	PF00018	0.731
LIG_UBA3_1	190	196	PF00899	0.392
MOD_CDK_SPxxK_3	53	60	PF00069	0.703
MOD_CK1_1	165	171	PF00069	0.507
MOD_CK1_1	19	25	PF00069	0.782
MOD_CK1_1	34	40	PF00069	0.662
MOD_CK2_1	134	140	PF00069	0.393
MOD_Cter_Amidation	1	4	PF01082	0.541
MOD_GlcNHglycan	122	125	PF01048	0.709
MOD_GlcNHglycan	136	139	PF01048	0.627
MOD_GlcNHglycan	168	171	PF01048	0.715
MOD_GlcNHglycan	206	209	PF01048	0.547
MOD_GlcNHglycan	21	24	PF01048	0.551
MOD_GlcNHglycan	222	225	PF01048	0.693
MOD_GlcNHglycan	33	36	PF01048	0.410
MOD_GlcNHglycan	92	95	PF01048	0.380
MOD_GSK3_1	120	127	PF00069	0.536
MOD_GSK3_1	162	169	PF00069	0.499
MOD_GSK3_1	19	26	PF00069	0.712
MOD_GSK3_1	230	237	PF00069	0.535
MOD_GSK3_1	27	34	PF00069	0.662
MOD_GSK3_1	62	69	PF00069	0.737
MOD_GSK3_1	7	14	PF00069	0.758
MOD_PIKK_1	105	111	PF00454	0.459
MOD_PKA_2	105	111	PF00069	0.460
MOD_PKA_2	163	169	PF00069	0.392
MOD_PKA_2	2	8	PF00069	0.773
MOD_PKA_2	233	239	PF00069	0.556
MOD_PKA_2	73	79	PF00069	0.730
MOD_Plk_4	7	13	PF00069	0.731
MOD_ProDKin_1	5	11	PF00069	0.728
MOD_ProDKin_1	53	59	PF00069	0.742
MOD_ProDKin_1	66	72	PF00069	0.698
TRG_DiLeu_BaEn_2	196	202	PF01217	0.444
TRG_ENDOCYTIC_2	155	158	PF00928	0.449
TRG_ENDOCYTIC_2	25	28	PF00928	0.777
TRG_ER_diArg_1	149	151	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF73	Leptomonas seymouri	50%	100%
A0A3Q8IPJ2	Leishmania donovani	100%	100%
A0A422NLZ4	Trypanosoma rangeli	38%	100%
A4HMQ5	Leishmania braziliensis	70%	100%
C9ZZC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AF55	Leishmania major	89%	100%
E9B6B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%