Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB90_LEIIN

TriTrypDb:

LINF_350024200

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4IB90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.674
CLV_C14_Caspase3-7	8	12	PF00656	0.564
CLV_NRD_NRD_1	32	34	PF00675	0.457
CLV_NRD_NRD_1	93	95	PF00675	0.402
CLV_PCSK_KEX2_1	32	34	PF00082	0.409
CLV_PCSK_KEX2_1	93	95	PF00082	0.438
CLV_PCSK_PC7_1	28	34	PF00082	0.375
CLV_PCSK_SKI1_1	303	307	PF00082	0.608
CLV_PCSK_SKI1_1	81	85	PF00082	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.609
DOC_CKS1_1	172	177	PF01111	0.610
DOC_CKS1_1	52	57	PF01111	0.649
DOC_MAPK_MEF2A_6	256	264	PF00069	0.421
DOC_PP2B_LxvP_1	135	138	PF13499	0.652
DOC_USP7_MATH_1	129	133	PF00917	0.674
DOC_USP7_MATH_1	195	199	PF00917	0.712
DOC_USP7_MATH_1	200	204	PF00917	0.576
DOC_USP7_MATH_1	220	224	PF00917	0.583
DOC_USP7_MATH_1	50	54	PF00917	0.672
DOC_WW_Pin1_4	171	176	PF00397	0.604
DOC_WW_Pin1_4	222	227	PF00397	0.656
DOC_WW_Pin1_4	44	49	PF00397	0.803
DOC_WW_Pin1_4	51	56	PF00397	0.749
LIG_14-3-3_CanoR_1	81	89	PF00244	0.599
LIG_Actin_WH2_2	12	30	PF00022	0.563
LIG_BIR_III_4	63	67	PF00653	0.664
LIG_BIR_III_4	70	74	PF00653	0.604
LIG_deltaCOP1_diTrp_1	97	108	PF00928	0.569
LIG_FHA_1	167	173	PF00498	0.604
LIG_FHA_1	82	88	PF00498	0.572
LIG_FHA_2	316	322	PF00498	0.370
LIG_FHA_2	72	78	PF00498	0.536
LIG_LIR_Gen_1	149	160	PF02991	0.570
LIG_LIR_Gen_1	174	180	PF02991	0.620
LIG_LIR_Gen_1	21	31	PF02991	0.573
LIG_LIR_Nem_3	149	155	PF02991	0.575
LIG_LIR_Nem_3	174	179	PF02991	0.617
LIG_LIR_Nem_3	21	27	PF02991	0.568
LIG_LIR_Nem_3	77	82	PF02991	0.642
LIG_NRBOX	312	318	PF00104	0.387
LIG_PDZ_Class_1	321	326	PF00595	0.434
LIG_Pex14_1	108	112	PF04695	0.563
LIG_Pex14_1	259	263	PF04695	0.310
LIG_PTB_Apo_2	170	177	PF02174	0.579
LIG_SH2_CRK	156	160	PF00017	0.560
LIG_SH2_CRK	24	28	PF00017	0.570
LIG_SH2_NCK_1	186	190	PF00017	0.566
LIG_SH2_SRC	186	189	PF00017	0.588
LIG_SH2_STAP1	156	160	PF00017	0.560
LIG_SH2_STAP1	294	298	PF00017	0.420
LIG_SH2_STAT5	178	181	PF00017	0.580
LIG_SH2_STAT5	24	27	PF00017	0.574
LIG_SH2_STAT5	79	82	PF00017	0.574
LIG_SH3_3	169	175	PF00018	0.602
MOD_CDC14_SPxK_1	225	228	PF00782	0.654
MOD_CDK_SPxK_1	222	228	PF00069	0.657
MOD_CK1_1	273	279	PF00069	0.310
MOD_CK1_1	315	321	PF00069	0.367
MOD_CK2_1	201	207	PF00069	0.718
MOD_CK2_1	315	321	PF00069	0.367
MOD_CK2_1	50	56	PF00069	0.755
MOD_CK2_1	71	77	PF00069	0.617
MOD_GlcNHglycan	125	128	PF01048	0.443
MOD_GlcNHglycan	130	134	PF01048	0.470
MOD_GlcNHglycan	197	200	PF01048	0.472
MOD_GlcNHglycan	239	244	PF01048	0.411
MOD_GlcNHglycan	276	279	PF01048	0.302
MOD_GlcNHglycan	295	298	PF01048	0.536
MOD_GlcNHglycan	70	74	PF01048	0.431
MOD_GSK3_1	18	25	PF00069	0.554
MOD_GSK3_1	220	227	PF00069	0.658
MOD_GSK3_1	270	277	PF00069	0.283
MOD_GSK3_1	315	322	PF00069	0.368
MOD_GSK3_1	50	57	PF00069	0.744
MOD_NEK2_1	252	257	PF00069	0.600
MOD_NEK2_1	26	31	PF00069	0.577
MOD_NEK2_1	274	279	PF00069	0.459
MOD_NEK2_1	293	298	PF00069	0.363
MOD_NEK2_1	305	310	PF00069	0.378
MOD_NEK2_1	320	325	PF00069	0.415
MOD_PIKK_1	117	123	PF00454	0.626
MOD_PIKK_1	201	207	PF00454	0.647
MOD_PIKK_1	305	311	PF00454	0.381
MOD_PKA_1	93	99	PF00069	0.603
MOD_PKA_2	93	99	PF00069	0.603
MOD_Plk_1	22	28	PF00069	0.558
MOD_Plk_1	239	245	PF00069	0.644
MOD_Plk_1	320	326	PF00069	0.386
MOD_Plk_4	22	28	PF00069	0.569
MOD_Plk_4	312	318	PF00069	0.513
MOD_ProDKin_1	171	177	PF00069	0.605
MOD_ProDKin_1	222	228	PF00069	0.655
MOD_ProDKin_1	44	50	PF00069	0.804
MOD_ProDKin_1	51	57	PF00069	0.748
TRG_DiLeu_BaEn_1	22	27	PF01217	0.565
TRG_DiLeu_BaEn_4	97	103	PF01217	0.593
TRG_ENDOCYTIC_2	156	159	PF00928	0.562
TRG_ENDOCYTIC_2	24	27	PF00928	0.574
TRG_ER_diArg_1	249	252	PF00400	0.612
TRG_ER_diArg_1	31	33	PF00400	0.652
TRG_ER_diArg_1	87	90	PF00400	0.629
TRG_NES_CRM1_1	8	22	PF08389	0.564
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9K1	Leptomonas seymouri	40%	98%
A0A3Q8IG78	Leishmania donovani	99%	100%
A4HML3	Leishmania braziliensis	70%	99%
E9AF14	Leishmania major	89%	100%
E9B670	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%