LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IB66_LEIIN
TriTrypDb:
LINF_350021500
Length:
639

Annotations

Annotations by Jardim et al.

Structural Proteins, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 11
GO:0042995 cell projection 2 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 11

Expansion

Sequence features

A4IB66
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB66

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 11
GO:0007017 microtubule-based process 2 11
GO:0007018 microtubule-based movement 3 11
GO:0009987 cellular process 1 11
GO:0010970 transport along microtubule 4 11
GO:0030705 cytoskeleton-dependent intracellular transport 4 11
GO:0031503 protein-containing complex localization 2 11
GO:0035735 intraciliary transport involved in cilium assembly 4 11
GO:0042073 intraciliary transport 3 11
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0099111 microtubule-based transport 4 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 11 15 PF00656 0.551
CLV_NRD_NRD_1 123 125 PF00675 0.638
CLV_NRD_NRD_1 142 144 PF00675 0.555
CLV_NRD_NRD_1 165 167 PF00675 0.558
CLV_NRD_NRD_1 206 208 PF00675 0.525
CLV_NRD_NRD_1 298 300 PF00675 0.613
CLV_NRD_NRD_1 331 333 PF00675 0.501
CLV_NRD_NRD_1 337 339 PF00675 0.510
CLV_NRD_NRD_1 429 431 PF00675 0.543
CLV_PCSK_KEX2_1 110 112 PF00082 0.566
CLV_PCSK_KEX2_1 123 125 PF00082 0.530
CLV_PCSK_KEX2_1 167 169 PF00082 0.617
CLV_PCSK_KEX2_1 206 208 PF00082 0.525
CLV_PCSK_KEX2_1 240 242 PF00082 0.542
CLV_PCSK_KEX2_1 298 300 PF00082 0.613
CLV_PCSK_KEX2_1 331 333 PF00082 0.487
CLV_PCSK_KEX2_1 337 339 PF00082 0.484
CLV_PCSK_KEX2_1 349 351 PF00082 0.432
CLV_PCSK_KEX2_1 532 534 PF00082 0.561
CLV_PCSK_PC1ET2_1 110 112 PF00082 0.566
CLV_PCSK_PC1ET2_1 167 169 PF00082 0.648
CLV_PCSK_PC1ET2_1 240 242 PF00082 0.511
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.582
CLV_PCSK_PC1ET2_1 532 534 PF00082 0.561
CLV_PCSK_SKI1_1 167 171 PF00082 0.540
CLV_PCSK_SKI1_1 240 244 PF00082 0.534
CLV_PCSK_SKI1_1 361 365 PF00082 0.488
CLV_PCSK_SKI1_1 397 401 PF00082 0.560
CLV_PCSK_SKI1_1 402 406 PF00082 0.558
CLV_PCSK_SKI1_1 412 416 PF00082 0.469
CLV_PCSK_SKI1_1 635 639 PF00082 0.646
CLV_Separin_Metazoa 362 366 PF03568 0.580
DEG_APCC_KENBOX_2 605 609 PF00400 0.609
DEG_Nend_UBRbox_3 1 3 PF02207 0.598
DEG_SPOP_SBC_1 40 44 PF00917 0.655
DOC_ANK_TNKS_1 69 76 PF00023 0.599
DOC_MAPK_DCC_7 76 85 PF00069 0.784
DOC_MAPK_gen_1 109 117 PF00069 0.499
DOC_MAPK_gen_1 358 366 PF00069 0.599
DOC_MAPK_gen_1 397 407 PF00069 0.535
DOC_MAPK_gen_1 475 484 PF00069 0.544
DOC_MAPK_MEF2A_6 185 194 PF00069 0.518
DOC_MAPK_MEF2A_6 400 407 PF00069 0.545
DOC_MAPK_MEF2A_6 475 484 PF00069 0.576
DOC_MAPK_MEF2A_6 76 85 PF00069 0.791
DOC_MAPK_NFAT4_5 400 408 PF00069 0.544
DOC_USP7_MATH_1 215 219 PF00917 0.584
DOC_USP7_MATH_1 380 384 PF00917 0.449
DOC_USP7_MATH_1 40 44 PF00917 0.649
DOC_USP7_MATH_1 455 459 PF00917 0.728
DOC_USP7_MATH_1 497 501 PF00917 0.620
DOC_USP7_MATH_1 54 58 PF00917 0.743
DOC_USP7_MATH_1 74 78 PF00917 0.710
DOC_USP7_MATH_1 86 90 PF00917 0.587
DOC_WW_Pin1_4 50 55 PF00397 0.699
DOC_WW_Pin1_4 59 64 PF00397 0.692
DOC_WW_Pin1_4 76 81 PF00397 0.780
LIG_14-3-3_CanoR_1 572 579 PF00244 0.603
LIG_14-3-3_CanoR_1 611 620 PF00244 0.572
LIG_14-3-3_CanoR_1 76 80 PF00244 0.785
LIG_Actin_WH2_2 144 161 PF00022 0.638
LIG_FHA_1 182 188 PF00498 0.487
LIG_FHA_1 189 195 PF00498 0.513
LIG_FHA_1 380 386 PF00498 0.591
LIG_FHA_1 387 393 PF00498 0.573
LIG_FHA_1 40 46 PF00498 0.663
LIG_FHA_1 440 446 PF00498 0.607
LIG_FHA_1 548 554 PF00498 0.557
LIG_FHA_1 565 571 PF00498 0.379
LIG_FHA_2 17 23 PF00498 0.635
LIG_FHA_2 491 497 PF00498 0.572
LIG_FHA_2 602 608 PF00498 0.572
LIG_HCF-1_HBM_1 342 345 PF13415 0.558
LIG_LIR_Gen_1 33 41 PF02991 0.623
LIG_LIR_Gen_1 468 476 PF02991 0.525
LIG_LIR_Nem_3 104 108 PF02991 0.526
LIG_LIR_Nem_3 33 38 PF02991 0.626
LIG_LIR_Nem_3 468 473 PF02991 0.607
LIG_PDZ_Class_2 634 639 PF00595 0.602
LIG_RPA_C_Fungi 255 267 PF08784 0.510
LIG_RPA_C_Fungi 494 506 PF08784 0.621
LIG_SH2_GRB2like 272 275 PF00017 0.585
LIG_SH2_PTP2 470 473 PF00017 0.627
LIG_SH2_SRC 12 15 PF00017 0.527
LIG_SH2_STAP1 272 276 PF00017 0.585
LIG_SH2_STAP1 530 534 PF00017 0.575
LIG_SH2_STAT3 345 348 PF00017 0.545
LIG_SH2_STAT5 105 108 PF00017 0.552
LIG_SH2_STAT5 12 15 PF00017 0.484
LIG_SH2_STAT5 421 424 PF00017 0.517
LIG_SH2_STAT5 470 473 PF00017 0.552
LIG_SH2_STAT5 530 533 PF00017 0.608
LIG_SH3_3 80 86 PF00018 0.742
LIG_SUMO_SIM_anti_2 253 259 PF11976 0.537
LIG_SUMO_SIM_anti_2 483 489 PF11976 0.539
LIG_SUMO_SIM_par_1 599 604 PF11976 0.469
LIG_SUMO_SIM_par_1 614 622 PF11976 0.436
LIG_TRAF2_1 179 182 PF00917 0.608
LIG_TRAF2_1 224 227 PF00917 0.570
LIG_TRAF2_1 289 292 PF00917 0.486
LIG_TRAF2_1 414 417 PF00917 0.522
LIG_TRAF2_1 566 569 PF00917 0.610
LIG_TRAF2_1 619 622 PF00917 0.592
LIG_UBA3_1 599 606 PF00899 0.391
MOD_CDK_SPxxK_3 63 70 PF00069 0.734
MOD_CK1_1 218 224 PF00069 0.605
MOD_CK1_1 34 40 PF00069 0.690
MOD_CK1_1 368 374 PF00069 0.550
MOD_CK1_1 528 534 PF00069 0.610
MOD_CK1_1 79 85 PF00069 0.701
MOD_CK1_1 91 97 PF00069 0.564
MOD_CK2_1 16 22 PF00069 0.625
MOD_CK2_1 286 292 PF00069 0.512
MOD_CK2_1 373 379 PF00069 0.538
MOD_CK2_1 490 496 PF00069 0.525
MOD_CK2_1 497 503 PF00069 0.543
MOD_CK2_1 517 523 PF00069 0.283
MOD_CK2_1 572 578 PF00069 0.555
MOD_CK2_1 601 607 PF00069 0.516
MOD_CK2_1 616 622 PF00069 0.591
MOD_DYRK1A_RPxSP_1 76 80 PF00069 0.803
MOD_GlcNHglycan 14 17 PF01048 0.612
MOD_GlcNHglycan 457 460 PF01048 0.754
MOD_GlcNHglycan 519 522 PF01048 0.611
MOD_GlcNHglycan 99 102 PF01048 0.612
MOD_GSK3_1 214 221 PF00069 0.540
MOD_GSK3_1 242 249 PF00069 0.595
MOD_GSK3_1 27 34 PF00069 0.695
MOD_GSK3_1 365 372 PF00069 0.548
MOD_GSK3_1 455 462 PF00069 0.687
MOD_GSK3_1 50 57 PF00069 0.701
MOD_GSK3_1 528 535 PF00069 0.576
MOD_GSK3_1 59 66 PF00069 0.708
MOD_GSK3_1 75 82 PF00069 0.665
MOD_GSK3_1 8 15 PF00069 0.587
MOD_GSK3_1 97 104 PF00069 0.576
MOD_N-GLC_1 497 502 PF02516 0.591
MOD_N-GLC_1 512 517 PF02516 0.560
MOD_N-GLC_1 59 64 PF02516 0.788
MOD_NEK2_1 158 163 PF00069 0.596
MOD_NEK2_1 208 213 PF00069 0.552
MOD_NEK2_1 31 36 PF00069 0.719
MOD_NEK2_1 41 46 PF00069 0.600
MOD_NEK2_1 88 93 PF00069 0.626
MOD_NEK2_2 215 220 PF00069 0.588
MOD_PIKK_1 16 22 PF00454 0.610
MOD_PIKK_1 547 553 PF00454 0.564
MOD_PIKK_1 564 570 PF00454 0.571
MOD_PIKK_1 590 596 PF00454 0.571
MOD_PK_1 532 538 PF00069 0.602
MOD_PKA_1 532 538 PF00069 0.602
MOD_PKA_2 158 164 PF00069 0.576
MOD_PKA_2 386 392 PF00069 0.574
MOD_PKA_2 459 465 PF00069 0.637
MOD_PKA_2 532 538 PF00069 0.602
MOD_PKA_2 75 81 PF00069 0.803
MOD_PKB_1 315 323 PF00069 0.606
MOD_Plk_1 243 249 PF00069 0.575
MOD_Plk_1 27 33 PF00069 0.666
MOD_Plk_1 286 292 PF00069 0.512
MOD_Plk_1 590 596 PF00069 0.479
MOD_Plk_1 606 612 PF00069 0.483
MOD_Plk_2-3 22 28 PF00069 0.655
MOD_Plk_2-3 373 379 PF00069 0.538
MOD_Plk_2-3 580 586 PF00069 0.519
MOD_Plk_2-3 622 628 PF00069 0.589
MOD_Plk_4 101 107 PF00069 0.584
MOD_Plk_4 34 40 PF00069 0.698
MOD_Plk_4 41 47 PF00069 0.722
MOD_Plk_4 532 538 PF00069 0.602
MOD_Plk_4 8 14 PF00069 0.492
MOD_Plk_4 88 94 PF00069 0.700
MOD_ProDKin_1 50 56 PF00069 0.698
MOD_ProDKin_1 59 65 PF00069 0.691
MOD_ProDKin_1 76 82 PF00069 0.778
MOD_SUMO_for_1 169 172 PF00179 0.603
MOD_SUMO_for_1 179 182 PF00179 0.592
MOD_SUMO_for_1 414 417 PF00179 0.602
MOD_SUMO_rev_2 161 169 PF00179 0.642
MOD_SUMO_rev_2 232 242 PF00179 0.468
MOD_SUMO_rev_2 287 295 PF00179 0.482
MOD_SUMO_rev_2 342 351 PF00179 0.507
MOD_SUMO_rev_2 520 526 PF00179 0.607
MOD_SUMO_rev_2 575 584 PF00179 0.585
TRG_DiLeu_BaEn_1 300 305 PF01217 0.611
TRG_DiLeu_BaEn_4 328 334 PF01217 0.554
TRG_ENDOCYTIC_2 105 108 PF00928 0.496
TRG_ENDOCYTIC_2 470 473 PF00928 0.555
TRG_ER_diArg_1 122 124 PF00400 0.642
TRG_ER_diArg_1 129 132 PF00400 0.570
TRG_ER_diArg_1 192 195 PF00400 0.586
TRG_ER_diArg_1 205 207 PF00400 0.509
TRG_ER_diArg_1 276 279 PF00400 0.497
TRG_ER_diArg_1 297 299 PF00400 0.588
TRG_ER_diArg_1 312 315 PF00400 0.609
TRG_ER_diArg_1 331 333 PF00400 0.573
TRG_NES_CRM1_1 181 196 PF08389 0.570
TRG_NES_CRM1_1 394 409 PF08389 0.540
TRG_NES_CRM1_1 615 630 PF08389 0.550
TRG_NLS_MonoExtC_3 166 172 PF00514 0.633
TRG_NLS_MonoExtN_4 166 171 PF00514 0.640
TRG_Pf-PMV_PEXEL_1 325 329 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 331 335 PF00026 0.486
TRG_Pf-PMV_PEXEL_1 350 355 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 397 401 PF00026 0.488
TRG_Pf-PMV_PEXEL_1 543 547 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5Z0 Leptomonas seymouri 72% 95%
A0A0S4J233 Bodo saltans 30% 78%
A0A1X0P6M5 Trypanosomatidae 46% 100%
A0A3Q8IHW5 Leishmania donovani 100% 100%
A4HMI6 Leishmania braziliensis 89% 100%
C9ZZH6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 97%
E9AEY7 Leishmania major 96% 100%
E9B643 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BTK9 Trypanosoma cruzi 45% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS