tRNA-uridine aminocarboxypropyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DTW domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IB80_LEIIN

TriTrypDb:

LINF_350022900

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB80

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.706
CLV_C14_Caspase3-7	252	256	PF00656	0.486
CLV_NRD_NRD_1	217	219	PF00675	0.562
CLV_NRD_NRD_1	41	43	PF00675	0.418
CLV_NRD_NRD_1	50	52	PF00675	0.323
CLV_PCSK_KEX2_1	2	4	PF00082	0.558
CLV_PCSK_KEX2_1	217	219	PF00082	0.567
CLV_PCSK_KEX2_1	41	43	PF00082	0.418
CLV_PCSK_KEX2_1	49	51	PF00082	0.331
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.549
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.347
CLV_PCSK_SKI1_1	50	54	PF00082	0.484
CLV_Separin_Metazoa	324	328	PF03568	0.563
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DEG_SPOP_SBC_1	250	254	PF00917	0.406
DOC_CYCLIN_RxL_1	18	29	PF00134	0.390
DOC_CYCLIN_RxL_1	46	57	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.257
DOC_MAPK_gen_1	161	170	PF00069	0.306
DOC_PP1_RVXF_1	139	146	PF00149	0.238
DOC_PP1_RVXF_1	22	29	PF00149	0.368
DOC_PP2B_LxvP_1	219	222	PF13499	0.506
DOC_PP2B_LxvP_1	308	311	PF13499	0.451
DOC_PP2B_LxvP_1	71	74	PF13499	0.257
DOC_PP4_FxxP_1	28	31	PF00568	0.300
DOC_USP7_MATH_1	212	216	PF00917	0.528
DOC_USP7_MATH_1	234	238	PF00917	0.744
DOC_USP7_MATH_1	313	317	PF00917	0.551
DOC_WW_Pin1_4	217	222	PF00397	0.596
DOC_WW_Pin1_4	240	245	PF00397	0.694
DOC_WW_Pin1_4	96	101	PF00397	0.238
LIG_14-3-3_CanoR_1	169	178	PF00244	0.296
LIG_14-3-3_CanoR_1	281	287	PF00244	0.450
LIG_APCC_ABBA_1	60	65	PF00400	0.251
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.238
LIG_BRCT_BRCA1_1	24	28	PF00533	0.289
LIG_eIF4E_1	54	60	PF01652	0.251
LIG_FHA_1	117	123	PF00498	0.238
LIG_FHA_2	244	250	PF00498	0.502
LIG_FHA_2	301	307	PF00498	0.448
LIG_LIR_Apic_2	25	31	PF02991	0.282
LIG_LIR_Gen_1	303	313	PF02991	0.392
LIG_LIR_Nem_3	106	110	PF02991	0.238
LIG_LIR_Nem_3	138	143	PF02991	0.300
LIG_LIR_Nem_3	163	168	PF02991	0.268
LIG_LIR_Nem_3	174	180	PF02991	0.210
LIG_LIR_Nem_3	192	198	PF02991	0.387
LIG_LIR_Nem_3	266	272	PF02991	0.278
LIG_LIR_Nem_3	292	298	PF02991	0.400
LIG_LIR_Nem_3	303	308	PF02991	0.349
LIG_LYPXL_yS_3	107	110	PF13949	0.238
LIG_SH2_CRK	56	60	PF00017	0.238
LIG_SH2_GRB2like	271	274	PF00017	0.283
LIG_SH2_PTP2	275	278	PF00017	0.288
LIG_SH2_PTP2	78	81	PF00017	0.257
LIG_SH2_STAP1	56	60	PF00017	0.251
LIG_SH2_STAT3	201	204	PF00017	0.293
LIG_SH2_STAT3	271	274	PF00017	0.283
LIG_SH2_STAT3	298	301	PF00017	0.450
LIG_SH2_STAT5	187	190	PF00017	0.238
LIG_SH2_STAT5	196	199	PF00017	0.238
LIG_SH2_STAT5	201	204	PF00017	0.238
LIG_SH2_STAT5	271	274	PF00017	0.283
LIG_SH2_STAT5	275	278	PF00017	0.288
LIG_SH2_STAT5	282	285	PF00017	0.403
LIG_SH2_STAT5	290	293	PF00017	0.405
LIG_SH2_STAT5	298	301	PF00017	0.308
LIG_SH2_STAT5	54	57	PF00017	0.241
LIG_SH2_STAT5	78	81	PF00017	0.257
LIG_SH2_STAT5	8	11	PF00017	0.474
LIG_SH3_3	102	108	PF00018	0.245
LIG_SH3_3	118	124	PF00018	0.218
LIG_SH3_3	306	312	PF00018	0.417
LIG_SH3_3	319	325	PF00018	0.558
LIG_SH3_3	77	83	PF00018	0.437
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.259
LIG_TYR_ITIM	105	110	PF00017	0.212
LIG_WW_3	324	328	PF00397	0.563
MOD_CDK_SPK_2	240	245	PF00069	0.558
MOD_CK1_1	172	178	PF00069	0.281
MOD_CK1_1	229	235	PF00069	0.736
MOD_CK1_1	237	243	PF00069	0.680
MOD_CK1_1	316	322	PF00069	0.670
MOD_CK1_1	96	102	PF00069	0.237
MOD_CK2_1	243	249	PF00069	0.505
MOD_CK2_1	8	14	PF00069	0.541
MOD_Cter_Amidation	215	218	PF01082	0.455
MOD_GlcNHglycan	213	217	PF01048	0.579
MOD_GlcNHglycan	236	239	PF01048	0.723
MOD_GlcNHglycan	283	286	PF01048	0.567
MOD_GlcNHglycan	295	298	PF01048	0.493
MOD_GSK3_1	146	153	PF00069	0.254
MOD_GSK3_1	183	190	PF00069	0.278
MOD_GSK3_1	22	29	PF00069	0.299
MOD_GSK3_1	229	236	PF00069	0.765
MOD_GSK3_1	250	257	PF00069	0.513
MOD_GSK3_1	316	323	PF00069	0.643
MOD_GSK3_1	89	96	PF00069	0.243
MOD_LATS_1	167	173	PF00433	0.316
MOD_N-GLC_1	301	306	PF02516	0.417
MOD_N-GLC_1	316	321	PF02516	0.630
MOD_NEK2_1	145	150	PF00069	0.279
MOD_NEK2_1	22	27	PF00069	0.338
MOD_NEK2_1	93	98	PF00069	0.238
MOD_NEK2_2	58	63	PF00069	0.259
MOD_PIKK_1	169	175	PF00454	0.281
MOD_PIKK_1	200	206	PF00454	0.293
MOD_PKA_2	160	166	PF00069	0.293
MOD_PKA_2	280	286	PF00069	0.453
MOD_Plk_1	116	122	PF00069	0.312
MOD_Plk_1	125	131	PF00069	0.355
MOD_Plk_1	146	152	PF00069	0.257
MOD_Plk_1	254	260	PF00069	0.369
MOD_Plk_1	301	307	PF00069	0.424
MOD_Plk_4	116	122	PF00069	0.238
MOD_Plk_4	172	178	PF00069	0.247
MOD_Plk_4	183	189	PF00069	0.305
MOD_ProDKin_1	217	223	PF00069	0.597
MOD_ProDKin_1	240	246	PF00069	0.690
MOD_ProDKin_1	96	102	PF00069	0.238
MOD_SUMO_rev_2	128	137	PF00179	0.220
MOD_SUMO_rev_2	228	235	PF00179	0.561
TRG_DiLeu_BaEn_1	263	268	PF01217	0.307
TRG_ENDOCYTIC_2	107	110	PF00928	0.238
TRG_ENDOCYTIC_2	140	143	PF00928	0.371
TRG_ENDOCYTIC_2	195	198	PF00928	0.238
TRG_ENDOCYTIC_2	275	278	PF00928	0.293
TRG_ENDOCYTIC_2	56	59	PF00928	0.238
TRG_ENDOCYTIC_2	78	81	PF00928	0.257
TRG_ER_diArg_1	217	219	PF00400	0.454
TRG_ER_diArg_1	33	36	PF00400	0.369
TRG_ER_diArg_1	50	52	PF00400	0.367
TRG_NLS_MonoCore_2	1	6	PF00514	0.650
TRG_NLS_MonoExtN_4	46	53	PF00514	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD7	Leptomonas seymouri	76%	100%
A0A0S4IR26	Bodo saltans	49%	100%
A0A1X0P5T8	Trypanosomatidae	64%	100%
A0A3S7X980	Leishmania donovani	100%	100%
A4HMK1	Leishmania braziliensis	85%	100%
C9ZZK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AF01	Leishmania major	94%	100%
E9B657	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q5RCQ0	Pongo abelii	33%	100%
Q8N5C7	Homo sapiens	33%	100%
Q9D8U7	Mus musculus	34%	100%
V5B8W4	Trypanosoma cruzi	62%	100%