LeishMANIAdb
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RNA-dependent RNA polymerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RNA-dependent RNA polymerase
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IB83_LEIIN
TriTrypDb:
LINF_350023200
Length:
739

Annotations

LeishMANIAdb annotations

Almost certainly non-TM

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB83

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.556
CLV_NRD_NRD_1 211 213 PF00675 0.605
CLV_NRD_NRD_1 320 322 PF00675 0.486
CLV_NRD_NRD_1 488 490 PF00675 0.464
CLV_NRD_NRD_1 502 504 PF00675 0.411
CLV_NRD_NRD_1 647 649 PF00675 0.450
CLV_PCSK_KEX2_1 102 104 PF00082 0.556
CLV_PCSK_KEX2_1 211 213 PF00082 0.534
CLV_PCSK_KEX2_1 488 490 PF00082 0.470
CLV_PCSK_KEX2_1 502 504 PF00082 0.412
CLV_PCSK_KEX2_1 647 649 PF00082 0.450
CLV_PCSK_SKI1_1 250 254 PF00082 0.418
CLV_PCSK_SKI1_1 336 340 PF00082 0.537
CLV_PCSK_SKI1_1 440 444 PF00082 0.419
CLV_PCSK_SKI1_1 569 573 PF00082 0.426
CLV_PCSK_SKI1_1 649 653 PF00082 0.602
CLV_PCSK_SKI1_1 708 712 PF00082 0.466
DOC_CKS1_1 661 666 PF01111 0.568
DOC_CYCLIN_RxL_1 284 295 PF00134 0.524
DOC_CYCLIN_RxL_1 424 432 PF00134 0.453
DOC_CYCLIN_yCln2_LP_2 625 631 PF00134 0.402
DOC_MAPK_gen_1 102 110 PF00069 0.558
DOC_MAPK_gen_1 437 444 PF00069 0.439
DOC_MAPK_RevD_3 526 540 PF00069 0.512
DOC_PP1_RVXF_1 285 292 PF00149 0.603
DOC_PP1_RVXF_1 438 445 PF00149 0.399
DOC_PP1_SILK_1 332 337 PF00149 0.589
DOC_PP4_FxxP_1 421 424 PF00568 0.420
DOC_PP4_FxxP_1 661 664 PF00568 0.560
DOC_USP7_MATH_1 135 139 PF00917 0.592
DOC_USP7_MATH_1 2 6 PF00917 0.739
DOC_USP7_MATH_1 234 238 PF00917 0.584
DOC_USP7_MATH_1 280 284 PF00917 0.670
DOC_USP7_MATH_1 337 341 PF00917 0.525
DOC_USP7_UBL2_3 339 343 PF12436 0.572
DOC_WW_Pin1_4 111 116 PF00397 0.417
DOC_WW_Pin1_4 420 425 PF00397 0.406
DOC_WW_Pin1_4 660 665 PF00397 0.533
LIG_14-3-3_CanoR_1 143 151 PF00244 0.499
LIG_14-3-3_CanoR_1 232 242 PF00244 0.531
LIG_14-3-3_CanoR_1 321 325 PF00244 0.468
LIG_14-3-3_CanoR_1 327 335 PF00244 0.446
LIG_14-3-3_CanoR_1 336 342 PF00244 0.439
LIG_14-3-3_CanoR_1 391 395 PF00244 0.552
LIG_14-3-3_CanoR_1 569 575 PF00244 0.452
LIG_14-3-3_CanoR_1 619 627 PF00244 0.424
LIG_14-3-3_CanoR_1 648 654 PF00244 0.562
LIG_14-3-3_CanoR_1 80 88 PF00244 0.522
LIG_Actin_WH2_2 195 213 PF00022 0.527
LIG_Actin_WH2_2 66 82 PF00022 0.467
LIG_APCC_ABBA_1 220 225 PF00400 0.461
LIG_BRCT_BRCA1_1 73 77 PF00533 0.494
LIG_Clathr_ClatBox_1 133 137 PF01394 0.422
LIG_deltaCOP1_diTrp_1 688 695 PF00928 0.412
LIG_EH_1 30 34 PF12763 0.548
LIG_eIF4E_1 611 617 PF01652 0.458
LIG_FHA_1 143 149 PF00498 0.557
LIG_FHA_1 329 335 PF00498 0.569
LIG_FHA_1 372 378 PF00498 0.599
LIG_FHA_1 466 472 PF00498 0.440
LIG_FHA_1 54 60 PF00498 0.574
LIG_FHA_1 548 554 PF00498 0.504
LIG_FHA_1 630 636 PF00498 0.457
LIG_FHA_2 321 327 PF00498 0.560
LIG_FHA_2 593 599 PF00498 0.544
LIG_FHA_2 635 641 PF00498 0.446
LIG_FHA_2 697 703 PF00498 0.478
LIG_IBAR_NPY_1 602 604 PF08397 0.488
LIG_LIR_Apic_2 418 424 PF02991 0.418
LIG_LIR_Gen_1 122 130 PF02991 0.541
LIG_LIR_Gen_1 228 235 PF02991 0.592
LIG_LIR_Gen_1 398 407 PF02991 0.468
LIG_LIR_Gen_1 482 490 PF02991 0.469
LIG_LIR_Nem_3 122 126 PF02991 0.555
LIG_LIR_Nem_3 214 219 PF02991 0.484
LIG_LIR_Nem_3 228 233 PF02991 0.494
LIG_LIR_Nem_3 251 256 PF02991 0.401
LIG_LIR_Nem_3 305 309 PF02991 0.502
LIG_LIR_Nem_3 374 379 PF02991 0.636
LIG_LIR_Nem_3 398 402 PF02991 0.397
LIG_LIR_Nem_3 448 454 PF02991 0.533
LIG_LIR_Nem_3 482 487 PF02991 0.483
LIG_LIR_Nem_3 510 515 PF02991 0.401
LIG_LIR_Nem_3 584 588 PF02991 0.446
LIG_LIR_Nem_3 626 630 PF02991 0.549
LIG_LIR_Nem_3 705 710 PF02991 0.439
LIG_NRBOX 527 533 PF00104 0.454
LIG_Pex14_2 249 253 PF04695 0.526
LIG_Pex14_2 417 421 PF04695 0.515
LIG_Pex14_2 623 627 PF04695 0.413
LIG_PTB_Apo_2 141 148 PF02174 0.530
LIG_PTB_Apo_2 505 512 PF02174 0.481
LIG_PTB_Phospho_1 141 147 PF10480 0.533
LIG_REV1ctd_RIR_1 441 450 PF16727 0.445
LIG_REV1ctd_RIR_1 708 715 PF16727 0.489
LIG_SH2_CRK 230 234 PF00017 0.541
LIG_SH2_CRK 399 403 PF00017 0.394
LIG_SH2_CRK 484 488 PF00017 0.489
LIG_SH2_GRB2like 506 509 PF00017 0.491
LIG_SH2_NCK_1 230 234 PF00017 0.541
LIG_SH2_NCK_1 45 49 PF00017 0.537
LIG_SH2_PTP2 123 126 PF00017 0.549
LIG_SH2_PTP2 376 379 PF00017 0.637
LIG_SH2_SRC 185 188 PF00017 0.534
LIG_SH2_SRC 484 487 PF00017 0.546
LIG_SH2_SRC 506 509 PF00017 0.489
LIG_SH2_SRC 604 607 PF00017 0.439
LIG_SH2_STAP1 230 234 PF00017 0.526
LIG_SH2_STAP1 245 249 PF00017 0.383
LIG_SH2_STAT3 312 315 PF00017 0.540
LIG_SH2_STAT3 392 395 PF00017 0.503
LIG_SH2_STAT5 123 126 PF00017 0.445
LIG_SH2_STAT5 147 150 PF00017 0.530
LIG_SH2_STAT5 185 188 PF00017 0.534
LIG_SH2_STAT5 22 25 PF00017 0.565
LIG_SH2_STAT5 230 233 PF00017 0.518
LIG_SH2_STAT5 307 310 PF00017 0.502
LIG_SH2_STAT5 351 354 PF00017 0.452
LIG_SH2_STAT5 376 379 PF00017 0.534
LIG_SH2_STAT5 392 395 PF00017 0.421
LIG_SH2_STAT5 420 423 PF00017 0.416
LIG_SH2_STAT5 45 48 PF00017 0.439
LIG_SH2_STAT5 486 489 PF00017 0.485
LIG_SH2_STAT5 506 509 PF00017 0.239
LIG_SH2_STAT5 604 607 PF00017 0.439
LIG_SH2_STAT5 734 737 PF00017 0.472
LIG_SH3_2 716 721 PF14604 0.552
LIG_SH3_3 184 190 PF00018 0.509
LIG_SH3_3 365 371 PF00018 0.532
LIG_SH3_3 651 657 PF00018 0.550
LIG_SH3_3 713 719 PF00018 0.472
LIG_SUMO_SIM_anti_2 114 120 PF11976 0.430
LIG_SUMO_SIM_par_1 109 114 PF11976 0.415
LIG_SUMO_SIM_par_1 117 122 PF11976 0.408
LIG_SUMO_SIM_par_1 549 557 PF11976 0.492
LIG_TRAF2_1 642 645 PF00917 0.446
LIG_TYR_ITIM 121 126 PF00017 0.547
LIG_TYR_ITIM 183 188 PF00017 0.525
LIG_TYR_ITSM 372 379 PF00017 0.625
LIG_UBA3_1 531 540 PF00899 0.510
LIG_WRC_WIRS_1 451 456 PF05994 0.498
LIG_WRC_WIRS_1 466 471 PF05994 0.352
MOD_CDK_SPxxK_3 420 427 PF00069 0.407
MOD_CK1_1 267 273 PF00069 0.478
MOD_CK1_1 329 335 PF00069 0.569
MOD_CK1_1 453 459 PF00069 0.511
MOD_CK1_1 81 87 PF00069 0.419
MOD_CK2_1 280 286 PF00069 0.656
MOD_CK2_1 308 314 PF00069 0.529
MOD_CK2_1 592 598 PF00069 0.555
MOD_CK2_1 634 640 PF00069 0.452
MOD_CK2_1 696 702 PF00069 0.438
MOD_GlcNHglycan 195 198 PF01048 0.502
MOD_GlcNHglycan 236 239 PF01048 0.550
MOD_GlcNHglycan 281 285 PF01048 0.690
MOD_GlcNHglycan 339 342 PF01048 0.560
MOD_GlcNHglycan 402 405 PF01048 0.396
MOD_GlcNHglycan 532 535 PF01048 0.532
MOD_GlcNHglycan 671 674 PF01048 0.541
MOD_GlcNHglycan 680 683 PF01048 0.501
MOD_GSK3_1 142 149 PF00069 0.616
MOD_GSK3_1 18 25 PF00069 0.543
MOD_GSK3_1 189 196 PF00069 0.477
MOD_GSK3_1 316 323 PF00069 0.536
MOD_GSK3_1 326 333 PF00069 0.513
MOD_GSK3_1 425 432 PF00069 0.434
MOD_GSK3_1 680 687 PF00069 0.500
MOD_N-GLC_1 507 512 PF02516 0.481
MOD_N-GLC_1 547 552 PF02516 0.499
MOD_NEK2_1 320 325 PF00069 0.471
MOD_NEK2_1 429 434 PF00069 0.425
MOD_NEK2_1 547 552 PF00069 0.558
MOD_NEK2_1 78 83 PF00069 0.432
MOD_NEK2_2 2 7 PF00069 0.729
MOD_PIKK_1 453 459 PF00454 0.443
MOD_PIKK_1 81 87 PF00454 0.419
MOD_PKA_1 211 217 PF00069 0.585
MOD_PKA_2 142 148 PF00069 0.558
MOD_PKA_2 211 217 PF00069 0.398
MOD_PKA_2 320 326 PF00069 0.472
MOD_PKA_2 390 396 PF00069 0.554
MOD_PKA_2 40 46 PF00069 0.498
MOD_PKA_2 618 624 PF00069 0.435
MOD_PKA_2 684 690 PF00069 0.528
MOD_PKA_2 79 85 PF00069 0.529
MOD_Plk_1 297 303 PF00069 0.466
MOD_Plk_1 507 513 PF00069 0.478
MOD_Plk_2-3 305 311 PF00069 0.414
MOD_Plk_4 256 262 PF00069 0.537
MOD_Plk_4 330 336 PF00069 0.525
MOD_Plk_4 372 378 PF00069 0.627
MOD_Plk_4 425 431 PF00069 0.433
MOD_Plk_4 450 456 PF00069 0.530
MOD_Plk_4 507 513 PF00069 0.408
MOD_Plk_4 527 533 PF00069 0.236
MOD_ProDKin_1 111 117 PF00069 0.411
MOD_ProDKin_1 420 426 PF00069 0.403
MOD_ProDKin_1 660 666 PF00069 0.533
MOD_SUMO_rev_2 169 178 PF00179 0.504
MOD_SUMO_rev_2 364 374 PF00179 0.496
TRG_DiLeu_BaEn_1 198 203 PF01217 0.456
TRG_DiLeu_BaEn_1 384 389 PF01217 0.533
TRG_DiLeu_BaEn_1 527 532 PF01217 0.448
TRG_DiLeu_BaLyEn_6 147 152 PF01217 0.453
TRG_DiLeu_BaLyEn_6 158 163 PF01217 0.477
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.593
TRG_DiLeu_BaLyEn_6 542 547 PF01217 0.488
TRG_ENDOCYTIC_2 123 126 PF00928 0.549
TRG_ENDOCYTIC_2 185 188 PF00928 0.534
TRG_ENDOCYTIC_2 216 219 PF00928 0.475
TRG_ENDOCYTIC_2 230 233 PF00928 0.480
TRG_ENDOCYTIC_2 376 379 PF00928 0.637
TRG_ENDOCYTIC_2 399 402 PF00928 0.392
TRG_ENDOCYTIC_2 451 454 PF00928 0.510
TRG_ENDOCYTIC_2 484 487 PF00928 0.483
TRG_ENDOCYTIC_2 707 710 PF00928 0.457
TRG_ER_diArg_1 210 212 PF00400 0.466
TRG_ER_diArg_1 487 489 PF00400 0.441
TRG_ER_diArg_1 646 648 PF00400 0.455
TRG_NES_CRM1_1 294 305 PF08389 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4C7 Leptomonas seymouri 84% 100%
A0A0S4ILQ1 Bodo saltans 59% 99%
A0A1X0P5V8 Trypanosomatidae 65% 100%
A0A3Q8IHX6 Leishmania donovani 100% 100%
A0A422NNY1 Trypanosoma rangeli 68% 100%
A4HMK4 Leishmania braziliensis 93% 100%
C9ZZK8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AF04 Leishmania major 98% 100%
E9B660 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
V5D9G0 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS