Protein phosphatase 1 regulatory subunit 22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine rich repeat/Leucine Rich Repeat - putative

Species:

Leishmania infantum

UniProt:

A4IB70_LEIIN

TriTrypDb:

LINF_350021900

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4IB70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB70

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.414
CLV_NRD_NRD_1	112	114	PF00675	0.747
CLV_NRD_NRD_1	232	234	PF00675	0.560
CLV_PCSK_FUR_1	246	250	PF00082	0.623
CLV_PCSK_KEX2_1	112	114	PF00082	0.747
CLV_PCSK_KEX2_1	232	234	PF00082	0.537
CLV_PCSK_KEX2_1	248	250	PF00082	0.435
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.586
CLV_PCSK_SKI1_1	232	236	PF00082	0.561
CLV_PCSK_SKI1_1	248	252	PF00082	0.411
DEG_APCC_DBOX_1	84	92	PF00400	0.557
DOC_CYCLIN_RxL_1	227	240	PF00134	0.570
DOC_CYCLIN_RxL_1	244	254	PF00134	0.585
DOC_MAPK_gen_1	244	253	PF00069	0.535
DOC_MAPK_MEF2A_6	213	221	PF00069	0.613
DOC_MAPK_MEF2A_6	23	30	PF00069	0.407
DOC_USP7_MATH_1	169	173	PF00917	0.659
DOC_USP7_MATH_1	294	298	PF00917	0.563
DOC_USP7_MATH_1	65	69	PF00917	0.480
DOC_USP7_MATH_1	93	97	PF00917	0.556
DOC_USP7_UBL2_3	244	248	PF12436	0.609
DOC_USP7_UBL2_3	257	261	PF12436	0.522
DOC_WW_Pin1_4	22	27	PF00397	0.484
LIG_14-3-3_CanoR_1	272	280	PF00244	0.415
LIG_14-3-3_CanoR_1	92	98	PF00244	0.568
LIG_Actin_WH2_2	266	283	PF00022	0.520
LIG_BIR_III_4	178	182	PF00653	0.696
LIG_BIR_III_4	240	244	PF00653	0.522
LIG_BRCT_BRCA1_1	163	167	PF00533	0.545
LIG_FHA_1	121	127	PF00498	0.603
LIG_FHA_1	23	29	PF00498	0.545
LIG_FHA_1	257	263	PF00498	0.541
LIG_FHA_1	38	44	PF00498	0.402
LIG_FHA_2	266	272	PF00498	0.526
LIG_HP1_1	93	97	PF01393	0.571
LIG_LIR_Gen_1	164	175	PF02991	0.556
LIG_LIR_Gen_1	295	306	PF02991	0.558
LIG_LIR_Nem_3	164	170	PF02991	0.547
LIG_LIR_Nem_3	295	301	PF02991	0.562
LIG_NRBOX	230	236	PF00104	0.504
LIG_PTB_Apo_2	102	109	PF02174	0.427
LIG_PTB_Phospho_1	102	108	PF10480	0.415
LIG_RPA_C_Fungi	168	180	PF08784	0.770
LIG_SH2_STAT5	24	27	PF00017	0.579
LIG_Sin3_3	303	310	PF02671	0.381
MOD_CDK_SPK_2	22	27	PF00069	0.460
MOD_CK1_1	197	203	PF00069	0.648
MOD_CK1_1	279	285	PF00069	0.561
MOD_CK1_1	84	90	PF00069	0.530
MOD_CK2_1	112	118	PF00069	0.732
MOD_CK2_1	265	271	PF00069	0.533
MOD_CK2_1	310	316	PF00069	0.398
MOD_Cter_Amidation	110	113	PF01082	0.728
MOD_GlcNHglycan	167	170	PF01048	0.686
MOD_GlcNHglycan	182	185	PF01048	0.450
MOD_GlcNHglycan	192	197	PF01048	0.728
MOD_GlcNHglycan	312	315	PF01048	0.531
MOD_GlcNHglycan	40	43	PF01048	0.517
MOD_GSK3_1	107	114	PF00069	0.641
MOD_GSK3_1	161	168	PF00069	0.575
MOD_GSK3_1	169	176	PF00069	0.565
MOD_GSK3_1	192	199	PF00069	0.755
MOD_GSK3_1	272	279	PF00069	0.547
MOD_GSK3_1	301	308	PF00069	0.483
MOD_N-GLC_1	136	141	PF02516	0.587
MOD_N-GLC_1	56	61	PF02516	0.539
MOD_NEK2_1	107	112	PF00069	0.659
MOD_NEK2_1	136	141	PF00069	0.567
MOD_NEK2_1	204	209	PF00069	0.699
MOD_NEK2_1	287	292	PF00069	0.539
MOD_NEK2_1	305	310	PF00069	0.319
MOD_NEK2_1	38	43	PF00069	0.455
MOD_NEK2_1	70	75	PF00069	0.424
MOD_NEK2_2	93	98	PF00069	0.509
MOD_PIKK_1	120	126	PF00454	0.619
MOD_PIKK_1	139	145	PF00454	0.363
MOD_PIKK_1	204	210	PF00454	0.731
MOD_PIKK_1	235	241	PF00454	0.529
MOD_PKA_1	112	118	PF00069	0.750
MOD_PKA_2	111	117	PF00069	0.753
MOD_PKA_2	131	137	PF00069	0.579
MOD_PKA_2	6	12	PF00069	0.570
MOD_PKA_2	84	90	PF00069	0.527
MOD_Plk_1	294	300	PF00069	0.496
MOD_Plk_1	56	62	PF00069	0.566
MOD_Plk_2-3	56	62	PF00069	0.534
MOD_Plk_4	1	7	PF00069	0.430
MOD_Plk_4	199	205	PF00069	0.735
MOD_Plk_4	301	307	PF00069	0.467
MOD_Plk_4	65	71	PF00069	0.435
MOD_ProDKin_1	22	28	PF00069	0.475
MOD_SUMO_rev_2	238	245	PF00179	0.578
TRG_DiLeu_BaEn_1	230	235	PF01217	0.478
TRG_DiLeu_LyEn_5	230	235	PF01217	0.502
TRG_ER_diArg_1	231	233	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	249	254	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E0	Leptomonas seymouri	51%	74%
A0A0S4KH47	Bodo saltans	27%	83%
A0A1X0P5U4	Trypanosomatidae	33%	88%
A0A3Q8IF21	Leishmania donovani	99%	72%
A0A422NQ71	Trypanosoma rangeli	35%	88%
A4HMJ0	Leishmania braziliensis	81%	100%
C9ZZH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	88%
E9AEZ1	Leishmania major	88%	100%