LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IBC2_LEIIN
TriTrypDb:
LINF_350028300
Length:
406

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBC2

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 271 275 PF00656 0.312
CLV_C14_Caspase3-7 55 59 PF00656 0.567
CLV_C14_Caspase3-7 72 76 PF00656 0.624
CLV_NRD_NRD_1 100 102 PF00675 0.480
CLV_NRD_NRD_1 103 105 PF00675 0.460
CLV_NRD_NRD_1 148 150 PF00675 0.525
CLV_NRD_NRD_1 237 239 PF00675 0.516
CLV_NRD_NRD_1 298 300 PF00675 0.356
CLV_NRD_NRD_1 320 322 PF00675 0.316
CLV_NRD_NRD_1 397 399 PF00675 0.414
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IMN6 Leptomonas seymouri 60% 92%
A0A0S4JDE7 Bodo saltans 42% 100%
A0A1X0P5P1 Trypanosomatidae 48% 100%
A0A3S5H7Z4 Leishmania donovani 100% 100%
A0A422NM18 Trypanosoma rangeli 48% 100%
A4HMQ4 Leishmania braziliensis 83% 100%
C9ZZC6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AF54 Leishmania major 94% 100%
E9B6B0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
V5BJA6 Trypanosoma cruzi 48% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS