Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB78_LEIIN

TriTrypDb:

LINF_350022700

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	204	210	PF00089	0.537
CLV_NRD_NRD_1	127	129	PF00675	0.546
CLV_NRD_NRD_1	181	183	PF00675	0.545
CLV_NRD_NRD_1	2	4	PF00675	0.535
CLV_PCSK_KEX2_1	129	131	PF00082	0.565
CLV_PCSK_KEX2_1	181	183	PF00082	0.545
CLV_PCSK_KEX2_1	206	208	PF00082	0.534
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.565
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.619
CLV_PCSK_SKI1_1	203	207	PF00082	0.517
CLV_Separin_Metazoa	155	159	PF03568	0.599
DOC_USP7_MATH_1	33	37	PF00917	0.612
DOC_USP7_MATH_1	58	62	PF00917	0.487
DOC_WW_Pin1_4	34	39	PF00397	0.602
DOC_WW_Pin1_4	41	46	PF00397	0.529
LIG_14-3-3_CanoR_1	128	135	PF00244	0.644
LIG_14-3-3_CanoR_1	18	24	PF00244	0.575
LIG_14-3-3_CanoR_1	3	9	PF00244	0.655
LIG_BIR_III_4	82	86	PF00653	0.467
LIG_FHA_1	67	73	PF00498	0.431
LIG_FHA_1	84	90	PF00498	0.375
LIG_FHA_2	21	27	PF00498	0.623
LIG_LIR_Nem_3	36	42	PF02991	0.611
LIG_NRBOX	200	206	PF00104	0.556
LIG_PCNA_PIPBox_1	115	124	PF02747	0.583
LIG_PCNA_yPIPBox_3	110	122	PF02747	0.586
LIG_PCNA_yPIPBox_3	169	178	PF02747	0.497
LIG_Pex14_2	49	53	PF04695	0.613
LIG_SH2_NCK_1	19	23	PF00017	0.625
LIG_SH2_STAP1	152	156	PF00017	0.480
LIG_SH2_STAT5	121	124	PF00017	0.549
LIG_SH2_STAT5	138	141	PF00017	0.566
LIG_SH2_STAT5	75	78	PF00017	0.433
LIG_SH2_STAT5	87	90	PF00017	0.445
LIG_SH3_3	39	45	PF00018	0.577
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.597
MOD_CDK_SPxK_1	34	40	PF00069	0.602
MOD_CDK_SPxxK_3	41	48	PF00069	0.545
MOD_CK1_1	20	26	PF00069	0.671
MOD_CK2_1	20	26	PF00069	0.615
MOD_GlcNHglycan	130	133	PF01048	0.545
MOD_GlcNHglycan	4	7	PF01048	0.629
MOD_GSK3_1	120	127	PF00069	0.571
MOD_N-GLC_1	190	195	PF02516	0.522
MOD_NEK2_1	2	7	PF00069	0.638
MOD_PIKK_1	98	104	PF00454	0.580
MOD_PKA_1	128	134	PF00069	0.577
MOD_PKA_2	17	23	PF00069	0.611
MOD_PKA_2	2	8	PF00069	0.571
MOD_Plk_1	190	196	PF00069	0.522
MOD_Plk_4	190	196	PF00069	0.480
MOD_Plk_4	58	64	PF00069	0.456
MOD_Plk_4	83	89	PF00069	0.442
MOD_ProDKin_1	34	40	PF00069	0.602
MOD_ProDKin_1	41	47	PF00069	0.521
MOD_SUMO_for_1	133	136	PF00179	0.614
MOD_SUMO_rev_2	123	127	PF00179	0.547
MOD_SUMO_rev_2	78	86	PF00179	0.441
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.595
TRG_ER_diArg_1	180	182	PF00400	0.542
TRG_NLS_MonoExtN_4	126	132	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T0	Leptomonas seymouri	80%	100%
A0A0S4KLR7	Bodo saltans	58%	100%
A0A1X0P7A8	Trypanosomatidae	62%	100%
A0A3Q8IG68	Leishmania donovani	100%	100%
A4HMJ9	Leishmania braziliensis	87%	100%
C9ZZK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AEZ9	Leishmania major	97%	100%
E9B655	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%