XK-related protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

XK-related protein

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB69_LEIIN

TriTrypDb:

LINF_350021800

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4IB69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.529
CLV_NRD_NRD_1	227	229	PF00675	0.542
CLV_NRD_NRD_1	259	261	PF00675	0.603
CLV_NRD_NRD_1	89	91	PF00675	0.319
CLV_PCSK_FUR_1	225	229	PF00082	0.512
CLV_PCSK_KEX2_1	173	175	PF00082	0.528
CLV_PCSK_KEX2_1	227	229	PF00082	0.542
CLV_PCSK_KEX2_1	259	261	PF00082	0.618
CLV_PCSK_KEX2_1	87	89	PF00082	0.348
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.366
CLV_PCSK_SKI1_1	14	18	PF00082	0.272
CLV_PCSK_SKI1_1	148	152	PF00082	0.368
DOC_CKS1_1	218	223	PF01111	0.684
DOC_CKS1_1	39	44	PF01111	0.446
DOC_MAPK_gen_1	87	96	PF00069	0.508
DOC_MAPK_MEF2A_6	140	149	PF00069	0.504
DOC_MAPK_MEF2A_6	89	98	PF00069	0.531
DOC_PP1_RVXF_1	109	115	PF00149	0.369
DOC_PP1_RVXF_1	138	144	PF00149	0.444
DOC_PP1_RVXF_1	146	153	PF00149	0.634
DOC_PP4_FxxP_1	152	155	PF00568	0.667
DOC_PP4_FxxP_1	79	82	PF00568	0.564
DOC_USP7_MATH_1	234	238	PF00917	0.661
DOC_WW_Pin1_4	185	190	PF00397	0.765
DOC_WW_Pin1_4	217	222	PF00397	0.694
DOC_WW_Pin1_4	232	237	PF00397	0.727
DOC_WW_Pin1_4	258	263	PF00397	0.748
DOC_WW_Pin1_4	265	270	PF00397	0.700
DOC_WW_Pin1_4	38	43	PF00397	0.444
LIG_14-3-3_CanoR_1	14	19	PF00244	0.490
LIG_14-3-3_CanoR_1	167	171	PF00244	0.614
LIG_14-3-3_CanoR_1	211	219	PF00244	0.761
LIG_14-3-3_CanoR_1	238	247	PF00244	0.661
LIG_14-3-3_CanoR_1	45	55	PF00244	0.423
LIG_EH1_1	143	151	PF00400	0.467
LIG_FHA_1	108	114	PF00498	0.368
LIG_FHA_1	136	142	PF00498	0.413
LIG_FHA_1	18	24	PF00498	0.340
LIG_FHA_1	195	201	PF00498	0.741
LIG_FHA_2	221	227	PF00498	0.768
LIG_LIR_Apic_2	215	221	PF02991	0.695
LIG_LIR_Apic_2	229	234	PF02991	0.706
LIG_LIR_Gen_1	133	144	PF02991	0.356
LIG_LIR_Gen_1	28	36	PF02991	0.425
LIG_LIR_Nem_3	133	139	PF02991	0.344
LIG_LIR_Nem_3	28	33	PF02991	0.425
LIG_MAD2	111	119	PF02301	0.450
LIG_PDZ_Class_2	273	278	PF00595	0.766
LIG_Pex14_1	114	118	PF04695	0.344
LIG_Pex14_1	75	79	PF04695	0.527
LIG_Pex14_2	21	25	PF04695	0.369
LIG_SH2_CRK	136	140	PF00017	0.344
LIG_SH2_STAT3	267	270	PF00017	0.655
LIG_SH2_STAT5	127	130	PF00017	0.444
LIG_SH2_STAT5	164	167	PF00017	0.628
LIG_SH2_STAT5	181	184	PF00017	0.775
LIG_SH2_STAT5	219	222	PF00017	0.714
LIG_SH2_STAT5	54	57	PF00017	0.344
LIG_SH2_STAT5	65	68	PF00017	0.340
LIG_SH3_3	113	119	PF00018	0.451
LIG_SH3_3	263	269	PF00018	0.780
LIG_SH3_3	36	42	PF00018	0.441
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.443
LIG_TYR_ITIM	134	139	PF00017	0.429
LIG_UBA3_1	145	151	PF00899	0.586
LIG_WRC_WIRS_1	18	23	PF05994	0.444
MOD_CDC14_SPxK_1	235	238	PF00782	0.701
MOD_CDK_SPxK_1	232	238	PF00069	0.791
MOD_CDK_SPxxK_3	38	45	PF00069	0.377
MOD_CK1_1	135	141	PF00069	0.369
MOD_CK1_1	179	185	PF00069	0.794
MOD_CK1_1	241	247	PF00069	0.739
MOD_CK1_1	268	274	PF00069	0.748
MOD_CK1_1	28	34	PF00069	0.458
MOD_CK1_1	44	50	PF00069	0.445
MOD_GlcNHglycan	212	215	PF01048	0.549
MOD_GlcNHglycan	270	273	PF01048	0.602
MOD_GSK3_1	10	17	PF00069	0.552
MOD_GSK3_1	130	137	PF00069	0.363
MOD_GSK3_1	162	169	PF00069	0.667
MOD_GSK3_1	185	192	PF00069	0.747
MOD_GSK3_1	234	241	PF00069	0.752
MOD_GSK3_1	34	41	PF00069	0.520
MOD_N-GLC_1	162	167	PF02516	0.492
MOD_NEK2_1	134	139	PF00069	0.356
MOD_NEK2_1	19	24	PF00069	0.323
MOD_NEK2_1	247	252	PF00069	0.723
MOD_NEK2_1	25	30	PF00069	0.342
MOD_NEK2_1	46	51	PF00069	0.337
MOD_NEK2_1	55	60	PF00069	0.306
MOD_NEK2_1	67	72	PF00069	0.345
MOD_NEK2_1	9	14	PF00069	0.548
MOD_NEK2_2	194	199	PF00069	0.726
MOD_PIKK_1	247	253	PF00454	0.809
MOD_PIKK_1	47	53	PF00454	0.316
MOD_PKA_2	166	172	PF00069	0.595
MOD_PKA_2	210	216	PF00069	0.764
MOD_PKA_2	44	50	PF00069	0.430
MOD_Plk_1	245	251	PF00069	0.789
MOD_Plk_4	14	20	PF00069	0.495
MOD_Plk_4	194	200	PF00069	0.750
MOD_Plk_4	25	31	PF00069	0.331
MOD_Plk_4	34	40	PF00069	0.202
MOD_Plk_4	55	61	PF00069	0.342
MOD_Plk_4	67	73	PF00069	0.344
MOD_ProDKin_1	185	191	PF00069	0.763
MOD_ProDKin_1	217	223	PF00069	0.694
MOD_ProDKin_1	232	238	PF00069	0.727
MOD_ProDKin_1	258	264	PF00069	0.747
MOD_ProDKin_1	265	271	PF00069	0.699
MOD_ProDKin_1	38	44	PF00069	0.441
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.599
TRG_ENDOCYTIC_2	136	139	PF00928	0.330
TRG_ENDOCYTIC_2	54	57	PF00928	0.344
TRG_ER_diArg_1	88	90	PF00400	0.535
TRG_NLS_MonoCore_2	86	91	PF00514	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T3	Leptomonas seymouri	50%	95%
A0A0S4KLI9	Bodo saltans	43%	100%
A0A3Q8IV65	Leishmania donovani	99%	100%
A0A3R7M240	Trypanosoma rangeli	40%	100%
A4HMI9	Leishmania braziliensis	65%	100%
E9AEZ0	Leishmania major	90%	100%
E9B646	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B3X7	Trypanosoma cruzi	42%	100%