LeishMANIAdb
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Putative cyclophilin 14

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cyclophilin 14
Gene product:
cyclophilin 14 - putative
Species:
Leishmania infantum
UniProt:
A4IB72_LEIIN
TriTrypDb:
LINF_350022100
Length:
444

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, cyclophilin 14 CYP14

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 9
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4IB72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB72

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0018193 peptidyl-amino acid modification 5 11
GO:0018208 peptidyl-proline modification 6 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 11
GO:0003824 catalytic activity 1 11
GO:0016853 isomerase activity 2 11
GO:0016859 cis-trans isomerase activity 3 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0005488 binding 1 1
GO:0016018 cyclosporin A binding 4 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 8 14 PF00089 0.507
CLV_NRD_NRD_1 137 139 PF00675 0.531
CLV_NRD_NRD_1 253 255 PF00675 0.482
CLV_NRD_NRD_1 436 438 PF00675 0.740
CLV_PCSK_FUR_1 135 139 PF00082 0.456
CLV_PCSK_KEX2_1 137 139 PF00082 0.460
CLV_PCSK_KEX2_1 253 255 PF00082 0.482
CLV_PCSK_KEX2_1 366 368 PF00082 0.586
CLV_PCSK_KEX2_1 438 440 PF00082 0.723
CLV_PCSK_PC1ET2_1 366 368 PF00082 0.586
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.723
CLV_PCSK_SKI1_1 152 156 PF00082 0.379
CLV_PCSK_SKI1_1 310 314 PF00082 0.482
DEG_APCC_DBOX_1 137 145 PF00400 0.650
DEG_APCC_DBOX_1 309 317 PF00400 0.282
DEG_Kelch_Keap1_1 71 76 PF01344 0.703
DEG_Nend_Nbox_1 1 3 PF02207 0.784
DEG_ODPH_VHL_1 385 398 PF01847 0.482
DOC_CYCLIN_RxL_1 134 145 PF00134 0.646
DOC_MAPK_DCC_7 20 30 PF00069 0.716
DOC_MAPK_gen_1 135 143 PF00069 0.666
DOC_MAPK_MEF2A_6 135 143 PF00069 0.654
DOC_MAPK_MEF2A_6 152 161 PF00069 0.570
DOC_MAPK_MEF2A_6 180 189 PF00069 0.392
DOC_PP1_RVXF_1 14 20 PF00149 0.686
DOC_USP7_MATH_1 24 28 PF00917 0.757
DOC_USP7_MATH_1 312 316 PF00917 0.280
DOC_USP7_MATH_2 300 306 PF00917 0.362
DOC_WW_Pin1_4 321 326 PF00397 0.271
DOC_WW_Pin1_4 38 43 PF00397 0.775
LIG_14-3-3_CanoR_1 138 144 PF00244 0.647
LIG_14-3-3_CanoR_1 152 161 PF00244 0.539
LIG_14-3-3_CanoR_1 310 320 PF00244 0.282
LIG_14-3-3_CanoR_1 408 414 PF00244 0.478
LIG_14-3-3_CanoR_1 48 54 PF00244 0.786
LIG_Actin_WH2_2 201 218 PF00022 0.353
LIG_BRCT_BRCA1_1 323 327 PF00533 0.282
LIG_FHA_1 299 305 PF00498 0.338
LIG_FHA_2 140 146 PF00498 0.671
LIG_FHA_2 153 159 PF00498 0.569
LIG_FHA_2 425 431 PF00498 0.412
LIG_LIR_Nem_3 219 225 PF02991 0.314
LIG_SH2_NCK_1 348 352 PF00017 0.362
LIG_SH2_NCK_1 393 397 PF00017 0.448
LIG_SH2_STAP1 172 176 PF00017 0.355
LIG_SH2_STAT3 336 339 PF00017 0.282
LIG_SH2_STAT5 192 195 PF00017 0.417
LIG_SH2_STAT5 222 225 PF00017 0.310
LIG_SH2_STAT5 247 250 PF00017 0.271
LIG_SH2_STAT5 298 301 PF00017 0.282
LIG_SH2_STAT5 369 372 PF00017 0.362
LIG_SH3_3 144 150 PF00018 0.621
LIG_SH3_3 18 24 PF00018 0.724
LIG_SUMO_SIM_anti_2 155 161 PF11976 0.561
LIG_SUMO_SIM_par_1 139 146 PF11976 0.657
LIG_TRAF2_1 427 430 PF00917 0.395
LIG_TYR_ITIM 220 225 PF00017 0.374
LIG_ULM_U2AF65_1 437 442 PF00076 0.686
MOD_CK1_1 29 35 PF00069 0.751
MOD_CK1_1 58 64 PF00069 0.717
MOD_CK2_1 139 145 PF00069 0.601
MOD_CK2_1 152 158 PF00069 0.463
MOD_CK2_1 424 430 PF00069 0.514
MOD_GlcNHglycan 31 34 PF01048 0.741
MOD_GlcNHglycan 332 335 PF01048 0.324
MOD_GlcNHglycan 38 41 PF01048 0.705
MOD_GlcNHglycan 409 412 PF01048 0.594
MOD_GlcNHglycan 432 435 PF01048 0.716
MOD_GlcNHglycan 49 52 PF01048 0.714
MOD_GlcNHglycan 94 97 PF01048 0.724
MOD_GSK3_1 194 201 PF00069 0.401
MOD_GSK3_1 223 230 PF00069 0.503
MOD_GSK3_1 298 305 PF00069 0.426
MOD_GSK3_1 32 39 PF00069 0.715
MOD_GSK3_1 376 383 PF00069 0.508
MOD_GSK3_1 420 427 PF00069 0.471
MOD_GSK3_1 55 62 PF00069 0.775
MOD_GSK3_1 88 95 PF00069 0.757
MOD_N-GLC_1 227 232 PF02516 0.447
MOD_NEK2_1 1 6 PF00069 0.719
MOD_NEK2_1 174 179 PF00069 0.480
MOD_NEK2_1 194 199 PF00069 0.409
MOD_NEK2_1 36 41 PF00069 0.686
MOD_NEK2_1 380 385 PF00069 0.502
MOD_NEK2_1 392 397 PF00069 0.491
MOD_PIKK_1 424 430 PF00454 0.678
MOD_PK_1 216 222 PF00069 0.395
MOD_PKA_1 253 259 PF00069 0.335
MOD_PKA_2 253 259 PF00069 0.335
MOD_PKA_2 407 413 PF00069 0.624
MOD_PKA_2 47 53 PF00069 0.757
MOD_PKA_2 68 74 PF00069 0.738
MOD_Plk_4 139 145 PF00069 0.566
MOD_Plk_4 216 222 PF00069 0.396
MOD_ProDKin_1 321 327 PF00069 0.319
MOD_ProDKin_1 38 44 PF00069 0.747
MOD_SUMO_for_1 125 128 PF00179 0.685
MOD_SUMO_rev_2 332 338 PF00179 0.480
MOD_SUMO_rev_2 397 405 PF00179 0.511
TRG_DiLeu_BaLyEn_6 39 44 PF01217 0.743
TRG_ENDOCYTIC_2 172 175 PF00928 0.335
TRG_ENDOCYTIC_2 222 225 PF00928 0.374
TRG_ENDOCYTIC_2 348 351 PF00928 0.447
TRG_ENDOCYTIC_2 393 396 PF00928 0.503
TRG_ER_diArg_1 135 138 PF00400 0.680
TRG_ER_diArg_1 436 439 PF00400 0.676
TRG_NES_CRM1_1 151 166 PF08389 0.567
TRG_NLS_MonoCore_2 436 441 PF00514 0.686
TRG_NLS_MonoExtN_4 437 442 PF00514 0.686
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJJ3 Leptomonas seymouri 69% 98%
A0A1X0P6T5 Trypanosomatidae 77% 100%
A0A3S7X941 Leishmania donovani 100% 100%
A0A422NQ98 Trypanosoma rangeli 72% 100%
A4HMJ2 Leishmania braziliensis 82% 100%
C9ZZI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
E9AEZ3 Leishmania major 94% 100%
E9B649 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BP10 Trypanosoma cruzi 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS