LeishMANIAdb
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Putative kinesin

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative kinesin
Gene product:
kinesin - putative
Species:
Leishmania infantum
UniProt:
A4IBA7_LEIIN
TriTrypDb:
LINF_350026000
Length:
698

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 31
NetGPI no yes: 0, no: 31
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 15
GO:0099080 supramolecular complex 2 15
GO:0099081 supramolecular polymer 3 15
GO:0099512 supramolecular fiber 4 15
GO:0099513 polymeric cytoskeletal fiber 5 15
GO:0110165 cellular anatomical entity 1 19
GO:0005737 cytoplasm 2 6
GO:0005871 kinesin complex 3 2
GO:0005875 microtubule associated complex 2 2
GO:0032991 protein-containing complex 1 2

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IBA7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBA7

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 32
GO:0007018 microtubule-based movement 3 32
GO:0009987 cellular process 1 32
GO:0006810 transport 3 2
GO:0030705 cytoskeleton-dependent intracellular transport 4 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 32
GO:0003774 cytoskeletal motor activity 1 32
GO:0003777 microtubule motor activity 2 32
GO:0003824 catalytic activity 1 14
GO:0005488 binding 1 32
GO:0005515 protein binding 2 32
GO:0005524 ATP binding 5 32
GO:0008017 microtubule binding 5 32
GO:0008092 cytoskeletal protein binding 3 32
GO:0015631 tubulin binding 4 32
GO:0016787 hydrolase activity 2 14
GO:0017076 purine nucleotide binding 4 32
GO:0030554 adenyl nucleotide binding 5 32
GO:0032553 ribonucleotide binding 3 32
GO:0032555 purine ribonucleotide binding 4 32
GO:0032559 adenyl ribonucleotide binding 5 32
GO:0035639 purine ribonucleoside triphosphate binding 4 32
GO:0036094 small molecule binding 2 32
GO:0043167 ion binding 2 32
GO:0043168 anion binding 3 32
GO:0097159 organic cyclic compound binding 2 32
GO:0097367 carbohydrate derivative binding 2 32
GO:0140657 ATP-dependent activity 1 32
GO:1901265 nucleoside phosphate binding 3 32
GO:1901363 heterocyclic compound binding 2 32
GO:0008574 plus-end-directed microtubule motor activity 3 2
GO:0016462 pyrophosphatase activity 5 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 83 87 PF00656 0.275
CLV_MEL_PAP_1 365 371 PF00089 0.217
CLV_NRD_NRD_1 216 218 PF00675 0.334
CLV_NRD_NRD_1 462 464 PF00675 0.560
CLV_NRD_NRD_1 491 493 PF00675 0.461
CLV_PCSK_KEX2_1 216 218 PF00082 0.278
CLV_PCSK_KEX2_1 278 280 PF00082 0.492
CLV_PCSK_KEX2_1 462 464 PF00082 0.518
CLV_PCSK_KEX2_1 491 493 PF00082 0.485
CLV_PCSK_KEX2_1 652 654 PF00082 0.449
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.492
CLV_PCSK_PC1ET2_1 652 654 PF00082 0.449
CLV_PCSK_SKI1_1 106 110 PF00082 0.348
CLV_PCSK_SKI1_1 144 148 PF00082 0.295
CLV_PCSK_SKI1_1 16 20 PF00082 0.250
CLV_PCSK_SKI1_1 167 171 PF00082 0.243
CLV_PCSK_SKI1_1 198 202 PF00082 0.318
CLV_PCSK_SKI1_1 317 321 PF00082 0.296
CLV_PCSK_SKI1_1 374 378 PF00082 0.321
CLV_PCSK_SKI1_1 386 390 PF00082 0.220
CLV_PCSK_SKI1_1 414 418 PF00082 0.374
CLV_PCSK_SKI1_1 482 486 PF00082 0.656
CLV_PCSK_SKI1_1 640 644 PF00082 0.449
CLV_PCSK_SKI1_1 652 656 PF00082 0.396
DEG_SCF_FBW7_1 624 631 PF00400 0.427
DOC_CYCLIN_yClb5_NLxxxL_5 368 376 PF00134 0.287
DOC_MAPK_gen_1 144 154 PF00069 0.262
DOC_MAPK_gen_1 479 488 PF00069 0.661
DOC_MAPK_gen_1 517 525 PF00069 0.590
DOC_MAPK_MEF2A_6 147 156 PF00069 0.237
DOC_MAPK_MEF2A_6 8 15 PF00069 0.310
DOC_PP1_RVXF_1 426 432 PF00149 0.472
DOC_PP4_FxxP_1 304 307 PF00568 0.350
DOC_PP4_FxxP_1 380 383 PF00568 0.260
DOC_USP7_MATH_1 221 225 PF00917 0.379
DOC_USP7_MATH_1 247 251 PF00917 0.441
DOC_USP7_MATH_1 266 270 PF00917 0.545
DOC_USP7_MATH_1 451 455 PF00917 0.552
DOC_USP7_MATH_1 484 488 PF00917 0.560
DOC_USP7_MATH_1 495 499 PF00917 0.424
DOC_USP7_MATH_1 55 59 PF00917 0.287
DOC_USP7_UBL2_3 485 489 PF12436 0.534
DOC_WW_Pin1_4 391 396 PF00397 0.279
DOC_WW_Pin1_4 624 629 PF00397 0.453
LIG_14-3-3_CanoR_1 133 141 PF00244 0.291
LIG_14-3-3_CanoR_1 491 500 PF00244 0.525
LIG_14-3-3_CanoR_1 653 658 PF00244 0.512
LIG_14-3-3_CanoR_1 8 14 PF00244 0.382
LIG_Actin_WH2_2 362 379 PF00022 0.417
LIG_Actin_WH2_2 535 551 PF00022 0.472
LIG_Actin_WH2_2 6 22 PF00022 0.273
LIG_APCC_ABBA_1 159 164 PF00400 0.269
LIG_APCC_ABBA_1 74 79 PF00400 0.260
LIG_APCC_ABBAyCdc20_2 468 474 PF00400 0.463
LIG_BIR_III_4 496 500 PF00653 0.396
LIG_BRCT_BRCA1_1 127 131 PF00533 0.254
LIG_BRCT_BRCA1_1 57 61 PF00533 0.279
LIG_Clathr_ClatBox_1 234 238 PF01394 0.260
LIG_Clathr_ClatBox_1 60 64 PF01394 0.399
LIG_CSK_EPIYA_1 311 315 PF00017 0.343
LIG_deltaCOP1_diTrp_1 294 299 PF00928 0.441
LIG_FHA_1 105 111 PF00498 0.269
LIG_FHA_1 313 319 PF00498 0.414
LIG_FHA_1 371 377 PF00498 0.279
LIG_FHA_1 455 461 PF00498 0.584
LIG_FHA_1 8 14 PF00498 0.392
LIG_FHA_2 184 190 PF00498 0.197
LIG_FHA_2 397 403 PF00498 0.219
LIG_FHA_2 420 426 PF00498 0.452
LIG_FHA_2 625 631 PF00498 0.674
LIG_FHA_2 70 76 PF00498 0.303
LIG_LIR_Apic_2 294 298 PF02991 0.618
LIG_LIR_Apic_2 302 307 PF02991 0.461
LIG_LIR_Gen_1 107 116 PF02991 0.249
LIG_LIR_Gen_1 128 139 PF02991 0.308
LIG_LIR_Gen_1 584 594 PF02991 0.432
LIG_LIR_Gen_1 62 67 PF02991 0.323
LIG_LIR_Gen_1 663 672 PF02991 0.572
LIG_LIR_Nem_3 107 111 PF02991 0.264
LIG_LIR_Nem_3 128 134 PF02991 0.287
LIG_LIR_Nem_3 361 367 PF02991 0.252
LIG_LIR_Nem_3 62 66 PF02991 0.304
LIG_LIR_Nem_3 663 667 PF02991 0.568
LIG_NRBOX 371 377 PF00104 0.261
LIG_PCNA_yPIPBox_3 163 173 PF02747 0.415
LIG_Pex14_1 295 299 PF04695 0.448
LIG_Pex14_2 63 67 PF04695 0.296
LIG_SH2_CRK 440 444 PF00017 0.479
LIG_SH2_CRK 664 668 PF00017 0.455
LIG_SH2_SRC 191 194 PF00017 0.329
LIG_SH2_SRC 77 80 PF00017 0.297
LIG_SH2_STAP1 314 318 PF00017 0.423
LIG_SH2_STAP1 440 444 PF00017 0.418
LIG_SH2_STAP1 473 477 PF00017 0.627
LIG_SH2_STAP1 77 81 PF00017 0.279
LIG_SH2_STAT5 191 194 PF00017 0.373
LIG_SH2_STAT5 314 317 PF00017 0.201
LIG_SH2_STAT5 593 596 PF00017 0.549
LIG_SH2_STAT5 65 68 PF00017 0.403
LIG_SH3_2 52 57 PF14604 0.308
LIG_SH3_3 187 193 PF00018 0.256
LIG_SH3_3 287 293 PF00018 0.588
LIG_SH3_3 49 55 PF00018 0.329
LIG_SUMO_SIM_anti_2 236 241 PF11976 0.370
LIG_SUMO_SIM_anti_2 250 255 PF11976 0.383
LIG_SUMO_SIM_anti_2 384 391 PF11976 0.243
LIG_SUMO_SIM_anti_2 521 527 PF11976 0.301
LIG_UBA3_1 511 519 PF00899 0.346
LIG_UBA3_1 589 595 PF00899 0.316
LIG_WRC_WIRS_1 60 65 PF05994 0.280
LIG_WRC_WIRS_1 654 659 PF05994 0.330
MOD_CK1_1 104 110 PF00069 0.287
MOD_CK1_1 219 225 PF00069 0.279
MOD_CK1_1 226 232 PF00069 0.268
MOD_CK1_1 282 288 PF00069 0.603
MOD_CK1_1 332 338 PF00069 0.281
MOD_CK1_1 344 350 PF00069 0.327
MOD_CK1_1 370 376 PF00069 0.282
MOD_CK1_1 381 387 PF00069 0.286
MOD_CK1_1 454 460 PF00069 0.537
MOD_CK1_1 59 65 PF00069 0.278
MOD_CK1_1 606 612 PF00069 0.481
MOD_CK1_1 644 650 PF00069 0.512
MOD_CK2_1 154 160 PF00069 0.241
MOD_CK2_1 355 361 PF00069 0.252
MOD_CK2_1 396 402 PF00069 0.263
MOD_CK2_1 419 425 PF00069 0.466
MOD_CK2_1 526 532 PF00069 0.502
MOD_CK2_1 607 613 PF00069 0.435
MOD_CK2_1 624 630 PF00069 0.593
MOD_CK2_1 69 75 PF00069 0.286
MOD_GlcNHglycan 103 106 PF01048 0.300
MOD_GlcNHglycan 127 130 PF01048 0.243
MOD_GlcNHglycan 175 178 PF01048 0.490
MOD_GlcNHglycan 23 26 PF01048 0.367
MOD_GlcNHglycan 244 247 PF01048 0.488
MOD_GlcNHglycan 284 287 PF01048 0.639
MOD_GlcNHglycan 331 334 PF01048 0.284
MOD_GlcNHglycan 435 438 PF01048 0.483
MOD_GlcNHglycan 474 478 PF01048 0.656
MOD_GlcNHglycan 493 496 PF01048 0.584
MOD_GlcNHglycan 497 500 PF01048 0.610
MOD_GlcNHglycan 528 531 PF01048 0.545
MOD_GlcNHglycan 570 573 PF01048 0.439
MOD_GSK3_1 219 226 PF00069 0.300
MOD_GSK3_1 340 347 PF00069 0.285
MOD_GSK3_1 363 370 PF00069 0.268
MOD_GSK3_1 378 385 PF00069 0.281
MOD_GSK3_1 396 403 PF00069 0.271
MOD_GSK3_1 491 498 PF00069 0.495
MOD_GSK3_1 55 62 PF00069 0.307
MOD_GSK3_1 603 610 PF00069 0.337
MOD_GSK3_1 624 631 PF00069 0.627
MOD_N-GLC_1 345 350 PF02516 0.274
MOD_N-GLC_1 370 375 PF02516 0.292
MOD_N-GLC_1 628 633 PF02516 0.703
MOD_N-GLC_1 674 679 PF02516 0.561
MOD_N-GLC_1 92 97 PF02516 0.249
MOD_NEK2_1 123 128 PF00069 0.358
MOD_NEK2_1 254 259 PF00069 0.543
MOD_NEK2_1 299 304 PF00069 0.462
MOD_NEK2_1 400 405 PF00069 0.253
MOD_NEK2_1 416 421 PF00069 0.412
MOD_NEK2_1 433 438 PF00069 0.471
MOD_NEK2_1 568 573 PF00069 0.475
MOD_NEK2_2 41 46 PF00069 0.301
MOD_NEK2_2 484 489 PF00069 0.597
MOD_PIKK_1 223 229 PF00454 0.394
MOD_PIKK_1 393 399 PF00454 0.285
MOD_PIKK_1 451 457 PF00454 0.550
MOD_PIKK_1 561 567 PF00454 0.516
MOD_PIKK_1 613 619 PF00454 0.556
MOD_PIKK_1 69 75 PF00454 0.262
MOD_PKA_1 216 222 PF00069 0.260
MOD_PKA_1 491 497 PF00069 0.560
MOD_PKA_2 216 222 PF00069 0.264
MOD_PKA_2 367 373 PF00069 0.299
MOD_PKA_2 491 497 PF00069 0.521
MOD_PKA_2 622 628 PF00069 0.625
MOD_PKA_2 7 13 PF00069 0.360
MOD_Plk_1 198 204 PF00069 0.266
MOD_Plk_1 340 346 PF00069 0.282
MOD_Plk_1 370 376 PF00069 0.282
MOD_Plk_1 400 406 PF00069 0.244
MOD_Plk_1 41 47 PF00069 0.251
MOD_Plk_1 521 527 PF00069 0.527
MOD_Plk_1 603 609 PF00069 0.427
MOD_Plk_1 674 680 PF00069 0.556
MOD_Plk_1 69 75 PF00069 0.260
MOD_Plk_1 92 98 PF00069 0.245
MOD_Plk_4 191 197 PF00069 0.275
MOD_Plk_4 299 305 PF00069 0.463
MOD_Plk_4 467 473 PF00069 0.632
MOD_Plk_4 56 62 PF00069 0.296
MOD_Plk_4 585 591 PF00069 0.486
MOD_Plk_4 674 680 PF00069 0.537
MOD_Plk_4 92 98 PF00069 0.254
MOD_ProDKin_1 391 397 PF00069 0.279
MOD_ProDKin_1 624 630 PF00069 0.448
MOD_SUMO_for_1 45 48 PF00179 0.307
MOD_SUMO_rev_2 136 143 PF00179 0.279
MOD_SUMO_rev_2 257 266 PF00179 0.558
MOD_SUMO_rev_2 268 274 PF00179 0.518
MOD_SUMO_rev_2 544 551 PF00179 0.459
MOD_SUMO_rev_2 633 642 PF00179 0.660
MOD_SUMO_rev_2 693 698 PF00179 0.627
TRG_DiLeu_BaEn_1 507 512 PF01217 0.515
TRG_DiLeu_BaEn_3 584 590 PF01217 0.495
TRG_DiLeu_BaLyEn_6 371 376 PF01217 0.260
TRG_ENDOCYTIC_2 440 443 PF00928 0.462
TRG_ENDOCYTIC_2 664 667 PF00928 0.478
TRG_ER_diArg_1 13 16 PF00400 0.291
TRG_ER_diArg_1 216 218 PF00400 0.410
TRG_ER_diArg_1 461 463 PF00400 0.516
TRG_ER_diArg_1 491 493 PF00400 0.626
TRG_NLS_MonoExtC_3 681 687 PF00514 0.322
TRG_NLS_MonoExtN_4 680 686 PF00514 0.334
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.231
TRG_Pf-PMV_PEXEL_1 463 467 PF00026 0.672
TRG_Pf-PMV_PEXEL_1 491 496 PF00026 0.653

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P672 Leptomonas seymouri 34% 66%
A0A0N1HVM1 Leptomonas seymouri 29% 75%
A0A0N1IM30 Leptomonas seymouri 73% 100%
A0A0S4IXS6 Bodo saltans 39% 68%
A0A0S4JN49 Bodo saltans 50% 96%
A0A1X0NQ03 Trypanosomatidae 24% 84%
A0A1X0P5Y8 Trypanosomatidae 60% 100%
A0A3Q8IBS7 Leishmania donovani 24% 100%
A0A3Q8IG88 Leishmania donovani 100% 100%
A0A3S7WX05 Leishmania donovani 30% 79%
A0A422MZ05 Trypanosoma rangeli 57% 100%
A0A422NEF2 Trypanosoma rangeli 36% 69%
A4HAQ7 Leishmania braziliensis 27% 100%
A4HHY2 Leishmania braziliensis 26% 100%
A4HMM9 Leishmania braziliensis 76% 100%
A4HZT3 Leishmania infantum 30% 79%
A4I562 Leishmania infantum 24% 100%
C9ZU98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 86%
C9ZV26 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 93%
C9ZVT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 69%
C9ZZN5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AF32 Leishmania major 92% 100%
E9B0F9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B687 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 99%
Q4Q7S4 Leishmania major 27% 100%
Q4QBU1 Leishmania major 31% 78%
V5B8X9 Trypanosoma cruzi 58% 99%
V5D733 Trypanosoma cruzi 25% 93%
V5DFA7 Trypanosoma cruzi 28% 100%
V5DQN8 Trypanosoma cruzi 32% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS