Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IB65_LEIIN

TriTrypDb:

LINF_350021400

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IB65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IB65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.717
CLV_NRD_NRD_1	228	230	PF00675	0.469
CLV_NRD_NRD_1	253	255	PF00675	0.489
CLV_PCSK_KEX2_1	228	230	PF00082	0.469
CLV_PCSK_KEX2_1	253	255	PF00082	0.479
CLV_PCSK_SKI1_1	244	248	PF00082	0.501
CLV_PCSK_SKI1_1	276	280	PF00082	0.454
CLV_PCSK_SKI1_1	72	76	PF00082	0.444
DEG_SCF_TRCP1_1	25	31	PF00400	0.535
DOC_MIT_MIM_1	347	356	PF04212	0.467
DOC_PP4_FxxP_1	144	147	PF00568	0.580
DOC_USP7_MATH_1	120	124	PF00917	0.792
DOC_USP7_MATH_1	189	193	PF00917	0.639
DOC_USP7_MATH_1	218	222	PF00917	0.564
DOC_USP7_MATH_1	311	315	PF00917	0.521
DOC_USP7_MATH_1	327	331	PF00917	0.532
DOC_USP7_MATH_1	50	54	PF00917	0.605
DOC_WW_Pin1_4	157	162	PF00397	0.677
DOC_WW_Pin1_4	54	59	PF00397	0.486
DOC_WW_Pin1_4	75	80	PF00397	0.581
DOC_WW_Pin1_4	88	93	PF00397	0.699
LIG_14-3-3_CanoR_1	320	328	PF00244	0.408
LIG_14-3-3_CanoR_1	95	104	PF00244	0.796
LIG_Actin_WH2_2	293	309	PF00022	0.566
LIG_APCC_ABBA_1	265	270	PF00400	0.424
LIG_EH1_1	240	248	PF00400	0.495
LIG_FHA_1	55	61	PF00498	0.611
LIG_LIR_Apic_2	142	147	PF02991	0.586
LIG_LIR_Gen_1	28	38	PF02991	0.590
LIG_LIR_Nem_3	263	269	PF02991	0.437
LIG_LIR_Nem_3	280	285	PF02991	0.550
LIG_LYPXL_S_1	265	269	PF13949	0.365
LIG_MAD2	4	12	PF02301	0.614
LIG_NRBOX	212	218	PF00104	0.522
LIG_PDZ_Class_3	351	356	PF00595	0.516
LIG_Pex14_2	265	269	PF04695	0.537
LIG_SH2_STAP1	30	34	PF00017	0.523
LIG_SH2_STAT3	283	286	PF00017	0.598
LIG_SH2_STAT5	166	169	PF00017	0.494
LIG_SH3_3	13	19	PF00018	0.628
LIG_SH3_3	3	9	PF00018	0.620
LIG_TRAF2_1	129	132	PF00917	0.751
LIG_WW_1	146	149	PF00397	0.656
MOD_CDK_SPxxK_3	54	61	PF00069	0.476
MOD_CDK_SPxxK_3	75	82	PF00069	0.553
MOD_CDK_SPxxK_3	88	95	PF00069	0.563
MOD_CK1_1	152	158	PF00069	0.626
MOD_CK1_1	160	166	PF00069	0.472
MOD_CK1_1	190	196	PF00069	0.521
MOD_CK1_1	28	34	PF00069	0.620
MOD_CK2_1	126	132	PF00069	0.688
MOD_CK2_1	189	195	PF00069	0.718
MOD_CK2_1	319	325	PF00069	0.415
MOD_GlcNHglycan	128	131	PF01048	0.682
MOD_GlcNHglycan	152	155	PF01048	0.544
MOD_GlcNHglycan	192	195	PF01048	0.656
MOD_GlcNHglycan	24	28	PF01048	0.665
MOD_GlcNHglycan	286	289	PF01048	0.635
MOD_GlcNHglycan	321	324	PF01048	0.459
MOD_GlcNHglycan	52	55	PF01048	0.689
MOD_GlcNHglycan	98	101	PF01048	0.681
MOD_GSK3_1	149	156	PF00069	0.736
MOD_GSK3_1	25	32	PF00069	0.617
MOD_GSK3_1	284	291	PF00069	0.560
MOD_GSK3_1	46	53	PF00069	0.622
MOD_NEK2_1	23	28	PF00069	0.596
MOD_PIKK_1	160	166	PF00454	0.559
MOD_PKA_2	149	155	PF00069	0.650
MOD_PKA_2	319	325	PF00069	0.455
MOD_Plk_4	11	17	PF00069	0.592
MOD_Plk_4	29	35	PF00069	0.568
MOD_Plk_4	327	333	PF00069	0.534
MOD_ProDKin_1	157	163	PF00069	0.674
MOD_ProDKin_1	54	60	PF00069	0.480
MOD_ProDKin_1	75	81	PF00069	0.591
MOD_ProDKin_1	88	94	PF00069	0.700
MOD_SUMO_rev_2	99	108	PF00179	0.553
TRG_DiLeu_BaEn_1	177	182	PF01217	0.555
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.439
TRG_ENDOCYTIC_2	266	269	PF00928	0.401
TRG_ENDOCYTIC_2	282	285	PF00928	0.546
TRG_ENDOCYTIC_2	30	33	PF00928	0.525
TRG_ER_diArg_1	241	244	PF00400	0.480
TRG_ER_diArg_1	349	352	PF00400	0.387
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKF7	Leptomonas seymouri	36%	100%
A0A3S7X929	Leishmania donovani	99%	100%
A4HMI5	Leishmania braziliensis	72%	100%
E9AEY6	Leishmania major	90%	100%
E9B642	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%