Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4205) - putative

Species:

Leishmania infantum

UniProt:

A4IBA5_LEIIN

TriTrypDb:

LINF_350025700

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBA5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.548
CLV_C14_Caspase3-7	226	230	PF00656	0.655
CLV_C14_Caspase3-7	510	514	PF00656	0.464
CLV_NRD_NRD_1	138	140	PF00675	0.654
CLV_NRD_NRD_1	37	39	PF00675	0.512
CLV_NRD_NRD_1	97	99	PF00675	0.566
CLV_PCSK_KEX2_1	174	176	PF00082	0.724
CLV_PCSK_KEX2_1	37	39	PF00082	0.512
CLV_PCSK_KEX2_1	398	400	PF00082	0.436
CLV_PCSK_KEX2_1	97	99	PF00082	0.566
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.691
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.436
CLV_PCSK_SKI1_1	147	151	PF00082	0.692
CLV_PCSK_SKI1_1	179	183	PF00082	0.670
CLV_PCSK_SKI1_1	347	351	PF00082	0.573
CLV_PCSK_SKI1_1	38	42	PF00082	0.621
CLV_PCSK_SKI1_1	4	8	PF00082	0.666
CLV_PCSK_SKI1_1	421	425	PF00082	0.411
CLV_PCSK_SKI1_1	477	481	PF00082	0.472
CLV_PCSK_SKI1_1	539	543	PF00082	0.436
CLV_PCSK_SKI1_1	621	625	PF00082	0.411
CLV_PCSK_SKI1_1	672	676	PF00082	0.402
CLV_Separin_Metazoa	466	470	PF03568	0.389
DEG_APCC_DBOX_1	37	45	PF00400	0.618
DEG_APCC_DBOX_1	525	533	PF00400	0.513
DEG_SCF_TRCP1_1	513	518	PF00400	0.397
DEG_SPOP_SBC_1	241	245	PF00917	0.615
DEG_SPOP_SBC_1	584	588	PF00917	0.383
DOC_ANK_TNKS_1	76	83	PF00023	0.560
DOC_CDC14_PxL_1	9	17	PF14671	0.663
DOC_MAPK_MEF2A_6	516	523	PF00069	0.436
DOC_PP1_RVXF_1	537	544	PF00149	0.389
DOC_PP1_RVXF_1	655	662	PF00149	0.436
DOC_PP2B_LxvP_1	519	522	PF13499	0.513
DOC_PP2B_LxvP_1	614	617	PF13499	0.474
DOC_USP7_MATH_1	241	245	PF00917	0.787
DOC_USP7_MATH_1	302	306	PF00917	0.720
DOC_USP7_MATH_1	580	584	PF00917	0.428
DOC_USP7_MATH_1	62	66	PF00917	0.630
DOC_USP7_MATH_1	681	685	PF00917	0.411
DOC_USP7_MATH_1	687	691	PF00917	0.411
DOC_USP7_UBL2_3	140	144	PF12436	0.683
DOC_WW_Pin1_4	180	185	PF00397	0.709
DOC_WW_Pin1_4	256	261	PF00397	0.800
DOC_WW_Pin1_4	585	590	PF00397	0.411
LIG_14-3-3_CanoR_1	139	148	PF00244	0.702
LIG_14-3-3_CanoR_1	179	184	PF00244	0.839
LIG_14-3-3_CanoR_1	526	530	PF00244	0.433
LIG_14-3-3_CanoR_1	61	70	PF00244	0.632
LIG_14-3-3_CanoR_1	672	678	PF00244	0.524
LIG_Actin_WH2_2	2	18	PF00022	0.632
LIG_Actin_WH2_2	454	471	PF00022	0.436
LIG_BRCT_BRCA1_1	487	491	PF00533	0.513
LIG_BRCT_BRCA1_1	657	661	PF00533	0.513
LIG_FHA_1	463	469	PF00498	0.492
LIG_FHA_1	526	532	PF00498	0.353
LIG_FHA_1	618	624	PF00498	0.411
LIG_FHA_1	651	657	PF00498	0.515
LIG_FHA_1	99	105	PF00498	0.594
LIG_FHA_2	195	201	PF00498	0.599
LIG_FHA_2	353	359	PF00498	0.389
LIG_FHA_2	408	414	PF00498	0.411
LIG_FHA_2	643	649	PF00498	0.411
LIG_FHA_2	83	89	PF00498	0.501
LIG_GBD_Chelix_1	404	412	PF00786	0.513
LIG_GBD_Chelix_1	486	494	PF00786	0.474
LIG_LIR_Apic_2	475	481	PF02991	0.411
LIG_LIR_Gen_1	452	461	PF02991	0.411
LIG_LIR_Gen_1	488	499	PF02991	0.513
LIG_LIR_Gen_1	609	617	PF02991	0.513
LIG_LIR_Nem_3	488	494	PF02991	0.513
LIG_LIR_Nem_3	609	614	PF02991	0.513
LIG_NRBOX	489	495	PF00104	0.513
LIG_REV1ctd_RIR_1	540	548	PF16727	0.513
LIG_SH2_GRB2like	592	595	PF00017	0.513
LIG_SH2_NCK_1	592	596	PF00017	0.478
LIG_SH2_STAP1	388	392	PF00017	0.411
LIG_SH2_STAP1	556	560	PF00017	0.411
LIG_SH2_STAT5	393	396	PF00017	0.411
LIG_SH2_STAT5	438	441	PF00017	0.436
LIG_SH2_STAT5	592	595	PF00017	0.387
LIG_SH3_3	110	116	PF00018	0.655
LIG_SH3_3	178	184	PF00018	0.628
LIG_SH3_3	372	378	PF00018	0.411
LIG_SH3_3	46	52	PF00018	0.417
LIG_SH3_3	595	601	PF00018	0.342
LIG_SUMO_SIM_anti_2	635	640	PF11976	0.513
LIG_SUMO_SIM_par_1	421	427	PF11976	0.367
LIG_SUMO_SIM_par_1	645	655	PF11976	0.396
LIG_TRAF2_1	18	21	PF00917	0.531
LIG_TRAF2_1	460	463	PF00917	0.389
LIG_WRC_WIRS_1	486	491	PF05994	0.513
MOD_CK1_1	170	176	PF00069	0.714
MOD_CK1_1	180	186	PF00069	0.775
MOD_CK1_1	205	211	PF00069	0.718
MOD_CK1_1	227	233	PF00069	0.715
MOD_CK1_1	240	246	PF00069	0.795
MOD_CK1_1	275	281	PF00069	0.655
MOD_CK1_1	436	442	PF00069	0.490
MOD_CK1_1	583	589	PF00069	0.375
MOD_CK2_1	251	257	PF00069	0.623
MOD_CK2_1	289	295	PF00069	0.757
MOD_CK2_1	407	413	PF00069	0.411
MOD_CK2_1	457	463	PF00069	0.377
MOD_CK2_1	642	648	PF00069	0.457
MOD_CK2_1	82	88	PF00069	0.515
MOD_CMANNOS	603	606	PF00535	0.513
MOD_GlcNHglycan	150	153	PF01048	0.738
MOD_GlcNHglycan	184	187	PF01048	0.823
MOD_GlcNHglycan	239	242	PF01048	0.825
MOD_GlcNHglycan	513	516	PF01048	0.360
MOD_GlcNHglycan	523	526	PF01048	0.351
MOD_GlcNHglycan	568	571	PF01048	0.409
MOD_GlcNHglycan	582	585	PF01048	0.418
MOD_GlcNHglycan	664	667	PF01048	0.413
MOD_GlcNHglycan	689	692	PF01048	0.411
MOD_GSK3_1	201	208	PF00069	0.685
MOD_GSK3_1	223	230	PF00069	0.702
MOD_GSK3_1	237	244	PF00069	0.815
MOD_GSK3_1	424	431	PF00069	0.424
MOD_GSK3_1	485	492	PF00069	0.515
MOD_GSK3_1	504	511	PF00069	0.411
MOD_GSK3_1	521	528	PF00069	0.220
MOD_GSK3_1	580	587	PF00069	0.442
MOD_GSK3_1	673	680	PF00069	0.411
MOD_N-GLC_1	167	172	PF02516	0.655
MOD_N-GLC_1	593	598	PF02516	0.499
MOD_N-GLC_1	632	637	PF02516	0.397
MOD_NEK2_1	201	206	PF00069	0.648
MOD_NEK2_1	251	256	PF00069	0.812
MOD_NEK2_1	341	346	PF00069	0.508
MOD_NEK2_1	40	45	PF00069	0.519
MOD_NEK2_1	424	429	PF00069	0.507
MOD_NEK2_1	468	473	PF00069	0.389
MOD_NEK2_1	489	494	PF00069	0.411
MOD_NEK2_1	534	539	PF00069	0.499
MOD_NEK2_1	590	595	PF00069	0.420
MOD_NEK2_1	652	657	PF00069	0.410
MOD_NEK2_1	677	682	PF00069	0.411
MOD_PIKK_1	259	265	PF00454	0.682
MOD_PKA_1	139	145	PF00069	0.687
MOD_PKA_2	170	176	PF00069	0.766
MOD_PKA_2	289	295	PF00069	0.757
MOD_PKA_2	436	442	PF00069	0.383
MOD_PKA_2	468	474	PF00069	0.411
MOD_PKA_2	515	521	PF00069	0.399
MOD_PKA_2	525	531	PF00069	0.351
MOD_PKA_2	607	613	PF00069	0.513
MOD_Plk_1	632	638	PF00069	0.397
MOD_Plk_2-3	308	314	PF00069	0.678
MOD_Plk_2-3	642	648	PF00069	0.411
MOD_Plk_4	272	278	PF00069	0.591
MOD_Plk_4	424	430	PF00069	0.436
MOD_Plk_4	468	474	PF00069	0.411
MOD_Plk_4	485	491	PF00069	0.411
MOD_Plk_4	515	521	PF00069	0.416
MOD_Plk_4	599	605	PF00069	0.362
MOD_Plk_4	673	679	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.515
MOD_ProDKin_1	180	186	PF00069	0.709
MOD_ProDKin_1	256	262	PF00069	0.800
MOD_ProDKin_1	585	591	PF00069	0.411
MOD_SUMO_for_1	78	81	PF00179	0.562
TRG_DiLeu_BaEn_1	100	105	PF01217	0.603
TRG_DiLeu_BaEn_1	21	26	PF01217	0.497
TRG_DiLeu_LyEn_5	100	105	PF01217	0.564
TRG_ENDOCYTIC_2	119	122	PF00928	0.613
TRG_ER_diArg_1	450	453	PF00400	0.443
TRG_ER_diArg_1	97	99	PF00400	0.566
TRG_NES_CRM1_1	84	96	PF08389	0.511
TRG_NLS_MonoCore_2	143	148	PF00514	0.676
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT4	Leptomonas seymouri	54%	100%
A0A3S7X9A6	Leishmania donovani	99%	100%
A4HMM7	Leishmania braziliensis	78%	100%
E9AF29	Leishmania major	92%	100%
E9B685	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%