SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SH3 domain/Variant SH3 domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IBA4_LEIIN

TriTrypDb:

LINF_350025600

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IBA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IBA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.721
CLV_C14_Caspase3-7	400	404	PF00656	0.686
CLV_C14_Caspase3-7	438	442	PF00656	0.740
CLV_NRD_NRD_1	237	239	PF00675	0.739
CLV_NRD_NRD_1	302	304	PF00675	0.341
CLV_NRD_NRD_1	316	318	PF00675	0.344
CLV_NRD_NRD_1	447	449	PF00675	0.737
CLV_NRD_NRD_1	451	453	PF00675	0.750
CLV_NRD_NRD_1	5	7	PF00675	0.822
CLV_NRD_NRD_1	8	10	PF00675	0.761
CLV_PCSK_FUR_1	314	318	PF00082	0.333
CLV_PCSK_FUR_1	6	10	PF00082	0.715
CLV_PCSK_KEX2_1	302	304	PF00082	0.357
CLV_PCSK_KEX2_1	316	318	PF00082	0.357
CLV_PCSK_KEX2_1	446	448	PF00082	0.785
CLV_PCSK_KEX2_1	451	453	PF00082	0.742
CLV_PCSK_KEX2_1	5	7	PF00082	0.771
CLV_PCSK_KEX2_1	8	10	PF00082	0.760
CLV_PCSK_PC7_1	447	453	PF00082	0.729
CLV_PCSK_SKI1_1	140	144	PF00082	0.446
CLV_PCSK_SKI1_1	317	321	PF00082	0.357
CLV_PCSK_SKI1_1	425	429	PF00082	0.770
DOC_CKS1_1	392	397	PF01111	0.691
DOC_CKS1_1	99	104	PF01111	0.593
DOC_CYCLIN_yClb5_NLxxxL_5	425	431	PF00134	0.654
DOC_PP4_FxxP_1	222	225	PF00568	0.719
DOC_USP7_MATH_1	115	119	PF00917	0.747
DOC_USP7_MATH_1	125	129	PF00917	0.655
DOC_USP7_MATH_1	460	464	PF00917	0.664
DOC_USP7_MATH_2	395	401	PF00917	0.701
DOC_WW_Pin1_4	121	126	PF00397	0.695
DOC_WW_Pin1_4	128	133	PF00397	0.616
DOC_WW_Pin1_4	194	199	PF00397	0.391
DOC_WW_Pin1_4	391	396	PF00397	0.675
DOC_WW_Pin1_4	98	103	PF00397	0.570
LIG_14-3-3_CanoR_1	153	159	PF00244	0.664
LIG_14-3-3_CanoR_1	193	198	PF00244	0.357
LIG_14-3-3_CanoR_1	238	244	PF00244	0.539
LIG_14-3-3_CanoR_1	340	345	PF00244	0.584
LIG_14-3-3_CanoR_1	429	434	PF00244	0.705
LIG_14-3-3_CanoR_1	461	465	PF00244	0.672
LIG_BRCT_BRCA1_1	218	222	PF00533	0.707
LIG_BRCT_BRCA1_1	346	350	PF00533	0.589
LIG_FHA_1	107	113	PF00498	0.744
LIG_FHA_1	137	143	PF00498	0.553
LIG_FHA_1	266	272	PF00498	0.508
LIG_FHA_1	426	432	PF00498	0.715
LIG_FHA_2	378	384	PF00498	0.567
LIG_FHA_2	392	398	PF00498	0.606
LIG_FHA_2	436	442	PF00498	0.769
LIG_FHA_2	464	470	PF00498	0.708
LIG_LIR_Apic_2	219	225	PF02991	0.707
LIG_LIR_Apic_2	322	327	PF02991	0.531
LIG_LIR_Gen_1	383	392	PF02991	0.537
LIG_LIR_Gen_1	66	75	PF02991	0.438
LIG_LIR_Nem_3	383	388	PF02991	0.535
LIG_LIR_Nem_3	66	70	PF02991	0.399
LIG_LIR_Nem_3	92	98	PF02991	0.357
LIG_Pex14_2	266	270	PF04695	0.567
LIG_SH2_CRK	324	328	PF00017	0.533
LIG_SH2_NCK_1	324	328	PF00017	0.533
LIG_SH2_STAP1	171	175	PF00017	0.391
LIG_SH2_STAP1	345	349	PF00017	0.629
LIG_SH2_STAP1	351	355	PF00017	0.507
LIG_SH2_STAT3	161	164	PF00017	0.623
LIG_SH2_STAT3	171	174	PF00017	0.438
LIG_SH2_STAT5	324	327	PF00017	0.581
LIG_SH2_STAT5	374	377	PF00017	0.561
LIG_SH2_STAT5	98	101	PF00017	0.556
LIG_SH3_3	430	436	PF00018	0.547
LIG_SH3_3	96	102	PF00018	0.493
LIG_TYR_ITIM	65	70	PF00017	0.438
MOD_CK1_1	119	125	PF00069	0.741
MOD_CK1_1	128	134	PF00069	0.673
MOD_CK1_1	322	328	PF00069	0.531
MOD_CK1_1	396	402	PF00069	0.741
MOD_CK1_1	4	10	PF00069	0.614
MOD_CK1_1	455	461	PF00069	0.775
MOD_CK1_1	463	469	PF00069	0.593
MOD_CK2_1	110	116	PF00069	0.639
MOD_CK2_1	391	397	PF00069	0.758
MOD_CK2_1	412	418	PF00069	0.681
MOD_Cter_Amidation	314	317	PF01082	0.369
MOD_GlcNHglycan	125	128	PF01048	0.733
MOD_GlcNHglycan	20	23	PF01048	0.696
MOD_GlcNHglycan	205	208	PF01048	0.383
MOD_GlcNHglycan	230	234	PF01048	0.751
MOD_GlcNHglycan	452	455	PF01048	0.789
MOD_GlcNHglycan	91	94	PF01048	0.361
MOD_GSK3_1	106	113	PF00069	0.671
MOD_GSK3_1	115	122	PF00069	0.658
MOD_GSK3_1	12	19	PF00069	0.783
MOD_GSK3_1	265	272	PF00069	0.518
MOD_GSK3_1	340	347	PF00069	0.579
MOD_GSK3_1	349	356	PF00069	0.510
MOD_GSK3_1	393	400	PF00069	0.734
MOD_GSK3_1	421	428	PF00069	0.683
MOD_GSK3_1	51	58	PF00069	0.623
MOD_GSK3_1	83	90	PF00069	0.379
MOD_N-GLC_1	278	283	PF02516	0.456
MOD_N-GLC_1	322	327	PF02516	0.504
MOD_N-GLC_1	425	430	PF02516	0.730
MOD_N-GLC_1	83	88	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	147	152	PF00069	0.505
MOD_NEK2_1	154	159	PF00069	0.589
MOD_NEK2_1	18	23	PF00069	0.591
MOD_NEK2_1	231	236	PF00069	0.532
MOD_NEK2_1	349	354	PF00069	0.584
MOD_NEK2_1	412	417	PF00069	0.755
MOD_NEK2_2	309	314	PF00069	0.391
MOD_NEK2_2	345	350	PF00069	0.503
MOD_PIKK_1	237	243	PF00454	0.533
MOD_PK_1	429	435	PF00069	0.550
MOD_PKA_2	136	142	PF00069	0.683
MOD_PKA_2	192	198	PF00069	0.357
MOD_PKA_2	237	243	PF00069	0.738
MOD_PKA_2	4	10	PF00069	0.720
MOD_PKA_2	412	418	PF00069	0.794
MOD_PKA_2	450	456	PF00069	0.815
MOD_PKA_2	460	466	PF00069	0.731
MOD_Plk_1	179	185	PF00069	0.438
MOD_Plk_1	278	284	PF00069	0.415
MOD_Plk_1	322	328	PF00069	0.505
MOD_Plk_1	396	402	PF00069	0.688
MOD_Plk_1	404	410	PF00069	0.753
MOD_Plk_1	73	79	PF00069	0.389
MOD_Plk_2-3	397	403	PF00069	0.727
MOD_Plk_4	125	131	PF00069	0.712
MOD_Plk_4	179	185	PF00069	0.427
MOD_Plk_4	345	351	PF00069	0.624
MOD_Plk_4	429	435	PF00069	0.679
MOD_Plk_4	460	466	PF00069	0.674
MOD_ProDKin_1	121	127	PF00069	0.696
MOD_ProDKin_1	128	134	PF00069	0.614
MOD_ProDKin_1	194	200	PF00069	0.391
MOD_ProDKin_1	391	397	PF00069	0.681
MOD_ProDKin_1	98	104	PF00069	0.583
MOD_SUMO_rev_2	50	58	PF00179	0.677
TRG_ENDOCYTIC_2	67	70	PF00928	0.438
TRG_ER_diArg_1	302	304	PF00400	0.358
TRG_ER_diArg_1	313	316	PF00400	0.360
TRG_ER_diArg_1	446	448	PF00400	0.783
TRG_ER_diArg_1	5	8	PF00400	0.808

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT1	Leptomonas seymouri	53%	100%
A0A0S4JH24	Bodo saltans	38%	100%
A0A3Q8IJ10	Leishmania donovani	99%	100%
A0A422NNS8	Trypanosoma rangeli	44%	100%
A4HMM6	Leishmania braziliensis	73%	99%
E9AF28	Leishmania major	91%	100%
E9B684	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%