Protein kinase domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IBA9_LEIIN

TriTrypDb:

LINF_350026200

Length:

664

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 376, 417, 418, 572, 650
Promastigote/Amastigote: 345, 348, 461, 465

Expansion

Sequence features

A4IBA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.703
CLV_NRD_NRD_1	341	343	PF00675	0.628
CLV_NRD_NRD_1	361	363	PF00675	0.664
CLV_NRD_NRD_1	386	388	PF00675	0.668
CLV_PCSK_KEX2_1	360	362	PF00082	0.655
CLV_PCSK_KEX2_1	386	388	PF00082	0.668
CLV_PCSK_KEX2_1	420	422	PF00082	0.648
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.648
CLV_PCSK_SKI1_1	503	507	PF00082	0.457
CLV_PCSK_SKI1_1	543	547	PF00082	0.468
CLV_PCSK_SKI1_1	74	78	PF00082	0.551
DEG_APCC_DBOX_1	73	81	PF00400	0.471
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DEG_SPOP_SBC_1	288	292	PF00917	0.668
DEG_SPOP_SBC_1	380	384	PF00917	0.692
DOC_CKS1_1	157	162	PF01111	0.435
DOC_CKS1_1	47	52	PF01111	0.530
DOC_CYCLIN_RxL_1	556	565	PF00134	0.472
DOC_CYCLIN_RxL_1	71	82	PF00134	0.478
DOC_MAPK_gen_1	488	495	PF00069	0.458
DOC_MAPK_gen_1	72	80	PF00069	0.477
DOC_MAPK_MEF2A_6	72	80	PF00069	0.461
DOC_PP1_RVXF_1	291	298	PF00149	0.670
DOC_PP1_SILK_1	484	489	PF00149	0.352
DOC_PP4_FxxP_1	157	160	PF00568	0.444
DOC_PP4_FxxP_1	457	460	PF00568	0.612
DOC_SPAK_OSR1_1	646	650	PF12202	0.502
DOC_USP7_MATH_1	111	115	PF00917	0.524
DOC_USP7_MATH_1	146	150	PF00917	0.620
DOC_USP7_MATH_1	215	219	PF00917	0.560
DOC_USP7_MATH_1	280	284	PF00917	0.536
DOC_USP7_MATH_1	288	292	PF00917	0.586
DOC_USP7_MATH_1	32	36	PF00917	0.626
DOC_USP7_MATH_1	380	384	PF00917	0.688
DOC_USP7_MATH_1	401	405	PF00917	0.717
DOC_USP7_MATH_1	415	419	PF00917	0.458
DOC_USP7_MATH_1	59	63	PF00917	0.613
DOC_USP7_MATH_1	594	598	PF00917	0.565
DOC_USP7_MATH_1	652	656	PF00917	0.577
DOC_USP7_MATH_1	658	662	PF00917	0.580
DOC_WW_Pin1_4	156	161	PF00397	0.488
DOC_WW_Pin1_4	244	249	PF00397	0.453
DOC_WW_Pin1_4	430	435	PF00397	0.718
DOC_WW_Pin1_4	439	444	PF00397	0.553
DOC_WW_Pin1_4	46	51	PF00397	0.646
DOC_WW_Pin1_4	462	467	PF00397	0.543
DOC_WW_Pin1_4	569	574	PF00397	0.619
DOC_WW_Pin1_4	582	587	PF00397	0.521
LIG_14-3-3_CanoR_1	112	116	PF00244	0.575
LIG_14-3-3_CanoR_1	370	380	PF00244	0.607
LIG_14-3-3_CanoR_1	381	386	PF00244	0.544
LIG_14-3-3_CanoR_1	421	425	PF00244	0.635
LIG_14-3-3_CanoR_1	527	536	PF00244	0.446
LIG_14-3-3_CanoR_1	646	654	PF00244	0.686
LIG_14-3-3_CanoR_1	659	663	PF00244	0.640
LIG_14-3-3_CanoR_1	72	77	PF00244	0.474
LIG_Actin_WH2_2	405	422	PF00022	0.533
LIG_Actin_WH2_2	546	564	PF00022	0.548
LIG_APCC_ABBA_1	158	163	PF00400	0.429
LIG_APCC_ABBA_1	435	440	PF00400	0.530
LIG_BRCT_BRCA1_1	217	221	PF00533	0.555
LIG_BRCT_BRCA1_1	269	273	PF00533	0.448
LIG_BRCT_BRCA1_1	3	7	PF00533	0.538
LIG_BRCT_BRCA1_1	69	73	PF00533	0.496
LIG_Clathr_ClatBox_1	618	622	PF01394	0.429
LIG_DLG_GKlike_1	342	349	PF00625	0.603
LIG_FHA_1	214	220	PF00498	0.609
LIG_FHA_1	252	258	PF00498	0.616
LIG_FHA_1	290	296	PF00498	0.657
LIG_FHA_1	454	460	PF00498	0.659
LIG_FHA_2	118	124	PF00498	0.542
LIG_FHA_2	162	168	PF00498	0.451
LIG_FHA_2	308	314	PF00498	0.587
LIG_FHA_2	423	429	PF00498	0.591
LIG_FHA_2	443	449	PF00498	0.605
LIG_FHA_2	47	53	PF00498	0.589
LIG_FHA_2	529	535	PF00498	0.448
LIG_FHA_2	546	552	PF00498	0.276
LIG_FHA_2	62	68	PF00498	0.535
LIG_IRF3_LxIS_1	186	192	PF10401	0.419
LIG_LIR_Apic_2	154	160	PF02991	0.460
LIG_LIR_Apic_2	454	460	PF02991	0.609
LIG_LIR_Apic_2	597	603	PF02991	0.572
LIG_LIR_Gen_1	200	211	PF02991	0.537
LIG_LIR_Nem_3	200	206	PF02991	0.532
LIG_LIR_Nem_3	224	229	PF02991	0.537
LIG_LIR_Nem_3	270	276	PF02991	0.445
LIG_LIR_Nem_3	4	10	PF02991	0.536
LIG_LIR_Nem_3	483	487	PF02991	0.405
LIG_LIR_Nem_3	70	76	PF02991	0.441
LIG_LYPXL_yS_3	226	229	PF13949	0.558
LIG_NRBOX	185	191	PF00104	0.485
LIG_Rb_pABgroove_1	344	352	PF01858	0.633
LIG_SH2_NCK_1	600	604	PF00017	0.530
LIG_SH2_NCK_1	637	641	PF00017	0.620
LIG_SH2_SRC	600	603	PF00017	0.572
LIG_SH2_STAP1	637	641	PF00017	0.612
LIG_SH2_STAT5	250	253	PF00017	0.405
LIG_SH2_STAT5	271	274	PF00017	0.516
LIG_SH2_STAT5	95	98	PF00017	0.442
LIG_SH3_1	600	606	PF00018	0.529
LIG_SH3_3	192	198	PF00018	0.464
LIG_SH3_3	225	231	PF00018	0.549
LIG_SH3_3	262	268	PF00018	0.450
LIG_SH3_3	600	606	PF00018	0.529
LIG_SH3_3	86	92	PF00018	0.469
LIG_SUMO_SIM_anti_2	235	242	PF11976	0.485
LIG_SUMO_SIM_anti_2	607	613	PF11976	0.438
LIG_SUMO_SIM_par_1	440	448	PF11976	0.602
LIG_TRAF2_1	121	124	PF00917	0.532
LIG_TRAF2_1	531	534	PF00917	0.494
LIG_TRAF2_1	535	538	PF00917	0.434
LIG_TRAF2_1	9	12	PF00917	0.612
LIG_UBA3_1	256	264	PF00899	0.478
MOD_CDC14_SPxK_1	433	436	PF00782	0.625
MOD_CDK_SPxK_1	430	436	PF00069	0.623
MOD_CK1_1	107	113	PF00069	0.502
MOD_CK1_1	149	155	PF00069	0.594
MOD_CK1_1	287	293	PF00069	0.593
MOD_CK1_1	308	314	PF00069	0.669
MOD_CK1_1	345	351	PF00069	0.598
MOD_CK1_1	35	41	PF00069	0.529
MOD_CK1_1	363	369	PF00069	0.657
MOD_CK1_1	374	380	PF00069	0.524
MOD_CK1_1	396	402	PF00069	0.753
MOD_CK1_1	42	48	PF00069	0.492
MOD_CK1_1	442	448	PF00069	0.681
MOD_CK1_1	451	457	PF00069	0.515
MOD_CK1_1	465	471	PF00069	0.562
MOD_CK1_1	57	63	PF00069	0.515
MOD_CK1_1	585	591	PF00069	0.657
MOD_CK1_1	81	87	PF00069	0.463
MOD_CK2_1	10	16	PF00069	0.566
MOD_CK2_1	117	123	PF00069	0.797
MOD_CK2_1	161	167	PF00069	0.497
MOD_CK2_1	207	213	PF00069	0.504
MOD_CK2_1	307	313	PF00069	0.580
MOD_CK2_1	422	428	PF00069	0.670
MOD_CK2_1	528	534	PF00069	0.451
MOD_GlcNHglycan	106	109	PF01048	0.444
MOD_GlcNHglycan	11	15	PF01048	0.504
MOD_GlcNHglycan	191	194	PF01048	0.485
MOD_GlcNHglycan	221	224	PF01048	0.613
MOD_GlcNHglycan	282	285	PF01048	0.561
MOD_GlcNHglycan	286	289	PF01048	0.591
MOD_GlcNHglycan	34	37	PF01048	0.574
MOD_GlcNHglycan	387	390	PF01048	0.677
MOD_GlcNHglycan	398	402	PF01048	0.533
MOD_GlcNHglycan	56	59	PF01048	0.705
MOD_GlcNHglycan	575	578	PF01048	0.630
MOD_GlcNHglycan	587	590	PF01048	0.542
MOD_GlcNHglycan	649	652	PF01048	0.758
MOD_GlcNHglycan	654	657	PF01048	0.559
MOD_GSK3_1	103	110	PF00069	0.492
MOD_GSK3_1	125	132	PF00069	0.566
MOD_GSK3_1	146	153	PF00069	0.554
MOD_GSK3_1	215	222	PF00069	0.658
MOD_GSK3_1	275	282	PF00069	0.475
MOD_GSK3_1	284	291	PF00069	0.571
MOD_GSK3_1	327	334	PF00069	0.628
MOD_GSK3_1	35	42	PF00069	0.581
MOD_GSK3_1	381	388	PF00069	0.675
MOD_GSK3_1	393	400	PF00069	0.683
MOD_GSK3_1	438	445	PF00069	0.631
MOD_GSK3_1	449	456	PF00069	0.602
MOD_GSK3_1	458	465	PF00069	0.537
MOD_GSK3_1	569	576	PF00069	0.565
MOD_GSK3_1	57	64	PF00069	0.536
MOD_GSK3_1	641	648	PF00069	0.664
MOD_N-GLC_1	32	37	PF02516	0.525
MOD_N-GLC_1	518	523	PF02516	0.513
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	104	109	PF00069	0.497
MOD_NEK2_1	189	194	PF00069	0.448
MOD_NEK2_1	34	39	PF00069	0.523
MOD_NEK2_1	373	378	PF00069	0.662
MOD_NEK2_1	385	390	PF00069	0.608
MOD_NEK2_1	43	48	PF00069	0.469
MOD_NEK2_1	438	443	PF00069	0.543
MOD_NEK2_1	54	59	PF00069	0.523
MOD_NEK2_1	545	550	PF00069	0.320
MOD_NEK2_1	568	573	PF00069	0.511
MOD_NEK2_1	647	652	PF00069	0.524
MOD_NEK2_1	78	83	PF00069	0.440
MOD_NEK2_2	415	420	PF00069	0.529
MOD_PIKK_1	232	238	PF00454	0.552
MOD_PIKK_1	371	377	PF00454	0.747
MOD_PIKK_1	422	428	PF00454	0.688
MOD_PIKK_1	545	551	PF00454	0.524
MOD_PIKK_1	562	568	PF00454	0.446
MOD_PIKK_1	59	65	PF00454	0.626
MOD_PK_1	420	426	PF00069	0.633
MOD_PK_1	625	631	PF00069	0.482
MOD_PKA_1	342	348	PF00069	0.605
MOD_PKA_1	360	366	PF00069	0.667
MOD_PKA_1	420	426	PF00069	0.645
MOD_PKA_2	111	117	PF00069	0.503
MOD_PKA_2	149	155	PF00069	0.568
MOD_PKA_2	280	286	PF00069	0.546
MOD_PKA_2	360	366	PF00069	0.667
MOD_PKA_2	371	377	PF00069	0.563
MOD_PKA_2	380	386	PF00069	0.589
MOD_PKA_2	393	399	PF00069	0.674
MOD_PKA_2	420	426	PF00069	0.645
MOD_PKA_2	645	651	PF00069	0.677
MOD_PKA_2	658	664	PF00069	0.568
MOD_Plk_1	594	600	PF00069	0.509
MOD_Plk_2-3	207	213	PF00069	0.550
MOD_Plk_4	161	167	PF00069	0.656
MOD_Plk_4	215	221	PF00069	0.558
MOD_Plk_4	235	241	PF00069	0.598
MOD_Plk_4	345	351	PF00069	0.548
MOD_Plk_4	594	600	PF00069	0.572
MOD_ProDKin_1	156	162	PF00069	0.481
MOD_ProDKin_1	244	250	PF00069	0.447
MOD_ProDKin_1	430	436	PF00069	0.720
MOD_ProDKin_1	439	445	PF00069	0.552
MOD_ProDKin_1	46	52	PF00069	0.648
MOD_ProDKin_1	462	468	PF00069	0.537
MOD_ProDKin_1	569	575	PF00069	0.626
MOD_ProDKin_1	582	588	PF00069	0.519
MOD_SUMO_rev_2	423	431	PF00179	0.618
TRG_DiLeu_BaEn_2	15	21	PF01217	0.504
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.477
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.485
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.438
TRG_ENDOCYTIC_2	226	229	PF00928	0.590
TRG_ENDOCYTIC_2	542	545	PF00928	0.456
TRG_ER_diArg_1	360	362	PF00400	0.659
TRG_ER_diArg_1	370	373	PF00400	0.697
TRG_ER_diArg_1	385	387	PF00400	0.488
TRG_ER_diArg_1	487	490	PF00400	0.582
TRG_NES_CRM1_1	608	622	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.731
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	562	566	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVJ7	Leptomonas seymouri	51%	87%
A0A3R7K4W1	Trypanosoma rangeli	26%	82%
A0A3S7X976	Leishmania donovani	100%	100%
A4HMN2	Leishmania braziliensis	76%	100%
E9AF34	Leishmania major	89%	95%
E9B689	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%