Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB98_LEIIN

TriTrypDb:

LINF_350025000

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.525
CLV_C14_Caspase3-7	621	625	PF00656	0.505
CLV_NRD_NRD_1	15	17	PF00675	0.556
CLV_NRD_NRD_1	3	5	PF00675	0.545
CLV_NRD_NRD_1	436	438	PF00675	0.699
CLV_NRD_NRD_1	565	567	PF00675	0.686
CLV_NRD_NRD_1	643	645	PF00675	0.483
CLV_NRD_NRD_1	658	660	PF00675	0.474
CLV_NRD_NRD_1	777	779	PF00675	0.515
CLV_NRD_NRD_1	800	802	PF00675	0.563
CLV_NRD_NRD_1	871	873	PF00675	0.502
CLV_PCSK_FUR_1	352	356	PF00082	0.545
CLV_PCSK_FUR_1	434	438	PF00082	0.690
CLV_PCSK_FUR_1	798	802	PF00082	0.564
CLV_PCSK_KEX2_1	15	17	PF00082	0.618
CLV_PCSK_KEX2_1	354	356	PF00082	0.541
CLV_PCSK_KEX2_1	436	438	PF00082	0.697
CLV_PCSK_KEX2_1	565	567	PF00082	0.639
CLV_PCSK_KEX2_1	585	587	PF00082	0.509
CLV_PCSK_KEX2_1	658	660	PF00082	0.467
CLV_PCSK_KEX2_1	776	778	PF00082	0.522
CLV_PCSK_KEX2_1	800	802	PF00082	0.563
CLV_PCSK_KEX2_1	871	873	PF00082	0.502
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.516
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.605
CLV_PCSK_PC7_1	773	779	PF00082	0.593
CLV_PCSK_SKI1_1	18	22	PF00082	0.625
CLV_PCSK_SKI1_1	241	245	PF00082	0.477
CLV_PCSK_SKI1_1	256	260	PF00082	0.403
CLV_PCSK_SKI1_1	388	392	PF00082	0.469
CLV_PCSK_SKI1_1	565	569	PF00082	0.690
CLV_PCSK_SKI1_1	589	593	PF00082	0.540
CLV_PCSK_SKI1_1	632	636	PF00082	0.384
CLV_PCSK_SKI1_1	685	689	PF00082	0.381
CLV_PCSK_SKI1_1	851	855	PF00082	0.612
CLV_PCSK_SKI1_1	87	91	PF00082	0.804
CLV_PCSK_SKI1_1	97	101	PF00082	0.570
DEG_APCC_DBOX_1	684	692	PF00400	0.378
DEG_COP1_1	442	452	PF00400	0.552
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DEG_SCF_FBW7_2	88	94	PF00400	0.644
DEG_SPOP_SBC_1	743	747	PF00917	0.655
DOC_ANK_TNKS_1	289	296	PF00023	0.512
DOC_CDC14_PxL_1	717	725	PF14671	0.402
DOC_CKS1_1	834	839	PF01111	0.553
DOC_CKS1_1	88	93	PF01111	0.696
DOC_CYCLIN_yClb3_PxF_3	322	328	PF00134	0.571
DOC_MAPK_gen_1	385	394	PF00069	0.472
DOC_MAPK_gen_1	644	652	PF00069	0.539
DOC_MAPK_gen_1	668	676	PF00069	0.418
DOC_MAPK_gen_1	773	781	PF00069	0.600
DOC_MAPK_MEF2A_6	230	239	PF00069	0.555
DOC_MAPK_MEF2A_6	644	652	PF00069	0.569
DOC_MAPK_MEF2A_6	698	707	PF00069	0.397
DOC_MAPK_NFAT4_5	645	653	PF00069	0.574
DOC_PP1_RVXF_1	352	359	PF00149	0.539
DOC_PP1_SILK_1	213	218	PF00149	0.441
DOC_PP2B_LxvP_1	547	550	PF13499	0.621
DOC_PP2B_LxvP_1	74	77	PF13499	0.591
DOC_PP4_FxxP_1	752	755	PF00568	0.592
DOC_USP7_MATH_1	160	164	PF00917	0.597
DOC_USP7_MATH_1	228	232	PF00917	0.555
DOC_USP7_MATH_1	263	267	PF00917	0.564
DOC_USP7_MATH_1	282	286	PF00917	0.332
DOC_USP7_MATH_1	288	292	PF00917	0.433
DOC_USP7_MATH_1	48	52	PF00917	0.591
DOC_USP7_MATH_1	573	577	PF00917	0.634
DOC_USP7_MATH_1	604	608	PF00917	0.633
DOC_USP7_MATH_1	75	79	PF00917	0.641
DOC_USP7_UBL2_3	585	589	PF12436	0.657
DOC_WW_Pin1_4	151	156	PF00397	0.431
DOC_WW_Pin1_4	203	208	PF00397	0.483
DOC_WW_Pin1_4	231	236	PF00397	0.658
DOC_WW_Pin1_4	24	29	PF00397	0.630
DOC_WW_Pin1_4	333	338	PF00397	0.611
DOC_WW_Pin1_4	439	444	PF00397	0.574
DOC_WW_Pin1_4	52	57	PF00397	0.577
DOC_WW_Pin1_4	733	738	PF00397	0.626
DOC_WW_Pin1_4	746	751	PF00397	0.557
DOC_WW_Pin1_4	833	838	PF00397	0.660
DOC_WW_Pin1_4	87	92	PF00397	0.692
LIG_14-3-3_CanoR_1	209	216	PF00244	0.511
LIG_14-3-3_CanoR_1	230	235	PF00244	0.555
LIG_14-3-3_CanoR_1	355	359	PF00244	0.447
LIG_14-3-3_CanoR_1	632	638	PF00244	0.460
LIG_14-3-3_CanoR_1	644	649	PF00244	0.476
LIG_14-3-3_CanoR_1	716	721	PF00244	0.457
LIG_14-3-3_CanoR_1	851	857	PF00244	0.539
LIG_Actin_WH2_2	194	211	PF00022	0.582
LIG_Actin_WH2_2	495	512	PF00022	0.502
LIG_Actin_WH2_2	669	687	PF00022	0.430
LIG_BIR_III_4	271	275	PF00653	0.408
LIG_BIR_III_4	98	102	PF00653	0.492
LIG_BRCT_BRCA1_1	162	166	PF00533	0.520
LIG_BRCT_BRCA1_1	444	448	PF00533	0.592
LIG_BRCT_BRCA1_1	748	752	PF00533	0.577
LIG_CaM_NSCaTE_8	342	349	PF13499	0.467
LIG_CtBP_PxDLS_1	704	709	PF00389	0.478
LIG_deltaCOP1_diTrp_1	157	161	PF00928	0.592
LIG_deltaCOP1_diTrp_1	305	312	PF00928	0.448
LIG_eIF4E_1	717	723	PF01652	0.405
LIG_FHA_1	304	310	PF00498	0.592
LIG_FHA_1	389	395	PF00498	0.546
LIG_FHA_1	509	515	PF00498	0.448
LIG_FHA_1	551	557	PF00498	0.785
LIG_FHA_1	633	639	PF00498	0.349
LIG_FHA_1	65	71	PF00498	0.547
LIG_FHA_1	717	723	PF00498	0.437
LIG_FHA_1	828	834	PF00498	0.618
LIG_FHA_1	859	865	PF00498	0.523
LIG_FHA_1	897	903	PF00498	0.643
LIG_FHA_1	907	913	PF00498	0.547
LIG_FHA_2	396	402	PF00498	0.422
LIG_FHA_2	517	523	PF00498	0.511
LIG_FHA_2	762	768	PF00498	0.573
LIG_FHA_2	816	822	PF00498	0.691
LIG_GBD_Chelix_1	420	428	PF00786	0.504
LIG_LIR_Apic_2	749	755	PF02991	0.586
LIG_LIR_Gen_1	305	315	PF02991	0.452
LIG_LIR_Gen_1	725	734	PF02991	0.437
LIG_LIR_Nem_3	104	109	PF02991	0.537
LIG_LIR_Nem_3	305	311	PF02991	0.452
LIG_LIR_Nem_3	477	482	PF02991	0.457
LIG_LIR_Nem_3	714	720	PF02991	0.423
LIG_LIR_Nem_3	725	730	PF02991	0.404
LIG_MYND_1	323	327	PF01753	0.548
LIG_NRBOX	126	132	PF00104	0.621
LIG_NRBOX	462	468	PF00104	0.460
LIG_NRBOX	485	491	PF00104	0.374
LIG_NRBOX	633	639	PF00104	0.370
LIG_NRBOX	687	693	PF00104	0.385
LIG_PCNA_yPIPBox_3	835	846	PF02747	0.532
LIG_SH2_CRK	718	722	PF00017	0.406
LIG_SH2_NCK_1	496	500	PF00017	0.481
LIG_SH2_NCK_1	859	863	PF00017	0.481
LIG_SH2_SRC	794	797	PF00017	0.616
LIG_SH2_STAP1	459	463	PF00017	0.360
LIG_SH2_STAP1	496	500	PF00017	0.481
LIG_SH2_STAT5	465	468	PF00017	0.387
LIG_SH2_STAT5	479	482	PF00017	0.411
LIG_SH2_STAT5	696	699	PF00017	0.486
LIG_SH2_STAT5	718	721	PF00017	0.413
LIG_SH2_STAT5	727	730	PF00017	0.412
LIG_SH3_1	85	91	PF00018	0.630
LIG_SH3_3	117	123	PF00018	0.510
LIG_SH3_3	23	29	PF00018	0.571
LIG_SH3_3	232	238	PF00018	0.573
LIG_SH3_3	320	326	PF00018	0.607
LIG_SH3_3	432	438	PF00018	0.628
LIG_SH3_3	576	582	PF00018	0.545
LIG_SH3_3	649	655	PF00018	0.559
LIG_SH3_3	727	733	PF00018	0.569
LIG_SH3_3	786	792	PF00018	0.541
LIG_SH3_3	811	817	PF00018	0.718
LIG_SH3_3	831	837	PF00018	0.567
LIG_SH3_3	85	91	PF00018	0.642
LIG_SH3_3	899	905	PF00018	0.642
LIG_SUMO_SIM_anti_2	60	69	PF11976	0.630
LIG_SUMO_SIM_par_1	635	643	PF11976	0.388
LIG_SUMO_SIM_par_1	880	886	PF11976	0.659
LIG_TRAF2_1	91	94	PF00917	0.647
LIG_TYR_ITIM	715	720	PF00017	0.426
LIG_UBA3_1	637	645	PF00899	0.414
MOD_CDC14_SPxK_1	206	209	PF00782	0.544
MOD_CDK_SPxK_1	203	209	PF00069	0.554
MOD_CDK_SPxK_1	735	741	PF00069	0.403
MOD_CDK_SPxxK_3	833	840	PF00069	0.567
MOD_CK1_1	231	237	PF00069	0.578
MOD_CK1_1	254	260	PF00069	0.505
MOD_CK1_1	266	272	PF00069	0.318
MOD_CK1_1	27	33	PF00069	0.630
MOD_CK1_1	310	316	PF00069	0.499
MOD_CK1_1	442	448	PF00069	0.596
MOD_CK1_1	475	481	PF00069	0.553
MOD_CK1_1	491	497	PF00069	0.320
MOD_CK1_1	66	72	PF00069	0.637
MOD_CK1_1	745	751	PF00069	0.655
MOD_CK1_1	822	828	PF00069	0.769
MOD_CK1_1	858	864	PF00069	0.509
MOD_CK2_1	122	128	PF00069	0.560
MOD_CK2_1	129	135	PF00069	0.559
MOD_CK2_1	395	401	PF00069	0.432
MOD_CK2_1	516	522	PF00069	0.613
MOD_CK2_1	535	541	PF00069	0.285
MOD_CK2_1	633	639	PF00069	0.384
MOD_CK2_1	761	767	PF00069	0.582
MOD_CMANNOS	158	161	PF00535	0.418
MOD_Cter_Amidation	2	5	PF01082	0.595
MOD_Cter_Amidation	583	586	PF01082	0.625
MOD_GlcNHglycan	162	165	PF01048	0.521
MOD_GlcNHglycan	230	233	PF01048	0.674
MOD_GlcNHglycan	333	336	PF01048	0.580
MOD_GlcNHglycan	343	346	PF01048	0.595
MOD_GlcNHglycan	347	350	PF01048	0.662
MOD_GlcNHglycan	370	373	PF01048	0.622
MOD_GlcNHglycan	41	44	PF01048	0.562
MOD_GlcNHglycan	439	442	PF01048	0.685
MOD_GlcNHglycan	469	472	PF01048	0.461
MOD_GlcNHglycan	575	578	PF01048	0.756
MOD_GlcNHglycan	607	610	PF01048	0.501
MOD_GlcNHglycan	752	755	PF01048	0.692
MOD_GlcNHglycan	77	80	PF01048	0.645
MOD_GlcNHglycan	823	827	PF01048	0.657
MOD_GlcNHglycan	885	888	PF01048	0.683
MOD_GSK3_1	182	189	PF00069	0.623
MOD_GSK3_1	24	31	PF00069	0.661
MOD_GSK3_1	280	287	PF00069	0.568
MOD_GSK3_1	303	310	PF00069	0.495
MOD_GSK3_1	313	320	PF00069	0.535
MOD_GSK3_1	341	348	PF00069	0.495
MOD_GSK3_1	39	46	PF00069	0.493
MOD_GSK3_1	444	451	PF00069	0.636
MOD_GSK3_1	48	55	PF00069	0.603
MOD_GSK3_1	484	491	PF00069	0.444
MOD_GSK3_1	550	557	PF00069	0.630
MOD_GSK3_1	605	612	PF00069	0.550
MOD_GSK3_1	640	647	PF00069	0.465
MOD_GSK3_1	742	749	PF00069	0.674
MOD_GSK3_1	815	822	PF00069	0.780
MOD_GSK3_1	83	90	PF00069	0.654
MOD_GSK3_1	847	854	PF00069	0.525
MOD_GSK3_1	883	890	PF00069	0.623
MOD_GSK3_1	892	899	PF00069	0.641
MOD_GSK3_1	906	913	PF00069	0.508
MOD_N-GLC_1	484	489	PF02516	0.528
MOD_N-GLC_1	605	610	PF02516	0.507
MOD_N-GLC_1	787	792	PF02516	0.540
MOD_NEK2_1	166	171	PF00069	0.508
MOD_NEK2_1	208	213	PF00069	0.523
MOD_NEK2_1	280	285	PF00069	0.480
MOD_NEK2_1	395	400	PF00069	0.466
MOD_NEK2_1	402	407	PF00069	0.395
MOD_NEK2_1	466	471	PF00069	0.402
MOD_NEK2_1	488	493	PF00069	0.421
MOD_NEK2_1	498	503	PF00069	0.417
MOD_NEK2_1	633	638	PF00069	0.389
MOD_NEK2_1	640	645	PF00069	0.466
MOD_NEK2_1	703	708	PF00069	0.372
MOD_NEK2_1	722	727	PF00069	0.409
MOD_NEK2_1	847	852	PF00069	0.491
MOD_PIKK_1	222	228	PF00454	0.580
MOD_PIKK_1	310	316	PF00454	0.442
MOD_PIKK_1	317	323	PF00454	0.567
MOD_PIKK_1	395	401	PF00454	0.432
MOD_PIKK_1	488	494	PF00454	0.439
MOD_PIKK_1	698	704	PF00454	0.379
MOD_PIKK_1	887	893	PF00454	0.536
MOD_PIKK_1	89	95	PF00454	0.621
MOD_PKA_1	354	360	PF00069	0.528
MOD_PKA_1	644	650	PF00069	0.533
MOD_PKA_2	208	214	PF00069	0.573
MOD_PKA_2	303	309	PF00069	0.594
MOD_PKA_2	354	360	PF00069	0.448
MOD_PKA_2	380	386	PF00069	0.496
MOD_PKA_2	475	481	PF00069	0.507
MOD_PKA_2	896	902	PF00069	0.592
MOD_PKB_1	16	24	PF00069	0.650
MOD_Plk_1	263	269	PF00069	0.514
MOD_Plk_1	484	490	PF00069	0.415
MOD_Plk_1	662	668	PF00069	0.455
MOD_Plk_2-3	618	624	PF00069	0.518
MOD_Plk_2-3	761	767	PF00069	0.582
MOD_Plk_4	241	247	PF00069	0.475
MOD_Plk_4	303	309	PF00069	0.482
MOD_Plk_4	444	450	PF00069	0.605
MOD_Plk_4	475	481	PF00069	0.517
MOD_Plk_4	484	490	PF00069	0.425
MOD_Plk_4	491	497	PF00069	0.355
MOD_Plk_4	498	504	PF00069	0.345
MOD_Plk_4	508	514	PF00069	0.466
MOD_Plk_4	633	639	PF00069	0.370
MOD_Plk_4	687	693	PF00069	0.385
MOD_Plk_4	703	709	PF00069	0.394
MOD_Plk_4	722	728	PF00069	0.394
MOD_ProDKin_1	151	157	PF00069	0.429
MOD_ProDKin_1	203	209	PF00069	0.473
MOD_ProDKin_1	231	237	PF00069	0.649
MOD_ProDKin_1	24	30	PF00069	0.629
MOD_ProDKin_1	333	339	PF00069	0.606
MOD_ProDKin_1	439	445	PF00069	0.571
MOD_ProDKin_1	52	58	PF00069	0.580
MOD_ProDKin_1	733	739	PF00069	0.628
MOD_ProDKin_1	746	752	PF00069	0.560
MOD_ProDKin_1	833	839	PF00069	0.648
MOD_ProDKin_1	87	93	PF00069	0.696
TRG_DiLeu_BaEn_1	126	131	PF01217	0.550
TRG_DiLeu_BaEn_1	595	600	PF01217	0.572
TRG_DiLeu_BaEn_4	595	601	PF01217	0.549
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.458
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.441
TRG_DiLeu_BaLyEn_6	629	634	PF01217	0.425
TRG_DiLeu_BaLyEn_6	718	723	PF01217	0.402
TRG_DiLeu_LyEn_5	126	131	PF01217	0.623
TRG_ENDOCYTIC_2	106	109	PF00928	0.671
TRG_ENDOCYTIC_2	459	462	PF00928	0.361
TRG_ENDOCYTIC_2	717	720	PF00928	0.413
TRG_ENDOCYTIC_2	727	730	PF00928	0.412
TRG_ER_diArg_1	14	16	PF00400	0.546
TRG_ER_diArg_1	434	437	PF00400	0.689
TRG_ER_diArg_1	473	476	PF00400	0.481
TRG_ER_diArg_1	657	659	PF00400	0.481
TRG_ER_diArg_1	775	778	PF00400	0.508
TRG_ER_diArg_1	871	873	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	659	663	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA60	Leptomonas seymouri	48%	99%
A0A3Q8IV80	Leishmania donovani	99%	100%
A4HMM0	Leishmania braziliensis	74%	100%
E9AF22	Leishmania major	94%	100%
E9B678	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%