Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBB5_LEIIN

TriTrypDb:

LINF_350027600

Length:

291

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBB5

PDB structure(s): 7ane_ao

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.352
CLV_C14_Caspase3-7	262	266	PF00656	0.514
CLV_C14_Caspase3-7	91	95	PF00656	0.515
CLV_NRD_NRD_1	259	261	PF00675	0.372
CLV_NRD_NRD_1	29	31	PF00675	0.375
CLV_PCSK_KEX2_1	191	193	PF00082	0.553
CLV_PCSK_KEX2_1	259	261	PF00082	0.372
CLV_PCSK_KEX2_1	29	31	PF00082	0.358
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.394
CLV_PCSK_PC7_1	255	261	PF00082	0.354
CLV_PCSK_SKI1_1	213	217	PF00082	0.345
CLV_PCSK_SKI1_1	62	66	PF00082	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.446
DOC_MAPK_gen_1	11	19	PF00069	0.370
DOC_MAPK_gen_1	26	34	PF00069	0.264
DOC_MAPK_MEF2A_6	110	118	PF00069	0.426
DOC_PP4_FxxP_1	131	134	PF00568	0.310
DOC_PP4_FxxP_1	286	289	PF00568	0.379
DOC_USP7_MATH_1	175	179	PF00917	0.550
DOC_USP7_MATH_1	269	273	PF00917	0.407
DOC_WW_Pin1_4	199	204	PF00397	0.347
DOC_WW_Pin1_4	273	278	PF00397	0.368
DOC_WW_Pin1_4	83	88	PF00397	0.636
LIG_14-3-3_CanoR_1	241	249	PF00244	0.327
LIG_14-3-3_CanoR_1	3	9	PF00244	0.468
LIG_BRCT_BRCA1_1	4	8	PF00533	0.502
LIG_FHA_1	225	231	PF00498	0.349
LIG_FHA_1	43	49	PF00498	0.338
LIG_FHA_1	59	65	PF00498	0.351
LIG_FHA_1	84	90	PF00498	0.726
LIG_FHA_2	138	144	PF00498	0.450
LIG_LIR_Apic_2	283	289	PF02991	0.395
LIG_LIR_Apic_2	71	77	PF02991	0.374
LIG_LIR_Gen_1	159	169	PF02991	0.346
LIG_LIR_Nem_3	159	164	PF02991	0.338
LIG_LIR_Nem_3	227	232	PF02991	0.519
LIG_LRP6_Inhibitor_1	104	110	PF00058	0.384
LIG_PTB_Apo_2	125	132	PF02174	0.297
LIG_SH2_CRK	171	175	PF00017	0.367
LIG_SH2_CRK	74	78	PF00017	0.455
LIG_SH2_NCK_1	74	78	PF00017	0.464
LIG_SH2_STAT5	117	120	PF00017	0.312
LIG_SH2_STAT5	18	21	PF00017	0.309
LIG_SH2_STAT5	248	251	PF00017	0.338
LIG_SH3_3	123	129	PF00018	0.309
LIG_SH3_3	200	206	PF00018	0.343
LIG_SH3_3	38	44	PF00018	0.458
LIG_TYR_ITIM	169	174	PF00017	0.347
MOD_CK1_1	243	249	PF00069	0.416
MOD_CK2_1	139	145	PF00069	0.487
MOD_CK2_1	175	181	PF00069	0.501
MOD_GlcNHglycan	235	238	PF01048	0.358
MOD_GSK3_1	269	276	PF00069	0.355
MOD_GSK3_1	58	65	PF00069	0.421
MOD_NEK2_1	1	6	PF00069	0.507
MOD_NEK2_1	116	121	PF00069	0.314
MOD_NEK2_1	169	174	PF00069	0.406
MOD_NEK2_2	254	259	PF00069	0.347
MOD_PIKK_1	137	143	PF00454	0.516
MOD_PIKK_1	235	241	PF00454	0.358
MOD_PKA_2	2	8	PF00069	0.425
MOD_PKA_2	240	246	PF00069	0.335
MOD_PKA_2	254	260	PF00069	0.360
MOD_PKA_2	28	34	PF00069	0.381
MOD_PKA_2	81	87	PF00069	0.607
MOD_Plk_1	282	288	PF00069	0.479
MOD_Plk_4	156	162	PF00069	0.346
MOD_Plk_4	43	49	PF00069	0.296
MOD_ProDKin_1	199	205	PF00069	0.345
MOD_ProDKin_1	273	279	PF00069	0.364
MOD_ProDKin_1	83	89	PF00069	0.637
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.437
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.482
TRG_ENDOCYTIC_2	161	164	PF00928	0.379
TRG_ENDOCYTIC_2	171	174	PF00928	0.323
TRG_ENDOCYTIC_2	21	24	PF00928	0.330
TRG_ENDOCYTIC_2	214	217	PF00928	0.365
TRG_ER_diArg_1	211	214	PF00400	0.368
TRG_ER_diArg_1	258	260	PF00400	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P378	Leptomonas seymouri	81%	100%
A0A0S4JD50	Bodo saltans	57%	100%
A0A1X0P6P5	Trypanosomatidae	71%	100%
A0A3S7X993	Leishmania donovani	99%	100%
A0A422MYC0	Trypanosoma rangeli	67%	100%
A4HMP6	Leishmania braziliensis	92%	100%
C9ZZD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9AF47	Leishmania major	96%	100%
E9B6A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BTH8	Trypanosoma cruzi	69%	100%