LeishMANIAdb
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rRNA processing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
rRNA processing protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4IB82_LEIIN
TriTrypDb:
Length:
274

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Eukaryotic rRNA processing EBP2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0030684 preribosome 3 1
GO:0030687 preribosome, large subunit precursor 4 1
GO:0032991 protein-containing complex 1 1
GO:0034399 nuclear periphery 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4IB82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB82

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 11
GO:0022613 ribonucleoprotein complex biogenesis 4 11
GO:0042254 ribosome biogenesis 5 10
GO:0044085 cellular component biogenesis 3 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0042273 ribosomal large subunit biogenesis 5 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 47 51 PF00656 0.689
CLV_NRD_NRD_1 17 19 PF00675 0.481
CLV_NRD_NRD_1 185 187 PF00675 0.294
CLV_NRD_NRD_1 220 222 PF00675 0.309
CLV_NRD_NRD_1 224 226 PF00675 0.295
CLV_NRD_NRD_1 8 10 PF00675 0.488
CLV_PCSK_FUR_1 221 225 PF00082 0.322
CLV_PCSK_KEX2_1 10 12 PF00082 0.486
CLV_PCSK_KEX2_1 121 123 PF00082 0.303
CLV_PCSK_KEX2_1 149 151 PF00082 0.303
CLV_PCSK_KEX2_1 16 18 PF00082 0.486
CLV_PCSK_KEX2_1 185 187 PF00082 0.294
CLV_PCSK_KEX2_1 210 212 PF00082 0.303
CLV_PCSK_KEX2_1 223 225 PF00082 0.308
CLV_PCSK_KEX2_1 245 247 PF00082 0.414
CLV_PCSK_KEX2_1 264 266 PF00082 0.311
CLV_PCSK_KEX2_1 271 273 PF00082 0.604
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.504
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.303
CLV_PCSK_PC1ET2_1 149 151 PF00082 0.322
CLV_PCSK_PC1ET2_1 210 212 PF00082 0.303
CLV_PCSK_PC1ET2_1 223 225 PF00082 0.303
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.446
CLV_PCSK_PC1ET2_1 264 266 PF00082 0.324
CLV_PCSK_PC7_1 206 212 PF00082 0.303
CLV_PCSK_SKI1_1 101 105 PF00082 0.303
CLV_PCSK_SKI1_1 12 16 PF00082 0.545
CLV_PCSK_SKI1_1 186 190 PF00082 0.303
CLV_PCSK_SKI1_1 242 246 PF00082 0.414
CLV_Separin_Metazoa 201 205 PF03568 0.303
DEG_SPOP_SBC_1 103 107 PF00917 0.322
DOC_CKS1_1 250 255 PF01111 0.414
DOC_CYCLIN_RxL_1 9 19 PF00134 0.572
DOC_PP1_RVXF_1 87 93 PF00149 0.414
DOC_PP4_FxxP_1 92 95 PF00568 0.303
DOC_USP7_MATH_1 103 107 PF00917 0.305
DOC_USP7_MATH_1 244 248 PF00917 0.364
DOC_USP7_MATH_1 66 70 PF00917 0.731
DOC_USP7_MATH_1 77 81 PF00917 0.611
DOC_USP7_UBL2_3 189 193 PF12436 0.303
DOC_USP7_UBL2_3 264 268 PF12436 0.375
DOC_WW_Pin1_4 249 254 PF00397 0.375
DOC_WW_Pin1_4 29 34 PF00397 0.731
LIG_14-3-3_CanoR_1 101 111 PF00244 0.317
LIG_14-3-3_CanoR_1 136 141 PF00244 0.325
LIG_14-3-3_CanoR_1 185 189 PF00244 0.414
LIG_FHA_1 105 111 PF00498 0.303
LIG_FHA_1 133 139 PF00498 0.400
LIG_FHA_2 86 92 PF00498 0.395
LIG_LIR_Apic_2 91 95 PF02991 0.324
LIG_LIR_Gen_1 152 163 PF02991 0.305
LIG_NRP_CendR_1 271 274 PF00754 0.658
LIG_PCNA_yPIPBox_3 221 234 PF02747 0.446
LIG_SH2_NCK_1 4 8 PF00017 0.520
LIG_SH2_SRC 4 7 PF00017 0.592
LIG_SH2_SRC 48 51 PF00017 0.737
LIG_SH2_STAP1 155 159 PF00017 0.303
LIG_SH2_STAP1 4 8 PF00017 0.452
LIG_SH2_STAT5 48 51 PF00017 0.705
LIG_SH3_3 60 66 PF00018 0.720
LIG_SUMO_SIM_par_1 130 135 PF11976 0.355
LIG_TRAF2_1 51 54 PF00917 0.748
MOD_CDK_SPK_2 249 254 PF00069 0.375
MOD_CDK_SPxxK_3 249 256 PF00069 0.375
MOD_CK1_1 106 112 PF00069 0.312
MOD_CK1_1 80 86 PF00069 0.344
MOD_CK2_1 136 142 PF00069 0.322
MOD_CK2_1 184 190 PF00069 0.388
MOD_CK2_1 29 35 PF00069 0.702
MOD_CK2_1 48 54 PF00069 0.532
MOD_CK2_1 85 91 PF00069 0.375
MOD_GlcNHglycan 79 82 PF01048 0.513
MOD_GSK3_1 102 109 PF00069 0.306
MOD_GSK3_1 132 139 PF00069 0.364
MOD_N-GLC_1 226 231 PF02516 0.452
MOD_NEK2_1 102 107 PF00069 0.288
MOD_NEK2_1 132 137 PF00069 0.331
MOD_NEK2_1 172 177 PF00069 0.346
MOD_NEK2_1 213 218 PF00069 0.375
MOD_PKA_2 184 190 PF00069 0.405
MOD_Plk_4 127 133 PF00069 0.349
MOD_ProDKin_1 249 255 PF00069 0.375
MOD_ProDKin_1 29 35 PF00069 0.734
MOD_SUMO_for_1 120 123 PF00179 0.303
MOD_SUMO_rev_2 237 247 PF00179 0.442
TRG_ENDOCYTIC_2 155 158 PF00928 0.294
TRG_ER_diArg_1 15 18 PF00400 0.585
TRG_ER_diArg_1 203 206 PF00400 0.303
TRG_ER_diArg_1 253 256 PF00400 0.397
TRG_ER_diArg_1 271 274 PF00400 0.628
TRG_NLS_Bipartite_1 210 227 PF00514 0.303
TRG_NLS_MonoCore_2 220 225 PF00514 0.305
TRG_NLS_MonoCore_2 8 13 PF00514 0.486
TRG_NLS_MonoExtC_3 220 225 PF00514 0.326
TRG_NLS_MonoExtN_4 221 227 PF00514 0.303
TRG_NLS_MonoExtN_4 242 249 PF00514 0.446
TRG_NLS_MonoExtN_4 9 14 PF00514 0.488
TRG_Pf-PMV_PEXEL_1 108 113 PF00026 0.375

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I326 Leptomonas seymouri 74% 100%
A0A0S4IQU9 Bodo saltans 58% 100%
A0A1X0P5U9 Trypanosomatidae 57% 100%
A0A3Q8IPE1 Leishmania donovani 100% 100%
A0A3R7KIH6 Trypanosoma rangeli 70% 100%
A4HMK3 Leishmania braziliensis 88% 100%
C9ZZK7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9AF03 Leishmania major 95% 100%
E9B659 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q9LUJ5 Arabidopsis thaliana 32% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS