LeishMANIAdb
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Putative mismatch repair protein PMS1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative mismatch repair protein PMS1
Gene product:
mismatch repair protein PMS1 - putative
Species:
Leishmania infantum
UniProt:
A4IB67_LEIIN
TriTrypDb:
LINF_350021600
Length:
840

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0032300 mismatch repair complex 2 9
GO:0032991 protein-containing complex 1 9
GO:0032389 MutLalpha complex 3 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4IB67
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB67

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 9
GO:0006259 DNA metabolic process 4 9
GO:0006281 DNA repair 5 9
GO:0006298 mismatch repair 6 9
GO:0006725 cellular aromatic compound metabolic process 3 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0006950 response to stress 2 9
GO:0006974 DNA damage response 4 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0033554 cellular response to stress 3 9
GO:0034641 cellular nitrogen compound metabolic process 3 9
GO:0043170 macromolecule metabolic process 3 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044260 obsolete cellular macromolecule metabolic process 3 9
GO:0046483 heterocycle metabolic process 3 9
GO:0050896 response to stimulus 1 9
GO:0051716 cellular response to stimulus 2 9
GO:0071704 organic substance metabolic process 2 9
GO:0090304 nucleic acid metabolic process 4 9
GO:1901360 organic cyclic compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003676 nucleic acid binding 3 9
GO:0003677 DNA binding 4 9
GO:0003690 double-stranded DNA binding 5 9
GO:0003824 catalytic activity 1 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0008094 ATP-dependent activity, acting on DNA 2 9
GO:0016462 pyrophosphatase activity 5 9
GO:0016787 hydrolase activity 2 9
GO:0016817 hydrolase activity, acting on acid anhydrides 3 9
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 9
GO:0016887 ATP hydrolysis activity 7 9
GO:0017076 purine nucleotide binding 4 9
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0030983 mismatched DNA binding 6 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140097 catalytic activity, acting on DNA 3 9
GO:0140299 small molecule sensor activity 1 9
GO:0140612 DNA damage sensor activity 2 9
GO:0140640 catalytic activity, acting on a nucleic acid 2 9
GO:0140657 ATP-dependent activity 1 9
GO:0140664 ATP-dependent DNA damage sensor activity 3 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 125 129 PF00656 0.594
CLV_C14_Caspase3-7 3 7 PF00656 0.538
CLV_C14_Caspase3-7 489 493 PF00656 0.702
CLV_C14_Caspase3-7 74 78 PF00656 0.640
CLV_NRD_NRD_1 10 12 PF00675 0.481
CLV_NRD_NRD_1 210 212 PF00675 0.474
CLV_NRD_NRD_1 360 362 PF00675 0.313
CLV_NRD_NRD_1 584 586 PF00675 0.676
CLV_NRD_NRD_1 93 95 PF00675 0.714
CLV_PCSK_KEX2_1 360 362 PF00082 0.294
CLV_PCSK_KEX2_1 430 432 PF00082 0.626
CLV_PCSK_KEX2_1 584 586 PF00082 0.673
CLV_PCSK_KEX2_1 798 800 PF00082 0.537
CLV_PCSK_KEX2_1 93 95 PF00082 0.717
CLV_PCSK_PC1ET2_1 360 362 PF00082 0.294
CLV_PCSK_PC1ET2_1 430 432 PF00082 0.706
CLV_PCSK_PC1ET2_1 798 800 PF00082 0.537
CLV_PCSK_SKI1_1 193 197 PF00082 0.487
CLV_PCSK_SKI1_1 259 263 PF00082 0.501
CLV_PCSK_SKI1_1 361 365 PF00082 0.331
CLV_PCSK_SKI1_1 430 434 PF00082 0.765
CLV_PCSK_SKI1_1 798 802 PF00082 0.490
DEG_APCC_DBOX_1 210 218 PF00400 0.344
DEG_APCC_DBOX_1 819 827 PF00400 0.443
DEG_Nend_Nbox_1 1 3 PF02207 0.519
DEG_SPOP_SBC_1 461 465 PF00917 0.750
DOC_CDC14_PxL_1 311 319 PF14671 0.412
DOC_CKS1_1 238 243 PF01111 0.581
DOC_CKS1_1 791 796 PF01111 0.466
DOC_CYCLIN_RxL_1 359 369 PF00134 0.364
DOC_CYCLIN_yCln2_LP_2 699 705 PF00134 0.364
DOC_MAPK_gen_1 563 572 PF00069 0.536
DOC_MAPK_gen_1 783 791 PF00069 0.331
DOC_MAPK_gen_1 798 804 PF00069 0.530
DOC_MAPK_MEF2A_6 37 45 PF00069 0.466
DOC_MAPK_MEF2A_6 566 574 PF00069 0.642
DOC_PIKK_1 368 375 PF02985 0.252
DOC_PP1_RVXF_1 273 279 PF00149 0.331
DOC_PP2B_LxvP_1 501 504 PF13499 0.686
DOC_PP2B_LxvP_1 699 702 PF13499 0.412
DOC_USP7_MATH_1 140 144 PF00917 0.411
DOC_USP7_MATH_1 145 149 PF00917 0.415
DOC_USP7_MATH_1 257 261 PF00917 0.489
DOC_USP7_MATH_1 330 334 PF00917 0.377
DOC_USP7_MATH_1 461 465 PF00917 0.743
DOC_USP7_MATH_1 539 543 PF00917 0.751
DOC_USP7_MATH_1 784 788 PF00917 0.349
DOC_USP7_UBL2_3 208 212 PF12436 0.529
DOC_USP7_UBL2_3 645 649 PF12436 0.425
DOC_WW_Pin1_4 237 242 PF00397 0.523
DOC_WW_Pin1_4 354 359 PF00397 0.427
DOC_WW_Pin1_4 414 419 PF00397 0.578
DOC_WW_Pin1_4 496 501 PF00397 0.760
DOC_WW_Pin1_4 692 697 PF00397 0.377
DOC_WW_Pin1_4 78 83 PF00397 0.561
DOC_WW_Pin1_4 790 795 PF00397 0.466
LIG_14-3-3_CanoR_1 165 169 PF00244 0.453
LIG_14-3-3_CanoR_1 259 268 PF00244 0.515
LIG_14-3-3_CanoR_1 275 281 PF00244 0.412
LIG_14-3-3_CanoR_1 407 414 PF00244 0.566
LIG_14-3-3_CanoR_1 416 424 PF00244 0.617
LIG_14-3-3_CanoR_1 623 631 PF00244 0.636
LIG_14-3-3_CanoR_1 806 814 PF00244 0.463
LIG_BRCT_BRCA1_1 132 136 PF00533 0.537
LIG_BRCT_BRCA1_1 278 282 PF00533 0.427
LIG_eIF4E_1 683 689 PF01652 0.466
LIG_FHA_1 157 163 PF00498 0.453
LIG_FHA_1 172 178 PF00498 0.423
LIG_FHA_1 21 27 PF00498 0.396
LIG_FHA_1 256 262 PF00498 0.484
LIG_FHA_1 284 290 PF00498 0.311
LIG_FHA_1 38 44 PF00498 0.208
LIG_FHA_1 497 503 PF00498 0.677
LIG_FHA_1 734 740 PF00498 0.345
LIG_FHA_1 768 774 PF00498 0.364
LIG_FHA_1 79 85 PF00498 0.511
LIG_FHA_1 820 826 PF00498 0.488
LIG_FHA_2 1 7 PF00498 0.504
LIG_FHA_2 102 108 PF00498 0.665
LIG_FHA_2 487 493 PF00498 0.768
LIG_FHA_2 633 639 PF00498 0.499
LIG_LIR_Apic_2 811 817 PF02991 0.456
LIG_LIR_Nem_3 262 268 PF02991 0.396
LIG_LIR_Nem_3 279 285 PF02991 0.208
LIG_LYPXL_yS_3 595 598 PF13949 0.601
LIG_MYND_1 500 504 PF01753 0.761
LIG_NRBOX 471 477 PF00104 0.665
LIG_Pex14_1 278 282 PF04695 0.331
LIG_Pex14_2 657 661 PF04695 0.331
LIG_SH2_CRK 265 269 PF00017 0.412
LIG_SH2_CRK 741 745 PF00017 0.379
LIG_SH2_CRK 748 752 PF00017 0.340
LIG_SH2_CRK 766 770 PF00017 0.189
LIG_SH2_NCK_1 748 752 PF00017 0.331
LIG_SH2_STAP1 352 356 PF00017 0.329
LIG_SH2_STAP1 685 689 PF00017 0.331
LIG_SH2_STAT5 206 209 PF00017 0.569
LIG_SH2_STAT5 456 459 PF00017 0.671
LIG_SH2_STAT5 642 645 PF00017 0.427
LIG_SH3_1 741 747 PF00018 0.466
LIG_SH3_3 223 229 PF00018 0.481
LIG_SH3_3 309 315 PF00018 0.331
LIG_SH3_3 599 605 PF00018 0.684
LIG_SH3_3 741 747 PF00018 0.364
LIG_SUMO_SIM_par_1 243 250 PF11976 0.457
LIG_SUMO_SIM_par_1 497 506 PF11976 0.724
LIG_TRAF2_1 366 369 PF00917 0.387
LIG_TRAF2_1 379 382 PF00917 0.402
LIG_TRAF2_1 386 389 PF00917 0.603
LIG_TYR_ITIM 746 751 PF00017 0.331
LIG_TYR_ITIM 764 769 PF00017 0.331
LIG_WRC_WIRS_1 282 287 PF05994 0.388
MOD_CDK_SPxK_1 354 360 PF00069 0.427
MOD_CDK_SPxxK_3 354 361 PF00069 0.427
MOD_CK1_1 130 136 PF00069 0.628
MOD_CK1_1 148 154 PF00069 0.404
MOD_CK1_1 156 162 PF00069 0.458
MOD_CK1_1 172 178 PF00069 0.456
MOD_CK1_1 281 287 PF00069 0.412
MOD_CK1_1 290 296 PF00069 0.412
MOD_CK1_1 420 426 PF00069 0.585
MOD_CK1_1 452 458 PF00069 0.721
MOD_CK1_1 505 511 PF00069 0.675
MOD_CK1_1 520 526 PF00069 0.727
MOD_CK1_1 532 538 PF00069 0.620
MOD_CK1_1 624 630 PF00069 0.633
MOD_CK1_1 730 736 PF00069 0.416
MOD_CK1_1 779 785 PF00069 0.328
MOD_CK1_1 86 92 PF00069 0.594
MOD_CK2_1 112 118 PF00069 0.738
MOD_CK2_1 172 178 PF00069 0.550
MOD_CK2_1 257 263 PF00069 0.498
MOD_CK2_1 523 529 PF00069 0.651
MOD_CK2_1 644 650 PF00069 0.489
MOD_CK2_1 705 711 PF00069 0.466
MOD_GlcNHglycan 118 121 PF01048 0.683
MOD_GlcNHglycan 155 158 PF01048 0.524
MOD_GlcNHglycan 242 245 PF01048 0.459
MOD_GlcNHglycan 253 256 PF01048 0.432
MOD_GlcNHglycan 292 295 PF01048 0.377
MOD_GlcNHglycan 298 301 PF01048 0.377
MOD_GlcNHglycan 384 387 PF01048 0.599
MOD_GlcNHglycan 419 422 PF01048 0.589
MOD_GlcNHglycan 451 454 PF01048 0.621
MOD_GlcNHglycan 483 489 PF01048 0.708
MOD_GlcNHglycan 510 513 PF01048 0.615
MOD_GlcNHglycan 525 528 PF01048 0.681
MOD_GlcNHglycan 542 545 PF01048 0.704
MOD_GlcNHglycan 606 609 PF01048 0.681
MOD_GlcNHglycan 618 621 PF01048 0.693
MOD_GlcNHglycan 707 710 PF01048 0.388
MOD_GlcNHglycan 751 754 PF01048 0.466
MOD_GlcNHglycan 8 11 PF01048 0.422
MOD_GSK3_1 112 119 PF00069 0.717
MOD_GSK3_1 126 133 PF00069 0.624
MOD_GSK3_1 156 163 PF00069 0.443
MOD_GSK3_1 164 171 PF00069 0.425
MOD_GSK3_1 17 24 PF00069 0.406
MOD_GSK3_1 212 219 PF00069 0.509
MOD_GSK3_1 240 247 PF00069 0.472
MOD_GSK3_1 251 258 PF00069 0.454
MOD_GSK3_1 283 290 PF00069 0.307
MOD_GSK3_1 452 459 PF00069 0.700
MOD_GSK3_1 502 509 PF00069 0.661
MOD_GSK3_1 517 524 PF00069 0.724
MOD_GSK3_1 575 582 PF00069 0.606
MOD_GSK3_1 621 628 PF00069 0.617
MOD_GSK3_1 701 708 PF00069 0.428
MOD_GSK3_1 78 85 PF00069 0.515
MOD_N-GLC_1 330 335 PF02516 0.412
MOD_N-GLC_1 346 351 PF02516 0.412
MOD_N-GLC_1 354 359 PF02516 0.405
MOD_NEK2_1 268 273 PF00069 0.412
MOD_NEK2_1 457 462 PF00069 0.582
MOD_NEK2_1 616 621 PF00069 0.678
MOD_NEK2_1 67 72 PF00069 0.556
MOD_NEK2_1 727 732 PF00069 0.391
MOD_NEK2_1 739 744 PF00069 0.277
MOD_NEK2_1 825 830 PF00069 0.375
MOD_NEK2_1 83 88 PF00069 0.401
MOD_NEK2_2 160 165 PF00069 0.563
MOD_NEK2_2 586 591 PF00069 0.701
MOD_PIKK_1 112 118 PF00454 0.757
MOD_PIKK_1 330 336 PF00454 0.362
MOD_PIKK_1 422 428 PF00454 0.579
MOD_PIKK_1 579 585 PF00454 0.679
MOD_PIKK_1 805 811 PF00454 0.462
MOD_PK_1 566 572 PF00069 0.640
MOD_PKA_2 164 170 PF00069 0.438
MOD_PKA_2 296 302 PF00069 0.331
MOD_PKA_2 406 412 PF00069 0.550
MOD_PKA_2 575 581 PF00069 0.678
MOD_PKA_2 624 630 PF00069 0.666
MOD_PKA_2 730 736 PF00069 0.466
MOD_PKA_2 785 791 PF00069 0.331
MOD_PKA_2 805 811 PF00069 0.481
MOD_PKA_2 819 825 PF00069 0.338
MOD_PKA_2 86 92 PF00069 0.535
MOD_PKB_1 623 631 PF00069 0.584
MOD_Plk_1 148 154 PF00069 0.390
MOD_Plk_1 20 26 PF00069 0.364
MOD_Plk_1 346 352 PF00069 0.405
MOD_Plk_1 572 578 PF00069 0.683
MOD_Plk_4 21 27 PF00069 0.331
MOD_Plk_4 244 250 PF00069 0.426
MOD_Plk_4 452 458 PF00069 0.706
MOD_Plk_4 462 468 PF00069 0.667
MOD_Plk_4 471 477 PF00069 0.495
MOD_Plk_4 785 791 PF00069 0.331
MOD_ProDKin_1 237 243 PF00069 0.520
MOD_ProDKin_1 354 360 PF00069 0.427
MOD_ProDKin_1 414 420 PF00069 0.579
MOD_ProDKin_1 496 502 PF00069 0.759
MOD_ProDKin_1 692 698 PF00069 0.377
MOD_ProDKin_1 78 84 PF00069 0.556
MOD_ProDKin_1 790 796 PF00069 0.466
MOD_SUMO_for_1 105 108 PF00179 0.793
MOD_SUMO_for_1 432 435 PF00179 0.689
MOD_SUMO_rev_2 30 39 PF00179 0.459
MOD_SUMO_rev_2 515 523 PF00179 0.716
MOD_SUMO_rev_2 524 532 PF00179 0.556
MOD_SUMO_rev_2 711 721 PF00179 0.412
MOD_SUMO_rev_2 730 739 PF00179 0.412
TRG_DiLeu_BaLyEn_6 229 234 PF01217 0.403
TRG_DiLeu_BaLyEn_6 41 46 PF01217 0.466
TRG_DiLeu_BaLyEn_6 79 84 PF01217 0.466
TRG_DiLeu_BaLyEn_6 821 826 PF01217 0.482
TRG_DiLeu_LyEn_5 497 502 PF01217 0.691
TRG_ENDOCYTIC_2 265 268 PF00928 0.412
TRG_ENDOCYTIC_2 595 598 PF00928 0.601
TRG_ENDOCYTIC_2 685 688 PF00928 0.331
TRG_ENDOCYTIC_2 748 751 PF00928 0.331
TRG_ENDOCYTIC_2 766 769 PF00928 0.331
TRG_ER_diArg_1 180 183 PF00400 0.537
TRG_ER_diArg_1 201 204 PF00400 0.475
TRG_ER_diArg_1 622 625 PF00400 0.696
TRG_NLS_MonoExtC_3 429 435 PF00514 0.706
TRG_NLS_MonoExtN_4 358 364 PF00514 0.412
TRG_Pf-PMV_PEXEL_1 232 236 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 27 31 PF00026 0.331
TRG_Pf-PMV_PEXEL_1 629 634 PF00026 0.610
TRG_Pf-PMV_PEXEL_1 652 656 PF00026 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4H3 Leptomonas seymouri 61% 100%
A0A3Q8IM41 Leishmania donovani 99% 100%
A4HMI7 Leishmania braziliensis 80% 100%
C9ZZH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AEY8 Leishmania major 93% 100%
E9B644 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P14242 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 96%
P54279 Mus musculus 26% 98%
V5BJF3 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS